IT1177061B - Derivato salino farmacologicamente attivo del 3-idrossi-5-(idrossimetil)-2-metilisonicotinaldeide fosfato - Google Patents
Derivato salino farmacologicamente attivo del 3-idrossi-5-(idrossimetil)-2-metilisonicotinaldeide fosfatoInfo
- Publication number
- IT1177061B IT1177061B IT23344/84A IT2334484A IT1177061B IT 1177061 B IT1177061 B IT 1177061B IT 23344/84 A IT23344/84 A IT 23344/84A IT 2334484 A IT2334484 A IT 2334484A IT 1177061 B IT1177061 B IT 1177061B
- Authority
- IT
- Italy
- Prior art keywords
- methylisonicotinaldehyde
- hydroxymethyl
- hydroxy
- phosphate
- pharmacologically active
- Prior art date
Links
- 229910019142 PO4 Inorganic materials 0.000 title 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 title 1
- 239000010452 phosphate Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- ZQUJIOBCBGSBKS-UHFFFAOYSA-N 1-pyrrolidin-1-yl-4-(2,4,6-trimethoxyphenyl)butan-2-one Chemical compound COC1=CC(OC)=CC(OC)=C1CCC(=O)CN1CCCC1 ZQUJIOBCBGSBKS-UHFFFAOYSA-N 0.000 abstract 1
- OWYLAEYXIQKAOL-UHFFFAOYSA-N 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone Chemical compound COC1=CC(OC)=CC(OC)=C1C(=O)CCCN1CCCC1 OWYLAEYXIQKAOL-UHFFFAOYSA-N 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT23344/84A IT1177061B (it) | 1984-10-26 | 1984-10-26 | Derivato salino farmacologicamente attivo del 3-idrossi-5-(idrossimetil)-2-metilisonicotinaldeide fosfato |
EP85112179A EP0183002B2 (en) | 1984-10-26 | 1985-09-25 | Pharmaceutically active salt derivative of 3-hydroxy -5-(hydroxymethyl)-2-methylisonicotinaldehyde phosphate |
AT85112179T ATE43604T1 (de) | 1984-10-26 | 1985-09-25 | Pharmazeutisch aktives salzderivat von 3-hydroxy- 5-(hydroxymethyl)-2methylisonicotinaldehydphosphat. |
DE8585112179T DE3570674D1 (en) | 1984-10-26 | 1985-09-25 | Pharmaceutically active salt derivative of 3-hydroxy -5-(hydroxymethyl)-2-methylisonicotinaldehyde phosphate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT23344/84A IT1177061B (it) | 1984-10-26 | 1984-10-26 | Derivato salino farmacologicamente attivo del 3-idrossi-5-(idrossimetil)-2-metilisonicotinaldeide fosfato |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8423344A0 IT8423344A0 (it) | 1984-10-26 |
IT1177061B true IT1177061B (it) | 1987-08-26 |
Family
ID=11206268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT23344/84A IT1177061B (it) | 1984-10-26 | 1984-10-26 | Derivato salino farmacologicamente attivo del 3-idrossi-5-(idrossimetil)-2-metilisonicotinaldeide fosfato |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0183002B2 (it) |
AT (1) | ATE43604T1 (it) |
DE (1) | DE3570674D1 (it) |
IT (1) | IT1177061B (it) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1241515B (it) * | 1990-07-30 | 1994-01-17 | Bromley Limited | Sali dell'acido nicotinico con composti aminobenzilici e loro impiego farmaceutico". |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1236531A (en) * | 1969-02-12 | 1971-06-23 | Soc D Etudes Prod Chimique | Adenin derivative |
BE759608A (fr) * | 1970-01-08 | 1971-06-01 | Soc D Etudes Prod Chimique | Mono pyridoxal phosphate de papaverine, son procede de preparation ainsi que son utilisation therapeutique |
FR2134218A1 (en) * | 1971-04-27 | 1972-12-08 | Penciolelli Madeleine | Phloroglucinol aminoketones - vasodilators and antispasmodics |
