ITTO20050549A1 - Materiale composito iniettabile atto ad essere utilizzato come sostituto osseo - Google Patents

Materiale composito iniettabile atto ad essere utilizzato come sostituto osseo

Info

Publication number
ITTO20050549A1
ITTO20050549A1 IT000549A ITTO20050549A ITTO20050549A1 IT TO20050549 A1 ITTO20050549 A1 IT TO20050549A1 IT 000549 A IT000549 A IT 000549A IT TO20050549 A ITTO20050549 A IT TO20050549A IT TO20050549 A1 ITTO20050549 A1 IT TO20050549A1
Authority
IT
Italy
Prior art keywords
composite material
substitute
bonus
material injectable
injectable
Prior art date
Application number
IT000549A
Other languages
English (en)
Italian (it)
Inventor
Luigi Ambrosio
Maria Pau Ginebra
Josep Anton Planell
Valeria Sanguinario
Original Assignee
Consiglio Nazionale Ricerche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consiglio Nazionale Ricerche filed Critical Consiglio Nazionale Ricerche
Priority to IT000549A priority Critical patent/ITTO20050549A1/it
Priority to AU2006274594A priority patent/AU2006274594B2/en
Priority to ZA200801928A priority patent/ZA200801928B/xx
Priority to AT06780262T priority patent/ATE465762T1/de
Priority to CN2006800286341A priority patent/CN101257937B/zh
Priority to PL06780262T priority patent/PL1924302T3/pl
Priority to NZ566086A priority patent/NZ566086A/en
Priority to US11/997,211 priority patent/US20080220086A1/en
Priority to DK06780262.9T priority patent/DK1924302T3/da
Priority to JP2008524655A priority patent/JP5180075B2/ja
Priority to SM200800013T priority patent/SMAP200800013A/it
Priority to ES06780262T priority patent/ES2345399T3/es
Priority to RU2008108014/15A priority patent/RU2407552C2/ru
Priority to CA002617721A priority patent/CA2617721A1/en
Priority to UAA200802792A priority patent/UA92027C2/ru
Priority to PCT/IB2006/052623 priority patent/WO2007015208A2/en
Priority to KR1020087005280A priority patent/KR101276632B1/ko
Priority to EP06780262A priority patent/EP1924302B1/en
Priority to BRPI0615994-0A priority patent/BRPI0615994A2/pt
Priority to PT06780262T priority patent/PT1924302E/pt
Priority to SI200630731T priority patent/SI1924302T1/sl
Priority to DE602006014004T priority patent/DE602006014004D1/de
Publication of ITTO20050549A1 publication Critical patent/ITTO20050549A1/it
Priority to US12/979,818 priority patent/US8231909B2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02Inorganic materials
    • A61L27/12Phosphorus-containing materials, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/46Special tools for implanting artificial joints
    • A61F2/4601Special tools for implanting artificial joints for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • A61F2002/2817Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00179Ceramics or ceramic-like structures
    • A61F2310/00293Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/06Flowable or injectable implant compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT000549A 2005-08-03 2005-08-03 Materiale composito iniettabile atto ad essere utilizzato come sostituto osseo ITTO20050549A1 (it)

Priority Applications (23)

Application Number Priority Date Filing Date Title
IT000549A ITTO20050549A1 (it) 2005-08-03 2005-08-03 Materiale composito iniettabile atto ad essere utilizzato come sostituto osseo
RU2008108014/15A RU2407552C2 (ru) 2005-08-03 2006-08-01 Инъецируемый композитный материал, пригодный для использования в качестве заменителя костной ткани
ES06780262T ES2345399T3 (es) 2005-08-03 2006-08-01 Material compuesto inyectable adecuado para uso como sustituto oseo.
AT06780262T ATE465762T1 (de) 2005-08-03 2006-08-01 Injizierbares kompositmaterial zur verwendung als knochenersatz
CN2006800286341A CN101257937B (zh) 2005-08-03 2006-08-01 适用作骨替代物的可注射复合材料及其用途和制备方法
PL06780262T PL1924302T3 (pl) 2005-08-03 2006-08-01 Wstrzykiwalny materiał kompozytowy odpowiedni do zastosowania jako substytut kości
NZ566086A NZ566086A (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute
US11/997,211 US20080220086A1 (en) 2005-08-03 2006-08-01 Injectable Composite Material Suitable for Use as a Bone Substitute
CA002617721A CA2617721A1 (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute
ZA200801928A ZA200801928B (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone sustitute
SM200800013T SMAP200800013A (it) 2005-08-03 2006-08-01 Materiale composito iniettabile atto ad essere utilizzato come sostituto osseo
AU2006274594A AU2006274594B2 (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute
JP2008524655A JP5180075B2 (ja) 2005-08-03 2006-08-01 代用骨としての使用に適した注射可能な複合材料
DK06780262.9T DK1924302T3 (da) 2005-08-03 2006-08-01 Injicerbart kompositmateriale egnet til anvendelse som knoglesubstitut
UAA200802792A UA92027C2 (ru) 2005-08-03 2006-08-01 Применение инъекционного композиционного материала как заменителя кости
PCT/IB2006/052623 WO2007015208A2 (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute
KR1020087005280A KR101276632B1 (ko) 2005-08-03 2006-08-01 뼈 대체물로서 사용하기에 적합한 주입가능한 복합 물질
EP06780262A EP1924302B1 (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute
BRPI0615994-0A BRPI0615994A2 (pt) 2005-08-03 2006-08-01 material composto injetável adequado para uso como um substituto para osso
PT06780262T PT1924302E (pt) 2005-08-03 2006-08-01 MATERIAL COMPËSITO INJECTáVEL ADEQUADO PARA UTILIZAÆO COMO SUBSTITUTO DO OSSO
SI200630731T SI1924302T1 (sl) 2005-08-03 2006-08-01 Injekcijski kompozitni material primeren za uporabo kot kostni nadomestek
DE602006014004T DE602006014004D1 (de) 2005-08-03 2006-08-01 Injizierbares kompositmaterial zur verwendung als knochenersatz
US12/979,818 US8231909B2 (en) 2005-08-03 2010-12-28 Injectable composite material suitable for use as a bone substitute

