ITMI971373A0 - - Google Patents
Info
- Publication number
- ITMI971373A0 ITMI971373A0 ITMI971373A ITMI971373A ITMI971373A0 IT MI971373 A0 ITMI971373 A0 IT MI971373A0 IT MI971373 A ITMI971373 A IT MI971373A IT MI971373 A ITMI971373 A IT MI971373A IT MI971373 A0 ITMI971373 A0 IT MI971373A0
- Authority
- IT
- Italy
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cephalosporin Compounds (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI001373A IT1292130B1 (it) | 1997-06-11 | 1997-06-11 | Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati |
| DE69808086T DE69808086T2 (de) | 1997-06-11 | 1998-06-08 | Ein verfahren zur herstellung von 1,4,7,10-tetraazacyclododecan-1,4,7-triessigsäure und deren derivaten |
| AU84369/98A AU738506B2 (en) | 1997-06-11 | 1998-06-08 | A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the derivatives thereof |
| PCT/EP1998/003408 WO1998056776A1 (en) | 1997-06-11 | 1998-06-08 | A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the derivatives thereof |
| ES98934925T ES2184302T3 (es) | 1997-06-11 | 1998-06-08 | Procedimiento para la preparacion del acido 1,4,7,10-tetraazaciclododecano-1,4,7-triacetico y derivados del mismo. |
| CN98803621A CN1117088C (zh) | 1997-06-11 | 1998-06-08 | 1,4,7,10－四氮杂环十二烷－1,4,7－三乙酸及其盐的制备方法 |
| CNB021495890A CN1215063C (zh) | 1997-06-11 | 1998-06-08 | 1，4，7，10－四氮杂环十二烷－1，4，7－三乙酸单－n－取代衍生物的制备方法 |
| JP50155499A JP4445042B2 (ja) | 1997-06-11 | 1998-06-08 | １，４，７，１０−テトラアザシクロドデカン−１，４，７−三酢酸及びその誘導体の調製のための方法 |
| AT98934925T ATE224379T1 (de) | 1997-06-11 | 1998-06-08 | Ein verfahren zur herstellung von 1,4,7,10- tetraazacyclododecan-1,4,7-triessigsäure und deren derivaten |
| IL13125598A IL131255A (en) | 1997-06-11 | 1998-06-08 | Process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the derivatives thereof |
| EP98934925A EP0989974B1 (en) | 1997-06-11 | 1998-06-08 | A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the derivatives thereof |
| IN1252MA1998 IN186470B (US06559137-20030506-C00182.png) | 1997-06-11 | 1998-06-10 | |
| ZA985023A ZA985023B (en) | 1997-06-11 | 1998-06-10 | A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the derivatives thereof |
| US09/095,016 US5962679A (en) | 1997-06-11 | 1998-06-10 | Process for the preparation of 1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetic acid and the derivatives thereof |
| US09/339,957 US6054581A (en) | 1997-06-11 | 1999-06-25 | Process for the preparation of 1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetic acid and the derivative thereof |
| NO19995924A NO312548B1 (no) | 1997-06-11 | 1999-12-03 | Fremgangsmåte ved fremstillingen av 1,4,7,10- tetraazacyklododekan-1,4,7-trieddiksyre og derivater derav |
| JP2009133854A JP5204724B2 (ja) | 1997-06-11 | 2009-06-03 | １，４，７，１０−テトラアザシクロドデカン−１，４，７−三酢酸及びその誘導体の調製のための方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI001373A IT1292130B1 (it) | 1997-06-11 | 1997-06-11 | Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI971373A0 true ITMI971373A0 (US06559137-20030506-C00182.png) | 1997-06-11 |
| ITMI971373A1 ITMI971373A1 (it) | 1998-12-11 |
| IT1292130B1 IT1292130B1 (it) | 1999-01-25 |
Family
ID=11377338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT97MI001373A IT1292130B1 (it) | 1997-06-11 | 1997-06-11 | Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati |
Country Status (14)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1292130B1 (it) * | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati |
| US6166201A (en) * | 1999-06-25 | 2000-12-26 | Dibra S.P.A. | Process for the preparation of 1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetic acid and the derivatives thereof |
| US6852854B1 (en) | 2002-10-01 | 2005-02-08 | Psiloquest Inc. | Preformed carboxylated active ester for labeling biomolecules |
| US6838557B1 (en) * | 2002-10-01 | 2005-01-04 | Board Of Regents The University Of Texas System | Process for making a chelating agent for labeling biomolecules using preformed active esters |
| CN100418957C (zh) * | 2003-07-08 | 2008-09-17 | 香港大学 | 三-n-烷基化的1,4,7,10-四氮杂环十二烷的合成 |
| DE102009053171B4 (de) | 2009-11-04 | 2011-07-21 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol) |
| CN103232403B (zh) * | 2013-05-09 | 2016-04-27 | 浙江凯普化工有限公司 | 一种氮杂环的制备方法 |
| JP6227760B2 (ja) * | 2013-05-30 | 2017-11-08 | ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． | 蛍光固形脂質ナノ粒子組成物およびその製法 |
| CN108084105B (zh) * | 2016-11-23 | 2020-07-24 | 四川科伦药物研究院有限公司 | 钆特醇中间体及其合成方法和利用该钆特醇中间体制备钆特醇的方法 |
