IT1406051B1 - Uso di hmgb1 come marcatore biologico di infiammazione intestinale umana, metodo non invasivo per la sua rilevazione in campioni fecali e kit relativo. - Google Patents

Uso di hmgb1 come marcatore biologico di infiammazione intestinale umana, metodo non invasivo per la sua rilevazione in campioni fecali e kit relativo.

Info

Publication number
IT1406051B1
IT1406051B1 ITRM2010A000442A ITRM20100442A IT1406051B1 IT 1406051 B1 IT1406051 B1 IT 1406051B1 IT RM2010A000442 A ITRM2010A000442 A IT RM2010A000442A IT RM20100442 A ITRM20100442 A IT RM20100442A IT 1406051 B1 IT1406051 B1 IT 1406051B1
Authority
IT
Italy
Prior art keywords
hmgb1
detection
biological marker
invasive method
human intestinal
Prior art date
Application number
ITRM2010A000442A
Other languages
English (en)
Italian (it)
Inventor
Salvatore Cucchiara
Laura Stronati
Roberta Vitali
Original Assignee
D M G Italia S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ITRM2010A000442A priority Critical patent/IT1406051B1/it
Application filed by D M G Italia S R L filed Critical D M G Italia S R L
Priority to CN2011800327624A priority patent/CN103069276A/zh
Priority to JP2013522346A priority patent/JP2013534313A/ja
Priority to BR112013002145A priority patent/BR112013002145A2/pt
Priority to MX2013001327A priority patent/MX2013001327A/es
Priority to AU2011287193A priority patent/AU2011287193B2/en
Priority to PCT/IT2011/000276 priority patent/WO2012017466A1/en
Priority to CA2807107A priority patent/CA2807107C/en
Priority to EA201390197A priority patent/EA201390197A1/ru
Priority to EP11754539.2A priority patent/EP2601525A1/en
Priority to PE2013000131A priority patent/PE20131062A1/es
Priority to US13/814,294 priority patent/US20130137123A1/en
Publication of ITRM20100442A1 publication Critical patent/ITRM20100442A1/it
Priority to IL223845A priority patent/IL223845A/en
Priority to CL2013000223A priority patent/CL2013000223A1/es
Application granted granted Critical
Publication of IT1406051B1 publication Critical patent/IT1406051B1/it

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ITRM2010A000442A 2010-08-05 2010-08-05 Uso di hmgb1 come marcatore biologico di infiammazione intestinale umana, metodo non invasivo per la sua rilevazione in campioni fecali e kit relativo. IT1406051B1 (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ITRM2010A000442A IT1406051B1 (it) 2010-08-05 2010-08-05 Uso di hmgb1 come marcatore biologico di infiammazione intestinale umana, metodo non invasivo per la sua rilevazione in campioni fecali e kit relativo.
EA201390197A EA201390197A1 (ru) 2010-08-05 2011-08-01 Применение hmgb1 в качестве биологического маркера воспалительных состояний кишечника, неинвазивный способ его определения в образцах фекалий и набор для этого
BR112013002145A BR112013002145A2 (pt) 2010-08-05 2011-08-01 uso de hmgb1 como um marcador biológico das condições inflamatórias intestinais, método não-invasivo para detecção das mesmas em amostras fecais e respectivo kit
MX2013001327A MX2013001327A (es) 2010-08-05 2011-08-01 Uso de hmgb1 como marcador biologico de afecciones intestinales inflamatorias, metodo no invasivo para su deteccion en muestras fecales y kit para su realizacion.
AU2011287193A AU2011287193B2 (en) 2010-08-05 2011-08-01 Use of HMGB1 as a biological marker of bowel inflammatory conditions, non-invasive method for its detection in fecal samples and kit thereof
PCT/IT2011/000276 WO2012017466A1 (en) 2010-08-05 2011-08-01 Use of hmgb1 as' a biological marker of bowel inflammatory conditions, non-invasive method for its detection in fecal samples and kit thereof
CN2011800327624A CN103069276A (zh) 2010-08-05 2011-08-01 Hmgb1作为炎性肠病病情的生物标志物的用途、其在粪便样品中的非侵入性检测方法及其试剂盒
JP2013522346A JP2013534313A (ja) 2010-08-05 2011-08-01 腸の炎症状態の生物学的マーカーとしてのｈｍｇｂ１の使用、糞便サンプル中のｈｍｇｂ１を検出するための非侵襲法およびそのキット
EP11754539.2A EP2601525A1 (en) 2010-08-05 2011-08-01 Use of hmgb1 as a biological marker of bowel inflammatory conditions, non-invasive method for its detection in fecal samples and kit thereof
PE2013000131A PE20131062A1 (es) 2010-08-05 2011-08-01 Uso de hmgb1 como marcador biologico de afecciones intestinales inflamatorias, metodo no invasivo para su deteccion en muestras fecales y kit para su realizacion
US13/814,294 US20130137123A1 (en) 2010-08-05 2011-08-01 Use of hmgb1 as a biological marker of bowel inflammatory conditions, non-invasive method for its detection in fecal samples and kit thereof
CA2807107A CA2807107C (en) 2010-08-05 2011-08-01 Use of hmgb1 as a biological marker of bowel inflammatory conditions, non-invasive method for its detection in fecal samples and kit thereof
IL223845A IL223845A (en) 2010-08-05 2012-12-24 Use of 1hmgb as a biomarker of intestinal inflammatory conditions, non-invasive methods for his diagnosis of faecal samples and kit
CL2013000223A CL2013000223A1 (es) 2010-08-05 2013-01-23 Uso de hmgb1 como marcador biologico de afecciones intestinales inflamatorias , metodo no invasivo para deteccion en muestras fecales y kit para su realizacion.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM2010A000442A IT1406051B1 (it) 2010-08-05 2010-08-05 Uso di hmgb1 come marcatore biologico di infiammazione intestinale umana, metodo non invasivo per la sua rilevazione in campioni fecali e kit relativo.

Publications (2)

Publication Number Publication Date
ITRM20100442A1 ITRM20100442A1 (it) 2012-02-06
IT1406051B1 true IT1406051B1 (it) 2014-02-06

Family

ID=43739596

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM2010A000442A IT1406051B1 (it) 2010-08-05 2010-08-05 Uso di hmgb1 come marcatore biologico di infiammazione intestinale umana, metodo non invasivo per la sua rilevazione in campioni fecali e kit relativo.

Country Status (14)

Country Link
US (1) US20130137123A1 (enExample)
EP (1) EP2601525A1 (enExample)
JP (1) JP2013534313A (enExample)
CN (1) CN103069276A (enExample)
AU (1) AU2011287193B2 (enExample)
BR (1) BR112013002145A2 (enExample)
CA (1) CA2807107C (enExample)
CL (1) CL2013000223A1 (enExample)
EA (1) EA201390197A1 (enExample)
IL (1) IL223845A (enExample)
IT (1) IT1406051B1 (enExample)
MX (1) MX2013001327A (enExample)
PE (1) PE20131062A1 (enExample)
WO (1) WO2012017466A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
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WO2019016753A1 (en) 2017-07-20 2019-01-24 Laura Stronati USE OF GELSOLIN AS A DIAGNOSTIC AND PROGNOSTIC MARKER OF INTESTINAL INFLAMMATORY DISEASES
WO2019016719A1 (en) 2017-07-20 2019-01-24 Laura Stronati USE OF RHO GDP DISSOCIATION INHIBITORY PROTEIN 2 AS A DIAGNOSTIC AND PROGNOSTIC MARKER FOR INFLAMMATORY BOWEL DISEASES

