JP2000128752A - Tooth enamel recalcification promoter and composition for oral cavity and food/drink - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject promoter safe even if used in compositions for oral cavity or foods/drinks, capable of effectively promoting the recalcification of decalcified tooth enamel and positively inhibiting dental caries. SOLUTION: This recalcification promoter comprises, as active ingredients, a sugar alcohol and calcium secondary phosphate (and sea algae and/or extract therefrom); wherein the sugar alcohol is pref. xylitol, while the sea algae pref. glue plant because of having significant effect. The other objective composition for oral cavity and food/drink are each obtained by adding the above recalcification promoter, or separately adding a sugar alcohol and calcium secondary phosphate (and sea algae and/or extract therefrom).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a remineralization accelerator for tooth enamel, to which a remineralization accelerator is added, or a sugar alcohol and dicalcium phosphate are separately added, or a sugar alcohol is added. , Dibasic calcium phosphate, seaweeds and / or extracts thereof are separately added to oral compositions and foods and drinks.

[0002]

2. Description of the Related Art In general, dental caries is caused by oral streptococci (cariogenic bacteria) such as Streptococcus mutans and Streptococcus sobrinus adhering to the tooth surface, and the action of glucosyltransferase enzymes of these bacteria. It starts with the formation of plaque (plaque), which is where glucan is produced and propagated. In the plaque, the acid generated by the bacteria metabolizing sugar, starch, and the like in the food residue demineralizes the tooth enamel, resulting in a so-called initial caries state.

[0003] Saliva contains calcium and phosphate,
These have the effect of restoring or remineralizing the demineralized portion to return the tooth to its original state. In other words, on the tooth surface, conflicting phenomena of demineralization and remineralization always occur and usually maintain a balance of ownership. However, the balance leans toward demineralization as the plaque increases and progresses to dental caries.

[0004] The crystals constituting the enamel on the tooth surface are:
Hexagonal hydroxyapatite Ca ₁₀ (PO ₄ )
In ₆ OH _2, and a phosphate or calcium.
The demineralization observed in early caries is the dissolution of the tooth enamel inorganic component, and the remineralization can be said to be the repair and regrowth of the remaining calcium phosphate crystals that have remained undissolved.

[0005] Hitherto, for the prevention of dental caries, a tooth adhesion inhibitor and an antibacterial agent for cariogenic bacteria, and a glucosyltransferase enzyme inhibitor for suppressing the formation of glucan by cariogenic bacteria have been developed. However, for example, an antibacterial agent is not a specific material exhibiting an antibacterial effect only on caries, and thus has a problem in safety, and a glucosyltransferase enzyme inhibitor has a problem that it is easily affected by saliva.

Further, hydroxyapatite having a crystal structure similar to the inorganic component of the tooth and fluoride are blended,
A tooth decay preventive composition for remineralizing the surface layer of tooth demineralization is known (Japanese Patent Publication No. 2-31049), but a fluoride such as sodium fluoride, sodium monofluorophosphate or stannous fluoride is used. There is a problem in terms of safety when it is added to an oral composition or a food or drink.

[0007] It is known that demineralized tooth enamel is remineralized by using a combination of hydroxyapatite fine particles and xylitol (Japanese Patent Application Laid-open No. Hei 9-175963). The obtained hydroxyapatite is a chemically stable compound with low reactivity, and strictly speaking, has a different crystal structure from hydroxyapatite constituting teeth in a living body, so that the effect of remineralization is not sufficient.

[0008] Further, an oral composition containing a liquefied calcium phosphate compound is also known (Japanese Patent Application Laid-Open No. Hei 8 (1996)).
JP-A-319224), the effect of remineralization is not sufficient with calcium phosphate alone.

[0009]

In view of the above, the present invention has no problem in safety even when used in oral compositions and foods and drinks, and has an effect of remineralizing demineralized tooth enamel. The purpose of the present invention is to provide a remineralization accelerator, an oral composition, and food and drink, which can promote carcinogenesis and can actively suppress dental caries.

[0010]

Means for Solving the Problems As a result of intensive studies, the present inventor has found that a combination of a sugar alcohol and dibasic calcium phosphate and further a combination of a seaweed and / or an extract thereof are used. As a result, the present inventors have found that the above object is achieved, and have completed the present invention.

