JOP20200025A1 - مركبات جديدة تنشط مسار Nrf2 - Google Patents

مركبات جديدة تنشط مسار Nrf2

Info

Publication number
JOP20200025A1
JOP20200025A1 JOP/2020/0025A JOP20200025A JOP20200025A1 JO P20200025 A1 JOP20200025 A1 JO P20200025A1 JO P20200025 A JOP20200025 A JO P20200025A JO P20200025 A1 JOP20200025 A1 JO P20200025A1
Authority
JO
Jordan
Prior art keywords
novel compounds
nrf2 pathway
compounds activating
activating
compounds
Prior art date
Application number
JOP/2020/0025A
Other languages
English (en)
Inventor
Canela Nuria Trallero
Casals Laia Miret
Bas Marta Paradis
Tomillero Ivan Ramos
Benitez Miriam Gongora
Paniagua Carlos Heras
Cubero Omar Brun
Palomera Fernando Albericio
Duran Carlos Puig
Stefan Geschwindner
Andrew Davis
Stephen Fiacco
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of JOP20200025A1 publication Critical patent/JOP20200025A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

يتعلق الاختراع الحالي بمركبات ببتيدية، حيث يكون للمركبات الببتيدية الصيغة (I)’، أو ملح مقبول صيدلانياً منه، أو ذوابة، أو أكسيد عند الموضع N، أو أيزومر فراغي منها: الصيغة (I)’ حيث R1؛ R2؛ s؛ t؛ u؛ Aa78 و G1 تكون كما تم تعريفها هنا. تكون المركبات الببتيدية مفيدة في تنشيط مسار Nrf2.
JOP/2020/0025A 2017-08-08 2018-08-08 مركبات جديدة تنشط مسار Nrf2 JOP20200025A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17382558 2017-08-08
PCT/EP2018/071536 WO2019030298A1 (en) 2017-08-08 2018-08-08 NEW COMPOUNDS THAT ACTIVATE THE NRF2 PATH

Publications (1)

Publication Number Publication Date
JOP20200025A1 true JOP20200025A1 (ar) 2020-02-04

Family

ID=59677167

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2020/0025A JOP20200025A1 (ar) 2017-08-08 2018-08-08 مركبات جديدة تنشط مسار Nrf2

Country Status (24)

Country Link
US (1) US20200255478A1 (ar)
EP (1) EP3665182A1 (ar)
JP (1) JP2020530022A (ar)
KR (1) KR20200035269A (ar)
CN (1) CN110997695A (ar)
AR (1) AR113100A1 (ar)
AU (1) AU2018314833B2 (ar)
BR (1) BR112019026306A2 (ar)
CA (1) CA3066698A1 (ar)
CL (1) CL2020000305A1 (ar)
CO (1) CO2020000617A2 (ar)
CR (1) CR20200056A (ar)
DO (1) DOP2020000017A (ar)
EA (1) EA202090432A1 (ar)
EC (1) ECSP20008530A (ar)
IL (1) IL272467A (ar)
JO (1) JOP20200025A1 (ar)
MA (1) MA49828A (ar)
MX (1) MX2020001481A (ar)
PE (1) PE20211460A1 (ar)
PH (1) PH12019502852A1 (ar)
SG (1) SG11201913161WA (ar)
TW (1) TW201919682A (ar)
WO (1) WO2019030298A1 (ar)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023111350A2 (en) * 2021-12-17 2023-06-22 3B Pharmaceuticals Gmbh Carbonic anhydrase ix ligands

