AT362795B - Verfahren zur herstellung von n-amidino-3,5diamino-6-subst.-2-pyrazincarboxamiden - Google Patents

Verfahren zur herstellung von n-amidino-3,5diamino-6-subst.-2-pyrazincarboxamiden

Info

Publication number
AT362795B
AT362795B AT0469078A AT469078A AT362795B AT 362795 B AT362795 B AT 362795B AT 0469078 A AT0469078 A AT 0469078A AT 469078 A AT469078 A AT 469078A AT 362795 B AT362795 B AT 362795B
Authority
AT
Austria
Prior art keywords
5diamino
subst
amidino
producing
carboxamides
Prior art date
Application number
AT0469078A
Other languages
English (en)
Other versions
ATA469078A (de
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ATA469078A publication Critical patent/ATA469078A/de
Application granted granted Critical
Publication of AT362795B publication Critical patent/AT362795B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT0469078A 1977-06-29 1978-06-28 Verfahren zur herstellung von n-amidino-3,5diamino-6-subst.-2-pyrazincarboxamiden AT362795B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/811,011 US4196292A (en) 1977-06-29 1977-06-29 6-Substituted amiloride derivatives

Publications (2)

Publication Number Publication Date
ATA469078A ATA469078A (de) 1980-11-15
AT362795B true AT362795B (de) 1981-06-10

Family

ID=25205286

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0469078A AT362795B (de) 1977-06-29 1978-06-28 Verfahren zur herstellung von n-amidino-3,5diamino-6-subst.-2-pyrazincarboxamiden

Country Status (12)

Country Link
US (1) US4196292A (de)
EP (1) EP0000200B1 (de)
JP (1) JPS5412389A (de)
AT (1) AT362795B (de)
DE (1) DE2861684D1 (de)
DK (1) DK290278A (de)
ES (1) ES471244A1 (de)
FI (1) FI781966A (de)
HU (1) HU178302B (de)
IT (1) IT1105454B (de)
NO (1) NO782230L (de)
PL (1) PL119097B1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362724A (en) * 1980-05-19 1982-12-07 Merck & Co., Inc. Method of treating edema and hypertension and pharmaceutical composition therefor in which the active ingredient comprises a novel substituted pyrazinyl-1,2,4-oxadiazole and a kaliuretic diuretic
US4594349A (en) * 1982-01-04 1986-06-10 Beyer Jr Karl H Hyperuretic agents
US4952582A (en) * 1982-01-04 1990-08-28 Beyer Jr Karl H Pyrazinoylguanidine and derivatives thereof having few polar substituents and being useful as hyperuretic agents
WO1990009792A1 (en) * 1989-03-03 1990-09-07 The General Hospital Corporation Topical application of amiloride or analogues thereof for treatment of inflammation
US6858615B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
EP3428153A1 (de) 2012-12-17 2019-01-16 Parion Sciences, Inc. 3,5-diamino-6-chlor-n-(n-(4-phenylbutyl) carbamimidoyl)-pyrazin-2-carboxamid-verbindungen
WO2014099676A1 (en) 2012-12-17 2014-06-26 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB286896A (en) * 1927-03-29 1928-03-15 Arthur William Howarth Improvements in smokers' pipes
US3305552A (en) * 1965-11-22 1967-02-21 Merck & Co Inc 3-aminopyrazinoic acids and process for their preparation
US3507865A (en) * 1967-04-27 1970-04-21 Merck & Co Inc 3-hydroxy- and 3-mercaptopyrazinamidoguanidines the corresponding ethers and thioethers and processes for their preparation
US3573306A (en) * 1969-03-05 1971-03-30 Merck & Co Inc Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides

Also Published As

Publication number Publication date
PL207947A1 (pl) 1979-10-22
IT1105454B (it) 1985-11-04
NO782230L (no) 1979-01-02
IT7849984A0 (it) 1978-06-22
ATA469078A (de) 1980-11-15
DE2861684D1 (en) 1982-04-29
HU178302B (en) 1982-04-28
ES471244A1 (es) 1979-10-01
JPS5412389A (en) 1979-01-30
PL119097B1 (en) 1981-11-30
FI781966A (fi) 1978-12-30
DK290278A (da) 1978-12-30
EP0000200A1 (de) 1979-01-10
EP0000200B1 (de) 1982-03-24
US4196292A (en) 1980-04-01

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee