IT1277073B1 - Derivati antraciclinici - Google Patents

Derivati antraciclinici

Info

Publication number
IT1277073B1
IT1277073B1 IT95MI002614A ITMI952614A IT1277073B1 IT 1277073 B1 IT1277073 B1 IT 1277073B1 IT 95MI002614 A IT95MI002614 A IT 95MI002614A IT MI952614 A ITMI952614 A IT MI952614A IT 1277073 B1 IT1277073 B1 IT 1277073B1
Authority
IT
Italy
Prior art keywords
anthracyclinic
derivatives
anthracyclinic derivatives
Prior art date
Application number
IT95MI002614A
Other languages
English (en)
Italian (it)
Inventor
Michele Caruso
Alberto Bargiotti
Cristina Geroni
Antonino Suarato
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of ITMI952614A0 publication Critical patent/ITMI952614A0/it
Publication of ITMI952614A1 publication Critical patent/ITMI952614A1/it
Application granted granted Critical
Publication of IT1277073B1 publication Critical patent/IT1277073B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT95MI002614A 1994-12-23 1995-12-13 Derivati antraciclinici IT1277073B1 (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9426075A GB2296495B (en) 1994-12-23 1994-12-23 Anthracycline derivatives

Publications (3)

Publication Number Publication Date
ITMI952614A0 ITMI952614A0 (de) 1995-12-13
ITMI952614A1 ITMI952614A1 (it) 1997-06-13
IT1277073B1 true IT1277073B1 (it) 1997-11-04

Family

ID=10766488

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI002614A IT1277073B1 (it) 1994-12-23 1995-12-13 Derivati antraciclinici

Country Status (4)

Country Link
JP (1) JP4081148B2 (de)
DE (1) DE19547958B4 (de)
GB (1) GB2296495B (de)
IT (1) IT1277073B1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2315067B (en) * 1996-07-11 2000-02-16 Pharmacia Spa Morpholinyl anthracycline derivatives
AU767394C (en) * 1999-12-29 2005-04-21 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
CA2519289A1 (en) * 2003-03-18 2004-09-30 Antonino Suarato Nemorubicin as radiosensitizer in combination with radiation therapy against tumors
WO2004082689A1 (en) * 2003-03-18 2004-09-30 Pharmacia Italia Spa Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor
ES2547552T3 (es) 2008-02-01 2015-10-07 Genentech, Inc. Metabolito de nemorrubicina y reactivos análogos, conjugados anticuerpo-fármaco y métodos
BRPI0911647A2 (pt) * 2008-04-11 2015-10-13 Tianjin Hemay Bio Tech Co Ltd compostos derivados de antibióticos de antraciclina com alta atividade, métodos de preeparação e uso dos mesmos.
CN101555264B (zh) * 2008-04-11 2014-09-03 天津和美生物技术有限公司 具有高活性的四环蒽醌类抗生素的衍生物及其制备和应用
KR101667062B1 (ko) 2008-07-15 2016-10-17 제넨테크, 인크. 안트라시클린 유도체 접합체, 그의 제조 방법 및 항-종양 화합물로서의 그의 용도
JP6008864B2 (ja) 2010-12-02 2016-10-19 ナーヴィアノ メディカル サイエンシズ エス．アール．エル． モルホリニルアントラサイクリン誘導体の調製方法
CN104125962B (zh) * 2012-03-06 2016-06-22 天津和美生物技术有限公司 四环蒽醌衍生物
DK2991993T3 (en) * 2013-04-29 2018-07-30 Nerviano Medical Sciences Srl NEW MORPHOLINYLANTHRACYCLINE DERIVATIVES
CN107001384A (zh) 2014-11-05 2017-08-01 内尔维阿诺医学科学有限公司 官能化的吗啉基蒽环类衍生物
CN110776501B (zh) * 2019-08-22 2021-04-02 联宁（苏州）生物制药有限公司 一种用于抗体药物偶联物的药物毒素pnu-159682的制备方法及其中间体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
JPS59212499A (ja) * 1983-05-13 1984-12-01 アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド 抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体
US4585859A (en) * 1983-05-24 1986-04-29 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Also Published As

Publication number Publication date
JPH08231581A (ja) 1996-09-10
ITMI952614A1 (it) 1997-06-13
DE19547958A1 (de) 1996-06-27
GB9426075D0 (en) 1995-02-22
ITMI952614A0 (de) 1995-12-13
JP4081148B2 (ja) 2008-04-23
DE19547958B4 (de) 2015-01-22
GB2296495A (en) 1996-07-03
GB2296495B (en) 1998-04-15

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Legal Events

Date Code Title Description
0001 Granted