IT8424200A0 - Peptidi retro-invertiti analoghi del potenziatore della bradichinina bpp 5a. - Google Patents

Peptidi retro-invertiti analoghi del potenziatore della bradichinina bpp 5a.

Info

Publication number
IT8424200A0
IT8424200A0 IT8424200A IT2420084A IT8424200A0 IT 8424200 A0 IT8424200 A0 IT 8424200A0 IT 8424200 A IT8424200 A IT 8424200A IT 2420084 A IT2420084 A IT 2420084A IT 8424200 A0 IT8424200 A0 IT 8424200A0
Authority
IT
Italy
Prior art keywords
bpp
inverted peptides
peptides analogues
bradykinin
enhancer
Prior art date
Application number
IT8424200A
Other languages
English (en)
Other versions
IT1178789B (it
Inventor
Antonio Silvio Verdini
Alessandro Sisto
Antonino Virdia
Original Assignee
Anic Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anic Spa filed Critical Anic Spa
Priority to IT24200/84A priority Critical patent/IT1178789B/it
Publication of IT8424200A0 publication Critical patent/IT8424200A0/it
Priority to EP85202099A priority patent/EP0185433A3/en
Priority to US06/811,487 priority patent/US4728725A/en
Priority to JP60289135A priority patent/JPS61155395A/ja
Priority to US06/821,449 priority patent/US4713367A/en
Application granted granted Critical
Publication of IT1178789B publication Critical patent/IT1178789B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IT24200/84A 1984-12-21 1984-12-21 Peptidi retro-invertiti analoghi del potenziatore della bradichinina bpp 5a IT1178789B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT24200/84A IT1178789B (it) 1984-12-21 1984-12-21 Peptidi retro-invertiti analoghi del potenziatore della bradichinina bpp 5a
EP85202099A EP0185433A3 (en) 1984-12-21 1985-12-18 Retro-inverted peptides analogues of bradykinin potentiator bpp 5a
US06/811,487 US4728725A (en) 1984-12-21 1985-12-20 Retro-inverted peptides analogues of Bradykinin Potentiator BPP5a
JP60289135A JPS61155395A (ja) 1984-12-21 1985-12-21 ｒｅｔｒｏ逆転ペプチド及びその合成法
US06/821,449 US4713367A (en) 1984-12-21 1986-01-22 Retro-inverso analogs of the bradykinin potentiating peptide BPP5a

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT24200/84A IT1178789B (it) 1984-12-21 1984-12-21 Peptidi retro-invertiti analoghi del potenziatore della bradichinina bpp 5a

Publications (2)

Publication Number Publication Date
IT8424200A0 true IT8424200A0 (it) 1984-12-21
IT1178789B IT1178789B (it) 1987-09-16

Family

ID=11212508

Family Applications (1)

Application Number Title Priority Date Filing Date
IT24200/84A IT1178789B (it) 1984-12-21 1984-12-21 Peptidi retro-invertiti analoghi del potenziatore della bradichinina bpp 5a

Country Status (4)

Country Link
US (2) US4728725A (it)
EP (1) EP0185433A3 (it)
JP (1) JPS61155395A (it)
IT (1) IT1178789B (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2052517T3 (es) * 1986-07-16 1994-07-16 Eniricerche Spa Analogos de tuftsina parcialmente retroinversos, metodo de preparacion de los mismos y composiciones farmaceuticas que los contienen.
US4927565A (en) * 1986-12-19 1990-05-22 Banyu Pharmaceutical Co., Ltd. 5-substituted amino-4-hydroxy-pentenoic acid derivatives and their use
US5200506A (en) * 1987-03-19 1993-04-06 Eniricerche S.P.A. Process for preparing new thymopentin retro-inverso analogs and fragments thereof and the intermediates obtained therein
HUT71860A (en) * 1992-08-27 1996-02-28 Deakin Res Ltd Retro-, inverso-, and retro-inverso synthetic peptide analogues
US5705481A (en) * 1992-11-06 1998-01-06 Merck Patent Gesellschaft Mit Beschrankter Haftung Cyclopeptides
US6458357B1 (en) 1997-09-09 2002-10-01 Myelos Corporation Retro-inverso neurotrophic and analgesic peptides
BR0101088A (pt) * 2001-03-19 2003-03-18 Biolab Sanus Farmaceutica Ltda Processo de isolamento e purificação de peptìdeos inibidores das vasopeptidases, com especificidade para o sìtio carboxìlico da enzima conversora da angiotensina, secretados pelas glândulas do veneno de serpentes (bpps), particularmente bothrops jararaca, ou produzidos endogenamente (evasins) possuindo ação vasodilatadora e anti-hipertensiva; processo de determinação da sequência de amido-ácidos dos peptìdios inibidores secretados pela glândula de veneno de serpentes (bpps) ou endógenos (evasins); processo de determinação da sequência de aminoácidos dos bpps por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca. processo de determinação da sequência de aminoácidos dos evasins por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca, processo de amplificação do cdna a partir das bibliotecas de cdna de pâncreas e/ou cérebro de serpentes, especificamente bothrops jararaca; processo de sìntese em fase sólida de peptìdeos inibidores das vasopeptidases com ação vasodilatadora e anti-hipertensiva, peptìdeos inibidores das vasopeptidases com ação anti-hipertensiva; utilização dos peptìdeos inibidores das vaso peptidases com ação vasodilatadora e anti-hipertensiva na obtenção de composições farmacêuticas; processo de determinação da atividade inibitória sobre as vasopeptidases e de atividade biológica sobre músculo liso, sistema cardiovascular e microcirculatório.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1190891B (it) * 1982-06-24 1988-02-24 Anic Spa Metodo per la sintesi in fase solida di polipeptidi retroinvertiti
IT1164225B (it) * 1983-05-13 1987-04-08 Anic Spa Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione

Also Published As

Publication number Publication date
US4728725A (en) 1988-03-01
IT1178789B (it) 1987-09-16
US4713367A (en) 1987-12-15
EP0185433A2 (en) 1986-06-25
JPS61155395A (ja) 1986-07-15
EP0185433A3 (en) 1988-11-09

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