JP2000103711A - Ixodid-controlling agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an ixodid-controlling agent capable of manifesting excellent controlling activities against Ixodidae by adding a specific compound. SOLUTION: This ixodid-controlling agent contains 1-(tetrahydrofuran-3-yl) methyl-3-methyl-2-nitroguanidine preferably in a proportion of 0.005-50 wt.% in the preparation. Haemaphysalis longicornis, Haemaphysalis japonica, Dermacentor recticulatus, Dermacentor taiwanensis, Haemaphysalis flava Ixodes ovatus Ixodes persulcatus and Boophilus microplus and the like are cited as the Ixodidae effectively controlled by the controlling agent. The amount to be applied is normally 0.01-1,000 mg/kg expressed in terms of the amount of the compound when an animal is treated, and ordinary about 0.1-10,000 mg/m2 when the agent is applied on a floor surface, in the outdoor or the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an agent for controlling ticks and a method for controlling ticks.

[0002]

2. Description of the Related Art Conventionally, organophosphorus compounds, pyrethroid compounds, and the like have been known as agents for controlling ticks that harm livestock and domestic animals such as pets. In the pest control field, the use of the same type of drug for a long period of time has often caused a problem of a reduction in the control effect on pests and pathogens to be controlled due to the development of drug resistance. Development is desired.

[0003]

Under these circumstances, the present inventors have repeatedly studied the development of a new tick control agent, and as a result, have found that 1- (tetrahydrofuran-3-yl) methyl-3
A drug containing -methyl-2-nitroguanidine has been found to show a specific effect in controlling ticks,
The present invention has been reached. That is, the present invention provides a tick control agent comprising 1- (tetrahydrofuran-3-yl) methyl-3-methyl-2-nitroguanidine as an active ingredient (hereinafter referred to as the present control agent), And a method for controlling ticks parasitic on livestock or pets, comprising treating the livestock or pet with the present pesticide.

[0004]

DETAILED DESCRIPTION OF THE INVENTION 1- (Tetrahydrofuran-3-
Il) Methyl-3-methyl-2-nitroguanidine (hereinafter, referred to as the present compound) is a compound known as an insecticidal active ingredient.

[0005] Ticks that can be effectively controlled by the present control agent include Haemaphysalis , a ectoparasite of livestock such as cattle and sheep and pets such as dogs and cats.
longicornis ), Haemaphysalis japoni
ca ), Dermacentor recticulatus ,
Tiger ticks ( Dermacentor taiwanensis ), red ticks ( Haemaphysalis flava ), Yamato ticks ( Ixodes o
vatus ), Schulze tick ( Ixodes persulcatus ), Ox tick ( Boophilus microplus ) and the like. Examples of target animals to which the present pesticide is applied include, in addition to the above-mentioned livestock and pets, rodents such as mice, rats, hamsters and squirrels, carnivores such as rabbits and ferrets, ducks, chickens and pigeons. Birds, etc. are also included.

[0006] The present control agent may consist of the present compound alone, but in practice, it is usually formulated into a formulation by appropriately adding a solid carrier, a liquid carrier, a formulation auxiliary and the like, and applied. Formulation forms include emulsions, oils, oily solutions, aqueous solutions, shampoos, suspensions and other solutions, powders, wettable powders, granules, pastes, microencapsulations, foams, aerosols, carbon dioxide Preparations, tablets, sheet preparations, resin preparations, injections, capsules, suppositories and the like can be mentioned, and a preferable preparation form is appropriately selected upon application.

The content of the compound of the present invention in a preparation may vary depending on the form of the preparation.
0% by weight.

[0008] These preparations can be prepared in a usual manner, for example, by mixing the present compound with a solid carrier or liquid carrier, and adding and mixing other formulation auxiliaries such as emulsifiers and fixing agents if necessary. Can be obtained by molding. Carriers and auxiliaries used in the formulation include, for example, the following.

Examples of the solid carrier include clay, kaolin, talc, bentonite, sericite, quartz, sulfur, activated carbon, calcium carbonate, diatomaceous earth, pumice, calcite,
Natural or synthetic minerals such as sepiolite, dolomite, silica, alumina, vermiculite and perlite, sawdust, corn cobs, coconut husks, fine granules such as tobacco stems, gelatin, petrolatum, methylcellulose, lanolin, Lard, liquid paraffin, cocoa butter and the like. As the liquid carrier, for example, xylene, toluene,
Alkyl naphthalene, phenyl xylyl ethane, kerosene, light oil, hexane, aromatic or aliphatic hydrocarbons such as cyclohexane, chlorobenzene, dichloromethane,
Dichloroethane, halogenated hydrocarbons such as trichloroethane, methanol, ethanol, isopropyl alcohol, butanol, hexanol, alcohols such as ethylene glycol, diethyl ether, ethylene glycol dimethyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, propylene glycol monomethyl ether, Ethers such as tetrahydrofuran and dioxane, esters such as ethyl acetate and butyl acetate, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone and cyclohexanone, nitriles such as acetonitrile and isobutyronitrile, and sulfoxides such as dimethyl sulfoxide; Acids such as N, N-dimethylformamide and N, N-dimethylacetamide Earth, soybean oil, vegetable oils such as cottonseed oil, orange oil, hyssop oil, plant essential oils of lemon oil, and the like,
Water.

[0010] Examples of the propellant in the foam, aerosol preparation and carbon dioxide preparation include propane gas, butane gas, chlorofluorocarbon gas, liquefied petroleum gas, dimethyl ether and carbon dioxide gas.

[0011] Examples of the base material in the resin preparation include vinyl chloride polymers and polyurethanes. These base materials may be used, if necessary, such as phthalate esters (dimethyl phthalate, dioctyl phthalate, etc.). And a plasticizer such as adipic acid ester and stearic acid. The resin preparation can be obtained by kneading the active ingredient compound in the base material using a usual kneading apparatus, and then molding it by injection molding, extrusion molding, press molding or the like. If necessary, an animal collar, an animal ear tag, or the like can be obtained through a molding, cutting, or other process.

[0012] As an auxiliary for pharmaceutical preparations, for example,
Nonionic emulsifiers such as polyoxyethylene fatty acid esters and polyoxyethylene fatty acid alcohol ethers; ionic emulsifiers such as alkyl sulfonates, alkyl sulfates and aryl sulfonates; dispersants such as lignin sulfonates and methyl cellulose; Fixing agents such as methylcellulose, gum arabic, polyvinyl alcohol, and polyvinyl acetate; coloring agents such as iron oxide, titanium oxide, Prussian blue, alizarin dye, azo dye, and phthalocyanine dye;

The present control agent may contain an active ingredient other than the present compound as appropriate. Active ingredients other than the present compound include, for example, pyrethroid compounds such as permethrin, phenothrin, allethrin, pyrethrin, praethrin, cyphenothrin, cyfluthrin, fenvalerate, fenpropatrin, transfluthrin, dichlorvos, tetrachlorovinphos, fenthion, Organic phosphorus compounds such as chlorpyrifos and diazinon,
Carbamate compounds such as propoxur, carbaryl, methoxadiazone, fenobcarb, lufenuron, chlorfluazuron, hexaflumuron, cyromazine, 1-
Chitin formation inhibitors such as (2,6-difluorobenzoyl) -3- [2-fluoro-4- (1,1,2,3,3,3-hexafluoropropoxy) phenyl] urea;
Juvenile hormone-like substances such as pyriproxyfen, methoprene, hydroprene, phenoxycarb, N-phenylpyrazole compounds, milbemycin, abamectin,
Animal endoparasiticides such as ivermectin, N, N-diethyl-m-triamide (Deet), limonene, linalool, citronellal, menthol, menthol, hinokitiol, geraniol, eucalyptol, indoxacarb, curan-3,4 -Pest repellents such as diols, and synergists such as PBO, S421, MGK264, IBTA, and Sinepirin 500.

The method of application to animals includes transdermal application,
Non-transdermal applications and the like can be mentioned.

In the case of transdermal application, for example, spot-on treatment or pour-on treatment for animals using oily or aqueous solutions; oils, emulsions, shampoos, powders, wettable powders, foams,
Uniform application treatment to the animal body surface using an aerosol preparation or the like;
Attaching to an animal's neck, ears, or the like using a resin preparation having a suitable shape such as a collar or an ear tag.
The spot-on treatment is a method in which a liquid preparation is applied to the skin between the shoulder blades of an animal or the like. Pour-on treatment is a method of applying a liquid formulation along the back line of the animal.

Non-transdermal applications include, for example, oral application, subcutaneous application, application by injection, transplantation, etc., and application to mucous membranes. Usually, tablets, resins, capsules, liquids, and injections are used. , Suppositories and the like. As a method for applying the present pesticide, transdermal application is preferred.

