ITUB20160413A1 - Metodo per determinare Helicobacter pylori - Google Patents
Metodo per determinare Helicobacter pyloriInfo
- Publication number
- ITUB20160413A1 ITUB20160413A1 ITUB2016A000413A ITUB20160413A ITUB20160413A1 IT UB20160413 A1 ITUB20160413 A1 IT UB20160413A1 IT UB2016A000413 A ITUB2016A000413 A IT UB2016A000413A IT UB20160413 A ITUB20160413 A IT UB20160413A IT UB20160413 A1 ITUB20160413 A1 IT UB20160413A1
- Authority
- IT
- Italy
- Prior art keywords
- helicobacter pylori
- determining
- determining helicobacter
- pylori
- helicobacter
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/56922—Campylobacter
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITUB2016A000413A ITUB20160413A1 (it) | 2016-02-05 | 2016-02-05 | Metodo per determinare Helicobacter pylori |
ES17712224T ES2882501T3 (es) | 2016-02-05 | 2017-02-03 | Método para determinar Helicobacter pylori |
JP2018540864A JP7015786B2 (ja) | 2016-02-05 | 2017-02-03 | ヘリコバクター・ピロリを判定するための方法 |
EP17712224.9A EP3411714B1 (en) | 2016-02-05 | 2017-02-03 | Method for determining helicobacter pylori |
CA3013547A CA3013547A1 (en) | 2016-02-05 | 2017-02-03 | Method for determining helicobacter pylori |
MX2018009505A MX2018009505A (es) | 2016-02-05 | 2017-02-03 | Metodo para determinar helicobacter pylori. |
PCT/IB2017/050611 WO2017134627A1 (en) | 2016-02-05 | 2017-02-03 | Method for determining helicobacter pylori |
BR112018015965A BR112018015965A2 (pt) | 2016-02-05 | 2017-02-03 | método para determinação de helicobacter pylori |
RU2018130349A RU2744190C1 (ru) | 2016-02-05 | 2017-02-03 | Способ определения Helicobacter pylori |
CN201780009847.8A CN108884489B (zh) | 2016-02-05 | 2017-02-03 | 用于确定幽门螺杆菌(Helicobacter pylori)的方法 |
US16/075,425 US11377681B2 (en) | 2016-02-05 | 2017-02-03 | Method for determining Helicobacter pylori |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITUB2016A000413A ITUB20160413A1 (it) | 2016-02-05 | 2016-02-05 | Metodo per determinare Helicobacter pylori |
Publications (1)
Publication Number | Publication Date |
---|---|
ITUB20160413A1 true ITUB20160413A1 (it) | 2017-08-05 |
Family
ID=55948929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITUB2016A000413A ITUB20160413A1 (it) | 2016-02-05 | 2016-02-05 | Metodo per determinare Helicobacter pylori |
Country Status (11)
Country | Link |
---|---|
US (1) | US11377681B2 (it) |
EP (1) | EP3411714B1 (it) |
JP (1) | JP7015786B2 (it) |
CN (1) | CN108884489B (it) |
BR (1) | BR112018015965A2 (it) |
CA (1) | CA3013547A1 (it) |
ES (1) | ES2882501T3 (it) |
IT (1) | ITUB20160413A1 (it) |
MX (1) | MX2018009505A (it) |
RU (1) | RU2744190C1 (it) |
WO (1) | WO2017134627A1 (it) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101979202B1 (ko) * | 2017-11-01 | 2019-05-15 | 연세대학교 원주산학협력단 | 퀀타매트릭스 어세이 플랫폼 기반 헬리코박터 파이로리균 및 그 균의 항생제 내성에 관련된 유전자의 검출을 확인할 수 있는 진단법 및 그 응용 |
SG11202102098WA (en) * | 2018-09-03 | 2021-04-29 | Visby Medical Inc | Devices and methods for antibiotic susceptibility testing |
CN109762877B (zh) * | 2019-01-21 | 2021-03-09 | 北京大学第三医院(北京大学第三临床医学院) | 从粪便中富集胃幽门螺杆菌治疗相关基因的方法及试剂盒 |
CN109797203A (zh) * | 2019-01-24 | 2019-05-24 | 杭州和壹基因科技有限公司 | 幽门螺杆菌检测体系及检测试剂盒和应用 |
EP4085149A4 (en) | 2020-01-03 | 2024-03-06 | Visby Medical Inc | ANTIBIOTIC SUSCEPTIBILITY TESTING DEVICES AND METHODS |
CN111304345A (zh) * | 2020-02-27 | 2020-06-19 | 中国人民解放军军事科学院军事医学研究院 | 幽门螺旋杆菌23S rRNA基因耐药突变的检测方法及其应用 |
CN111455073A (zh) * | 2020-03-26 | 2020-07-28 | 温州医科大学附属第一医院 | 幽门螺旋杆菌分型与耐药检测的扩增和测序引物及试剂盒 |
WO2023121098A1 (ko) * | 2021-12-23 | 2023-06-29 | 주식회사 이노제닉스 | 피시알-리버스 블랏 교잡 어세이 기반 헬리코박터 파이로리균 및 그 균의 항생제 내성에 관련된 유전자의 동시 검출을 확인할 수 있는 개선된 진단법 및 그 응용 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000029618A1 (en) * | 1998-11-12 | 2000-05-25 | University Of Virginia Patent Foundation | Non-invasive detection of helicobacter pylori infection |
CN101665824A (zh) * | 2009-09-24 | 2010-03-10 | 周玉贵 | 一种检测幽门螺杆菌克拉霉素耐药基因的生物芯片及其制备方法和应用 |
WO2014087055A1 (en) * | 2012-12-05 | 2014-06-12 | Amplidiag Oy | Method for detecting helicobacter pylori dna in a stool sample |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6312894B1 (en) | 1995-04-03 | 2001-11-06 | Epoch Pharmaceuticals, Inc. | Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders |
