ITBG990060A1 - PHYTO-DERIVED DISINFECTANT SOLUTION FOR VETERINARY USE FOR ENDO-BREAST TREATMENT ANTI-MASTITIS ON MILK ANIMALS. - Google Patents
PHYTO-DERIVED DISINFECTANT SOLUTION FOR VETERINARY USE FOR ENDO-BREAST TREATMENT ANTI-MASTITIS ON MILK ANIMALS. Download PDFInfo
- Publication number
- ITBG990060A1 ITBG990060A1 IT1999BG000060A ITBG990060A ITBG990060A1 IT BG990060 A1 ITBG990060 A1 IT BG990060A1 IT 1999BG000060 A IT1999BG000060 A IT 1999BG000060A IT BG990060 A ITBG990060 A IT BG990060A IT BG990060 A1 ITBG990060 A1 IT BG990060A1
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- IT
- Italy
- Prior art keywords
- endo
- mastitis
- phyto
- disinfectant solution
- veterinary use
- Prior art date
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- 241001465754 Metazoa Species 0.000 title claims description 8
- 208000004396 mastitis Diseases 0.000 title claims description 8
- 239000008267 milk Substances 0.000 title claims description 7
- 235000013336 milk Nutrition 0.000 title claims description 7
- 210000004080 milk Anatomy 0.000 title claims description 7
- 239000000645 desinfectant Substances 0.000 title claims description 5
- 238000011282 treatment Methods 0.000 title claims description 5
- 239000000284 extract Substances 0.000 claims description 9
- WRYLYDPHFGVWKC-UHFFFAOYSA-N 4-terpineol Chemical compound CC(C)C1(O)CCC(C)=CC1 WRYLYDPHFGVWKC-UHFFFAOYSA-N 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 241000366182 Melaleuca alternifolia Species 0.000 claims description 5
- 241000241413 Propolis Species 0.000 claims description 5
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 5
- 229940069949 propolis Drugs 0.000 claims description 5
- WRYLYDPHFGVWKC-SNVBAGLBSA-N 4-Terpineol Natural products CC(C)[C@]1(O)CCC(C)=CC1 WRYLYDPHFGVWKC-SNVBAGLBSA-N 0.000 claims description 4
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 claims description 3
- PSMFFFUWSMZAPB-UHFFFAOYSA-N Eukalyptol Natural products C1CC2CCC1(C)COCC2(C)C PSMFFFUWSMZAPB-UHFFFAOYSA-N 0.000 claims description 3
- 241001483078 Phyto Species 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 claims description 3
- 239000003349 gelling agent Substances 0.000 claims description 3
- 238000001256 steam distillation Methods 0.000 claims description 3
- 240000001432 Calendula officinalis Species 0.000 claims description 2
- 235000005881 Calendula officinalis Nutrition 0.000 claims description 2
- 229940002386 calendula officinalis extract Drugs 0.000 claims description 2
- 239000000419 plant extract Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 239000000341 volatile oil Substances 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 235000013365 dairy product Nutrition 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 230000001632 homeopathic effect Effects 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229930006978 terpinene Natural products 0.000 description 2
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 description 1
- 241000132025 Calendula Species 0.000 description 1
- 235000003880 Calendula Nutrition 0.000 description 1
- 239000004155 Chlorine dioxide Substances 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000378467 Melaleuca Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 235000019398 chlorine dioxide Nutrition 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 229930003658 monoterpene Natural products 0.000 description 1
- 150000002773 monoterpene derivatives Chemical class 0.000 description 1
- 235000002577 monoterpenes Nutrition 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 1
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000011458 pharmacological treatment Methods 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 229930004725 sesquiterpene Natural products 0.000 description 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- -1 terpene alcohols Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
DESCRIZIONE DESCRIPTION
Questa invenzione si riferisce ad una soluzione disinfettante fito-derivata ad uso veterinario per il trattamento éndo-mammario anti-mastite su animali da latte. This invention refers to a phyto-derived disinfectant solution for veterinary use for the anti-mastitis endo-mammary treatment on dairy animals.