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000549A ITTO20050549A1 (it) 2005-08-03 2005-08-03 Materiale composito iniettabile atto ad essere utilizzato come sostituto osseo

Publications (1)

Publication Number Publication Date
ITTO20050549A1 true ITTO20050549A1 (it) 2007-02-04

Family

ID=37667630

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000549A ITTO20050549A1 (it) 2005-08-03 2005-08-03 Materiale composito iniettabile atto ad essere utilizzato come sostituto osseo

Country Status (22)

Country Link
US (2) US20080220086A1 (enExample)
EP (1) EP1924302B1 (enExample)
JP (1) JP5180075B2 (enExample)
KR (1) KR101276632B1 (enExample)
CN (1) CN101257937B (enExample)
AT (1) ATE465762T1 (enExample)
AU (1) AU2006274594B2 (enExample)
BR (1) BRPI0615994A2 (enExample)
CA (1) CA2617721A1 (enExample)
DE (1) DE602006014004D1 (enExample)
DK (1) DK1924302T3 (enExample)
ES (1) ES2345399T3 (enExample)
IT (1) ITTO20050549A1 (enExample)
NZ (1) NZ566086A (enExample)
PL (1) PL1924302T3 (enExample)
PT (1) PT1924302E (enExample)
RU (1) RU2407552C2 (enExample)
SI (1) SI1924302T1 (enExample)
SM (1) SMAP200800013A (enExample)
UA (1) UA92027C2 (enExample)
WO (1) WO2007015208A2 (enExample)
ZA (1) ZA200801928B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235592B2 (en) 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
US20070098799A1 (en) * 2005-10-28 2007-05-03 Zimmer, Inc. Mineralized Hydrogels and Methods of Making and Using Hydrogels
WO2007067697A2 (en) 2005-12-07 2007-06-14 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
US8110242B2 (en) 2006-03-24 2012-02-07 Zimmer, Inc. Methods of preparing hydrogel coatings
US7731988B2 (en) 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
US8062739B2 (en) 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
US7947784B2 (en) 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US8034362B2 (en) 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces
US20100226956A1 (en) 2009-03-06 2010-09-09 Per Kjellin Production of moldable bone substitute
JP6952348B2 (ja) 2015-07-24 2021-10-20 トリンプ アイピー ピーティーワイ リミテッド 殺菌性ポリマー及びポリマーと細胞との複合体ならびにそれらの合成
JP2020067494A (ja) * 2018-10-22 2020-04-30 ウェトラブ株式会社 脳神経外科手術用頭部モデル

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3635316B2 (ja) * 1996-11-25 2005-04-06 株式会社アドバンス 球状セラミックス多孔体の製造方法
RU2251405C2 (ru) * 2000-03-27 2005-05-10 Шотт Глас Композиции для косметических препаратов, средств личной гигиены, компонентов очищающего действия, пищевых добавок, способы их получения и применения
US6949251B2 (en) 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
WO2003035576A1 (en) * 2001-10-21 2003-05-01 National Institute Of Advanced Industrial Science And Technology Porous article of sintered calcium phosphate, process for producing the same and artificial bone and histomorphological scaffold using the same
SI1675608T1 (sl) * 2003-09-12 2007-08-31 Wyeth Corp Injektibilne trdne paličice kalcijevega fosfata za dajanje osteogenih proteinov

Also Published As

Publication number Publication date
EP1924302A2 (en) 2008-05-28
CA2617721A1 (en) 2007-02-08
AU2006274594B2 (en) 2011-12-22
KR20080041678A (ko) 2008-05-13
US20080220086A1 (en) 2008-09-11
RU2407552C2 (ru) 2010-12-27
ZA200801928B (en) 2009-07-29
US20110091554A1 (en) 2011-04-21
KR101276632B1 (ko) 2013-06-18
ATE465762T1 (de) 2010-05-15
ES2345399T3 (es) 2010-09-22
NZ566086A (en) 2011-03-31
PT1924302E (pt) 2010-07-27
BRPI0615994A2 (pt) 2011-05-31
CN101257937B (zh) 2013-03-20
SMP200800013B (it) 2008-02-27
WO2007015208A2 (en) 2007-02-08
UA92027C2 (ru) 2010-09-27
RU2008108014A (ru) 2009-09-10
JP2009502405A (ja) 2009-01-29
DE602006014004D1 (de) 2010-06-10
WO2007015208A3 (en) 2007-05-31
US8231909B2 (en) 2012-07-31
AU2006274594A1 (en) 2007-02-08
PL1924302T3 (pl) 2010-10-29
SMAP200800013A (it) 2008-02-27
CN101257937A (zh) 2008-09-03
DK1924302T3 (da) 2010-07-26
EP1924302B1 (en) 2010-04-28
JP5180075B2 (ja) 2013-04-10
SI1924302T1 (sl) 2010-09-30

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