| KR101971435B1 (ko) | 2017-08-29 | 2019-04-24 | 주식회사 엔지켐생명과학 | 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법 |
| WO2020084504A1 (en) * | 2018-10-24 | 2020-04-30 | Biophore India Pharmaceuticals Pvt. Ltd | Novel process for the preparation of macrocyclic chelant 2,2',2''-(10-(2-hydroxypropyl)-1,4,7,10-tetra azacyclododecane-1,4,7-triyl) triacetic acid and it's complexes with paramagnetic metal ions |
| US20200397924A1 (en) * | 2019-01-28 | 2020-12-24 | Hubei Tianshu Pharmaceutical Co., Ltd | Preparation method of intermediate of gadolinium-based ionic contrast agent and use thereof |
| CN111039885B (zh) * | 2019-12-06 | 2021-03-05 | 广州康瑞泰药业有限公司 | 一种制备高纯度考布曲钙的方法 |
| KR20210114742A (ko) * | 2020-03-11 | 2021-09-24 | 주식회사 엔지켐생명과학 | 칼테리돌의 제조방법 |
| CN113549025B (zh) * | 2021-07-14 | 2023-07-25 | 江苏美迪克化学品有限公司 | 一种1,4,7,10-四氮杂环十二烷-1,4,7-三乙酸及其钠盐的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| FR2644453A1 (fr) * | 1989-03-20 | 1990-09-21 | Centre Nat Rech Scient | Procede de preparation de tetramines cycliques monofonctionnalisees |
| IT1243801B (it) * | 1990-08-29 | 1994-06-28 | Bracco Ind Chimica Spa | Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione |
| US5410043A (en) * | 1991-12-06 | 1995-04-25 | Schering Aktiengesellschaft | Process for the production of mono-N-substituted tetraaza macrocycles |
| DE4237943C2 (de) * | 1992-11-06 | 1997-10-23 | Schering Ag | Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate |
| DE4218744C2 (de) * | 1992-06-04 | 1997-11-06 | Schering Ag | Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe |
| DE4318369C1 (de) * | 1993-05-28 | 1995-02-09 | Schering Ag | Verwendung von makrocyclischen Metallkomplexen als Temperatursonden |
| WO1995027705A1 (en) * | 1994-04-08 | 1995-10-19 | Bracco International B.V. | Aromatic amide compounds and metal chelates thereof |
| IT1292130B1 (it) * | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati |
| IT1292128B1 (it) * | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici |
-
1997
- 1997-06-11 IT IT97MI001373A patent/IT1292130B1/it active IP Right Grant
-
1998
- 1998-06-08 DE DE69808086T patent/DE69808086T2/de not_active Expired - Lifetime
- 1998-06-08 IL IL13125598A patent/IL131255A/en not_active IP Right Cessation
- 1998-06-08 WO PCT/EP1998/003408 patent/WO1998056776A1/en active IP Right Grant
- 1998-06-08 CN CN98803621A patent/CN1117088C/zh not_active Expired - Lifetime
- 1998-06-08 AT AT98934925T patent/ATE224379T1/de not_active IP Right Cessation
- 1998-06-08 AU AU84369/98A patent/AU738506B2/en not_active Expired
- 1998-06-08 JP JP50155499A patent/JP4445042B2/ja not_active Expired - Lifetime
- 1998-06-08 EP EP98934925A patent/EP0989974B1/en not_active Expired - Lifetime
- 1998-06-08 ES ES98934925T patent/ES2184302T3/es not_active Expired - Lifetime
- 1998-06-08 CN CNB021495890A patent/CN1215063C/zh not_active Expired - Lifetime
- 1998-06-10 ZA ZA985023A patent/ZA985023B/xx unknown
- 1998-06-10 IN IN1252MA1998 patent/IN186470B/en unknown
- 1998-06-10 US US09/095,016 patent/US5962679A/en not_active Expired - Lifetime
-
1999
- 1999-06-25 US US09/339,957 patent/US6054581A/en not_active Expired - Lifetime
- 1999-12-03 NO NO19995924A patent/NO312548B1/no not_active IP Right Cessation
-
2009
- 2009-06-03 JP JP2009133854A patent/JP5204724B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NO995924D0 (no) | 1999-12-03 |
| DE69808086T2 (de) | 2003-06-05 |
| JP2009242405A (ja) | 2009-10-22 |
| CN1473819A (zh) | 2004-02-11 |
| US6054581A (en) | 2000-04-25 |
| CN1251094A (zh) | 2000-04-19 |
| NO312548B1 (no) | 2002-05-27 |
| ATE224379T1 (de) | 2002-10-15 |
| JP4445042B2 (ja) | 2010-04-07 |
| IL131255A (en) | 2004-01-04 |
| CN1215063C (zh) | 2005-08-17 |
| ZA985023B (en) | 1999-01-20 |
| AU8436998A (en) | 1998-12-30 |
| EP0989974B1 (en) | 2002-09-18 |
| IN186470B (US06559137-20030506-C00182.png) | 2001-09-08 |
| ES2184302T3 (es) | 2003-04-01 |
| NO995924L (no) | 2000-01-26 |
| DE69808086D1 (de) | 2002-10-24 |
| EP0989974A1 (en) | 2000-04-05 |
| US5962679A (en) | 1999-10-05 |
| IL131255A0 (en) | 2001-01-28 |
| ITMI971373A1 (it) | 1998-12-11 |
| CN1117088C (zh) | 2003-08-06 |
| WO1998056776A1 (en) | 1998-12-17 |
| JP2002503238A (ja) | 2002-01-29 |
| IT1292130B1 (it) | 1999-01-25 |
| JP5204724B2 (ja) | 2013-06-05 |
| AU738506B2 (en) | 2001-09-20 |
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| 0001 | Granted |