The tooth enamel remineralization accelerator according to the present invention comprises a sugar alcohol and dibasic calcium phosphate as active ingredients, or a sugar alcohol and dibasic calcium phosphate, seaweed and / or an extract thereof. An active ingredient. Xylitol is preferred as the sugar alcohol, and funori is preferred as the seaweed because of its remarkable effect.

The oral composition and the food and drink of the present invention may contain the above-mentioned tooth enamel remineralization accelerator, or
Sugar alcohol and dicalcium phosphate are added separately, or sugar alcohol, dicalcium phosphate,
It is produced by separately adding seaweed and / or its extract.

In the above, examples of the sugar alcohol include xylitol, sorbitol, mannitol, arabitol, erythritol, lactitol, maltitol, palatinit and the like, with xylitol being particularly preferred.

Xylitol is a sugar alcohol having five carbons, and is widely recognized in specific components of plants and in human metabolic systems. In addition, xylitol is expressed in p
It is a non-acid-producing sweetener that does not reduce H at all, and the habitual intake of xylitol is attributed to the cariogenic bacteria Streptococcus mutans and Streptococcus sobrinus.
It has also been reported that the number of streptococci in the oral cavity is reduced from the oral cavity.

In addition, dicalcium phosphate (CaHPO)
₄ · nH ₂ O; n = 0 to 2) is the Japanese Pharmacopoeia (JP),
It is known under the name of cosmetic raw material standard, calcium hydrogen phosphate for dental use, calcium monohydrogen phosphate for food additives, and calcium hydrogen phosphate dihydrate for JIS reagent special grade. The dibasic calcium phosphate has many anhydrous salts and dihydrate salts, and is a tasteless and odorless crystalline powder belonging to a hexagonal or orthorhombic system.

The hydroxyapatite crystal constituting the enamel on the tooth surface is composed of calcium phosphate and is considered to be an effective source of calcium and phosphoric acid. The xylitol increases saliva secretion,
It is known that it acts as a carrier for calcium and does not lower the pH, and thus has a required remineralization promoting action. However, the present inventor is the first to find that remineralization of tooth enamel is remarkably promoted by the combined use of xylitol and dibasic calcium phosphate.

The use of the above-mentioned sugar alcohol and dicalcium phosphate in combination with a remineralization accelerator in oral compositions or foods and drinks can sufficiently promote remineralization of tooth enamel. It was also found that remineralization can be remarkably promoted by using seaweed and / or an extract thereof in combination.

As the seaweeds, as red algae, the order of the order of Bosnaceae, Chinorimo, Benidomidro, Osmanthus,
From the order of the sea elephant, the order of the order of the order, the order of the creatures, the order of the scallop, the order of the order of the order, the order of the order of the order, the order of the order of the order of the order of the algae, as brown algae, the order of the order Shimidori, the order of the order of the order of the order, the order of the order of the order, the order of the order of the eyes, the order of the order of the asteraceae, the order of the order of the key to the order, the order of the order of the order, the order of the order of the order, the order of the order of the order of the order, the order of the order of the fennel, From the order Laminaria, the order Habamata, etc., as a green algae, it can be appropriately selected and used from the order of the algae, the order of the order Hibidodera, the order of the blue, the order of the green, the order of the moss, the order of the miller, etc. It is preferred to use.

This funori is of the order Kryktonemi
ales) Endocladiaceae
tis), which are seaweeds distributed mainly in the North Pacific Ocean.
rcata), mahunori (G.tenax), hanafunori (G.comp)
lanata) have been collected. Funori has been edible as a miso soup ingredient, sashimi clam, buckwheat binder or seaweed salad ingredient. In addition, the funori is called "Kazunasai" in "Honzo-no-Tsukume" and is described as having an antipyretic effect and combing stones such as gallstones, and there is no problem in safety.

The above-described seaweeds may be used alone after chopping or pulverizing after drying as required, or once obtaining an extract and granulating or pulverizing it. Of course, they may be used in combination.