PT104744A (pt) * | 2009-09-11 | 2011-03-11 | Univ Do Minho | Sondas de ácido péptido nucleico, estojo e método para detectar helicobacter pylori e/ou da sua resposta à claritromicina e respectivas aplicações |
-
2016
- 2016-02-05 IT ITUB2016A000413A patent/ITUB20160413A1/it unknown
-
2017
- 2017-02-03 BR BR112018015965A patent/BR112018015965A2/pt not_active Application Discontinuation
- 2017-02-03 RU RU2018130349A patent/RU2744190C1/ru active
- 2017-02-03 US US16/075,425 patent/US11377681B2/en active Active
- 2017-02-03 EP EP17712224.9A patent/EP3411714B1/en active Active
- 2017-02-03 CN CN201780009847.8A patent/CN108884489B/zh active Active
- 2017-02-03 JP JP2018540864A patent/JP7015786B2/ja active Active
- 2017-02-03 ES ES17712224T patent/ES2882501T3/es active Active
- 2017-02-03 MX MX2018009505A patent/MX2018009505A/es unknown
- 2017-02-03 WO PCT/IB2017/050611 patent/WO2017134627A1/en active Application Filing
- 2017-02-03 CA CA3013547A patent/CA3013547A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000029618A1 (en) * | 1998-11-12 | 2000-05-25 | University Of Virginia Patent Foundation | Non-invasive detection of helicobacter pylori infection |
CN101665824A (zh) * | 2009-09-24 | 2010-03-10 | 周玉贵 | 一种检测幽门螺杆菌克拉霉素耐药基因的生物芯片及其制备方法和应用 |
WO2014087055A1 (en) * | 2012-12-05 | 2014-06-12 | Amplidiag Oy | Method for detecting helicobacter pylori dna in a stool sample |
Non-Patent Citations (6)
Title |
---|
AKIKO NAKAMURA ET AL: "Determination of mutations of the 23S rRNA gene of Helicobacter?pylori by allele specific primer-polymerase chain reaction method", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 22, no. 7, 1 July 2007 (2007-07-01), AU, pages 1057 - 1063, XP055288549, ISSN: 0815-9319, DOI: 10.1111/j.1440-1746.2006.04546.x * |
C. SCHABEREITER-GURTNER ET AL: "Novel Real-Time PCR Assay for Detection of Helicobacter pylori Infection and Simultaneous Clarithromycin Susceptibility Testing of Stool and Biopsy Specimens", JOURNAL OF CLINICAL MICROBIOLOGY, vol. 42, no. 10, 1 October 2004 (2004-10-01), pages 4512 - 4518, XP055098248, ISSN: 0095-1137, DOI: 10.1128/JCM.42.10.4512-4518.2004 * |
ISABEL C. A. SCALETSKY ET AL: "Application of Real-Time PCR Stool Assay for Helicobacter pylori Detection and Clarithromycin Susceptibility Testing in Brazilian Children", HELICOBACTER, vol. 16, no. 4, 1 August 2011 (2011-08-01), US, pages 311 - 315, XP055288584, ISSN: 1083-4389, DOI: 10.1111/j.1523-5378.2011.00845.x * |
LYUDMILA BOYANOVA ET AL: "Clarithromycin Resistance Mutations in Helicobacter pylori in Association with Virulence Factors and Antibiotic Susceptibility of the Strains", MICROBIAL DRUG RESISTANCE., vol. 22, no. 3, 30 November 2015 (2015-11-30), US, pages 227 - 232, XP055288522, ISSN: 1076-6294, DOI: 10.1089/mdr.2015.0199 * |
TAKAHISA FURUTA ET AL: "Modified allele-specific primer-polymerase chain reaction method for analysis of susceptibility of Helicobacter pylori strains to clarithromycin", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 22, no. 11, 1 November 2007 (2007-11-01), AU, pages 1810 - 1815, XP055288517, ISSN: 0815-9319, DOI: 10.1111/j.1440-1746.2007.04919.x * |
YUAN LI ET AL: "Detection of clarithromycin resistance in Helicobacter pylori following noncryogenic storage of rapid urease tests for 30 days", JOURNAL OF DIGESTIVE DISEASES, vol. 13, no. 1, 21 December 2011 (2011-12-21), pages 54 - 59, XP055288524, ISSN: 1751-2972, DOI: 10.1111/j.1751-2980.2011.00549.x * |
Also Published As
Publication number | Publication date |
---|---|
JP2019506169A (ja) | 2019-03-07 |
EP3411714A1 (en) | 2018-12-12 |
MX2018009505A (es) | 2019-05-06 |
US11377681B2 (en) | 2022-07-05 |
RU2744190C1 (ru) | 2021-03-03 |
BR112018015965A2 (pt) | 2018-12-18 |
US20190211381A1 (en) | 2019-07-11 |
JP7015786B2 (ja) | 2022-02-03 |
ES2882501T3 (es) | 2021-12-02 |
CN108884489A (zh) | 2018-11-23 |
EP3411714B1 (en) | 2021-03-24 |
WO2017134627A1 (en) | 2017-08-10 |
CA3013547A1 (en) | 2017-08-10 |
CN108884489B (zh) | 2022-06-14 |
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