IT1302898B1 - Uso di amtolmetine guacil per la produzione di farmaci ad effettoantiinfiammatorio nelle infiammazioni intestinali. - Google Patents
Uso di amtolmetine guacil per la produzione di farmaci ad effettoantiinfiammatorio nelle infiammazioni intestinali.Info
- Publication number
- IT1302898B1 IT1302898B1 IT1998RM000745A ITRM980745A IT1302898B1 IT 1302898 B1 IT1302898 B1 IT 1302898B1 IT 1998RM000745 A IT1998RM000745 A IT 1998RM000745A IT RM980745 A ITRM980745 A IT RM980745A IT 1302898 B1 IT1302898 B1 IT 1302898B1
- Authority
- IT
- Italy
- Prior art keywords
- production
- ammoline
- guacil
- drugs
- inflammatory effect
- Prior art date
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 206010061218 Inflammation Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 230000000968 intestinal effect Effects 0.000 title 1
- CWJNMKKMGIAGDK-UHFFFAOYSA-N amtolmetin guacil Chemical group COC1=CC=CC=C1OC(=O)CNC(=O)CC(N1C)=CC=C1C(=O)C1=CC=C(C)C=C1 CWJNMKKMGIAGDK-UHFFFAOYSA-N 0.000 abstract 2
- 229950003227 amtolmetin guacil Drugs 0.000 abstract 2
- 206010047141 Vasodilatation Diseases 0.000 abstract 1
- 230000000146 antalgic effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940124599 anti-inflammatory drug Drugs 0.000 abstract 1
- 229940127218 antiplatelet drug Drugs 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 201000005060 thrombophlebitis Diseases 0.000 abstract 1
- 230000001732 thrombotic effect Effects 0.000 abstract 1
- 230000024883 vasodilation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyrrole Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998RM000745A IT1302898B1 (it) | 1998-12-03 | 1998-12-03 | Uso di amtolmetine guacil per la produzione di farmaci ad effettoantiinfiammatorio nelle infiammazioni intestinali. |
| EP05111060A EP1709963B1 (en) | 1998-12-03 | 1999-12-03 | Use of amtolmetin guacyl for the production of a drug for counteracting blood platelet aggregation |
| AT05111060T ATE433748T1 (de) | 1998-12-03 | 1999-12-03 | Verwendung von amtolmetin guacyl zur herstellung eines medikamentes zur verhinderung von blutplättchenaggregation |
| PCT/IT1999/000398 WO2000032188A2 (en) | 1998-12-03 | 1999-12-03 | Use of amtolmetin guacyl as an antiinflammatory drug |
| JP2000584883A JP2003512293A (ja) | 1998-12-03 | 1999-12-03 | 腸炎のための抗炎症薬を製造するためにアムトルメチングアシルの使用 |
| AU16801/00A AU1680100A (en) | 1998-12-03 | 1999-12-03 | Use of amtolmetin guacyl for the production of anti-inflammatory drugs for intestinal inflammations |
| DE69941019T DE69941019D1 (de) | 1998-12-03 | 1999-12-03 | Verwendung von Amtolmetin Guacyl zur Herstellung eines Medikamentes zur Verhinderung von Blutplättchenaggregation |
| CA002634658A CA2634658A1 (en) | 1998-12-03 | 1999-12-03 | Use of amtolmetin guacyl for the production of anti-inflammatory drugs for intestinal inflammations |
| CA002353727A CA2353727C (en) | 1998-12-03 | 1999-12-03 | Use of amtolmetin guacyl for the production of anti-inflammatory drugs for intestinal inflammations |
| HU0104491A HUP0104491A3 (en) | 1998-12-03 | 1999-12-03 | Use of amtolmetin guacyl for the production of anti-inflammatory drugs for intestinal inflammations |
| DE69940979T DE69940979D1 (de) | 1998-12-03 | 1999-12-03 | Verwendung von amtolmetin guacyl für die behandlung von intestinalen entzündungen |