The present control agent can also be applied in a suitable formulation such as dusts, granules, oils, aerosol preparations, wettable powders, etc. to floors other than animals and to the habitat area of ticks such as outdoors.

The application rate of the present pesticide varies depending on the place where it is to be treated. For example, when applied to animals, the application rate is usually 0.01 to 1000 mg / kg as the amount of the present compound, and it is applied to floors, outdoors, etc. Sometimes, usually 0.1 to 10000 mg
/ M ² .

[0019]

The present invention will be described below in more detail with reference to examples. Formulation Example 1 10 parts by weight of the present compound and 90 parts by weight of diethylene glycol monomethyl ether are mixed to obtain a spot-on preparation or a pour-on preparation.

Test Example 1 A predetermined amount of an acetone solution containing the present compound, 7 cm in diameter
Was uniformly treated on the bottom surface of a glass Petri dish and air-dried. 10 to 20 juvenile mites of Haemaphysalis longicornis were released into a glass Petri dish, the upper part of the Petri dish was covered with Parafilm, and the number of lethals 24 hours later was observed. Each triplicate was performed. Table 1 shows the test results.

[0021]

[Table 1] Test Example 2 Thirty to fifty ticks of Haemaphysalis longicornis were placed on both ears of a rabbit (Std: NZW type, female, 2.4 kg in live weight), and a cotton bag (5 × 1) was used.
(0 cm), and the ears were covered with a tape so as not to come off. Two days later, after the ticks that had not settled on the ears were removed, the number of larval mites infested on the ears was confirmed, and 10 parts by weight of the present compound and 90 parts by weight of diethylene glycol monoethyl ether were applied to the external skin of the ears. This mixture was treated with 0.1 ml of each ear in a total of 0.2 ml. As a result of examining the number of dead mites 3 days after the treatment, the mortality was 95%.

Comparative Test Example 1 A predetermined amount of an acetone solution containing the present compound was applied to filter paper. Tangles were applied around the filter paper to prevent mites from escaping. Release about 20 adult mites of Dermatophagoides farinae or Dermatophagoides farinae on filter paper, forcibly contact them,
The number of deaths after 24 hours was observed. Each two replicates were performed. Table 2 shows the test results.

[0023]

[Table 2]

Comparative Test Example 2 Forty female adult mites of the spider mite, Tetranychus urticae, were inoculated with Cryptomeria japonica 7 days after sowing. One day after the inoculation, 30 ml of a water diluent of the wettable powder containing the present compound, which had the following formulation, was uniformly treated uniformly with the spider mite inoculated with the spider mite. Eight days after the treatment, the damage of the primary leaves and the first true leaves was examined.
In addition, as a control, the degree of damage to the untreated drug, Thornashi green beans, was simultaneously investigated and used as a control. Table 3 shows the results. (Wettable powder formulation) The present compound 0.05 Solpol 5039 (manufactured by Toho Chemical) 10.0 Demol SNB (manufactured by Kao) 2.0 Toxir GU-N (manufactured by Tokuyama Soda) 45.0 Cellogen 7A (manufactured by Daiichi Kogyo Seiyaku) ) 1.0 SP clay (manufactured by Katsumitsuyama) balance 100.0

[0025]

[Table 3] * 1 Damage 100: Damage similar to control 0: No damage from spider mites

Test Example 2 Rabbits (Std: NZW strain, female, 2.4 kg live weight) were placed on both ears of each tick, Haemaphysalis longi.
cornis ) on a cotton bag (5
× 10 cm) to cover the ears, and fixed with tape so as not to come off. Two days later, after the ticks that had not settled on the ears were removed, the number of larval mites infested on the ears was confirmed, and 10 parts by weight of the present compound and 90 parts by weight of diethylene glycol monoethyl ether were applied to the external skin of the ears. Mixture
One ear was treated with 0.1 ml each, for a total of 0.2 ml. As a result of examining the number of dead mites 3 days after the treatment, the mortality was 95%.

[0027]

The control agent of the present invention can exert an excellent control effect on ticks.

Claims (4)

[Claims] 1. A tick control agent comprising 1- (tetrahydrofuran-3-yl) methyl-3-methyl-2-nitroguanidine as an active ingredient. 2. The control agent according to claim 1, which is used for livestock or pets. 3. A tick parasitic on livestock or pets, which is treated with a control agent containing 1- (tetrahydrofuran-3-yl) methyl-3-methyl-2-nitroguanidine as an active ingredient. Control methods 4. The method according to claim 3, wherein the treatment with the control agent is performed on the body surface of livestock or pets.