ITRM20040561A1 - Uso della acetil l-carnitina in combinazione con propionil l-carnitina e sildenafil per il trattamento della disfunzione erettile. - Google Patents
Uso della acetil l-carnitina in combinazione con propionil l-carnitina e sildenafil per il trattamento della disfunzione erettile.Info
- Publication number
- ITRM20040561A1 ITRM20040561A1 IT000561A ITRM20040561A ITRM20040561A1 IT RM20040561 A1 ITRM20040561 A1 IT RM20040561A1 IT 000561 A IT000561 A IT 000561A IT RM20040561 A ITRM20040561 A IT RM20040561A IT RM20040561 A1 ITRM20040561 A1 IT RM20040561A1
- Authority
- IT
- Italy
- Prior art keywords
- carnitine
- sildenafil
- propionyl
- acetyl
- treatment
- Prior art date
Links
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 title abstract 4
- 208000010228 Erectile Dysfunction Diseases 0.000 title abstract 2
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 title abstract 2
- UFAHZIUFPNSHSL-MRVPVSSYSA-N O-propanoyl-L-carnitine Chemical compound CCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C UFAHZIUFPNSHSL-MRVPVSSYSA-N 0.000 title abstract 2
- 201000001881 impotence Diseases 0.000 title abstract 2
- 229960003310 sildenafil Drugs 0.000 title abstract 2
- 235000005911 diet Nutrition 0.000 abstract 1
- 230000000378 dietary effect Effects 0.000 abstract 1
- 230000009429 distress Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000642 iatrogenic effect Effects 0.000 abstract 1
- 210000001931 lesser pelvis Anatomy 0.000 abstract 1
- 210000004977 neurovascular bundle Anatomy 0.000 abstract 1
- 210000003899 penis Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000561A ITRM20040561A1 (it) | 2004-11-11 | 2004-11-11 | Uso della acetil l-carnitina in combinazione con propionil l-carnitina e sildenafil per il trattamento della disfunzione erettile. |
| SI200530953T SI1811988T1 (sl) | 2004-11-11 | 2005-10-19 | Uporaba acetil l-karnitina v kombinaciji s propionil l-karnitinom in sildenafilom za zdravljenje erektilne disfunkcije |
| AT05798477T ATE456950T1 (de) | 2004-11-11 | 2005-10-19 | Verwendung von acetyl l-carnitin in kombination mit propionyl l-carnitin und sildenafil zur behandlung von erektiler dysfunktion |
| EP05798477A EP1811988B1 (en) | 2004-11-11 | 2005-10-19 | Use of acetyl l-carnitine in combination with propionyl l-carnitine and sildenafil for the treatment of erectile dysfunction |
| KR1020077013019A KR101455275B1 (ko) | 2004-11-11 | 2005-10-19 | 발기 부전의 치료를 위한 아세틸 엘 카르니틴과 프로피오닐엘 카르니틴 및 실데나필과의 병용된 용도 |
| DE602005019251T DE602005019251D1 (de) | 2004-11-11 | 2005-10-19 | Verwendung von acetyl l-carnitin in kombination mit propionyl l-carnitin und sildenafil zur behandlung von erektiler dysfunktion |
| DK05798477.5T DK1811988T3 (da) | 2004-11-11 | 2005-10-19 | Anvendelse af acetyl-L-carnitin i kombination med propionyl-L-carnitin og sildenafil til behandling af erektil dysfunktion |
| JP2007540521A JP5080263B2 (ja) | 2004-11-11 | 2005-10-19 | 勃起不全の治療のためのプロピオニルｌ−カルニチンおよびシルデナフィルと組み合わせてのアセチルｌ−カルニチンの使用 |
| US11/719,011 US8003652B2 (en) | 2004-11-11 | 2005-10-19 | Use of acetyl L-carnitine in combination with propionyl L-carnitine and Sildenafil for the treatment of erectile dysfunction |