| TR2001/01566T TR200101566T2 (tr) | 1998-12-03 | 1999-12-03 | Bağırsak iltihaplanmalarında iltihap yok edici ilaçların üretimi için amtolmetin guasilin kullanımı. |
| PL381264A PL201414B1 (pl) | 1998-12-03 | 1999-12-03 | Zastosowanie guacylu amtolmetyny do wytwarzania leku zapobiegającego agregacji płytek krwi |
| PL99348645A PL195790B1 (pl) | 1998-12-03 | 1999-12-03 | Zastosowanie guacylu amtolmetyny do wytwarzania leków przeciwzapalnych |
| EP99959678A EP1135122B1 (en) | 1998-12-03 | 1999-12-03 | Use of amtolmetin guacyl as for the treatment of intestinal inflammations |
| KR1020067014455A KR100660487B1 (ko) | 1998-12-03 | 1999-12-03 | 암톨메틴 구아실의 혈소판 응집 저해용 약물의 제조를 위한용도 |
| KR1020017006919A KR100627750B1 (ko) | 1998-12-03 | 1999-12-03 | 암톨메틴 구아실의 장내 염증용 소염제 제조를 위한 용도 |
| AT99959678T ATE433321T1 (de) | 1998-12-03 | 1999-12-03 | Verwendung von amtolmetin guacyl für die behandlung von intestinalen entzündungen |
| US09/857,432 US6495590B1 (en) | 1998-12-03 | 1999-12-03 | Use of amtolmetin guacyl for the production of anti-inflammatory drugs for intestinal inflammations |
| BG105552A BG65575B1 (bg) | 1998-12-03 | 2001-05-31 | Използване на амтолметин гуацил за получаване на противовъзпалителни лекарствени средства за лечение на чревни възпаления |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998RM000745A IT1302898B1 (it) | 1998-12-03 | 1998-12-03 | Uso di amtolmetine guacil per la produzione di farmaci ad effettoantiinfiammatorio nelle infiammazioni intestinali. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM980745A0 ITRM980745A0 (it) | 1998-12-03 |
| ITRM980745A1 ITRM980745A1 (it) | 2000-06-03 |
| IT1302898B1 true IT1302898B1 (it) | 2000-10-10 |
Family
ID=11406239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT1998RM000745A IT1302898B1 (it) | 1998-12-03 | 1998-12-03 | Uso di amtolmetine guacil per la produzione di farmaci ad effettoantiinfiammatorio nelle infiammazioni intestinali. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6495590B1 (bg) |
| EP (2) | EP1709963B1 (bg) |
| JP (1) | JP2003512293A (bg) |
| KR (2) | KR100660487B1 (bg) |
| AT (2) | ATE433748T1 (bg) |
| AU (1) | AU1680100A (bg) |
| BG (1) | BG65575B1 (bg) |
| CA (2) | CA2353727C (bg) |
| DE (2) | DE69940979D1 (bg) |
| HU (1) | HUP0104491A3 (bg) |
| IT (1) | IT1302898B1 (bg) |
| PL (2) | PL195790B1 (bg) |
| TR (1) | TR200101566T2 (bg) |
| WO (1) | WO2000032188A2 (bg) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1210673B (it) | 1982-02-26 | 1989-09-20 | Medosan Ind Biochimi | Antinfiammatoria amidi pirrolacetiche ad attivita' |
| US5889041A (en) * | 1995-07-14 | 1999-03-30 | Medosan Ricerca S.R.L. | Method for treating an inflammatory pathological condition |
| IT1278144B1 (it) | 1995-07-14 | 1997-11-17 | Medosan Ricerca Srl | Impiego dell'amtolmetineguacil (med 15) come farmaco antisecretivo sulla secrezione gastrica e quindi gastroprotettivo. |
| US6180658B1 (en) * | 1995-07-14 | 2001-01-30 | Medosan Ricerca S.R.L. | Method for counteracting blood platelet aggregation in a patient in need thereof |
| ITMI962356A1 (it) * | 1996-11-13 | 1998-05-13 | Uni Degli Studi Di Brescia D I | Uso di composti derivati da molecole ad attivita' antinfiammatoria di tipo non steroideo per la prevenzione e il trattamento di |
| PT1024807E (pt) * | 1997-08-08 | 2003-09-30 | Sigma Tau Ind Farmaceuti | Utilizacao do composto 2-metoxifenil-1-metil-5p-metilbenzoil-pirrol-2-acetamido-acetato para a producao de um farmaco anti-inflamatorio que previne a hipersecrecao gastrica e a debilitacao renal |
| WO1999007363A1 (en) | 1997-08-08 | 1999-02-18 | Medosan, Ricerca S.R.L. | Use of the compound 2-methoxyphenyl-1-methyl-5p-methylbenzoyl-pyrrol-2-acetamido acetate for the production of an anti-inflammatory drug with prevention of gastric hypersecretion and renal impairment |
-
1998
- 1998-12-03 IT IT1998RM000745A patent/IT1302898B1/it active IP Right Grant
-
1999
- 1999-12-03 DE DE69940979T patent/DE69940979D1/de not_active Expired - Fee Related
- 1999-12-03 TR TR2001/01566T patent/TR200101566T2/xx unknown
- 1999-12-03 HU HU0104491A patent/HUP0104491A3/hu unknown
- 1999-12-03 DE DE69941019T patent/DE69941019D1/de not_active Expired - Fee Related
- 1999-12-03 CA CA002353727A patent/CA2353727C/en not_active Expired - Fee Related
- 1999-12-03 AT AT05111060T patent/ATE433748T1/de not_active IP Right Cessation
- 1999-12-03 KR KR1020067014455A patent/KR100660487B1/ko not_active IP Right Cessation
- 1999-12-03 JP JP2000584883A patent/JP2003512293A/ja active Pending
- 1999-12-03 PL PL99348645A patent/PL195790B1/pl not_active IP Right Cessation
- 1999-12-03 AU AU16801/00A patent/AU1680100A/en not_active Abandoned
- 1999-12-03 CA CA002634658A patent/CA2634658A1/en not_active Abandoned
- 1999-12-03 US US09/857,432 patent/US6495590B1/en not_active Expired - Fee Related
- 1999-12-03 AT AT99959678T patent/ATE433321T1/de not_active IP Right Cessation
- 1999-12-03 EP EP05111060A patent/EP1709963B1/en not_active Expired - Lifetime
- 1999-12-03 EP EP99959678A patent/EP1135122B1/en not_active Expired - Lifetime
- 1999-12-03 KR KR1020017006919A patent/KR100627750B1/ko not_active IP Right Cessation
- 1999-12-03 PL PL381264A patent/PL201414B1/pl not_active IP Right Cessation
- 1999-12-03 WO PCT/IT1999/000398 patent/WO2000032188A2/en active IP Right Grant
-
2001
- 2001-05-31 BG BG105552A patent/BG65575B1/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2353727C (en) | 2009-09-22 |
| ITRM980745A1 (it) | 2000-06-03 |
| JP2003512293A (ja) | 2003-04-02 |
| DE69941019D1 (de) | 2009-07-30 |
| EP1709963A2 (en) | 2006-10-11 |
| ATE433748T1 (de) | 2009-07-15 |
| TR200101566T2 (tr) | 2001-10-22 |
| KR100627750B1 (ko) | 2006-09-26 |
| BG65575B1 (bg) | 2009-01-30 |
| WO2000032188A2 (en) | 2000-06-08 |
| PL348645A1 (en) | 2002-06-03 |
| EP1709963B1 (en) | 2009-06-17 |
| EP1709963A3 (en) | 2007-12-26 |
| KR20010108001A (ko) | 2001-12-07 |
| KR20060089247A (ko) | 2006-08-08 |
| HUP0104491A3 (en) | 2002-12-28 |
| KR100660487B1 (ko) | 2006-12-22 |
| EP1135122B1 (en) | 2009-06-10 |
| DE69940979D1 (de) | 2009-07-23 |
| WO2000032188A3 (en) | 2000-10-26 |
| CA2353727A1 (en) | 2000-06-08 |
| PL195790B1 (pl) | 2007-10-31 |
| PL201414B1 (pl) | 2009-04-30 |
| ATE433321T1 (de) | 2009-06-15 |
| ITRM980745A0 (it) | 1998-12-03 |
| HUP0104491A2 (hu) | 2002-04-29 |
| BG105552A (bg) | 2001-12-29 |
| US6495590B1 (en) | 2002-12-17 |
| CA2634658A1 (en) | 2000-06-08 |
| EP1135122A2 (en) | 2001-09-26 |
| AU1680100A (en) | 2000-06-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |