JP2000095667A - Skin lotion - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin lotion having potent effects for preventing and improving a skin roughness by containing an extract of tea leaves and/or fruits, and a compound selected from serine, alanine, edetate, etc. SOLUTION: This skin lotion is obtained by containing (A) 0.001-5.0 wt.%, preferably 0.01-1.0 wt.% extract of leaves and/or fruits of Thea sinensiss Linne, (B) 0.01-10.0 wt.%, preferably 0.1-5.0 wt.% >=1 compound selected from serine, alanine, trimethylglycine, edetate, ethylenediaminehydroxyethyl triacetic acid trisodium salt. As the method for obtaining the component (A), e.g. a method for heating for refluxing a prepared material from tea leaves (a green tea) for a set period of time, filtering and then concentrating or diluting to obtain an extract, can be used. As the extracting solvent, water, a lower alcohol such as ethanol, 1,3-butylene glycol, glycerol, etc., are preferable.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin,
More specifically, the present invention relates to an external preparation for skin having a high skin roughness preventing and skin roughening improving effect.

[0002]

2. Description of the Related Art Conventionally, amino acids, polyhydric alcohols, saccharides, and the like have been blended in skin external preparations for the purpose of imparting a moisturizing effect. Although these components have no problem in terms of the moisturizing effect, they cannot be said to be sufficient in view of the anti-aging effect, and the effect could not be expected.

[0003] The inventors of the present invention have conducted intensive studies as to whether or not there is any one having excellent skin roughness prevention and skin roughness improvement effects.
Extract of leaf and / or fruit of tea tree (Thea sinensiss Linne), serine, alanine, trimethylglycine, edetate, ethylenediaminehydroxyethyl triacetic acid 3
It has been found that this object can be achieved by adding at least one compound selected from sodium, and the present invention has been completed.

[0004]

That is, the present invention relates to an extract of leaves and / or fruits of tea tree (Thea sinensiss Linne), serine, alanine, trimethylglycine, edetate and ethylenediaminehydroxyethyl triacetic acid.
An external preparation for skin, characterized by containing one or more compounds selected from sodium.

Hereinafter, the configuration of the present invention will be described in detail. The method for extracting leaves and / or fruits of tea tree (Thea sinensiss Linne) used in the present invention is not particularly limited.
After heating and refluxing for a certain period of time from the leaves (green tea) made from leaves, an extract obtained by filtering and concentrating or diluting can be used.

The extraction solvent is not particularly limited, and water and an organic solvent are used. In the present invention, an extract extracted with water, a lower alcohol such as ethanol, 1,3-butylene glycol, glycerin and the like is preferable.

[0007] The amount of the above extract in the external preparation for skin is
0.001 to 5.0% by weight, preferably 0.01 to
1.0% by weight. If the amount is less than 0.001% by weight, a sufficient effect cannot be obtained, and if the amount exceeds 5.0% by weight, no increase in the effect is observed.

[0008] One or more compounds selected from the group consisting of serine, alanine, trimethylglycine, edetate and trisodium ethylenediaminehydroxyethyl triacetate used in the present invention may have a compounding amount of 0.01-10.
0% by weight, more preferably 0.1 to 5.0% by weight. These compounds can be used alone or in combination of two or more.

[0009] In addition to the above essential components, the skin external preparation of the present invention contains other components usually used in skin external preparations such as cosmetics and pharmaceuticals, such as avocado oil, palm oil, peanut oil, tallow, rice bran oil, Jojoba oil, carnauba wax, lanolin, liquid paraffin, oxystearic acid, isostearyl palmitate, oils such as isostearyl alcohol, glycerin, sorbitol, polyethylene glycol, pyrrolidone carboxylic acid and salts thereof, collagen,
Humectants such as hyaluronic acid and its salts, chondroitin sulfate and its salts, UV absorbers such as amyl paradimethylaminobenzoate, urocanic acid, ethyl diisopropylcinnamate, and antioxidants such as sodium erysorbate, sage extract, and parahydroxyanisole Agent, sodium stearyl sulfate, diethanolamine cetyl sulfate,
Detergents such as cetyltrimethylammonium saccharin, polyethylene glycol isostearate, and glyceryl arachiate; preservatives such as ethylparaben and butylparaben; extracts such as oak, orange, sicon, peony, assembly, birch, loquat, and glycyrrhizic acid derivatives Anti-inflammatory agents such as glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, placental extracts, glutathione, yukinoshita extracts, whitening agents such as ascorbic acid derivatives, carrots, aloe, mallow, iris, grapes, yoquinin, loofah , Extract such as lily, royal jelly, photosensitizer, cholesterol derivative, activator such as various amino acids, saffron, senkyu, ginger, hypericum, ononis, rosemary, garlic, etc. Exudates, blood circulation promoters such as γ-oryzanol, dextran sodium sulfate, sulfur, antiseborrheic agents such as thiantole, fragrance, water, alcohol, thickeners such as carboxyvinyl polymers, titanium yellow, carsamine, safflower red and the like A coloring agent and the like can be appropriately compounded as needed.

The dosage form of the external preparation for skin of the present invention is optional.
Any dosage form, such as a solution system, a solubilizing system, an emulsifying system, a powder dispersion system, a water-oil two-layer system, a water-oil-powder three-layer system, may be used.

The use of the external preparation for skin of the present invention is also optional. Facial cosmetics such as lotions, emulsions, creams, packs, etc., makeup cosmetics such as foundations, lipsticks, eye shadows, etc., body cosmetics, and aromatic cosmetics Paints, detergents, ointments and the like.

[0012]

EXAMPLES Next, the present invention will be specifically described with reference to Examples and Comparative Examples. The present invention is not limited by this. The compounding amount is% by weight.

Example 1 A. Cetanol 0.5% by weight Vaseline 2.0 Squalane 7.0 Self-emulsifying glyceryl monostearate 2.5 Polyoxyethylene sorbitan monostearate (20EO) 1.5 Pantothenyl ethyl ether 0.5 Jojoba oil 5.0 B. Propylene glycol 5.0 Glycerin 5.0 Vegum (montmorillonite) 5.0 Green tea leaf extract 0.1 Trimethylglycine 1.0 Potassium hydroxide 0.3 Water Residue (Production method) A (oil phase) and B (water) Phase) are each heated to 70 ° C. and completely dissolved. Add A to B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain a cream.

Example 2 A cream was prepared in the same manner as in Example 1 except that serine was used instead of trimethylglycine.

Example 3 A cream was prepared in the same manner as in Example 1 except that alanine was used instead of trimethylglycine.

Example 4 A cream was prepared in the same manner as in Example 1 except that trimethylglycine in Example 1 was replaced with edetic acid disodium salt.

Example 5 A cream was prepared in the same manner as in Example 1 except that trimethylglycine in Example 1 was replaced with trisodium ethylenediaminehydroxyethyl triacetate.

Comparative Example 1 A cream was prepared in the same manner as in Example 1 except that the green tea leaf extract was replaced with water.

Comparative Example 2 A cream was prepared in the same manner as in Example 1 except that water was used instead of trimethylglycine.

Test on Prevention of Roughness and Improvement of Roughness Using the creams of the formulas of Examples 1 to 5 and Comparative Examples 1 and 2, tests of the effect of preventing and improving the roughness of a human body panel were performed. That is, the skin surface morphology of a healthy female person (face) was observed by a microscope (17 ×) using a replica of the skin using a replica method using myristin resin.

From the skin pattern state and the peeling state of the stratum corneum, 30 persons (rough skin panels) judged to have rough skin evaluations 1 and 2 based on the criteria shown in Table 1 were used. The obtained cream and the cream obtained in the comparative example were used 2 times a day.
Coated once. Two weeks later, a replica was again taken to observe the condition of the skin, and evaluated according to the criteria shown in Table 1. Table 2 shows the results.

[0022]

[Table 1] ─────────────────────────── Evaluation score ──────────────── ─────────── 1 Skin sulcus and skin hills disappear. Extensive stratum corneum turning. 2 Skin sulcus and skin hills are unclear. Turn of the stratum corneum. 3 Skin sulcus and skin ridge are observed but flat. 4 Skin sulcus and skin hills are clear. 5 Skin sulcus and skin hills are clear and well-organized. ───────────────────────────

[0023]

[Table 2] レ プ リ カ Replica Example Comparative Example Evaluation ────── ───────────── ────────── 1 2 3 4 5 1 2 ──────────────────── ────────────── 10 people 0 people 0 people 0 people 0 people 0 people 9 people 5 people 2 1 people 2 people 0 people 1 people 2 people 6 people 6 people 3 1 people 2 people 5 Name 2 people 0 people 4 people 6 people 4 6 people 8 people 7 people 9 people 8 people 1 people 2 people 5 12 people 8 people 8 people 8 people 10 people 0 people 0 people ─────────── ───────────────────────

From the above results, a cream was used in which an extract of green tea leaves and one or more compounds selected from serine, alanine, trimethylglycine, edetate and trisodium ethylenediaminehydroxyethyl triacetate were used. The remarkable effects of preventing and improving rough skin were observed on the facial part as compared with the facial part using other creams.

Example 6 Cream A. Stearic acid 10.0 wt% Stearyl alcohol 4.0 Butyl stearate 8.0 Monoglycerin stearate 2.0 Vitamin E acetate 0.5 Vitamin A palmitate 0.1 Macadamia nut oil 1.0 Oil obtained from green tea seeds 3.0 Fragrance 0.4 Preservative appropriate amount B. Glycerin 4.0 1,2-pentanediol 3.0 Sodium hyaluronate 1.0 Potassium hydroxide 0.4 Serine 0.01 Magnesium ascorbate 0.1 L-Arginine hydrochloride 0.01 Trisodium edetate 0 .05 Purified water residue (Preparation method) The oil phase of A and the aqueous phase of B were each heated to 70 ° C. and completely dissolved. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain a cream.

Example 7 Cream A. Cetanol 4.0% by weight Vaseline 7.0 Isopropyl myristate 8.0 Squalane 15.0 Monoglycerin stearate 2.2 POE (20) Sorbitan monostearate 2.8 Vitamin E nicotinate 2.0 Fragrance 0.3 Oxidation Appropriate amount of inhibitor Preservative appropriate amount B. Glycerin 10.0 Acetylated hyaluronic acid 0.02 Green tea leaf extract 1.0 Dipropylene glycol 4.0 Sodium pyrrolidonecarboxylate 1.0 Alanine 3.0 Disodium edetate 0.01 Purified water Residue (Preparation method) A cream was obtained according to Example 6.

Example 8 Emulsion A. Squalane 5.0% by weight Oleyl oleate 3.0 Vaseline 2.0 Sorbitan sesquioleate 0.8 Polyoxyethylene oleyl ether (20EO) 1.2 Evening primrose oil 0.5 Perfume 0.3 Preservative Appropriate amount 1,3-butylene glycol 4.5 Green tea leaf extract 1.5 acetylated hyaluronic acid 0.001 ethanol 3.0 carboxyvinyl polymer 0.2 potassium hydroxide 0.1 L-arginine L-aspartate 0 0.01 edetate 0.05 Purified water residue (Preparation method) An emulsion was obtained according to Example 6.

Example 9 Foundation A. Cetanol 3.5% by weight Deodorized lanolin 4.0 Jojoba oil 5.0 Vaseline 2.0 Squalane 6.0 Monoglycerin stearate 2.5 POE (60) hydrogenated castor oil 1.5 POE (20) cetyl ether 1. 0 pyridoxine tripalmitate 0.1 preservative appropriate amount perfume 0.3 B. Propylene glycol 10.0 Green tea fruit extract 0.1 Compound powder 12.0 Histidine 5.0 Ethylenediaminehydroxyethyl triacetate trisodium 1.0 Purified water residue (Preparation method) A foundation was obtained according to Example 6.

Example 10 Toner A. Ethanol 5.0 wt% POE oleyl alcohol ether 2.0 2-ethylhexyl-p-dimethylaminobenzoate 0.18 fragrance 0.05 B. 1,3-butylene glycol 9.5 sodium pyrrolidonecarboxylate 0.5 green tea leaf extract 5.0 nicotinamide 0.3 glycerin 5.0 trimethylglycine 5.0 hydroxypropyl β-cyclodextrin 1.0 lysine 0 .05 Purified water residue (Preparation method) The alcohol phase of A was added to the aqueous phase of B and solubilized to obtain a lotion.

Example 11 Pack (1) Polyvinyl alcohol 10.0% by weight (2) Polyethylene glycol (molecular weight 400) 0.4 (3) Glycerin 3.0 (4) Ethanol (95%) 8.0 (5) Green tea leaf extract 0.1 (6) Alanine 0.1 (7) Preservative 0.1 (8) Fragrance 0.1 (9) Purified water residue (Preparation method) At room temperature (4), (7), Mix and dissolve (8), (1), (2), (3)
After mixing and dissolving (5), (6) and (9) at 80 ° C., the mixture was stirred and added, and then allowed to cool to room temperature to obtain a pack.

[0031]

EFFECTS OF THE INVENTION The external preparation for skin of the present invention is
sinensiss Linne) by combining leaf and / or fruit extract with at least one selected from serine, alanine, trimethylglycine, edetate, and trisodium ethylenediaminehydroxyethyl triacetate to prevent rough skin and improve rough skin The effect is that the action can be significantly increased without side effects.

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 4C083 AA111 AA112 AA122 AB032 AB442 AC012 AC022 AC072 AC102 AC112 AC172 AC182 AC242 AC352 AC392 AC422 AC432 AC442 AC531 AC532 AC581 AC582 AC612 AC622 AC642 AD042 AD092 AD112 AD252 AD332 AD512 AD622 AD63251 CC02 CC04 CC05 CC07 CC12 DD12 DD23 DD31 EE12

Claims (3)

[Claims] 1. An extract of leaves and / or berries of tea tree (Thea sinensiss Linne) and one or more compounds selected from serine, alanine, trimethylglycine, edetate and trisodium ethylenediaminehydroxyethyl triacetate. And an external preparation for skin, characterized by comprising: 2. The extract of the leaf and / or fruit of tea tree (Thea sinensiss Linne) is 0.001 to 5.0% by weight, and serine, alanine, trimethylglycine,
Edetate and ethylenediaminehydroxyethyl 3
The skin external preparation according to claim 1, wherein one or more compounds selected from trisodium acetate are contained in an amount of 0.01 to 10.0% by weight. 3. The external preparation for skin according to claim 1, which is an external preparation for preventing rough skin.