CN101257937B - 适用作骨替代物的可注射复合材料及其用途和制备方法 - Google Patents

适用作骨替代物的可注射复合材料及其用途和制备方法 Download PDF

Info

Publication number
CN101257937B
CN101257937B CN2006800286341A CN200680028634A CN101257937B CN 101257937 B CN101257937 B CN 101257937B CN 2006800286341 A CN2006800286341 A CN 2006800286341A CN 200680028634 A CN200680028634 A CN 200680028634A CN 101257937 B CN101257937 B CN 101257937B
Authority
CN
China
Prior art keywords
polyvinyl alcohol
composite material
tricalcium phosphate
injectable composite
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800286341A
Other languages
English (en)
Chinese (zh)
Other versions
CN101257937A (zh
Inventor
L·安布罗西奥
V·桑吉纳里奥
M·P·希内夫拉
J·A·普拉内尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consiglio Nazionale delle Richerche CNR
Original Assignee
Consiglio Nazionale delle Richerche CNR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consiglio Nazionale delle Richerche CNR filed Critical Consiglio Nazionale delle Richerche CNR
Publication of CN101257937A publication Critical patent/CN101257937A/zh
Application granted granted Critical
Publication of CN101257937B publication Critical patent/CN101257937B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2/4601—Special tools for implanting artificial joints for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2006800286341A 2005-08-03 2006-08-01 适用作骨替代物的可注射复合材料及其用途和制备方法 Expired - Fee Related CN101257937B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000549A ITTO20050549A1 (it) 2005-08-03 2005-08-03 Materiale composito iniettabile atto ad essere utilizzato come sostituto osseo
ITTO2005A000549 2005-08-03
PCT/IB2006/052623 WO2007015208A2 (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute

Publications (2)

Publication Number Publication Date
CN101257937A CN101257937A (zh) 2008-09-03
CN101257937B true CN101257937B (zh) 2013-03-20

Family

ID=37667630

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800286341A Expired - Fee Related CN101257937B (zh) 2005-08-03 2006-08-01 适用作骨替代物的可注射复合材料及其用途和制备方法

Country Status (22)

Country Link
US (2) US20080220086A1 (enExample)
EP (1) EP1924302B1 (enExample)
JP (1) JP5180075B2 (enExample)
KR (1) KR101276632B1 (enExample)
CN (1) CN101257937B (enExample)
AT (1) ATE465762T1 (enExample)
AU (1) AU2006274594B2 (enExample)
BR (1) BRPI0615994A2 (enExample)
CA (1) CA2617721A1 (enExample)
DE (1) DE602006014004D1 (enExample)
DK (1) DK1924302T3 (enExample)
ES (1) ES2345399T3 (enExample)
IT (1) ITTO20050549A1 (enExample)
NZ (1) NZ566086A (enExample)
PL (1) PL1924302T3 (enExample)
PT (1) PT1924302E (enExample)
RU (1) RU2407552C2 (enExample)
SI (1) SI1924302T1 (enExample)
SM (1) SMAP200800013A (enExample)
UA (1) UA92027C2 (enExample)
WO (1) WO2007015208A2 (enExample)
ZA (1) ZA200801928B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235592B2 (en) 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
US20070098799A1 (en) * 2005-10-28 2007-05-03 Zimmer, Inc. Mineralized Hydrogels and Methods of Making and Using Hydrogels
WO2007067697A2 (en) 2005-12-07 2007-06-14 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
US8110242B2 (en) 2006-03-24 2012-02-07 Zimmer, Inc. Methods of preparing hydrogel coatings
US7731988B2 (en) 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
US8062739B2 (en) 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
US7947784B2 (en) 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US8034362B2 (en) 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces
US20100226956A1 (en) 2009-03-06 2010-09-09 Per Kjellin Production of moldable bone substitute
JP6952348B2 (ja) 2015-07-24 2021-10-20 トリンプ アイピー ピーティーワイ リミテッド 殺菌性ポリマー及びポリマーと細胞との複合体ならびにそれらの合成
JP2020067494A (ja) * 2018-10-22 2020-04-30 ウェトラブ株式会社 脳神経外科手術用頭部モデル

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1449818A1 (en) * 2001-10-21 2004-08-25 National Institute of Advanced Industrial Science and Technology Porous article of sintered calcium phosphate, process for producing the same and artificial bone and histomorphological scaffold using the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3635316B2 (ja) * 1996-11-25 2005-04-06 株式会社アドバンス 球状セラミックス多孔体の製造方法
RU2251405C2 (ru) * 2000-03-27 2005-05-10 Шотт Глас Композиции для косметических препаратов, средств личной гигиены, компонентов очищающего действия, пищевых добавок, способы их получения и применения
US6949251B2 (en) 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
SI1675608T1 (sl) * 2003-09-12 2007-08-31 Wyeth Corp Injektibilne trdne paličice kalcijevega fosfata za dajanje osteogenih proteinov