Come è noto, un grave problema aleggiante nella produzione industriale di latte è costituito dalle mastiti. Tali infiammazioni mammarie sono generalmente distinte in mastiti “contagiose" e mastiti di tipo "ambientale”. Le prime sono sostenute da germi a localizzazione endomammaria, soprattutto Staph. Agalactiae e Staph. Aureus. I citati agenti patogeni a localizzazione endo-mammaria sono attualmente combattuti con battericidi di vario tipo: per esempio, clorexidina digluconato, diossido di cloro. I battericidi attualmente usati hanno, spesso, dei principi attivi basati sull’azione di antibiotici dagli effetti collaterali indesiderati non sempre conoscibili, giacché si estrinsecano in tempi molto lunghi ed in patologie che solo con grandi sperimentazioni (non sempre economicamente possibili) potrebbero essere riconducibili all'uso di tali antibiotici. Anche perché, la notevole attenzione veterinaria rivolta agli animali da latte (e con particolare riguardo alle mucche), rende assai probabile la presenza in essi di altri antibiotici, che potrebbero determinare pericolose reazioni anafilattiche. In ogni caso, considerando che dette sostanze antibiotiche sono, di fatto, in circolo neH’organismo delle bovine da latte in argomento, si può ben comprendere la possibilità che esse possano trasferire tali pericolose sostanze anche nel latte da esse prodotto. As is well known, mastitis is a serious problem in the industrial production of milk. These mammary inflammations are generally divided into “contagious” mastitis and “environmental” type mastitis. The former are supported by intramammary germs, especially Staph. Agalactiae and Staph. Aureus. The aforementioned pathogens with endo-mammary localization are currently combated with various types of bactericides: for example, chlorhexidine digluconate, chlorine dioxide. The bactericides currently used often have active ingredients based on the action of antibiotics with undesirable side effects that are not always known, since they manifest themselves in a very long time and in pathologies that only with large trials (not always economically possible) could be traced back to use of such antibiotics. Also because, the considerable veterinary attention paid to dairy animals (and with particular regard to cows), makes it very probable the presence in them of other antibiotics, which could cause dangerous anaphylactic reactions. In any case, considering that said antibiotic substances are, in fact, circulating in the organism of the dairy cows in question, it is possible to understand the possibility that they can transfer these dangerous substances even in the milk they produce.
Da quanto sopra detto si può comprendere come i risultati, che derivano dalla generalità dei citati prodotti anti-mastite di concezione allopatica, sono dei risultati con una loro specificità: una specificità in termini di costi globali degli interventi, in termini di salute della mammella, in termini di igienicità del latte prodotto dagli animali in trattamento farmacologico. From the above it can be understood how the results, which derive from the generality of the aforementioned anti-mastitis products of allopathic conception, are results with their own specificity: a specificity in terms of overall costs of the interventions, in terms of breast health, in terms of the hygiene of the milk produced by animals under pharmacological treatment.
Per ovviare a tali gravi inconvenienti intrinseci degli usuali farmaci antibiotici (o comunque disinfettanti allopatici) si sta tentando addirittura di ricorrere a terapie omeopatiche. Infatti, sicuramente l'impiego di sostanze omeopatiche non lascia residui tossici nel corpo dell'animale o nel latte da esso prodotto, ma resta il fatto che l’omeopatia è basata su concetti assurdi e non accettabili dal moderno pensiero scientifico che rendono aleatori gli eventuali successi ottenibili. To obviate these serious intrinsic drawbacks of the usual antibiotic drugs (or in any case allopathic disinfectants), attempts are even being made to resort to homeopathic therapies. In fact, certainly the use of homeopathic substances does not leave toxic residues in the animal's body or in the milk produced by it, but the fact remains that homeopathy is based on absurd and unacceptable concepts by modern scientific thought that make any eventual random achievable successes.
Benché la complessità delle diagnosi omeopatiche porti ad un “quadro clinico” di complessità talmente vasta da poter attribuire l'insuccesso terapico alla scarsa perizia dell'omeopata, resta il fatto che l’omeopatia è relegabile a livello di pura superstizione. Although the complexity of homeopathic diagnoses leads to a "clinical picture" of such vast complexity that the therapeutic failure can be attributed to the lack of expertise of the homeopath, the fact remains that homeopathy is relegated to the level of pure superstition.