| PT05798477T PT1811988E (pt) | 2004-11-11 | 2005-10-19 | Utilização de acetil l-carnitina em combinação com propionilo l-carnitina e sildenafil para o tratamento da disfunção eréctil |
| PCT/EP2005/011238 WO2006050794A1 (en) | 2004-11-11 | 2005-10-19 | Use of acetyl l-carnitine in combination with propionyl l-carnitine and sildenafil for the treatment of erectile dysfunction |
| ES05798477T ES2339265T3 (es) | 2004-11-11 | 2005-10-19 | Uso de acetil l-carnitina en combinacion con propionil l-carnitina y sildenafil para el tratamiento de la difuncion erectil. |
| CA2585654A CA2585654C (en) | 2004-11-11 | 2005-10-19 | Use of acetyl l-carnitine in combination with propionyl l-carnitine and sildenafil for the treatment of erectile dysfunction |
| MX2007005518A MX2007005518A (es) | 2004-11-11 | 2005-10-19 | Uso de acetil l-carnitina en combinacion con propionil l-carnitina y sildenafil para el tratamiento de disfuncion erectil. |
| PL05798477T PL1811988T3 (pl) | 2004-11-11 | 2005-10-19 | Zastosowanie acetylo-L-karnityny w połączeniu z propionylo-L-karnityną i sildenafilem do leczenia zaburzenia erekcji |
| CY20101100362T CY1110239T1 (el) | 2004-11-11 | 2010-04-23 | Χρηση ακετυλο-l-kapnιτινη σε συνδυασμο με προπιονυλο-l-καρνιτινη και σιλδεναφιλη για τη θεραπευτικη αγωγη της στυτικης δυσλειτουργιας |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000561A ITRM20040561A1 (it) | 2004-11-11 | 2004-11-11 | Uso della acetil l-carnitina in combinazione con propionil l-carnitina e sildenafil per il trattamento della disfunzione erettile. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITRM20040561A1 true ITRM20040561A1 (it) | 2005-02-11 |
Family
ID=35501123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT000561A ITRM20040561A1 (it) | 2004-11-11 | 2004-11-11 | Uso della acetil l-carnitina in combinazione con propionil l-carnitina e sildenafil per il trattamento della disfunzione erettile. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8003652B2 (enExample) |
| EP (1) | EP1811988B1 (enExample) |
| JP (1) | JP5080263B2 (enExample) |
| KR (1) | KR101455275B1 (enExample) |
| AT (1) | ATE456950T1 (enExample) |
| CA (1) | CA2585654C (enExample) |
| CY (1) | CY1110239T1 (enExample) |
| DE (1) | DE602005019251D1 (enExample) |
| DK (1) | DK1811988T3 (enExample) |
| ES (1) | ES2339265T3 (enExample) |
| IT (1) | ITRM20040561A1 (enExample) |
| MX (1) | MX2007005518A (enExample) |
| PL (1) | PL1811988T3 (enExample) |
| PT (1) | PT1811988E (enExample) |
| SI (1) | SI1811988T1 (enExample) |
| WO (1) | WO2006050794A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010222347A (ja) * | 2009-02-24 | 2010-10-07 | Daiichi Sankyo Healthcare Co Ltd | Ｐｄｅ５阻害剤及びカルニチンを含有する医薬組成物 |
| WO2012000634A1 (de) | 2010-06-29 | 2012-01-05 | Georg Bambach | Pharmazeutische zusammensetzung zur behandlung von erektiler dysfunktion |