The method for obtaining the seaweed extract is not particularly limited. For example, the extraction is carried out using water or an organic solvent, particularly an organic solvent compatible with water. The extract can be further fractionated and purified by an organic solvent, column chromatography or the like, and used for use.

Further, the above seaweed or its extract is dissolved or dispersed in a suitable liquid carrier, or
Mixed with or adsorbed on a suitable powder carrier,
In some cases, an emulsifier, a dispersant, a suspending agent, a spreading agent, a penetrant, a wetting agent, a stabilizer, or the like may be added, and the composition may be formulated into an emulsion, a wettable powder, a powder, or a tablet for use. It is.

The oral composition of the present invention includes toothpaste,
Examples include dentifrices such as powdered toothpastes and liquid toothpastes, mouthwashes, gum massage creams, gargle tablets, troches and the like.
In addition, as food and drink, chewing gum, candy,
Confectionery such as tablet confections, gummy jelly, chocolate, biscuits, snacks, etc., ice creams, sorbets, frozen desserts such as ice desserts, beverages, bread, hot cakes, dairy products, meat products such as hams and sausages, fish products such as kamaboko and chikuwa , Side dishes, pudding, soup, jam and the like.

The amount of sugar alcohol, dibasic calcium phosphate, seaweed and / or its extract to be added to the oral composition or the food or drink is difficult to determine unconditionally depending on the form of the oral composition or the food or drink. However, it is preferably 1.0 to 98.0% by weight, 0.01% to 10.0% by weight, and 0.01% to 5.0% by weight, respectively.

In the present invention, as a method for adding a sugar alcohol, dibasic calcium phosphate, seaweed and / or an extract thereof to an oral composition or a food or drink, the method may be carried out at any time during the production process of the product. It may be mixed with the remaining raw materials. In addition, in the production of an oral composition or food or drink by adding the sugar alcohol, dicalcium phosphate, seaweed and / or an extract thereof,
They may be mixed in advance, that is, added as the remineralization accelerator of the present invention according to claims 1 to 4, or separately, that is, separately added sugar alcohol and dicalcium phosphate, or , Sugar alcohol, dibasic calcium phosphate, seaweed and / or an extract thereof may be separately added. Hereinafter, examples and test examples of the present invention will be described, but the scope of the present invention is not limited thereto.

[0026]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Preparation of powdered Funori extract A 50 g of Fukunori was washed with water, extracted with 1 liter of hot water for 2 hours, filtered to remove impurities, and the purified filtrate was taken up in 6 liters of methanol. The extract was put therein to precipitate, centrifuged, dried, pulverized and pulverized to obtain 8 g of a powdery funori extract.

Preparation of Powdered Funori Extract B 50 g of Fukuronori was washed with water, immersed in 1 liter of water all day and night, filtered to remove impurities, and the filtrate was concentrated. I got

Preparation of Powdered Ogonori Extract and Powdered Kombu Extract 2 g of powdered Ogonori extract and 7 g of powdered kelp extract were obtained in the same manner as for the extract of Funori.

Example 1 1000 parts by weight of xylitol and dibasic calcium phosphate 1
The parts by weight were mixed well to obtain a remineralization accelerator as a powder.

Example 2 1000 parts by weight of xylitol, dibasic calcium phosphate 1
Parts by weight and 0.5 part by weight of the powdered Funori extract A were mixed well to obtain a remineralization accelerator as a powder.

Remineralization promoting effect test 1 Referring to the method of the remineralization promoting effect confirmation test using human extracted teeth described in Dental Science Vol. 89, No. 9, 1441-1455 (1989). I went as follows. The surface of the enamel block of the human extracted tooth was entirely coated with sticky wax, leaving a 3 × 4 mm window, and heated to 50 ° C. 0.01M acetic acid / sodium acetate buffer (pH
4.0) for 2 days to form a demineralized layer (see FIG. 1). Thereafter, half of the window was covered with wax to prepare a test tooth enamel block.

The remineralization treatment was performed at 50 mM KCl, 1 m
M potassium phosphate, pH 7.3 KCl buffer containing 0.1 mM MgCl ₂ was used to prepare the following six types of solutions, which were heated to 37 ° C., and each of them was subjected to a test tooth enamel. One block each was immersed for two weeks. However, each solution was replaced with a new solution every two days.

