EA202090432A1 - Новые соединения, активирующие путь nrf2 - Google Patents

Новые соединения, активирующие путь nrf2

Info

Publication number
EA202090432A1
EA202090432A1 EA202090432A EA202090432A EA202090432A1 EA 202090432 A1 EA202090432 A1 EA 202090432A1 EA 202090432 A EA202090432 A EA 202090432A EA 202090432 A EA202090432 A EA 202090432A EA 202090432 A1 EA202090432 A1 EA 202090432A1
Authority
EA
Eurasian Patent Office
Prior art keywords
activating
nrf2
way
new connections
present
Prior art date
Application number
EA202090432A
Other languages
English (en)
Inventor
Карлос Пуч Дуран
Фернандо Альберисио Паломера
Мириам Гонгора Бенитес
Марта Парадис Бас
Лаия Мирет Касальс
Иван Рамос Томильеро
Стивен Фьякко
Эндрю Дейвис
Штефан Гешвинднер
Омар Брун Куберо
Карлос Эрас Паньягуа
Нурия Тральеро Канела
Original Assignee
Альмираль, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Альмираль, С.А. filed Critical Альмираль, С.А.
Publication of EA202090432A1 publication Critical patent/EA202090432A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Настоящее изобретение относится к пептидным соединениям, которые представляют собой соединения формулы (I)', или их фармацевтически приемлемым солям, или сольватам, или N-оксидам, или стереоизомерам, где значения R, R, s, t, u, Aaи Gявляются такими, как определено в настоящем изобретении. Эти пептидные соединения применимы для активации пути Nrf2.
EA202090432A 2017-08-08 2018-08-08 Новые соединения, активирующие путь nrf2 EA202090432A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17382558 2017-08-08
PCT/EP2018/071536 WO2019030298A1 (en) 2017-08-08 2018-08-08 NEW COMPOUNDS THAT ACTIVATE THE NRF2 PATH

Publications (1)

Publication Number Publication Date
EA202090432A1 true EA202090432A1 (ru) 2020-06-08

Family

ID=59677167

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090432A EA202090432A1 (ru) 2017-08-08 2018-08-08 Новые соединения, активирующие путь nrf2

Country Status (24)

Country Link
US (1) US20200255478A1 (ru)
EP (1) EP3665182A1 (ru)
JP (1) JP2020530022A (ru)
KR (1) KR20200035269A (ru)
CN (1) CN110997695A (ru)
AR (1) AR113100A1 (ru)
AU (1) AU2018314833B2 (ru)
BR (1) BR112019026306A2 (ru)
CA (1) CA3066698A1 (ru)
CL (1) CL2020000305A1 (ru)
CO (1) CO2020000617A2 (ru)
CR (1) CR20200056A (ru)
DO (1) DOP2020000017A (ru)
EA (1) EA202090432A1 (ru)
EC (1) ECSP20008530A (ru)
IL (1) IL272467A (ru)
JO (1) JOP20200025A1 (ru)
MA (1) MA49828A (ru)
MX (1) MX2020001481A (ru)
PE (1) PE20211460A1 (ru)
PH (1) PH12019502852A1 (ru)
SG (1) SG11201913161WA (ru)
TW (1) TW201919682A (ru)
WO (1) WO2019030298A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023111350A2 (en) * 2021-12-17 2023-06-22 3B Pharmaceuticals Gmbh Carbonic anhydrase ix ligands

Family Cites Families (29)

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AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
DE4239402A1 (de) 1992-11-24 1994-05-26 Bayer Ag Pulverinhalator
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DE10129703A1 (de) 2001-06-22 2003-01-02 Sofotec Gmbh & Co Kg Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren
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SI1616592T1 (sl) 2004-07-16 2011-03-31 Almirall Sa Inhalator za uporabo farmacevtskih snovi v prahu in vloĹľek za prah za uporabo s tem inhalatorjem
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JP2011523557A (ja) 2008-06-04 2011-08-18 メディカル リサーチ カウンシル ペプチド
JP2012051826A (ja) * 2010-08-31 2012-03-15 Toray Ind Inc 環状ペプチド及びその修飾ペプチド並びにＫｅｌｃｈ様ＥＣＨ結合タンパク質１の結合阻害物質のスクリーニング方法
KR102183273B1 (ko) 2011-05-05 2020-11-27 사렙타 쎄러퓨틱스, 인코퍼레이티드 펩타이드 올리고뉴클레오타이드 접합체
EP2751128B1 (en) 2011-08-30 2021-03-03 United Kingdom Research and Innovation Cell-penetrating peptides having a central hydrophobic domain
JP2015067579A (ja) * 2013-09-30 2015-04-13 国立大学法人東北大学 細胞透過性ペプチド及び当該ペプチドを含む医薬組成物。

Also Published As

Publication number Publication date
PE20211460A1 (es) 2021-08-05
EP3665182A1 (en) 2020-06-17
MA49828A (fr) 2020-06-17
TW201919682A (zh) 2019-06-01
DOP2020000017A (es) 2020-02-28
AU2018314833B2 (en) 2020-03-19
KR20200035269A (ko) 2020-04-02
AR113100A1 (es) 2020-01-29
IL272467A (en) 2020-03-31
AU2018314833A1 (en) 2020-01-02
JP2020530022A (ja) 2020-10-15
ECSP20008530A (es) 2020-05-29
BR112019026306A2 (pt) 2020-07-14
WO2019030298A1 (en) 2019-02-14
CA3066698A1 (en) 2019-02-14
CO2020000617A2 (es) 2020-05-05
CL2020000305A1 (es) 2020-06-26
CR20200056A (es) 2020-03-16
PH12019502852A1 (en) 2020-09-28
JOP20200025A1 (ar) 2020-02-04
MX2020001481A (es) 2020-03-20
SG11201913161WA (en) 2020-01-30
US20200255478A1 (en) 2020-08-13
CN110997695A (zh) 2020-04-10

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