ITMI20000559A0 - Esteri polisaccaridici di n-derivati di acido glutammico - Google Patents

Esteri polisaccaridici di n-derivati di acido glutammico

Info

Publication number
ITMI20000559A0
ITMI20000559A0 IT2000MI000559A ITMI20000559A ITMI20000559A0 IT MI20000559 A0 ITMI20000559 A0 IT MI20000559A0 IT 2000MI000559 A IT2000MI000559 A IT 2000MI000559A IT MI20000559 A ITMI20000559 A IT MI20000559A IT MI20000559 A0 ITMI20000559 A0 IT MI20000559A0
Authority
IT
Italy
Prior art keywords
derivatives
polysaccharide esters
glutammic acid
glutammic
acid
Prior art date
Application number
IT2000MI000559A
Other languages
English (en)
Inventor
Alessandro Rastrelli
Giuliana Miglierini
Luca Stucchi
Original Assignee
Cooperativa Ct Ricerch Soc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cooperativa Ct Ricerch Soc filed Critical Cooperativa Ct Ricerch Soc
Publication of ITMI20000559A0 publication Critical patent/ITMI20000559A0/it
Priority to IT2000MI000559A priority Critical patent/IT1318403B1/it
Priority to JP2001566669A priority patent/JP2003526720A/ja
Priority to US10/221,703 priority patent/US6844328B2/en
Priority to ES01931536T priority patent/ES2248322T3/es
Priority to AT01931536T priority patent/ATE304363T1/de
Priority to MXPA02009057A priority patent/MXPA02009057A/es
Priority to BR0109294-4A priority patent/BR0109294A/pt
Priority to EP01931536A priority patent/EP1274446B1/en
Priority to AU58286/01A priority patent/AU784655B2/en
Priority to CA002403063A priority patent/CA2403063A1/en
Priority to DE60113398T priority patent/DE60113398T2/de
Priority to CNB018066461A priority patent/CN1203071C/zh
Priority to IL15169601A priority patent/IL151696A0/xx
Priority to PCT/EP2001/003050 priority patent/WO2001068105A1/en
Priority to KR1020027012221A priority patent/KR20020093845A/ko
Publication of ITMI20000559A1 publication Critical patent/ITMI20000559A1/it
Priority to ZA200208299A priority patent/ZA200208299B/en
Application granted granted Critical
Publication of IT1318403B1 publication Critical patent/IT1318403B1/it
Priority to US10/950,879 priority patent/US20050065112A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
IT2000MI000559A 2000-03-17 2000-03-17 Esteri polisaccaridici di n-derivati di acido glutammico. IT1318403B1 (it)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IT2000MI000559A IT1318403B1 (it) 2000-03-17 2000-03-17 Esteri polisaccaridici di n-derivati di acido glutammico.
AU58286/01A AU784655B2 (en) 2000-03-17 2001-03-16 Polysaccharidic esters of N-derivatives of glutamic acid
DE60113398T DE60113398T2 (de) 2000-03-17 2001-03-16 Polysaccharidester von n-derivaten der glutaminsäure
ES01931536T ES2248322T3 (es) 2000-03-17 2001-03-16 Esteres polisacaridos de derivados n- del acido glutamico.
AT01931536T ATE304363T1 (de) 2000-03-17 2001-03-16 Polysaccharidester von n-derivaten der glutaminsäure
MXPA02009057A MXPA02009057A (es) 2000-03-17 2001-03-16 Esteres polisacaridos de n-derivados de acido glutamico.
BR0109294-4A BR0109294A (pt) 2000-03-17 2001-03-16 •ster polissacarìdico, composições farmacêuticas, uso do éster polissacarìdico, e, processo para a preparação dos ésteres polissacarìdicos
EP01931536A EP1274446B1 (en) 2000-03-17 2001-03-16 Polysaccharidic esters of n-derivatives of glutamic acid
JP2001566669A JP2003526720A (ja) 2000-03-17 2001-03-16 グルタミン酸ｎ−誘導体の多糖エステル
CA002403063A CA2403063A1 (en) 2000-03-17 2001-03-16 Polysaccharidic esters of n-derivatives of glutamic acid
US10/221,703 US6844328B2 (en) 2000-03-17 2001-03-16 Polysaccharidic esters of N-derivatives of glutamic acid
CNB018066461A CN1203071C (zh) 2000-03-17 2001-03-16 谷氨酸n－衍生物的多糖酯
IL15169601A IL151696A0 (en) 2000-03-17 2001-03-16 Polysaccharidic esters of n-derivatives of glutamic acid
PCT/EP2001/003050 WO2001068105A1 (en) 2000-03-17 2001-03-16 Polysaccharidic esters of n-derivatives of glutamic acid
KR1020027012221A KR20020093845A (ko) 2000-03-17 2001-03-16 글루탐산 ｎ-유도체의 다당류 에스테르
ZA200208299A ZA200208299B (en) 2000-03-17 2002-10-15 Polysaccharidic esters of N-derivatives of glutamic acid.
US10/950,879 US20050065112A1 (en) 2000-03-17 2004-09-27 Polysaccharidic esters of N-derivatives of glutamic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI000559A IT1318403B1 (it) 2000-03-17 2000-03-17 Esteri polisaccaridici di n-derivati di acido glutammico.

