IT8848118A0 - Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergico - Google Patents
Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergicoInfo
- Publication number
- IT8848118A0 IT8848118A0 IT8848118A IT4811888A IT8848118A0 IT 8848118 A0 IT8848118 A0 IT 8848118A0 IT 8848118 A IT8848118 A IT 8848118A IT 4811888 A IT4811888 A IT 4811888A IT 8848118 A0 IT8848118 A0 IT 8848118A0
- Authority
- IT
- Italy
- Prior art keywords
- uridine
- pharmacological treatment
- disorders due
- altered dopamine
- balance
- Prior art date
Links
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 title 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 title 1
- 229960003638 dopamine Drugs 0.000 title 1
- 238000011458 pharmacological treatment Methods 0.000 title 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 title 1
- 229940045145 uridine Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT48118/88A IT1219667B (it) | 1988-06-21 | 1988-06-21 | Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergico |
CA000600276A CA1327003C (en) | 1988-06-21 | 1989-05-24 | Pharmacological use of uridine in the treatment of nervous disorders |
JP1150354A JPH0623109B2 (ja) | 1988-06-21 | 1989-06-13 | 脳神経障害治療用薬剤 |
EP89830264A EP0348360B1 (en) | 1988-06-21 | 1989-06-14 | Pharmacological use of uridine in the treatment of nervous disorders |
DE68912419T DE68912419T2 (de) | 1988-06-21 | 1989-06-14 | Verwendung von Uridin zur Behandlung nervöser Störungen. |
AT89830264T ATE100322T1 (de) | 1988-06-21 | 1989-06-14 | Verwendung von uridin zur behandlung nervoeser stoerungen. |
US07/367,615 US4960759A (en) | 1988-06-21 | 1989-06-19 | Pharmacological use of uridine in the treatment of nervous disorders |
KR1019890008467A KR900000092A (ko) | 1988-06-21 | 1989-06-20 | 신경 장애의 치료에 있어서 유리딘의 약리학적 용도 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT48118/88A IT1219667B (it) | 1988-06-21 | 1988-06-21 | Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergico |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8848118A0 true IT8848118A0 (it) | 1988-06-21 |
IT1219667B IT1219667B (it) | 1990-05-24 |
Family
ID=11264638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT48118/88A IT1219667B (it) | 1988-06-21 | 1988-06-21 | Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergico |
Country Status (8)
Country | Link |
---|---|
US (1) | US4960759A (it) |
EP (1) | EP0348360B1 (it) |
JP (1) | JPH0623109B2 (it) |
KR (1) | KR900000092A (it) |
AT (1) | ATE100322T1 (it) |
CA (1) | CA1327003C (it) |
DE (1) | DE68912419T2 (it) |
IT (1) | IT1219667B (it) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2634374B1 (fr) * | 1988-07-19 | 1993-10-15 | Laboratoires Serobiologiques | Agents photoprotecteurs, cytophotoprotecteurs cutanes ayant une activite photoprotectrice des cellules constitutives, fonctionnelles de la peau, en particulier des cellules de langerhans, a base de composes nucleiques : nucleoprotides, ribonucleotides et desoxyribonucleotides, ribonucleosides et desoxyribonucleosides, compositions cosmetiques ou dermo-pharmaceutiques contenant un tel agent ainsi que des nouveaux composes en soi |
WO1994026280A1 (en) * | 1993-05-19 | 1994-11-24 | Korea Green Cross Corporation | Remedy for arthritis containing uridine as active ingredient |
US5962459A (en) * | 1996-05-28 | 1999-10-05 | Polifarma S.P.A. | Therapeutic active agent for treatment of neuron degenerative diseases |
IT1290781B1 (it) * | 1996-05-28 | 1998-12-10 | Polifarma Spa | Agente attivo terapeutico per il trattamento di malattie degenerative neuronali. |
US7910548B2 (en) * | 1997-06-06 | 2011-03-22 | Amylin Pharmaceuticals, Inc. | Methods for treating obesity |
US20060069061A1 (en) * | 1998-07-31 | 2006-03-30 | Dick Wurtman | Compositions containing uridine and choline, and methods utilizing same |
US8314064B2 (en) | 1998-07-31 | 2012-11-20 | Massachusetts Institute Of Technology | Uridine administration stimulates membrane production |