KCl buffer KC containing 0.02% by weight of dicalcium phosphate
1 buffer The powder of Example 1, ie, K containing 0.02% by weight of dibasic calcium phosphate and 20% by weight of xylitol.
Cl buffer The powder of Example 2, that is, a KCl buffer containing 0.02% by weight of dibasic calcium phosphate, 20% by weight of xylitol, and 0.01% by weight of powdered Funori extract A 0.02% by weight of tribasic calcium phosphate KC containing weight%
1 buffer KCl buffer containing 0.02% by weight of tribasic calcium phosphate and 20% by weight of xylitol

After the remineralization treatment, the wax of each test tooth enamel block was removed and a polyester resin (Regolac) was removed.
Resin), 100 μm polished sections were prepared, and contact microradiograms (CMR) were taken. The photographing conditions were 10 kV, 3 mA, irradiation time 30 minutes, and photographed simultaneously with an aluminum foil step wedge as a reference.
Development was carried out according to a general method.

Microradiography (MR)
The degree of remineralization resulting from the above was visually evaluated in the following six stages. Remineralization level 0 No remineralization is observed in the enamel demineralized layer. Remineralization 1 Remineralization is slightly recognized on the surface of demineralized enamel. Remineralization 2 Remineralization is relatively strong on the surface of the demineralized enamel. Alternatively, remineralization is observed in the enamel demineralized surface layer and deep layer. Remineralization degree 3 Remineralization is generally observed from the enamel demineralized surface layer to the deep layer. Remineralization degree 4 A strong remineralization is generally observed from the enamel demineralized surface layer to the deep layer. Remineralization degree 5 Remineralization is recognized almost completely from the enamel demineralized surface layer to the entire deep layer.

The results of microradiography (MR) of the test tooth enamel block after the remineralization treatment are shown in FIGS. FIG. 1 shows the MR after treatment with the KCl buffer, in which no remineralization is observed in the enamel demineralized layer (remineralization degree 0). FIG. 2 shows the MR after treatment with the KCl buffer, in which relatively strong remineralization is recognized from the enamel demineralized surface layer (remineralization degree 2). FIG. 3 shows the MR after treatment with the KCl buffer solution, in which remineralization is observed throughout the enamel demineralized surface layer and deep layer (remineralization degree 3). FIG. 4 shows the MR after treatment with the KCl buffer solution. Intense remineralization is observed from the enamel demineralized surface layer to the deep layer (remineralization degree 4). FIG. 5 shows the MR after treatment with the KCl buffer, in which no remineralization was observed in the enamel demineralized layer (remineralization degree 0). FIG. 6 shows the MR after treatment with the KCl buffer, in which no remineralization is observed in the enamel demineralized layer (remineralization degree 0).

According to the above, it has been confirmed that dicalcium phosphate has a remineralization promoting effect, and it is recognized that the remineralization promoting effect is significantly increased by using xylitol in combination. It is also recognized that the combined use of dibasic calcium phosphate, xylitol, and funnel extract further remarkably enhances its remineralization effect. In contrast, tricalcium phosphate having a structure close to apatite has no remineralization promoting effect. This indicates that dicalcium phosphate is effective as calcium phosphate having a remineralizing effect on tooth enamel.

Examples 3 and 4 (chewing gum) Chewing gums of Examples 3 and 4 and Comparative Example 1 were prepared according to the formulation shown in Table 1 using dibasic calcium phosphate and xylitol, palatinit and maltitol as sugar alcohols.

[0039]

[Table 1]

Remineralization promoting effect test 2 The remineralization promoting effect of the chewing gums of Examples 3, 4 and Comparative Example 1 was evaluated by the following method. The operation of extracting the active ingredient of chewing gum is described in "Basic research for comprehensively evaluating the cariogenicity of foods and sugar substitutes (Project No. 0).
4304045) 1993 Scientific Research Grants Research Results Report (Principal Investigator Tadashi Yamada);

Each of the chewing gums of Examples 3 and 4 and Comparative Example 1 is fragmented and 10 g is weighed. For each, 1 mM CaCl ₂ , 0.6 mM
KH ₂ PO ₄ , containing 100 mM NaCl, 50 m
50 ml of a remineralization solution (60 ° C.) adjusted to pH 7.3 with an M KOH solution was added, and the mixture was crushed well with a glass rod to elute the components. Further, the same remineralization solution (60 ° C.) ) After adding 50 ml and performing the elution operation again, the fine gum base was removed by centrifugation to obtain three types of chewing gum extracts corresponding to the chewing gums of Examples 3, 4 and Comparative Example 1.

