IT1295405B1 - Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di - Google Patents
Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza diInfo
- Publication number
- IT1295405B1 IT1295405B1 IT97RM000586A ITRM970586A IT1295405B1 IT 1295405 B1 IT1295405 B1 IT 1295405B1 IT 97RM000586 A IT97RM000586 A IT 97RM000586A IT RM970586 A ITRM970586 A IT RM970586A IT 1295405 B1 IT1295405 B1 IT 1295405B1
- Authority
- IT
- Italy
- Prior art keywords
- increase
- survival rate
- receptoral
- angiotensin
- antagonist
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 230000004083 survival effect Effects 0.000 title abstract 2
- 102000005862 Angiotensin II Human genes 0.000 title 1
- 101800000733 Angiotensin-2 Proteins 0.000 title 1
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 title 1
- 229950006323 angiotensin ii Drugs 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 239000002083 C09CA01 - Losartan Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 229960000519 losartan potassium Drugs 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97RM000586A IT1295405B1 (it) | 1997-09-30 | 1997-09-30 | Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di |
| JP2000513573A JP2001517698A (ja) | 1997-09-30 | 1998-09-30 | 腎移植患者の生存率を増大させる薬剤の製造のためのアンギオテンシンｉｉ受容体アンタゴニストの使用 |
| AU93666/98A AU754852B2 (en) | 1997-09-30 | 1998-09-30 | Use of an angiotensin II receptor antagonist for the preparation of drugs to increase the survival rate of renal transplant patients |
| CA002303217A CA2303217C (en) | 1997-09-30 | 1998-09-30 | Use of an angiotensin ii receptor antagonist for the preparation of drugs to increase the survival rate of renal transplant patients |
| DE1998621252 DE69821252T2 (de) | 1997-09-30 | 1998-09-30 | Verwendung eines Angiotensin-II Antagonisten zur Herstellung von Arzneistoffen zur Erhöhung der Überlebensrate von Nierentransplantationspatienten |
| ES98946713T ES2213296T3 (es) | 1997-09-30 | 1998-09-30 | Uso de un antagonista del receptor de angiotensina ii para la preparacion de medicamentos para aumentar la tasa de supervivencia de pacientes con trasplante renal. |
| PT98946713T PT1019048E (pt) | 1997-09-30 | 1998-09-30 | Uso de um antagonista do receptor da angiotensina ii para a preparacao de farmacos para aumentar a taxa de sobrevivencia de pacientes sujeitos a transplante renal |
| EP98946713A EP1019048B1 (en) | 1997-09-30 | 1998-09-30 | Use of an angiotensin ii receptor antagonist for the preparation of drugs to increase the survival rate of renal transplant patients |
| AT98946713T ATE258051T1 (de) | 1997-09-30 | 1998-09-30 | Verwendung von einem angiotensin ii antagonist zur herstellung eines arzneistoffs zur steigerung der überlebung von nieren transplantieren patienten |
| DK98946713T DK1019048T3 (da) | 1997-09-30 | 1998-09-30 | Anvendelse af en angiotensin II-reseptorantagonist til fremstilling af lægemidler til forøgelse af overlevelsesfrekvensen af nyretransplanterede patienter |
| PCT/IT1998/000259 WO1999016437A1 (en) | 1997-09-30 | 1998-09-30 | Use of an angiotensin ii receptor antagonist for the preparation of drugs to increase the survival rate of renal transplant patients |
| US10/076,396 US6576652B2 (en) | 1997-09-30 | 2002-02-19 | Use of an angiotensin II receptor antagonist for the preparation of drugs to increase the survival rate of renal transplant patients |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97RM000586A IT1295405B1 (it) | 1997-09-30 | 1997-09-30 | Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITRM970586A1 ITRM970586A1 (it) | 1999-03-30 |
| IT1295405B1 true IT1295405B1 (it) | 1999-05-12 |
Family
ID=11405271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT97RM000586A IT1295405B1 (it) | 1997-09-30 | 1997-09-30 | Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6576652B2 (enExample) |
| EP (1) | EP1019048B1 (enExample) |
| JP (1) | JP2001517698A (enExample) |
| AT (1) | ATE258051T1 (enExample) |