Scopo della presente invenzione è quello di definire un prodotto farmacologico di concezione allopatica che risulti idoneo per un impiego endo-mammario. Altro scopo è quello di definire un prodotto, come sopra, che non crei complicazioni per la salute dell’animale. Altro scopo è quello di definire un prodotto che consenta l'utilizzazione del latte anche se munto subito dopo il trattamento. Questi ed altri scopo appariranno come raggiunti dalla seguente descrizione, illustrante una soluzione disinfettante fito-derivata ad uso veterinario per il trattamento endo-mammario anti-mastite su animali da latte avente la particolarità di associare proprietà antiinfiammatorie derivanti da estratti vegetali di Melaleuca Alternifolia, Achinacea, Angustifolia, Calendula officinalis, Propoli, disciolti in acqua con tecnologia notoria secondo le seguenti percentuali: The object of the present invention is to define a pharmacological product of allopathic conception which is suitable for intra-mammary use. Another purpose is to define a product, as above, that does not create complications for the health of the animal. Another purpose is to define a product which allows the use of milk even if milked immediately after treatment. These and other purposes will appear as achieved by the following description, illustrating a phyto-derived disinfectant solution for veterinary use for the endo-mammary anti-mastitis treatment on dairy animals having the particularity of associating anti-inflammatory properties deriving from plant extracts of Melaleuca Alternifolia, Achinacea , Angustifolia, Calendula officinalis, Propolis, dissolved in water with known technology according to the following percentages:
0,2% - 2,5% Olio essenziale ottenuto per distillazione in corrente di vapore del fogliame della Melaleuca Alternifolia con contenuto minimo di TERPINEN-4-OL del 35% e con contenuto massimo di 1 ,8 CINEOLO del 5%; 0.2% - 2.5% Essential oil obtained by steam distillation of the foliage of Melaleuca Alternifolia with a minimum content of 35% TERPINEN-4-OL and a maximum content of 1, 8 CINEOL of 5%;
0,5% - 1 ,5% estratto di ACHINACEA ANGUSTIFOLIA; 0,5% - 1 ,5% estratto di PROPOLI; 0.5% - 1.5% ACHINACEA ANGUSTIFOLIA extract; 0.5% - 1.5% PROPOLIS extract;
0,5% - 1 ,5% estratto di CALENDULA OFFICINALE; detti estratti essendo disciolti in quantità di acqua quanto basta a 100 ed essendo associati ad agenti gelificanti, preferibilmente Carbomer in percentuale dal 0, 1 al 0,5%. L’olio di Melaleuca di cui sopra è estratto per distillazione in corrente di vapore del fogliame della Melaleuca Alternifolia. Esso è composto da una miscela di monoterpeni, sesquiterpeni ed alcoli terpenici in cui il contenuto in TERPINEN-4-OL non è inferiore al 30% per svolgere la migliore azione germicida ed il contenuto in 1 ,8 CINEOLO non supera il 15%, per non generare irritazione delle mucose. La percentuale massima del TERPINEN-4-OL, oltre la quale non aumenta il potere battericida, è del 40%. Tra gli altri componenti importanti presenti nel citato olio (che ne comprende oltre 90) sono citabili: 0.5% - 1.5% OFFICINALE CALENDULA extract; said extracts being dissolved in a quantity of water sufficient to 100 and being associated with gelling agents, preferably Carbomer in a percentage from 0.1 to 0.5%. The aforementioned Melaleuca oil is extracted by steam distillation of the foliage of Melaleuca Alternifolia. It is composed of a mixture of monoterpenes, sesquiterpenes and terpene alcohols in which the content in TERPINEN-4-OL is not less than 30% to perform the best germicidal action and the content in 1, 8 CINEOL does not exceed 15%, for do not generate irritation of the mucous membranes. The maximum percentage of TERPINEN-4-OL, beyond which the bactericidal power does not increase, is 40%. Among the other important components present in the aforementioned oil (which includes over 90), the following can be mentioned:
a - terpineol, in quantità variabili dal 1 ,5 al 8%; a - terpineol, in quantities ranging from 1.5 to 8%;
τ - terpinene, in quantità variabile dal 10 al 28%; τ - terpinene, in quantities ranging from 10 to 28%;
a - terpinene, in quantità variabile dal 5 al 13%; a - terpinene, in quantities ranging from 5 to 13%;
p - cymene, in quantità variabile dal 0,5 al 12%. p - cymene, in quantities ranging from 0.5 to 12%.