In each of the three chewing gum extracts, three tooth enamel blocks for testing were immersed at 37 ° C. for 2 weeks. During this time, the extract was replaced with a new chewing gum extract every two days. The results of microradiography (MR) of each test tooth enamel block were visually evaluated for the degree of remineralization on a six-point scale in the same manner as in the remineralization accelerating effect test 1; The remineralization degree according to Comparative Example 4 and Comparative Example 1 was calculated as an average value of each of the three test tooth enamel blocks, and is shown in a graph in FIG.

The chewing gum of Comparative Example 1 (without addition of dicalcium phosphate) had a remineralization degree of 1.67, whereas the chewing gum of Example 3 (gum with 0.2% of dicalcium phosphate) was re-calculated. Calcification degree 3.00, chewing gum of Example 4
05% added gum) had a remineralization degree of 2.67, and a remineralization promoting effect was recognized depending on the concentration of dibasic calcium phosphate.

Examples 5 and 6 (tablets) Tablets of Examples 5 and 6 and Comparative Example 2 were prepared according to the formulation shown in Table 2 using dibasic calcium phosphate and xylitol as a sugar alcohol.

[0045]

[Table 2]

Remineralization promoting effect test 3 The remineralization promoting effect of the tablets of Examples 5, 6 and Comparative Example 2 was evaluated by the following method. The extraction procedure of the active ingredient of tablet confections is described in "Basic Research for Comprehensively Evaluating Caries Inducibility of Foods and Sugar Substitutes (Project No. 043004045)" YADA Tadashi); p86-89 ".

Each of the tablet confections of Examples 5 and 6 and Comparative Example 2 is fragmented and 10 g is weighed. To each of them, 100 ml of a remineralization solution (60 ° C.) having the same composition as in the remineralization promoting effect test 2 was added and dissolved, and three kinds corresponding to each of the tablets of Examples 5, 6 and Comparative Example 2 were dissolved. A tablet confectionery extract was obtained.

As in the case of the remineralization accelerating effect test 2, three tooth enamel blocks for testing were immersed in each of the three types of tablet confectionery extract at 37 ° C. for 2 weeks. During this period, the tablet was replaced with a new one every two days.
The results of microradiography (MR) of each test tooth enamel block were visually evaluated for the degree of remineralization in six steps in the same manner as in the remineralization accelerating effect test 1, and the results of Example 5 above were obtained. , 6 and Comparative Example 2 were calculated as the average value of each of the three test tooth enamel blocks, and are shown in a graph in FIG.

The tablet confectionery of Comparative Example 2 (without addition of dicalcium phosphate) had a remineralization degree of 1.67, whereas the tablet confectionery of Example 5 (with 0.2% of calcium diphosphate) had recalcified lime. The tablet confection of Example 6 (addition of 0.05% of dibasic calcium phosphate) had a degree of recalcification of 2.33, and exhibited a remineralization promoting effect depending on the concentration of dicalcium phosphate.

Example 7 (Tablet Confectionery) Tablets of Example 7 and Comparative Example 3 were prepared according to the formulation shown in Table 3 using dibasic calcium phosphate and xylitol as sugar alcohol, and powdered Funori extract A.

[0051]

[Table 3]

Remineralization promoting effect test 4 The remineralization promoting effect of the tablet confections of Example 7 and Comparative Example 3 was carried out in the same manner as in the remineralization promoting effect test 3. Then, the results of each test tooth enamel block by microradiography (MR) were visually evaluated for the degree of remineralization in six steps in the same manner as in the remineralization promoting effect test 1, and the results of Examples 7 and The degree of remineralization according to Comparative Example 3 was 3
The average value of the test tooth enamel blocks was calculated and shown in a graph in FIG.

