IT1282024B1 - Idrossi derivati di azabicicloottil-tetra-e-esaidrobenz(d,e) isochinolone - Google Patents

Idrossi derivati di azabicicloottil-tetra-e-esaidrobenz(d,e) isochinolone

Info

Publication number
IT1282024B1
IT1282024B1 IT95MI001449A ITMI951449A IT1282024B1 IT 1282024 B1 IT1282024 B1 IT 1282024B1 IT 95MI001449 A IT95MI001449 A IT 95MI001449A IT MI951449 A ITMI951449 A IT MI951449A IT 1282024 B1 IT1282024 B1 IT 1282024B1
Authority
IT
Italy
Prior art keywords
hexaidrobenz
azabicycloottyl
isoquinolone
tetra
hydroxy derivatives
Prior art date
Application number
IT95MI001449A
Other languages
English (en)
Inventor
Jacob Berger
Robin Douglas Clark
Paul Edward Weller
Douglas Leslie Wren
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ITMI951449A0 publication Critical patent/ITMI951449A0/it
Publication of ITMI951449A1 publication Critical patent/ITMI951449A1/it
Application granted granted Critical
Publication of IT1282024B1 publication Critical patent/IT1282024B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT95MI001449A 1994-07-28 1995-07-06 Idrossi derivati di azabicicloottil-tetra-e-esaidrobenz(d,e) isochinolone IT1282024B1 (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/282,110 US5492914A (en) 1994-07-28 1994-07-28 2-(1-azabicyclo[2.2.2]oct-3 s-yl)-6-hydroxy-2,4,5,6-tetrahydro-1H-benz[DE]is[2.2.2]oct-3's-yl)-6-hydroxy-2,3,3a,4,5,6-hexahydro-1h-benz [DE]isoquinolin-1-one and individual stereoisomers thereof

Publications (3)

Publication Number Publication Date
ITMI951449A0 ITMI951449A0 (it) 1995-07-06
ITMI951449A1 ITMI951449A1 (it) 1997-01-06
IT1282024B1 true IT1282024B1 (it) 1998-03-06

Family

ID=23080144

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI001449A IT1282024B1 (it) 1994-07-28 1995-07-06 Idrossi derivati di azabicicloottil-tetra-e-esaidrobenz(d,e) isochinolone

Country Status (5)

Country Link
US (1) US5492914A (it)
JP (1) JP2705723B2 (it)
DE (1) DE19526233B4 (it)
FR (1) FR2723092B1 (it)
IT (1) IT1282024B1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL211057B1 (pl) * 2002-05-13 2012-04-30 Hoffmann La Roche Pochodne benzoksazyny, sposób ich wytwarzania, środek farmaceutyczny i zastosowanie pochodnych benzoksazyny
TWI355936B (en) 2003-02-18 2012-01-11 Helsinn Healthcare Sa Uses of palonosetron hydrochloride
EP2499137A1 (en) * 2009-11-13 2012-09-19 Helsinn Healthcare S.A. Palonosetron metabolites

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356906A (en) * 1989-10-27 1994-10-18 The Du Pont Merck Pharmaceutical Company (N-phthalimidoalkyl) piperidines useful as treatments for psychosis
NO175309C (no) * 1989-11-28 1994-09-28 Syntex Inc Analogifremgangsmåte for fremstilling av nye, terapeutisk virksomme tricykliske, nitrogenholdige forbindelser
US5202318A (en) * 1990-05-14 1993-04-13 Syntex (U.S.A.) Inc. Tricyclic compounds acting at serotonin receptor subtypes
AU7618991A (en) * 1990-05-14 1991-11-14 Syntex (U.S.A.) Inc. Novel tricyclic compounds
FR2673944B1 (fr) * 1991-03-13 1995-03-10 Sanofi Elf Derives de l'1,8-naphtalimide, leur procede de preparation et les compositions pharmaceutiques les contenant.

Also Published As

Publication number Publication date
DE19526233B4 (de) 2006-09-07
ITMI951449A0 (it) 1995-07-06
FR2723092B1 (fr) 1997-08-01
JP2705723B2 (ja) 1998-01-28
FR2723092A1 (fr) 1996-02-02
ITMI951449A1 (it) 1997-01-06
US5492914A (en) 1996-02-20
DE19526233A1 (de) 1996-02-01
JPH0841059A (ja) 1996-02-13

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Legal Events

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0001 Granted