Publications (3)

Publication Number Publication Date
ITMI20000559A0 true ITMI20000559A0 (it) 2000-03-17
ITMI20000559A1 ITMI20000559A1 (it) 2001-09-17
IT1318403B1 IT1318403B1 (it) 2003-08-25

Family

ID=11444509

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000MI000559A IT1318403B1 (it) 2000-03-17 2000-03-17 Esteri polisaccaridici di n-derivati di acido glutammico.

Country Status (16)

Country Link
US (2) US6844328B2 (it)
EP (1) EP1274446B1 (it)
JP (1) JP2003526720A (it)
KR (1) KR20020093845A (it)
CN (1) CN1203071C (it)
AT (1) ATE304363T1 (it)
AU (1) AU784655B2 (it)
BR (1) BR0109294A (it)
CA (1) CA2403063A1 (it)
DE (1) DE60113398T2 (it)
ES (1) ES2248322T3 (it)
IL (1) IL151696A0 (it)
IT (1) IT1318403B1 (it)
MX (1) MXPA02009057A (it)
WO (1) WO2001068105A1 (it)
ZA (1) ZA200208299B (it)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318403B1 (it) * 2000-03-17 2003-08-25 Cooperativa Ct Ricerche Poly T Esteri polisaccaridici di n-derivati di acido glutammico.
US7507724B2 (en) 2001-01-16 2009-03-24 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
US7906492B2 (en) 2001-01-16 2011-03-15 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
ITTS20010016A1 (it) * 2001-06-20 2002-12-20 Ct Ricerche Poly Tec H A R L S Polisaccaridi regioselettivamente reticolati.
JP4524078B2 (ja) * 2002-05-31 2010-08-11 富士フイルム株式会社 磁性粒子およびその製造方法、並びに、磁気記録媒体およびその製造方法
US8088916B2 (en) 2004-03-05 2012-01-03 Denki Kagaku Kogyo Kabushiki Kaisha Hyaluronic acid-methotrexate conjugate
JP5001645B2 (ja) * 2004-04-02 2012-08-15 電気化学工業株式会社 ヒアルロン酸−メトトレキサート結合体
ATE450273T1 (de) * 2005-05-18 2009-12-15 Eurand Pharmaceuticals Ltd Proliferationshemmendes arzneimittel
CN100391585C (zh) * 2005-08-08 2008-06-04 武汉大学 二烷基谷氨酸糖酯表面活性剂及其制备方法和用途
US8323644B2 (en) 2006-01-17 2012-12-04 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
IE20060049A1 (en) * 2006-01-25 2007-08-08 Eurand Pharmaceuticals Ltd A novel drug delivery system: use of hyaluronic acid as a carrier moleclue for different classes of therapeutic active agents
IE20060565A1 (en) * 2006-07-28 2008-02-06 Eurand Pharmaceuticals Ltd Drug delivery system based on regioselectively amidated hyaluronic acid
ITMI20072416A1 (it) * 2007-12-21 2009-06-22 Sigea Srl Derivati polisaccaridici dell'acido lipoico, loro preparazione ed uso come dermocosmetici e presidi medicali
CN102337296A (zh) * 2011-07-05 2012-02-01 天津大学 葡聚糖—胍基丁胺聚阳离子转基因载体及其制备方法和应用
KR101467076B1 (ko) * 2013-02-20 2014-12-02 성균관대학교산학협력단 히알루론산-메토트렉세이트 접합체를 포함하는 관절염 예방 또는 치료용 약학적 조성물 및 이의 제조방법
BR112016026596A2 (pt) 2014-06-26 2017-08-15 Hoffmann La Roche Derivados de indolin-2-ona ou pirrolo-piridin-2-ona, seu uso, composição farmacêutica e combinação
CN108349942B (zh) 2015-11-06 2021-03-30 豪夫迈·罗氏有限公司 用于治疗cns和相关疾病的二氢吲哚-2-酮衍生物
MY197370A (en) 2015-11-06 2023-06-14 Hoffmann La Roche Indolin-2-one derivatives
WO2024110843A1 (en) 2022-11-21 2024-05-30 Segena Corporation S.A. Enhancing oligonucleotide immunomodulatory activity through dianophore long-lasting modification: methods and applications