BE863754A (fr) * | 1978-02-08 | 1978-05-29 | Dechamps Pierre | Nouveaux derives de la vincamine utilisables comme regulateurs de la circulation cerebrale |
-
1984
- 1984-10-26 IT IT23344/84A patent/IT1177061B/it active
-
1985
- 1985-09-25 DE DE8585112179T patent/DE3570674D1/de not_active Expired
- 1985-09-25 EP EP85112179A patent/EP0183002B2/en not_active Expired - Lifetime
- 1985-09-25 AT AT85112179T patent/ATE43604T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0183002B1 (en) | 1989-05-31 |
EP0183002A1 (en) | 1986-06-04 |
DE3570674D1 (en) | 1989-07-06 |
EP0183002B2 (en) | 1994-11-30 |
IT8423344A0 (it) | 1984-10-26 |
ATE43604T1 (de) | 1989-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5332822A (en) | Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors | |
US4279911A (en) | Amine derivatives and pharmaceutical compositions containing them | |
FI905280A0 (fi) | Menetelmä valmistaa terapeuttisesti aktiivista bentsopyridopiperidiini-, piperidylideeni- ja -piperatsiiniyhdistettä | |
FR2416889A1 (fr) | Derives esters de l'acide dihydro-1,4-pyridine-dicarboxylique-3,5, medicaments a base de ces derives et leur procede de production | |
US4002766A (en) | Antiarrhythmia methods | |
NO874350L (no) | Fremgangsmaate for fremstilling av antibakterielle forbindelser. | |
CH618425A5 (it) | ||
CA1243018A (en) | Compounds derived from diphenyl-methylene-ethilamine, their method of preparation, the pharmaceutical compositions containing them and their use in human medicine | |
DE10130374A1 (de) | Substituierte N-Acyl-anilinderivate, deren Herstellung und deren Verwendung als Arzneimittel | |
IT1177061B (it) | Derivato salino farmacologicamente attivo del 3-idrossi-5-(idrossimetil)-2-metilisonicotinaldeide fosfato | |
EP0110869B1 (de) | Thienylessigsäureamidderivate und pharmazeutisch verträgliche Säureadditionssalze hiervon sowie Verfahren zu deren Herstellung | |
FR2450820A1 (fr) | Nouveaux derives d'acides 1- (o-mercaptoacyl) -4,5-dihydropyrazole-5-carboxyliques, utiles notamment comme agents hypotenseurs, et leur procede de preparation | |
RO78106A (ro) | Procedeu pentru prepararea unor derivati de z-2-acil-aminopropeonati 3-monosubstituiti | |
BRPI0611635A2 (pt) | derivado de benzeno 1,2-di(cìclico)substituìdo | |
KR880001477B1 (ko) | 니플룸산 모르폴리노에틸에스테르 디니플루메이트의 제조방법 | |
JPH023633A (ja) | 新規トリ置換アミン、その製造方法および該アミンを含有する、心臓および循環器疾病の治療薬 | |
IT1180218B (it) | Derivato salino farmacologicamente attivo dell'acido 1,2,3,6, tetraidro-1,3-dimetil-2,6-dioxopurina-7-acetico | |
EP0137426A2 (de) | Neue 2-Mercaptothiazolderivate, Verfarhen zu deren Herstellung sowie die Verwendung von 2-Mercaptothiazolderivaten in Arzneimitteln | |
IT1198234B (it) | Processo stereoconvergente per la preparazione di acidi carbossilici otticamente attivi | |
US3853892A (en) | 4-{8 para-(1-hydroxyethyl)-phenyl{9 piperidines | |
US2662890A (en) | Products having physostigmine-like action | |
FR2370052A1 (fr) | Lactames utiles notamment comme medicaments et leur procede de preparation | |
FR2381760A1 (fr) | Nouveau derive pyridyl-piperazine et procede pour sa preparation | |
SU540866A1 (ru) | Способ получени 1,2-ди-(1-пиперазил)этана | |
US2767116A (en) | 1, 3-disubstituted-2-streptomycyl-tetrahydroimidazole, acid addition salts thereof, and therapeutic compositions containing same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971030 |