The tablet confection of Comparative Example 3 (without addition of dicalcium phosphate and funori extract) had a remineralization degree of 1.67, whereas the tablet confection of Example 7 (calcium diphosphate, xylitol and funori) Extract) showed that the remineralization degree was 4.33, and that the combined use of dibasic calcium phosphate, xylitol and funori extract significantly promoted remineralization.

FIG. 10 shows the results of MR after the test tooth enamel block was treated with the tablet confectionery extract of Comparative Example 3. The remineralization was performed not only on the enamel demineralized surface layer but also on the deep layer. Is observed (remineralization degree 2). FIG.
Similarly, the results of the MR after treating the test tooth enamel block with the tablet confectionery extract of Example 7 are shown.
Remineralization is almost completely observed from the enamel demineralized surface layer to the deep layer (remineralization degree 5).

The mixing ratios (numbers are% by weight) of Examples 8 to 25 are shown below. Example 8 (chewing gum) Gum base 20.0 Palatinose 55.0 Palatinit 22.5 Softener 1.0 Dibasic calcium phosphate 0.8 Powdered funori extract A 0.7

Example 9 (chewing gum) Gum base 20.0 Sorbitol 55.0 Maltitol 23.8 Softener 1.0 Dibasic calcium phosphate 0.2

Example 10 (chewing gum) Gum base 20.0 Xylitol 55.0 Palatinose 23.95 Softener 1.0 Dibasic calcium phosphate 0.05

Example 11 (Chewing gum) Gum base 20.0 Xylitol 75.0 Reduced maltose 3.8 Softener 1.0 Powdered funori extract A 0.2

Example 12 (Chewing gum) Gum base 20.0 Xylitol 55.0 Maltitol 22.5 Softener 1.0 Dibasic calcium phosphate 1.0 Powdered gogonori extract 0.5

Example 13 (chewing gum) Gum base 20.0 Xylitol 55.0 Erythritol 22.8 Softener 1.0 Dibasic calcium phosphate 1.0 Powdered kelp extract 0.2

Example 14 (candy) Xylitol 48.0 Reduced maltose starch syrup 36.5 Dibasic calcium phosphate 0.5 Funori extract of powder A 0.5 Perfume 0.5 Purified water 14.0

Example 15 (candy) Palatinit 48.0 Reduced maltose syrup 36.0 Dicalcium phosphate 0.5 Perfume 0.5 Purified water 15.0

Example 16 (Tablets) Xylitol 75.0 Lactose 20.9 Glycerin Fatty Acid Ester 0.2 Dibasic Calcium Phosphate 0.05 Powder Funori Extract A 0.05 Purified Water 3.8

Example 17 (tablets) Xylitol 75.0 Palatinit 20.0 Glycerin fatty acid ester 0.2 Dibasic calcium phosphate 0.5 Purified water 4.3

Example 18 (chocolate) Cocoa mass 15.0 whole milk powder 25.0 xylitol 40.5 dibasic calcium phosphate 0.5 cocoa butter 18.0 emulsifier 0.3 perfume 0.2 powder Funori extract A 0. 5

Example 19 (chocolate) cocoa mass 15.0 whole milk powder 25.0 xylitol 41.0 dibasic calcium phosphate 0.5 cocoa butter 18.0 emulsifier 0.3 flavor 0.2

Example 20 (Ice cream) Cream (fat ratio: 45%) 25.0 Milk (fat ratio: 3.7%) 35.0 Skim milk powder (unsweetened) 24.3 Xylitol 10.2 Dicalcium phosphate 0.2 1 Corn Syrup 4.6 Stabilizer 0.77 Powdered Funori Extract A 0.03

Example 21 (Beverage) Sweetened dextrose liquid sugar 0.3 Xylitol 8.7 Acidulant 1.0 Fragrance 0.3 Dibasic calcium phosphate 0.1 Funori extract A 0.3 of powder Purified water 89.3

Example 22 (Toothpaste) Aluminum hydroxide 35.0 Silicic anhydride 15.0 Xylitol 10.0 Dibasic calcium phosphate 0.2 Sodium lauryl sulfate 1.0 Fragrance 0.5 Powder Funori extract A 0.3 Purified water 38.0

