IT1277073B1 - Derivati antraciclinici - Google Patents

Derivati antraciclinici

Info

Publication number
IT1277073B1
IT1277073B1 IT95MI002614A ITMI952614A IT1277073B1 IT 1277073 B1 IT1277073 B1 IT 1277073B1 IT 95MI002614 A IT95MI002614 A IT 95MI002614A IT MI952614 A ITMI952614 A IT MI952614A IT 1277073 B1 IT1277073 B1 IT 1277073B1
Authority
IT
Italy
Prior art keywords
anthracyclinic
derivatives
anthracyclinic derivatives
Prior art date
Application number
IT95MI002614A
Other languages
English (en)
Italian (it)
Inventor
Michele Caruso
Alberto Bargiotti
Cristina Geroni
Antonino Suarato
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of ITMI952614A0 publication Critical patent/ITMI952614A0/it
Publication of ITMI952614A1 publication Critical patent/ITMI952614A1/it
Application granted granted Critical
Publication of IT1277073B1 publication Critical patent/IT1277073B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT95MI002614A 1994-12-23 1995-12-13 Derivati antraciclinici IT1277073B1 (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9426075A GB2296495B (en) 1994-12-23 1994-12-23 Anthracycline derivatives

Publications (3)

Publication Number Publication Date
ITMI952614A0 ITMI952614A0 (cs) 1995-12-13
ITMI952614A1 ITMI952614A1 (it) 1997-06-13
IT1277073B1 true IT1277073B1 (it) 1997-11-04

Family

ID=10766488

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI002614A IT1277073B1 (it) 1994-12-23 1995-12-13 Derivati antraciclinici

Country Status (4)

Country Link
JP (1) JP4081148B2 (cs)
DE (1) DE19547958B4 (cs)
GB (1) GB2296495B (cs)
IT (1) IT1277073B1 (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2315067B (en) * 1996-07-11 2000-02-16 Pharmacia Spa Morpholinyl anthracycline derivatives
WO2001049698A1 (en) * 1999-12-29 2001-07-12 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
EP1605951A1 (en) * 2003-03-18 2005-12-21 Pharmacia Italia S.p.A. Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor
AU2004222526A1 (en) * 2003-03-18 2004-09-30 Pharmacia Italia S.P.A. Nemorubicin as radiosensitizer in combination with radiation therapy against tumors
EP2240495B1 (en) 2008-02-01 2015-07-15 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
US9115165B2 (en) 2008-04-11 2015-08-25 Tianjin Hemay Bio-Tech Co., Ltd. Tetracyclic anthraquinone antibiotic derivatives with high activity, process for preparing the same and use thereof
ES2655243T3 (es) * 2008-04-11 2018-02-19 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Derivados antibióticos de antraciclina con alta actividad, métodos de preparación y usos de los mismos
AU2009270988A1 (en) 2008-07-15 2010-01-21 Genentech, Inc. Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds
KR101897307B1 (ko) 2010-12-02 2018-09-10 네르비아노 메디칼 사이언시스 에스.알.엘. 모르폴리닐 안트라사이클린 유도체의 제조 방법
EP2824108B8 (en) * 2012-03-06 2017-07-12 Tianjin Hemay Oncology Pharmaceutical Co., Ltd. Tetracyclic anthraquinone derivatives
US9828405B2 (en) 2013-04-29 2017-11-28 Nerviano Medical Sciences S.R.L. Morpholinyl anthracycline derivatives
US20170312290A1 (en) 2014-11-05 2017-11-02 Nerviano Medical Sciences S.R.L. Functionalized morpholinyl anthracycline derivatives
CN110776501B (zh) * 2019-08-22 2021-04-02 联宁（苏州）生物制药有限公司 一种用于抗体药物偶联物的药物毒素pnu-159682的制备方法及其中间体
WO2025092728A1 (zh) * 2023-10-30 2025-05-08 上海皓元生物医药科技有限公司 一种pnu-159682的中间体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
JPS59212499A (ja) * 1983-05-13 1984-12-01 アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド 抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体
US4585859A (en) * 1983-05-24 1986-04-29 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Also Published As

Publication number Publication date
DE19547958B4 (de) 2015-01-22
GB2296495A (en) 1996-07-03
ITMI952614A0 (cs) 1995-12-13
GB2296495B (en) 1998-04-15
ITMI952614A1 (it) 1997-06-13
DE19547958A1 (de) 1996-06-27
GB9426075D0 (en) 1995-02-22
JP4081148B2 (ja) 2008-04-23
JPH08231581A (ja) 1996-09-10

Similar Documents

Publication Publication Date Title
FI954829L (fi) Aroyylipiperidiinijohdannaiset
NO952854D0 (no) 1-arylpyrimidin-derivater
DE59508427D1 (de) 3-aryl-4-hydroxy-delta 3 -dihydrothiophenon-derivate
EP0708091A3 (en) Indoloyl-guanidines derivatives
DE69430587D1 (de) Pyrimidin-acyclonukleosid-derivate
ITMI940238A0 (it) Derivati azaciclici
FI971227L (fi) Pyramidinyylipyratsolijohdannaisia
IT1277073B1 (it) Derivati antraciclinici
IT1307327B1 (it) Derivati idroisochinolinici sostituiti
IT1277597B1 (it) Derivati di diarilalchenilammina
DE69527786D1 (de) Diaminomethyliden-derivate
FI964853A7 (fi) Deasetoksitaksolijohdannaiset
ITMI941099A0 (it) Derivati chinolinici
DE59509209D1 (de) Diphenyloxazolin-derivate
DE69510792D1 (de) Naphtochinonderivate
FI955026L (fi) Alkyyli-5-metyylisulfonyylibentsoyyliguanidiinijohdannaisia
ITMI941191A0 (it) 1-b-metil-2-tiol carbapen derivati
IT1273610B (it) Derivati della purporogallina
FI963122A7 (fi) Karbamoyylimetyyliureajohdannaiset
ITMI941863A0 (it) Derivati idrosochinolinici sostiuiti
ITMI941688A0 (it) Nuovi derivati isocefalosporanici
ITMI940202A0 (it) Derivati di idroisochinolina
ITMI940203A0 (it) Derivati di idroisochinolina
ITMI940467A0 (it) Derivati idantoinici
IT1276168B1 (it) Derivati chinolinici

Legal Events

Date Code Title Description
0001 Granted