FR2381760A1 - Nouveau derive pyridyl-piperazine et procede pour sa preparation - Google Patents

Nouveau derive pyridyl-piperazine et procede pour sa preparation

Info

Publication number
FR2381760A1
FR2381760A1 FR7805255A FR7805255A FR2381760A1 FR 2381760 A1 FR2381760 A1 FR 2381760A1 FR 7805255 A FR7805255 A FR 7805255A FR 7805255 A FR7805255 A FR 7805255A FR 2381760 A1 FR2381760 A1 FR 2381760A1
Authority
FR
France
Prior art keywords
pyridyl
preparation
propane
acid addition
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7805255A
Other languages
English (en)
Other versions
FR2381760B1 (fr
Inventor
Arpad Molnar
Karoly Felfoldi
Mihaly Bartok
Egon Karpati
Laszlo Szporny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of FR2381760A1 publication Critical patent/FR2381760A1/fr
Application granted granted Critical
Publication of FR2381760B1 publication Critical patent/FR2381760B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Nouveau 3-Ø4(2'-pyridyl)-pypérazin-1-ylõ-(3,4,5-triméthoxybenzoyloxy)-propane et ses sels d'addition acide. La préparation de ces composés consiste à faire réagir le 3-Ø4-(2'-pyridyl)-pipérazin-1-ylõ-hydroxy-propane avec l'acide 3,4,5-triméthoxybenzoïque ou avec un dérivé de celui-ci capable d'acylation ou à faire réagir la 4-(2'-pyridyl)-pipérazine avec un 1-(3,4,5-triméthoxy-benzoyloxy)-3-halogéno-propane et éventuellement à transformer le produit obtenu en sel d'addition acide. Application du nouveau composé et de ses sels d'addition acides physiologiquement acceptables comme médicaments fortement antiarythmiques.
FR7805255A 1977-02-25 1978-02-23 Nouveau derive pyridyl-piperazine et procede pour sa preparation Granted FR2381760A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77RI617A HU173380B (hu) 1977-02-25 1977-02-25 Sposob poluchenija novogo proizvodnogo piridil-piperazina i kislo-additivnykh solejj

Publications (2)

Publication Number Publication Date
FR2381760A1 true FR2381760A1 (fr) 1978-09-22
FR2381760B1 FR2381760B1 (fr) 1982-09-17

Family

ID=11001019

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7805255A Granted FR2381760A1 (fr) 1977-02-25 1978-02-23 Nouveau derive pyridyl-piperazine et procede pour sa preparation

Country Status (24)

Country Link
US (1) US4196206A (fr)
JP (1) JPS53105486A (fr)
AR (1) AR215290A1 (fr)
AT (1) AT361488B (fr)
AU (1) AU514106B2 (fr)
BE (1) BE864296A (fr)
CA (1) CA1098129A (fr)
CH (1) CH635337A5 (fr)
DE (1) DE2807169A1 (fr)
ES (1) ES467224A1 (fr)
FI (1) FI66350C (fr)
FR (1) FR2381760A1 (fr)
GB (1) GB1569084A (fr)
GR (1) GR64159B (fr)
HU (1) HU173380B (fr)
IL (1) IL54038A (fr)
IN (1) IN149333B (fr)
NL (1) NL7802031A (fr)
NO (1) NO147837C (fr)
PT (1) PT67703B (fr)
SE (1) SE429863B (fr)
SU (2) SU718010A3 (fr)
YU (1) YU40506B (fr)
ZA (1) ZA781018B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
JPS59192887U (ja) * 1983-06-09 1984-12-21 カシオ計算機株式会社 プリント基板の取付構造
IT1191845B (it) * 1986-01-20 1988-03-23 Dompe Farmaceutici Spa Alchiloli derivati farmacologicamente attivi
JPH03104641U (fr) * 1990-01-30 1991-10-30

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2205515A1 (fr) * 1972-11-08 1974-05-31 Hokuriku Pharmaceutical

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2958694A (en) * 1959-06-22 1960-11-01 Janssen Paul Adriaan Jan 1-(aroylalkyl)-4-(2'-pyridyl) piperazines
DE1670360A1 (de) * 1966-07-02 1970-10-29 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von Derivaten des Piperazins
US4038279A (en) * 1972-12-23 1977-07-26 Boehringer Ingelheim Gmbh N-aryl-n'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2205515A1 (fr) * 1972-11-08 1974-05-31 Hokuriku Pharmaceutical

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/68 *

Also Published As

Publication number Publication date
SU718010A3 (ru) 1980-02-25
ES467224A1 (es) 1978-11-16
FI66350B (fi) 1984-06-29
FI66350C (fi) 1984-10-10
IL54038A (en) 1981-06-29
PT67703B (en) 1979-09-20
ZA781018B (en) 1979-01-31
SE429863B (sv) 1983-10-03
JPS5527907B2 (fr) 1980-07-24
NL7802031A (nl) 1978-08-29
YU40278A (en) 1982-10-31
GR64159B (en) 1980-02-05
FR2381760B1 (fr) 1982-09-17
DE2807169A1 (de) 1978-09-14
GB1569084A (en) 1980-06-11
SE7801949L (sv) 1978-08-26
NO147837B (no) 1983-03-14
AT361488B (de) 1981-03-10
IN149333B (fr) 1981-10-24
HU173380B (hu) 1979-04-28
NO780635L (no) 1978-08-28
ATA127878A (de) 1980-08-15
US4196206A (en) 1980-04-01
AU3355178A (en) 1979-08-30
BE864296A (fr) 1978-06-16
CH635337A5 (de) 1983-03-31
JPS53105486A (en) 1978-09-13
FI780624A (fi) 1978-08-26
CA1098129A (fr) 1981-03-24
AU514106B2 (en) 1981-01-22
YU40506B (en) 1986-02-28
SU862825A3 (ru) 1981-09-07
NO147837C (no) 1983-06-22
AR215290A1 (es) 1979-09-28
PT67703A (en) 1978-03-01

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