IT7849984A0 - Procedimento per la preparazione di amiloride e di altri suoi derivati 6-sostituiti - Google Patents
Procedimento per la preparazione di amiloride e di altri suoi derivati 6-sostituitiInfo
- Publication number
- IT7849984A0 IT7849984A0 IT7849984A IT4998478A IT7849984A0 IT 7849984 A0 IT7849984 A0 IT 7849984A0 IT 7849984 A IT7849984 A IT 7849984A IT 4998478 A IT4998478 A IT 4998478A IT 7849984 A0 IT7849984 A0 IT 7849984A0
- Authority
- IT
- Italy
- Prior art keywords
- amiloride
- procedure
- preparation
- substituted derivatives
- derivatives
- Prior art date
Links
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 title 1
- 229960002576 amiloride Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/811,011 US4196292A (en) | 1977-06-29 | 1977-06-29 | 6-Substituted amiloride derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7849984A0 true IT7849984A0 (it) | 1978-06-22 |
IT1105454B IT1105454B (it) | 1985-11-04 |
Family
ID=25205286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT49984/78A IT1105454B (it) | 1977-06-29 | 1978-06-22 | Procedimento per la preparazione di amiloride e di altri suoi derivati 6-sostituiti |
Country Status (12)
Country | Link |
---|---|
US (1) | US4196292A (it) |
EP (1) | EP0000200B1 (it) |
JP (1) | JPS5412389A (it) |
AT (1) | AT362795B (it) |
DE (1) | DE2861684D1 (it) |
DK (1) | DK290278A (it) |
ES (1) | ES471244A1 (it) |
FI (1) | FI781966A (it) |
HU (1) | HU178302B (it) |
IT (1) | IT1105454B (it) |
NO (1) | NO782230L (it) |
PL (1) | PL119097B1 (it) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4362724A (en) * | 1980-05-19 | 1982-12-07 | Merck & Co., Inc. | Method of treating edema and hypertension and pharmaceutical composition therefor in which the active ingredient comprises a novel substituted pyrazinyl-1,2,4-oxadiazole and a kaliuretic diuretic |
US4594349A (en) * | 1982-01-04 | 1986-06-10 | Beyer Jr Karl H | Hyperuretic agents |
US4952582A (en) * | 1982-01-04 | 1990-08-28 | Beyer Jr Karl H | Pyrazinoylguanidine and derivatives thereof having few polar substituents and being useful as hyperuretic agents |
WO1990009792A1 (en) * | 1989-03-03 | 1990-09-07 | The General Hospital Corporation | Topical application of amiloride or analogues thereof for treatment of inflammation |
US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
US6858614B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
US6903105B2 (en) * | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
US20090253714A1 (en) * | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
US20070021439A1 (en) * | 2005-07-25 | 2007-01-25 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers |
AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
AU2013363215B2 (en) | 2012-12-17 | 2018-03-01 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds |
EP3150585A1 (en) | 2012-12-17 | 2017-04-05 | Parion Sciences, Inc. | Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity |
US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB286896A (en) * | 1927-03-29 | 1928-03-15 | Arthur William Howarth | Improvements in smokers' pipes |
US3305552A (en) * | 1965-11-22 | 1967-02-21 | Merck & Co Inc | 3-aminopyrazinoic acids and process for their preparation |
US3507865A (en) * | 1967-04-27 | 1970-04-21 | Merck & Co Inc | 3-hydroxy- and 3-mercaptopyrazinamidoguanidines the corresponding ethers and thioethers and processes for their preparation |
US3573306A (en) * | 1969-03-05 | 1971-03-30 | Merck & Co Inc | Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides |
-
1977
- 1977-06-29 US US05/811,011 patent/US4196292A/en not_active Expired - Lifetime
-
1978
- 1978-06-20 FI FI781966A patent/FI781966A/fi not_active Application Discontinuation
- 1978-06-22 HU HU78ME2174A patent/HU178302B/hu unknown
- 1978-06-22 IT IT49984/78A patent/IT1105454B/it active
- 1978-06-27 PL PL1978207947A patent/PL119097B1/pl unknown
- 1978-06-28 DE DE7878100264T patent/DE2861684D1/de not_active Expired
- 1978-06-28 AT AT0469078A patent/AT362795B/de not_active IP Right Cessation
- 1978-06-28 DK DK290278A patent/DK290278A/da unknown
- 1978-06-28 NO NO782230A patent/NO782230L/no unknown
- 1978-06-28 ES ES471244A patent/ES471244A1/es not_active Expired
- 1978-06-28 EP EP78100264A patent/EP0000200B1/en not_active Expired
- 1978-06-29 JP JP7924078A patent/JPS5412389A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AT362795B (de) | 1981-06-10 |
PL119097B1 (en) | 1981-11-30 |
DK290278A (da) | 1978-12-30 |
DE2861684D1 (en) | 1982-04-29 |
ES471244A1 (es) | 1979-10-01 |
FI781966A (fi) | 1978-12-30 |
IT1105454B (it) | 1985-11-04 |
PL207947A1 (pl) | 1979-10-22 |
EP0000200B1 (en) | 1982-03-24 |
EP0000200A1 (en) | 1979-01-10 |
HU178302B (en) | 1982-04-28 |
NO782230L (no) | 1979-01-02 |
ATA469078A (de) | 1980-11-15 |
US4196292A (en) | 1980-04-01 |
JPS5412389A (en) | 1979-01-30 |
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