| AU (1) | AU754852B2 (enExample) |
| CA (1) | CA2303217C (enExample) |
| DE (1) | DE69821252T2 (enExample) |
| DK (1) | DK1019048T3 (enExample) |
| ES (1) | ES2213296T3 (enExample) |
| IT (1) | IT1295405B1 (enExample) |
| PT (1) | PT1019048E (enExample) |
| WO (1) | WO1999016437A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6638937B2 (en) | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| BR0102252B1 (pt) | 2001-04-10 | 2013-10-22 | Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso | |
| DE60304175T2 (de) | 2002-04-29 | 2007-03-15 | Teva Pharmaceutical Industries Ltd. | Verfahren zur herstellung von losartan und losartan-kaliumsalz |
| WO2005097109A1 (en) * | 2004-04-01 | 2005-10-20 | Daniel Batlle | Methods for achieving a protective ace2 expression level |
| US20050282877A1 (en) * | 2004-04-13 | 2005-12-22 | Becker Bryan N | Method of decreasing inflammation in kidney transplantion using angiotensin receptor blockers |
| US7531560B2 (en) * | 2004-11-10 | 2009-05-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Anti-cytokine heterocyclic compounds |
| JP5697593B2 (ja) * | 2009-04-28 | 2015-04-08 | 第一三共株式会社 | 新規溶媒和物結晶 |
| NO2944633T3 (enExample) * | 2012-11-14 | 2018-06-30 | ||
| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
| AU2019246406B2 (en) * | 2018-03-29 | 2025-01-23 | Bruno Reichart | Compositions for prolonging the survival after orthopic and heteropic xenogeneic heart, kidney, lung or liver transplantations |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH528514A (de) | 1969-05-22 | 1972-09-30 | Bayer Ag | Verfahren zur Herstellung von Acylimidazolen |
| JPS54148788A (en) | 1978-05-15 | 1979-11-21 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative and its preparation |
| JPS55313A (en) | 1978-06-13 | 1980-01-05 | Kissei Pharmaceut Co Ltd | Imidazole derivative |
| DK531479A (da) | 1979-01-19 | 1980-07-20 | Pfizer | Fremgangsmaade til fremstilling af imidazolderivater og salte deraf |
| JPS5671074A (en) | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
| JPS5671073A (en) | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | Imidazole derivative |
| DE3106150A1 (de) | 1981-02-13 | 1982-09-16 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | "verfahren zur herstellung von imidazolessigsaeurederivaten" |
| JPS58157768A (ja) | 1982-03-16 | 1983-09-19 | Takeda Chem Ind Ltd | ４−クロロ−２−フエニルイミダゾ−ル−５−酢酸誘導体 |
| PT78388B (en) | 1983-04-12 | 1986-09-15 | Smithkline Beckman Corp | Dopamine-beta-hydroxylase inhibitors |
| FI833794A0 (fi) | 1983-10-18 | 1983-10-18 | Farmos Oy | Substituerade 2-merkapto-imidazoler |
| US5138069A (en) | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| US5064825A (en) * | 1989-06-01 | 1991-11-12 | Merck & Co., Inc. | Angiotensin ii antagonists |
| EP0505098A1 (en) * | 1991-03-19 | 1992-09-23 | Merck & Co. Inc. | Imidazole derivatives bearing acidic functional groups as angiotensin II antagonists |
| US5492904A (en) * | 1991-05-15 | 1996-02-20 | E. I. Du Pont De Nemours And Company | Composition of angiotensin-II receptor antagonists and calcium channel blockers |
| US5130439A (en) | 1991-11-18 | 1992-07-14 | Lo Young S | Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists |
| DK0643704T3 (da) | 1991-11-18 | 2004-01-19 | Merck & Co Inc | Tetrazolylphenylboronsyremellemprodukter til syntese af All-receptor antagonister |
| US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| US5310929A (en) * | 1992-08-06 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists |
| US5395844A (en) * | 1993-06-10 | 1995-03-07 | The Du Pont Merck Pharmaceutical Company | Imidazole 5-position substituted angiotensin II antagonists |
| PT853477E (pt) * | 1995-10-06 | 2003-01-31 | Novartis Ag | Antagonistas de receptores at1 para prevencao e tratamento de insuficiencia renal pos-isquemica e para proteccao de rim isquemico |
| EP0868179A4 (en) * | 1995-12-12 | 2002-01-30 | Merck & Co Inc | NEW USE OF LOSARTAN |
