JP2000074900A5 - - Google Patents
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- Publication number
- JP2000074900A5 JP2000074900A5 JP1998243634A JP24363498A JP2000074900A5 JP 2000074900 A5 JP2000074900 A5 JP 2000074900A5 JP 1998243634 A JP1998243634 A JP 1998243634A JP 24363498 A JP24363498 A JP 24363498A JP 2000074900 A5 JP2000074900 A5 JP 2000074900A5
- Authority
- JP
- Japan
- Prior art keywords
- target compound
- recognition target
- vial
- artificial receptor
- evaluating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 7
- 108010031480 Artificial Receptors Proteins 0.000 claims 5
- 238000011156 evaluation Methods 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 239000011541 reaction mixture Substances 0.000 claims 3
- 230000036462 Unbound Effects 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 239000006228 supernatant Substances 0.000 claims 2
- 239000010409 thin film Substances 0.000 claims 2
- 238000005037 combinatorial chemistry Methods 0.000 claims 1
- 230000000379 polymerizing Effects 0.000 claims 1
Claims (5)
- 認識対象化合物、機能性モノマーおよび架橋剤を含む反応混合物をバイアル中で重合させてバイアル内に生成ポリマーの薄膜を形成させ、
バイアル内を洗浄して認識対象化合物等を生成ポリマーから除去し、
バイアル内へ該認識対象化合物と同一または異なる認識対象化合物の溶液を注入した後、
該溶液の上清液中に含まれる未結合の認識対象化合物の量を測定し、その結果に基づいて人工レセプターを評価することを特徴とする人工レセプターの評価方法。 - 認識対象化合物、機能性モノマーおよび架橋剤を含む反応混合物をバイアル中で重合させてバイアル内に生成ポリマーの薄膜を形成させた後、
該反応混合物の上清液中に含まれる未結合の認識対象化合物の量を測定し、その結果に基づいて人工レセプターを評価することを特徴とする人工レセプターの評価方法。 - 使用されるバイアルが複数である請求項1または2に記載の評価方法。
- コンビナトリアルケミストリーの手法により行なわれる請求項3に記載の評価方法。
- 請求項1〜4のいずれか1項に記載の評価方法により選択された人工レセプター。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24363498A JP4197773B2 (ja) | 1998-08-28 | 1998-08-28 | 人工レセプターの評価方法 |
US09/266,942 US6177513B1 (en) | 1998-08-28 | 1999-03-12 | Method for evaluating artificial receptors |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24363498A JP4197773B2 (ja) | 1998-08-28 | 1998-08-28 | 人工レセプターの評価方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2000074900A JP2000074900A (ja) | 2000-03-14 |
JP2000074900A5 true JP2000074900A5 (ja) | 2005-10-27 |
JP4197773B2 JP4197773B2 (ja) | 2008-12-17 |
Family
ID=17106747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP24363498A Expired - Fee Related JP4197773B2 (ja) | 1998-08-28 | 1998-08-28 | 人工レセプターの評価方法 |
Country Status (2)
Country | Link |
---|---|
US (1) | US6177513B1 (ja) |
JP (1) | JP4197773B2 (ja) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6884842B2 (en) | 1997-10-14 | 2005-04-26 | Alnis Biosciences, Inc. | Molecular compounds having complementary surfaces to targets |
SE0003048D0 (sv) * | 2000-08-30 | 2000-08-30 | Mip Technologies Ab Forsknings | Techniques for combinatorial synthesis and screening of Molecularly Imprinted Polymers |
US7232861B2 (en) | 2000-09-12 | 2007-06-19 | Koji Sode | Enzyme-mimicking polymers |
WO2002059184A2 (en) * | 2001-01-24 | 2002-08-01 | Virginia Commonwealth University | Molecular imprinting of small particles, and production of small particles from solid state reactants |
US6849701B2 (en) * | 2001-03-02 | 2005-02-01 | E. I. Du Pont De Nemours And Company | Droplet polymerization method for synthesis of molecularly imprinted polymers |
WO2003001203A2 (en) * | 2001-06-22 | 2003-01-03 | Symyx Technologies, Inc. | Inverse chromatography methods and apparatus for evaluation of interactions between modifying agents and receptors |
JP4190343B2 (ja) * | 2002-05-09 | 2008-12-03 | ダイセル化学工業株式会社 | 分子認識高分子化合物の製造方法 |
US6833274B2 (en) * | 2002-05-28 | 2004-12-21 | The Johns Hopkins University | Cortisol sensor |
DE10261910A1 (de) * | 2002-12-30 | 2004-07-15 | Polymerics Gmbh | Adsorbermaterial für Blut-, Blutplasma- und Albuminreinigungsverfahren |
EP1681568A1 (en) * | 2003-10-29 | 2006-07-19 | Hidechika Okada | Artificial antibody comprising complementary peptide |
WO2005068980A1 (en) * | 2004-01-07 | 2005-07-28 | The Research Foundation Of State University Of New York | Protein imprinted polymers with integrated emission sites |
JP2006137805A (ja) * | 2004-11-10 | 2006-06-01 | Tohoku Univ | 対象化合物を捕捉することができるモレキュラーインプリンテッドポリマー、その調製方法、およびモレキュラーインプリンテッドポリマーにより対象試料中の対象化合物を捕捉する方法 |
DE102004063633B4 (de) * | 2004-12-28 | 2011-12-15 | Polymerics Gmbh | Verwendung eines Sorbens zur Festphasenextraktion (solid phase extraction, SPE) |
GB0509275D0 (en) * | 2005-05-06 | 2005-06-15 | Univ Cranfield | Synthetic receptor |
GB0605427D0 (en) * | 2006-03-17 | 2006-04-26 | Univ Cranfield | Materials For Binding Drugs Of Abuse |
JP5007905B2 (ja) * | 2007-08-29 | 2012-08-22 | 公立大学法人大阪府立大学 | 分子鋳型を有するポリマーを備えたセンサー |
CN101829550B (zh) * | 2010-05-24 | 2012-07-25 | 河南师范大学 | 加替沙星分子印迹聚合物吸附剂及其制备工艺 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3243937B2 (ja) | 1994-06-27 | 2002-01-07 | 富士電機株式会社 | バイオミメティックセンサ |
JPH0850632A (ja) | 1994-08-04 | 1996-02-20 | Nippon Steel Corp | 手書き文字切り出し方法および装置 |
-
1998
- 1998-08-28 JP JP24363498A patent/JP4197773B2/ja not_active Expired - Fee Related
-
1999
- 1999-03-12 US US09/266,942 patent/US6177513B1/en not_active Expired - Fee Related
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