| WO2018070971A1 (ru) * | 2016-10-10 | 2018-04-19 | Товарыство З Обмэжэною Видповидальнистю Науково-Выробныча Фирма "Микрохим" | Фармацевтическая композиция в форме оромукозного спрея для лечения эректильной дисфункции и легочной артериальной гипертензии |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1077260B1 (en) | 1999-08-13 | 2010-03-31 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Parvovirus NS1 variants |
| IT1306722B1 (it) * | 1999-10-08 | 2001-10-02 | Sigma Tau Healthscience Spa | Composizione per la prevenzione e/o il trattamento di disfunzionicircolatorie, comprendente derivati della l-carnitina ed estratti di |
| JP2001233770A (ja) * | 2000-02-23 | 2001-08-28 | Dountsuendorufaa Udo | 勃起機能不全治療用の経口薬の組合わせ |
| ITRM20010621A1 (it) * | 2001-10-18 | 2003-04-18 | Aldo Fassi | Sali metallici non igroscopici e idrosolubili di alcanoil l-carnitine, integratori dietetici che li contengono e kit dietetici, per contrast |
| ITRM20010708A1 (it) * | 2001-12-04 | 2003-06-04 | Sigma Tau Ind Farmaceuti | Uso di una alcanoil l-carnitina per il trattamento della disfunzione erettile. |
| ITRM20020620A1 (it) * | 2002-12-13 | 2004-06-14 | Sigma Tau Ind Farmaceuti | Uso delle carnitine per la prevenzione e/o il trattamento dei disturbi causati dall'andropausa. |
-
2004
- 2004-11-11 IT IT000561A patent/ITRM20040561A1/it unknown
-
2005
- 2005-10-19 AT AT05798477T patent/ATE456950T1/de active
- 2005-10-19 DE DE602005019251T patent/DE602005019251D1/de not_active Expired - Lifetime
- 2005-10-19 ES ES05798477T patent/ES2339265T3/es not_active Expired - Lifetime
- 2005-10-19 CA CA2585654A patent/CA2585654C/en not_active Expired - Fee Related
- 2005-10-19 WO PCT/EP2005/011238 patent/WO2006050794A1/en not_active Ceased
- 2005-10-19 PT PT05798477T patent/PT1811988E/pt unknown
- 2005-10-19 PL PL05798477T patent/PL1811988T3/pl unknown
- 2005-10-19 US US11/719,011 patent/US8003652B2/en not_active Expired - Fee Related
- 2005-10-19 JP JP2007540521A patent/JP5080263B2/ja not_active Expired - Fee Related
- 2005-10-19 KR KR1020077013019A patent/KR101455275B1/ko not_active Expired - Fee Related
- 2005-10-19 DK DK05798477.5T patent/DK1811988T3/da active
- 2005-10-19 EP EP05798477A patent/EP1811988B1/en not_active Expired - Lifetime
- 2005-10-19 SI SI200530953T patent/SI1811988T1/sl unknown
- 2005-10-19 MX MX2007005518A patent/MX2007005518A/es active IP Right Grant
-
2010
- 2010-04-23 CY CY20101100362T patent/CY1110239T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8003652B2 (en) | 2011-08-23 |
| DE602005019251D1 (de) | 2010-03-25 |
| CA2585654C (en) | 2013-04-02 |
| WO2006050794A1 (en) | 2006-05-18 |
| JP2008531466A (ja) | 2008-08-14 |
| CA2585654A1 (en) | 2006-05-18 |
| ATE456950T1 (de) | 2010-02-15 |
| PL1811988T3 (pl) | 2010-07-30 |
| PT1811988E (pt) | 2010-04-08 |
| EP1811988A1 (en) | 2007-08-01 |
| SI1811988T1 (sl) | 2010-10-29 |
| DK1811988T3 (da) | 2010-05-17 |
| EP1811988B1 (en) | 2010-02-03 |
| CY1110239T1 (el) | 2015-01-14 |
| ES2339265T3 (es) | 2010-05-18 |
| MX2007005518A (es) | 2007-05-18 |
| JP5080263B2 (ja) | 2012-11-21 |
| US20080090906A1 (en) | 2008-04-17 |
| KR101455275B1 (ko) | 2014-10-27 |
| KR20070085961A (ko) | 2007-08-27 |
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