ITMI20081874A1 - Procedimento per la preparazione di gemcitabina cloridrato - Google Patents

Procedimento per la preparazione di gemcitabina cloridrato

Info

Publication number
ITMI20081874A1
ITMI20081874A1 IT001874A ITMI20081874A ITMI20081874A1 IT MI20081874 A1 ITMI20081874 A1 IT MI20081874A1 IT 001874 A IT001874 A IT 001874A IT MI20081874 A ITMI20081874 A IT MI20081874A IT MI20081874 A1 ITMI20081874 A1 IT MI20081874A1
Authority
IT
Italy
Prior art keywords
chloridrate
gemcitabine
procedure
preparation
gemcitabine chloridrate
Prior art date
Application number
IT001874A
Other languages
English (en)
Inventor
Paolo Anesa
Maria Argese
Giuseppe Guazzi
Alberto Varalli
Original Assignee
Prime Europ Therapeuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prime Europ Therapeuticals filed Critical Prime Europ Therapeuticals
Priority to ITMI2008A001874A priority Critical patent/IT1393062B1/it
Priority to EP09173606A priority patent/EP2180005A1/en
Priority to US12/582,955 priority patent/US8299239B2/en
Publication of ITMI20081874A1 publication Critical patent/ITMI20081874A1/it
Application granted granted Critical
Publication of IT1393062B1 publication Critical patent/IT1393062B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ITMI2008A001874A 2008-10-23 2008-10-23 Procedimento per la preparazione di gemcitabina cloridrato IT1393062B1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ITMI2008A001874A IT1393062B1 (it) 2008-10-23 2008-10-23 Procedimento per la preparazione di gemcitabina cloridrato
EP09173606A EP2180005A1 (en) 2008-10-23 2009-10-21 Process for the preparation of gemcitabine chlorohydrate
US12/582,955 US8299239B2 (en) 2008-10-23 2009-10-21 Process for the preparation of gemcitabine hydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2008A001874A IT1393062B1 (it) 2008-10-23 2008-10-23 Procedimento per la preparazione di gemcitabina cloridrato

Publications (2)

Publication Number Publication Date
ITMI20081874A1 true ITMI20081874A1 (it) 2010-04-24
IT1393062B1 IT1393062B1 (it) 2012-04-11

Family

ID=40943731

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2008A001874A IT1393062B1 (it) 2008-10-23 2008-10-23 Procedimento per la preparazione di gemcitabina cloridrato

Country Status (3)

Country Link
US (1) US8299239B2 (it)
EP (1) EP2180005A1 (it)
IT (1) IT1393062B1 (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101899072B (zh) * 2010-07-23 2012-09-12 宁波市天衡制药有限公司 基于硼氢化钠还原法制备吉西他滨中间体
CN102659884B (zh) * 2012-04-23 2014-07-02 南京臣功制药股份有限公司 盐酸吉西他滨的提纯方法
CN104109182B (zh) * 2013-04-17 2016-08-10 中国医药研究开发中心有限公司 一种制备盐酸吉西他滨的方法
CN104250277A (zh) * 2013-06-27 2014-12-31 上海朴颐化学科技有限公司 一种盐酸吉西他滨的纯化制备方法
CN104817599B (zh) * 2015-03-20 2018-02-27 南京欧信医药技术有限公司 一种5‑羟基四氢呋喃衍生物的合成方法
CN109651459B (zh) * 2019-01-24 2020-09-08 江苏八巨药业有限公司 一种吉西他滨中间体甲磺酰酯的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US20040158059A1 (en) * 2003-02-10 2004-08-12 Giancarlo Tamerlani Process for the preparation of ribofuranose derivatives
WO2005095430A1 (en) * 2004-03-31 2005-10-13 Ramesh Babu Polturi An improved process for the manufacture of high pure gemcitabine hydrochloride
WO2006095359A1 (en) * 2005-03-10 2006-09-14 Sms Pharmaceuticals Limited Synthesis of 2-deoxy-2, 2-di fluoro-d-ribo furanose-3, 5 di(4-methy/4-nitro-chloro)benzoate and its conversion to gemcitabine hydrochloride thereof
WO2007049294A1 (en) * 2005-10-28 2007-05-03 Arch Pharmalabs Limited An improved process for preparation of gemcitabine hydrochloride.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
WO2007112473A1 (en) * 2006-03-31 2007-10-11 Mayne Pharma Limited Purification of a difluoronucleoside anomer using aqueous acid solution
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US20040158059A1 (en) * 2003-02-10 2004-08-12 Giancarlo Tamerlani Process for the preparation of ribofuranose derivatives
WO2005095430A1 (en) * 2004-03-31 2005-10-13 Ramesh Babu Polturi An improved process for the manufacture of high pure gemcitabine hydrochloride
WO2006095359A1 (en) * 2005-03-10 2006-09-14 Sms Pharmaceuticals Limited Synthesis of 2-deoxy-2, 2-di fluoro-d-ribo furanose-3, 5 di(4-methy/4-nitro-chloro)benzoate and its conversion to gemcitabine hydrochloride thereof
WO2007049294A1 (en) * 2005-10-28 2007-05-03 Arch Pharmalabs Limited An improved process for preparation of gemcitabine hydrochloride.

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; WANG, YINGHUA ET AL: "Synthesis of gemcitabine hydrochloride", XP002542350, retrieved from STN Database accession no. 2008:1103450 *
ZHONGGUO YIYAO GONGYE ZAZHI , 38(4), 249-251 CODEN: ZYGZEA; ISSN: 1001-8255, 2007 *

Also Published As

Publication number Publication date
EP2180005A1 (en) 2010-04-28
US8299239B2 (en) 2012-10-30
IT1393062B1 (it) 2012-04-11
US20100105887A1 (en) 2010-04-29

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