Tale olio è presente nella soluzione di cui all’invenzione in una percentuale variabile dal 0,2 al 2,5%, dipendentemente da formulazioni che siano finalizzate ad un assorbimento più o meno rapido. L’insieme dei citati prodotti della formula è complementare ad una percentuale di acqua "quanto basta” a 100. Tale acqua è di tipo deinineralizzato con osmosi inversa e prefiltrazione da 1 micron; tale acqua è inoltre sterilizzata mediante idonee lampade a raggi ultravioletti. This oil is present in the solution of the invention in a variable percentage from 0.2 to 2.5%, depending on formulations that are aimed at a more or less rapid absorption. The set of the aforementioned products of the formula is complementary to a percentage of "quantum enough" water at 100. This water is deinineralized with reverse osmosis and 1 micron pre-filtration; this water is also sterilized by suitable ultraviolet lamps.
Per quanto riguarda gli altri principi attivi della soluzione, l'estratto di ÀCHINACEA ANGUSTIFOLIA svolge un’azione anti-batterica ed anti-infiammatoria locale per la mammella ed:un’azione disintossiccante per l’organismo. L’estratto dì CALENDULA OFFICINALIS svolge un’azione anti-infiammatoria protettiva sul parenchima mammario nonché, in modo blando, anche un’azione batteriostatica. L’estratto di PROPOLI, è anch’esso un prodotto dotato di azione anti-batterica ed anti-infiammatoria; esso è particolarmente idoneo ad espletare un’azione sinergica con gli altri agenti anti-batterici. As for the other active ingredients of the solution, the ÀCHINACEA ANGUSTIFOLIA extract has a local anti-bacterial and anti-inflammatory action for the breast and: a detoxifying action for the body. The CALENDULA OFFICINALIS extract has a protective anti-inflammatory action on the breast parenchyma as well as, in a mild way, also a bacteriostatic action. PROPOLIS extract is also a product with anti-bacterial and anti-inflammatory action; it is particularly suitable for performing a synergistic action with other anti-bacterial agents.
Per stabilizzare la soluzione è impiegato un agente gelificante, preferibilmente del tipo commercialmente noto come CARBOMER. A gelling agent, preferably of the type commercially known as CARBOMER, is used to stabilize the solution.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999BG000060A IT1307902B1 (en) | 1999-12-24 | 1999-12-24 | PHYTO-DERIVED DISINFECTANT SOLUTION FOR VETERINARY USE FOR ENDO-BREAST TREATMENT ANTI-MASTITIS ON MILK ANIMALS. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999BG000060A IT1307902B1 (en) | 1999-12-24 | 1999-12-24 | PHYTO-DERIVED DISINFECTANT SOLUTION FOR VETERINARY USE FOR ENDO-BREAST TREATMENT ANTI-MASTITIS ON MILK ANIMALS. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITBG990060A0 ITBG990060A0 (en) | 1999-12-24 |
ITBG990060A1 true ITBG990060A1 (en) | 2001-06-25 |
IT1307902B1 IT1307902B1 (en) | 2001-11-19 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT1999BG000060A IT1307902B1 (en) | 1999-12-24 | 1999-12-24 | PHYTO-DERIVED DISINFECTANT SOLUTION FOR VETERINARY USE FOR ENDO-BREAST TREATMENT ANTI-MASTITIS ON MILK ANIMALS. |
Country Status (1)
Country | Link |
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IT (1) | IT1307902B1 (en) |
-
1999
- 1999-12-24 IT IT1999BG000060A patent/IT1307902B1/en active
Also Published As
Publication number | Publication date |
---|---|
IT1307902B1 (en) | 2001-11-19 |
ITBG990060A0 (en) | 1999-12-24 |
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