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1449818A1 (en) * 2001-10-21 2004-08-25 National Institute of Advanced Industrial Science and Technology Porous article of sintered calcium phosphate, process for producing the same and artificial bone and histomorphological scaffold using the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BOHNER M, et al..Injectability of calcium phosphate pastes.《BIOMATERIALS》.2005,第26卷(第13期),1553-1563. *
LANDI,E. et al..Calcium phosphate ceramics as drug-delivery system for anticancer therapy.《KEY ENGINEERING MATERIALS》.2001,第192-195卷901-904. *
TAS,A.C..Preparation of porous bioceramics by a simple PVA-processing route.《KEY ENGINEERING MATERIALS》.2004,第264-268卷2079-2082. *

Also Published As

Publication number Publication date
EP1924302A2 (en) 2008-05-28
CA2617721A1 (en) 2007-02-08
ITTO20050549A1 (it) 2007-02-04
AU2006274594B2 (en) 2011-12-22
KR20080041678A (ko) 2008-05-13
US20080220086A1 (en) 2008-09-11
RU2407552C2 (ru) 2010-12-27
ZA200801928B (en) 2009-07-29
US20110091554A1 (en) 2011-04-21
KR101276632B1 (ko) 2013-06-18
ATE465762T1 (de) 2010-05-15
ES2345399T3 (es) 2010-09-22
NZ566086A (en) 2011-03-31
PT1924302E (pt) 2010-07-27
BRPI0615994A2 (pt) 2011-05-31
SMP200800013B (it) 2008-02-27
WO2007015208A2 (en) 2007-02-08
UA92027C2 (ru) 2010-09-27
RU2008108014A (ru) 2009-09-10
JP2009502405A (ja) 2009-01-29
DE602006014004D1 (de) 2010-06-10
WO2007015208A3 (en) 2007-05-31
US8231909B2 (en) 2012-07-31
AU2006274594A1 (en) 2007-02-08
PL1924302T3 (pl) 2010-10-29
SMAP200800013A (it) 2008-02-27
CN101257937A (zh) 2008-09-03
DK1924302T3 (da) 2010-07-26
EP1924302B1 (en) 2010-04-28
JP5180075B2 (ja) 2013-04-10
SI1924302T1 (sl) 2010-09-30

Similar Documents

Publication Publication Date Title
US8231909B2 (en) Injectable composite material suitable for use as a bone substitute
CN101496909B (zh) 聚多糖/磷酸钙复合骨水泥及其制备方法
CN101057979B (zh) 可注射自固化磷酸钙骨组织修复材料及其制备方法与应用
CN102526798B (zh) 可注射复合骨水泥及其制备方法
KR102160719B1 (ko) 주사성, 생분해성 골시멘트 및 이를 제조 및 사용하는 방법
CN108635624B (zh) 一种抗溃散型可注射的磷酸镁基骨水泥
CN104591679B (zh) 一种改性氯氧镁骨水泥及其制备方法和应用
CN100425295C (zh) 预混合型膏状磷酸钙骨水泥
CN110062635A (zh) α-TCP、硅酸盐和磷酸化氨基酸的组合物
CN101284150B (zh) 聚合物增强硅酸钙复合多孔骨水泥
RU2494721C1 (ru) Биосовместимый костнозамещающий материал и способ получения его
CN113750289B (zh) 基于磷酸钙的有机-无机复合生物活性材料及其制备方法
CN119792634A (zh) 一种可成孔的能够增加骨把持力的复合骨水泥及其制备方法和应用
CN101716380A (zh) 可注射成型的骨修复复合材料及制备方法
CN105536059A (zh) 一种自修复可注射骨水泥及制备方法
JP3965249B2 (ja) リン酸カルシウムセメント及びリン酸カルシウムセメント組成物
CN104645418A (zh) 一种可注射型骨水泥及制备方法
CN105461941A (zh) 一种自固化高强度大分子胶的制备方法
TWI805355B (zh) 抗沖刷能力之可塑型的骨科組合物
LORENC Reologické vlastnosti termosenzitivních kostních cementů obohacených o bioaktivní látky
CN104940993B (zh) 一种复合微囊化人工细胞的可注射人工骨
CN117919482A (zh) 一种骨组织植入物粘合剂及其制备方法和应用
BR102019009073A2 (pt) cimento ósseo injetável de cura rápida reforçado com óxido de grafeno e seu método de preparação

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130320

Termination date: 20200801