US20050203053A1 (en) * | 1999-07-30 | 2005-09-15 | Wurtman Richard J. | Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function |
US20070004670A1 (en) * | 1998-07-31 | 2007-01-04 | Richard Wurtman | Compositions containing citicoline, and methods of use thereof |
US8143234B2 (en) | 1998-07-31 | 2012-03-27 | Massachusetts Institute Of Technology | Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function |
US8518882B2 (en) * | 1998-07-31 | 2013-08-27 | Massachusetts Institute Of Technology | Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same |
WO2000006174A1 (en) | 1998-07-31 | 2000-02-10 | Massachusetts Institute Of Technology | Methods for increasing cytidine levels in vivo and treating cytidine-dependent human diseases |
US7915233B1 (en) | 1998-08-31 | 2011-03-29 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
US6472378B2 (en) * | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
US7807654B2 (en) | 1998-08-31 | 2010-10-05 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
NZ513926A (en) | 1999-02-23 | 2001-09-28 | Univ California | Methods of treatment of mitochondrial disorders |
ES2425114T3 (es) * | 2000-03-16 | 2013-10-11 | The Mclean Hospital Corporation | CDP-colina y uridina para el tratamiento del abuso del acohol |
US6727231B1 (en) | 2000-10-12 | 2004-04-27 | Repligen Corporation | Uridine therapy for patients with elevated purine levels |
AUPR951101A0 (en) * | 2001-12-13 | 2002-01-24 | Centre For Molecular Biology And Medicine | Method of treatment |
CA2542023A1 (en) * | 2003-10-08 | 2005-09-22 | The Mclean Hospital Corporation | Methods of treating psychiatric, substance abuse, and other disorders using combinations containing omega-3 fatty acids |
US9572830B2 (en) * | 2004-05-13 | 2017-02-21 | Massachusetts Institute Of Technology | Uridine effects on dopamine release |
US8318798B2 (en) | 2005-11-24 | 2012-11-27 | National University Corporation Hokkaldo University | Therapeutic agent for neurodegenerative disease |
EP1897937A1 (en) * | 2006-09-07 | 2008-03-12 | NeuroProgen GmbH Leipzig | Method of culturing NPCs |
CN101896119A (zh) | 2007-11-02 | 2010-11-24 | 麻省理工学院 | 尿苷饮食添加顺应性方法及其用途 |
US20100041621A1 (en) * | 2008-08-15 | 2010-02-18 | Perry Renshaw | Methods and compositions for improving cognitive performance |
CN102548555A (zh) | 2009-07-31 | 2012-07-04 | 克莱拉有限公司 | 用于治疗帕金森病的组合物和方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1178044B (it) * | 1984-10-09 | 1987-09-03 | Polifarma Spa | Agente attivo farmaceutico per il trattamento di patologie cerebrali a base di uridina |
JPH0669953B2 (ja) * | 1985-08-16 | 1994-09-07 | 日産化学工業株式会社 | 脳脊髄系神経栄養剤 |
ATE93236T1 (de) * | 1987-10-28 | 1993-09-15 | Pro Neuron Inc | Acylatiertes uridin und cytidin und deren verwendungen. |
-
1988
- 1988-06-21 IT IT48118/88A patent/IT1219667B/it active
-
1989
- 1989-05-24 CA CA000600276A patent/CA1327003C/en not_active Expired - Fee Related
- 1989-06-13 JP JP1150354A patent/JPH0623109B2/ja not_active Expired - Fee Related
- 1989-06-14 AT AT89830264T patent/ATE100322T1/de not_active IP Right Cessation
- 1989-06-14 DE DE68912419T patent/DE68912419T2/de not_active Expired - Fee Related
- 1989-06-14 EP EP89830264A patent/EP0348360B1/en not_active Expired - Lifetime
- 1989-06-19 US US07/367,615 patent/US4960759A/en not_active Expired - Lifetime
- 1989-06-20 KR KR1019890008467A patent/KR900000092A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ATE100322T1 (de) | 1994-02-15 |
EP0348360A2 (en) | 1989-12-27 |
IT1219667B (it) | 1990-05-24 |
KR900000092A (ko) | 1990-01-30 |
DE68912419D1 (de) | 1994-03-03 |
US4960759A (en) | 1990-10-02 |
CA1327003C (en) | 1994-02-15 |
EP0348360B1 (en) | 1994-01-19 |
EP0348360A3 (en) | 1991-10-23 |
JPH0245425A (ja) | 1990-02-15 |
JPH0623109B2 (ja) | 1994-03-30 |
DE68912419T2 (de) | 1994-08-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19960621 |