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983000150A1 (en) * 1981-07-02 1983-01-20 Walton, Alan, G. Glycosaminoglycan drug complexes
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US5554386A (en) 1986-07-03 1996-09-10 Advanced Magnetics, Inc. Delivery of therapeutic agents to receptors using polysaccharides
DD267497A1 (de) * 1987-11-11 1989-05-03 Akad Wissenschaften Ddr Verfahren zur bindung von methotrexat an polysaccharide
DE3904119A1 (de) 1989-02-11 1990-08-16 Hoechst Ag Polymerfixiertes methotrexat, verfahren zur herstellung und verwendung
US5733891A (en) 1990-10-18 1998-03-31 Shiseido Co., Ltd. Compound for medicinal ingredient and hyaluronic acid and process for producing the same
US5698556A (en) * 1995-06-07 1997-12-16 Chan; Carcy L. Methotrexate analogs and methods of using same
IT1286510B1 (it) 1996-11-29 1998-07-15 Cooperativa Centro Ricerche Po Esteri butirrici ad attivita' antiproliferativa e composizioni farmaceutiche che li contengono
CA2208924A1 (en) 1997-07-09 1999-01-09 Hyal Pharmaceutical Corporation Sparing paclitaxel by the use of hyaluronan
IT1295298B1 (it) * 1997-10-08 1999-05-04 Cooperativa Centro Ricerche Po Polisaccaridi carbossilati 6-sostituiti
IT1318403B1 (it) * 2000-03-17 2003-08-25 Cooperativa Ct Ricerche Poly T Esteri polisaccaridici di n-derivati di acido glutammico.

Also Published As

Publication number Publication date
IT1318403B1 (it) 2003-08-25
ATE304363T1 (de) 2005-09-15
US20050065112A1 (en) 2005-03-24
ITMI20000559A1 (it) 2001-09-17
KR20020093845A (ko) 2002-12-16
AU784655B2 (en) 2006-05-18
EP1274446B1 (en) 2005-09-14
WO2001068105A1 (en) 2001-09-20
ES2248322T3 (es) 2006-03-16
EP1274446A1 (en) 2003-01-15
CN1418103A (zh) 2003-05-14
IL151696A0 (en) 2003-04-10
AU5828601A (en) 2001-09-24
US20030158125A1 (en) 2003-08-21
CN1203071C (zh) 2005-05-25
CA2403063A1 (en) 2001-09-20
BR0109294A (pt) 2002-12-17
MXPA02009057A (es) 2004-09-06
ZA200208299B (en) 2003-12-15
DE60113398D1 (de) 2005-10-20
JP2003526720A (ja) 2003-09-09
US6844328B2 (en) 2005-01-18
DE60113398T2 (de) 2006-06-29

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