Example 23 (Mouthwash) Xylitol 20.0 Glycerin 10.0 Sodium lauryl sulfate 1.0 Calcium dibasic phosphate 0.5 Fragrance 0.3 Powdered Funori extract A 0.5 Purified water 67.7

Example 24 (Mouthwash) Xylitol 7.4 Dibasic calcium phosphate 0.5 Glycerin 10.0 Sodium lauryl sulfate 1.5 Fragrance 0.6 Purified water 80.0

Example 25 (Mouthwash) Sorbitol 7.4 Dibasic calcium phosphate 0.2 Glycerin 10.0 Sodium lauryl sulfate 1.5 Perfume 0.6 Powdery funori extract B 0.3 Purified water 80.0

[Brief description of the drawings]

FIG. 1 is a diagram showing the results of microradiography (MR) after a test tooth enamel block on which a demineralized layer is formed is treated with a KCl buffer solution.

FIG. 2 shows a test tooth enamel block on which a decalcified layer is formed, and dicalcium phosphate at 0.02% by weight.
It is a figure which shows the result of MR after the process by the containing KCl buffer solution.

FIG. 3 shows a test tooth enamel block on which a demineralized layer is also formed, which is treated with the powder of Example 1, ie, a KCl buffer solution containing 0.02% by weight of dibasic calcium phosphate and 20% by weight of xylitol. It is a figure showing a result of MR.

FIG. 4 shows a test tooth enamel block on which a demineralized layer is formed in the same manner as the powder of Example 2, that is, 0.02% by weight of dibasic calcium phosphate, 20% by weight of xylitol, and 0.01% by weight of funori extract A. It is a figure which shows the result of MR after the process by the containing KCl buffer solution.

FIG. 5 is a view showing the results of MR after treating the tooth enamel block for test on which a demineralized layer was formed with a KCl buffer solution containing 0.02% by weight of tribasic calcium phosphate.

FIG. 6 is a view showing the results of MR after treating the tooth enamel block for test on which a demineralized layer is formed with a KCl buffer solution containing 0.02% by weight of tribasic calcium phosphate and 20% by weight of xylitol. is there.

FIG. 7 shows the degree of remineralization of the test tooth enamel having the demineralized layer formed thereon, from the results of MR after treatment with each of the chewing gum extracts of Comparative Example 1 and Examples 3 and 4. It is a graph shown.

FIG. 8 shows the degree of remineralization of the test tooth enamel, on which a demineralized layer was also formed, from the results of MR after treatment with each tablet extract of Comparative Example 2 and Examples 5 and 6. FIG.

FIG. 9 shows the degree of remineralization of the test tooth enamel also formed with a demineralized layer, from the results of MR after treatment with each tablet extract of Comparative Example 3 and Example 7. It is a graph.

FIG. 10 is a view showing the result of MR after treating the tooth enamel block for test on which a demineralized layer was similarly formed with the tablet confectionery extract of Comparative Example 3.

FIG. 11 is a view showing the results of MR after the test tooth enamel block on which a demineralized layer was formed was treated with the tablet confectionery extract of Example 7.

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Claims (6)

[Claims] 1. A remineralization accelerator for tooth enamel, comprising a sugar alcohol and dicalcium phosphate as active ingredients. 2. A remineralization accelerator for tooth enamel, comprising a sugar alcohol, dicalcium phosphate, seaweed and / or an extract thereof as an active ingredient. 3. The remineralization accelerator for tooth enamel according to claim 1, wherein the sugar alcohol is xylitol. 4. The remineralization accelerator for tooth enamel according to claim 2, wherein the seaweed extract is a fungus extract. 5. The tooth enamel remineralization promoter according to claim 1, 2, 3, or 4, or a sugar alcohol and dibasic calcium phosphate are separately added, or a sugar alcohol, An oral composition characterized by being manufactured by separately adding dicalcium phosphate, seaweed and / or an extract thereof. 6. A tooth mineral enamel remineralization promoter according to claim 1, 2, 3, or 4, or a sugar alcohol and a dicalcium phosphate are separately added, or a sugar alcohol, A food or drink produced by separately adding dibasic calcium phosphate, seaweed and / or an extract thereof.