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT7920688V0 (it) 1979-02-05 1979-02-05 Chiesi Paolo Parma Inalatore per sostanze medicamentose pulverulente, con combinata funzione di dosatore.
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US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
FI69963C (fi) 1984-10-04 1986-09-12 Orion Yhtymae Oy Doseringsanordning
DE3927170A1 (de) 1989-08-17 1991-02-21 Boehringer Ingelheim Kg Inhalator
IT1237118B (it) 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
US5201308A (en) 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
SG45171A1 (en) 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
GB9015522D0 (en) 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
WO1992003175A1 (en) 1990-08-11 1992-03-05 Fisons Plc Inhalation device
DE4027391A1 (de) 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
EP0640354B1 (en) 1990-09-26 2001-12-05 Pharmachemie B.V. Whirl chamber powder inhaler
GB9026025D0 (en) 1990-11-29 1991-01-16 Boehringer Ingelheim Kg Inhalation device
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
DE4239402A1 (de) 1992-11-24 1994-05-26 Bayer Ag Pulverinhalator
MY115140A (en) 1992-12-18 2003-04-30 Schering Corp Inhaler for powdered medications
BR9604977A (pt) 1995-04-14 1998-06-09 Glaxo Wellcome Inc Inalador de dose medida sistema inalador de dose medida e uso do mesmo
HU220227B (hu) 1995-06-21 2001-11-28 Asta Medica A.G. Gyógyszerporos patron integrált adagolószerkezettel és inhalálókészülék poralakú gyógyszerekhez
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
DE10129703A1 (de) 2001-06-22 2003-01-02 Sofotec Gmbh & Co Kg Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren
DK2351844T3 (da) 2003-04-29 2014-09-22 Sarepta Therapeutics Inc Præparater til forøgelse af transport- og antisense-effektivitet af nukleinsyreanalog i celler
SI1616592T1 (sl) 2004-07-16 2011-03-31 Almirall Sa Inhalator za uporabo farmacevtskih snovi v prahu in vloĹľek za prah za uporabo s tem inhalatorjem
ES2478670T3 (es) 2007-02-28 2014-07-22 Leo Pharma A/S Nuevos inhibidores de la fosfodiesterasa
JP2011523557A (ja) 2008-06-04 2011-08-18 メディカル リサーチ カウンシル ペプチド
JP2012051826A (ja) * 2010-08-31 2012-03-15 Toray Ind Inc 環状ペプチド及びその修飾ペプチド並びにＫｅｌｃｈ様ＥＣＨ結合タンパク質１の結合阻害物質のスクリーニング方法
KR102183273B1 (ko) 2011-05-05 2020-11-27 사렙타 쎄러퓨틱스, 인코퍼레이티드 펩타이드 올리고뉴클레오타이드 접합체
EP2751128B1 (en) 2011-08-30 2021-03-03 United Kingdom Research and Innovation Cell-penetrating peptides having a central hydrophobic domain
JP2015067579A (ja) * 2013-09-30 2015-04-13 国立大学法人東北大学 細胞透過性ペプチド及び当該ペプチドを含む医薬組成物。

Also Published As

Publication number Publication date
PE20211460A1 (es) 2021-08-05
EP3665182A1 (en) 2020-06-17
MA49828A (fr) 2020-06-17
TW201919682A (zh) 2019-06-01
DOP2020000017A (es) 2020-02-28
AU2018314833B2 (en) 2020-03-19
KR20200035269A (ko) 2020-04-02
AR113100A1 (es) 2020-01-29
IL272467A (en) 2020-03-31
AU2018314833A1 (en) 2020-01-02
JP2020530022A (ja) 2020-10-15
ECSP20008530A (es) 2020-05-29
BR112019026306A2 (pt) 2020-07-14
WO2019030298A1 (en) 2019-02-14
CA3066698A1 (en) 2019-02-14
CO2020000617A2 (es) 2020-05-05
CL2020000305A1 (es) 2020-06-26
CR20200056A (es) 2020-03-16
PH12019502852A1 (en) 2020-09-28
MX2020001481A (es) 2020-03-20
SG11201913161WA (en) 2020-01-30
EA202090432A1 (ru) 2020-06-08
US20200255478A1 (en) 2020-08-13
CN110997695A (zh) 2020-04-10

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