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WO2015067913A1 (en) 2013-11-07 2015-05-14 Diagnodus Limited Biomarkers
EP4091624A1 (en) 2013-03-15 2022-11-23 Protagonist Therapeutics, Inc. Hepcidin analogues and uses thereof
CA2949215C (en) 2014-05-16 2023-03-14 Protagonist Therapeutics, Inc. .alpha.4.beta.7 integrin thioether peptide antagonists
SG10201810154WA (en) 2014-07-17 2018-12-28 Protagonist Therapeutics Inc Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
CA3009834A1 (en) 2015-12-30 2017-07-06 Protagonist Therapeutics, Inc. Analogues of hepcidin mimetics with improved in vivo half lives
WO2018022937A1 (en) 2016-07-27 2018-02-01 Protagonist Therapeutics, Inc. Peptide inhibitors of interleukin-23 and their use to treat inflammatory diseases
US20200064357A1 (en) * 2016-11-09 2020-02-27 Protagonist Therapeutics, Inc. Methods for determining and monitoring gastrointestinal inflammation
ES2944359T3 (es) 2017-05-12 2023-06-20 Evonik Operations Gmbh Procedimiento de detección de enfermedades inducidas por C. perfringens en una bandada de aves
WO2019157268A1 (en) 2018-02-08 2019-08-15 Protagonist Therapeutics, Inc. Conjugated hepcidin mimetics
KR20200128413A (ko) * 2018-03-02 2020-11-12 에보니크 오퍼레이션즈 게엠베하 오보트랜스페린을 결정함으로써 동물에서의 장 장벽 기능상실을 검출하기 위한 시험관내 방법
CN109030817A (zh) * 2018-07-04 2018-12-18 长沙都正医学检验有限责任公司 Hmgb1检测试剂盒及其制备方法
CA3104418A1 (en) 2018-07-12 2020-01-16 Protagonist Therapeutics, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
BR112021011158A2 (pt) 2018-12-14 2021-08-31 Evonik Operations Gmbh Método in vitro para detectar disbiose intestinal aviária, uso do dito método e uso de isoleucil-arginina ou isômeros desta
US11684653B2 (en) * 2019-03-06 2023-06-27 The Cleveland Clinic Foundation Compositions and method for reducing virulence of microorganisms
MX2022008740A (es) 2020-01-15 2022-09-23 Janssen Biotech Inc Peptidos inhibidores del receptor de interleucina-23 y su uso para tratar enfermedades inflamatorias.
SMT202500254T1 (it) 2020-01-15 2025-09-12 Janssen Biotech Inc Inibitori peptidici del recettore dell'interleuchina-23 e loro uso per trattare malattie infiammatorie
AU2021383828A1 (en) 2020-11-20 2023-07-06 Janssen Pharmaceutica Nv Compositions of peptide inhibitors of interleukin-23 receptor
KR20240034224A (ko) 2021-07-14 2024-03-13 얀센 바이오테크 인코포레이티드 인터류킨-23 수용체의 지질화된 펩티드 억제제
CN116973572B (zh) * 2023-06-02 2025-03-07 东南大学附属中大医院 基于血、粪便铁蛋白检测评估肠屏障损伤严重程度的方法
CN117825719B (zh) * 2024-01-04 2026-07-17 复旦大学附属中山医院 用于嗜酸性肉芽肿性多血管炎诊断的蛋白质组合物

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US6822078B2 (en) * 1996-07-17 2004-11-23 Kaneka Corp. Diagnostic drugs for autoimmune diseases
US6355623B2 (en) * 1998-09-24 2002-03-12 Hopital-Sainte-Justine Method of treating IBD/Crohn's disease and related conditions wherein drug metabolite levels in host blood cells determine subsequent dosage
US6303321B1 (en) * 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
WO2004079368A2 (en) * 2003-03-08 2004-09-16 Auvation Ltd Markers for colorectal cancer
JP2008520552A (ja) * 2004-10-22 2008-06-19 メディミューン，インコーポレーテッド Ｈｍｇｂ１に対する高親和性の抗体およびその使用法
US20090297546A1 (en) * 2006-12-20 2009-12-03 Shino-Test Corporation Avian-derived antibody capable of binding specifically to human hmgb1, immunological determination method for human hmgb1, and immunological determination reagent for human hmgb1
EA201000131A1 (ru) * 2007-08-02 2010-08-30 АйЭсЭс ИММЬЮН СИСТЕМ СТИМУЛЕЙШН АБ Диагностика, определение стадии и мониторинг воспалительного заболевания кишечника
KR20100124326A (ko) * 2008-03-14 2010-11-26 엑사젠 다이어그노스틱스, 인코포레이티드 염증성 장 질병 및 과민성 장 증후군에 대한 생체마커

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019016753A1 (en) 2017-07-20 2019-01-24 Laura Stronati USE OF GELSOLIN AS A DIAGNOSTIC AND PROGNOSTIC MARKER OF INTESTINAL INFLAMMATORY DISEASES
WO2019016719A1 (en) 2017-07-20 2019-01-24 Laura Stronati USE OF RHO GDP DISSOCIATION INHIBITORY PROTEIN 2 AS A DIAGNOSTIC AND PROGNOSTIC MARKER FOR INFLAMMATORY BOWEL DISEASES

Also Published As

Publication number Publication date
CA2807107C (en) 2017-01-03
WO2012017466A1 (en) 2012-02-09
CN103069276A (zh) 2013-04-24
CA2807107A1 (en) 2012-02-09
EA201390197A1 (ru) 2013-06-28
AU2011287193A1 (en) 2013-06-13
WO2012017466A8 (en) 2013-07-11
BR112013002145A2 (pt) 2016-05-24
US20130137123A1 (en) 2013-05-30
AU2011287193B2 (en) 2015-08-13
CL2013000223A1 (es) 2014-03-28
ITRM20100442A1 (it) 2012-02-06
MX2013001327A (es) 2013-03-08
EP2601525A1 (en) 2013-06-12
PE20131062A1 (es) 2013-10-16
JP2013534313A (ja) 2013-09-02
IL223845A (en) 2016-06-30

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