-
1997
- 1997-09-30 IT IT97RM000586A patent/IT1295405B1/it active IP Right Grant
-
1998
- 1998-09-30 DE DE1998621252 patent/DE69821252T2/de not_active Expired - Lifetime
- 1998-09-30 DK DK98946713T patent/DK1019048T3/da active
- 1998-09-30 WO PCT/IT1998/000259 patent/WO1999016437A1/en not_active Ceased
- 1998-09-30 JP JP2000513573A patent/JP2001517698A/ja active Pending
- 1998-09-30 AU AU93666/98A patent/AU754852B2/en not_active Ceased
- 1998-09-30 EP EP98946713A patent/EP1019048B1/en not_active Expired - Lifetime
- 1998-09-30 PT PT98946713T patent/PT1019048E/pt unknown
- 1998-09-30 ES ES98946713T patent/ES2213296T3/es not_active Expired - Lifetime
- 1998-09-30 AT AT98946713T patent/ATE258051T1/de active
- 1998-09-30 CA CA002303217A patent/CA2303217C/en not_active Expired - Fee Related
-
2002
- 2002-02-19 US US10/076,396 patent/US6576652B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999016437A1 (en) | 1999-04-08 |
| PT1019048E (pt) | 2004-05-31 |
| EP1019048A1 (en) | 2000-07-19 |
| CA2303217A1 (en) | 1999-04-08 |
| US6576652B2 (en) | 2003-06-10 |
| DE69821252T2 (de) | 2004-11-18 |
| DK1019048T3 (da) | 2004-05-03 |
| AU754852B2 (en) | 2002-11-28 |
| CA2303217C (en) | 2005-08-09 |
| DE69821252D1 (de) | 2004-02-26 |
| ES2213296T3 (es) | 2004-08-16 |
| ATE258051T1 (de) | 2004-02-15 |
| AU9366698A (en) | 1999-04-23 |
| ITRM970586A1 (it) | 1999-03-30 |
| US20020115702A1 (en) | 2002-08-22 |
| JP2001517698A (ja) | 2001-10-09 |
| EP1019048B1 (en) | 2004-01-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Wong et al. | Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent. | |
| IT1295405B1 (it) | Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di | |
| CA2085584A1 (en) | Treatment of chronic renal failure with imidazole angiotensin-ii receptor antagonists | |
| EP1327631A3 (en) | Fused heterocyclic compounds, their production and use as angiotensin II antagonists | |
| GEP20094627B (en) | High drug load tablet | |
| TW200626148A (en) | Heterocyclic derivatives and their use as therapeutic agents | |
| BR0215202A (pt) | Compostos antagonistas seletivos a2b de pirimidina, sua sìntese e uso | |
| TW200626155A (en) | Heterocyclic derivatives and their use as therapeutic agents | |
| TW200626592A (en) | Heterocyclic derivatives and their use as therapeutic agents | |
| TW200626154A (en) | Heterocyclic derivatives and their use as therapeutic agents | |
| TW200626139A (en) | Heterocyclic derivatives and their use as therapeutic agents | |
| DK1049700T3 (da) | Kemokinreceptorantagonister og fremgangsmåder til anvendelse deraf | |
| WO2000067735A3 (en) | USE OF SELECTIVE ANTAGONISTS OF THE α1b-ADRENERGIC RECEPTOR FOR IMPROVEMENT OF SEXUAL DYSFUNCTION | |
| CA2123900A1 (en) | Tetrazolylphenylboronic Acid Intermediates for the Synthesis of AII Receptor Antagonists | |
| GB2352972A (en) | Use of dexmedetomidine for icu sedation | |
| CA2643005A1 (en) | Imidazole-5-carboxylic acid derivatives,the preparation method therefor and the uses thereof | |
| DK0752854T3 (da) | Pyrimidin- eller triazincarboxylsyrederivater til anvendelse som lægemiddel | |
| RU2001105092A (ru) | Имидазольные соединения и их применение в качестве ингибиторов аденозиндезаминазы | |
| TR200001412T2 (tr) | Çok miktarda ilaç içeren, derhal ve modifike bir salgılama sağlayan oral doz formülasyonları ve bunların imal edilmesi için proses. | |
| US20020058686A1 (en) | Medicament | |
| CY1110950T1 (el) | Ενωσεις ιμιδαζολιδινονυλ αμινοπυριμιδινης για τη θεραπευτικη αντιμετωπιση του καρκινου | |
| US6028091A (en) | Medicament | |
| CA2421826A1 (en) | Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists | |
| SG165152A1 (en) | Chemokine receptor antagonists and methods of use thereof | |
| van Meel et al. | Hypotensive effects of the angiotensin II antagonist telmisartan in conscious chronically-instrumented transgenic rats |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |