IT1123568B - Derivato della diidropiridina,procedimenti per la sua preparazione e composizione farmaceutica che lo contiene - Google Patents
Derivato della diidropiridina,procedimenti per la sua preparazione e composizione farmaceutica che lo contieneInfo
- Publication number
- IT1123568B IT1123568B IT25558/79A IT2555879A IT1123568B IT 1123568 B IT1123568 B IT 1123568B IT 25558/79 A IT25558/79 A IT 25558/79A IT 2555879 A IT2555879 A IT 2555879A IT 1123568 B IT1123568 B IT 1123568B
- Authority
- IT
- Italy
- Prior art keywords
- derivate
- dihydropyridine
- procedures
- preparation
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7836132 | 1978-09-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7925558A0 IT7925558A0 (it) | 1979-09-07 |
IT1123568B true IT1123568B (it) | 1986-04-30 |
Family
ID=10499539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT25558/79A IT1123568B (it) | 1978-09-08 | 1979-09-07 | Derivato della diidropiridina,procedimenti per la sua preparazione e composizione farmaceutica che lo contiene |
Country Status (6)
Country | Link |
---|---|
US (2) | US4307103A (it) |
JP (2) | JPS5540678A (it) |
DE (1) | DE2935772A1 (it) |
FR (1) | FR2435471A1 (it) |
GB (1) | GB2034693B (it) |
IT (1) | IT1123568B (it) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
JPS5762257A (en) * | 1980-10-03 | 1982-04-15 | Yoshitomi Pharmaceut Ind Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid ester or its salt |
CS228917B2 (en) | 1981-03-14 | 1984-05-14 | Pfizer | Method of preparing substituted derivatives of 1,4-dihydropyridine |
JPS57171968A (en) * | 1981-04-17 | 1982-10-22 | Kyowa Hakko Kogyo Co Ltd | 1,4-dihydropyridine derivative |
JPS57175164A (en) * | 1981-04-18 | 1982-10-28 | Banyu Pharmaceut Co Ltd | 1,4-dihydropyridine derivative and its preparation |
JPS57200386A (en) * | 1981-06-04 | 1982-12-08 | Yoshitomi Pharmaceut Ind Ltd | Novel 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its salts |
DE3208628A1 (de) * | 1982-03-10 | 1983-09-22 | Bayer Ag, 5090 Leverkusen | Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
ZA83959B (en) * | 1982-03-10 | 1984-09-26 | Sandoz Ltd | 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them |
JPS58208271A (ja) * | 1982-04-30 | 1983-12-03 | Kyowa Hakko Kogyo Co Ltd | 1,4−ジヒドロピリジン誘導体 |
IL68604A0 (en) * | 1982-05-21 | 1983-09-30 | Haessle Ab | Processes for preparing therapeutically active dihydropyridines and intermediates for the processes |
ATE20064T1 (de) * | 1982-07-22 | 1986-06-15 | Pfizer | Anti-ischaemische und antihypertensive dihydropyridin-derivate. |
PH19166A (en) * | 1982-09-04 | 1986-01-16 | Pfizer | Dihydropyridined,pharmaceutical compositions and method of use |
EP0107293A3 (en) * | 1982-09-04 | 1984-06-06 | Pfizer Limited | Dihydropyridines |
EP0111453A1 (de) * | 1982-12-10 | 1984-06-20 | Ciba-Geigy Ag | Amid-Verbindungen |
US4515799A (en) * | 1983-02-02 | 1985-05-07 | Pfizer Inc. | Dihydropyridine anti-ischaemic and antihypertensive agents |
US4686217A (en) * | 1983-04-27 | 1987-08-11 | Fisons Plc | Calcium antagonist 2-fluoroalkyl-1,4-dihydropyridines |
JPS60104065A (ja) * | 1983-11-09 | 1985-06-08 | Teijin Ltd | 1,4―ジヒドロピリジン―3.5―ジカルボン酸ジエステル誘導体の製造法 |
AU561213B2 (en) * | 1983-06-02 | 1987-04-30 | Teijin Limited | 1, 4-dihydropyridine derivative |
EP0141222B1 (en) * | 1983-09-26 | 1989-04-12 | Nissan Chemical Industries Ltd. | Dihydropyridine-5-phosphonic acid cyclic ester |
US5137889A (en) * | 1983-12-02 | 1992-08-11 | Otsuka Pharmaceutical Co., Ltd. | Dihydropyridine derivatives and process for preparing the same |
JPS60120861A (ja) * | 1983-12-02 | 1985-06-28 | Otsuka Pharmaceut Co Ltd | ジヒドロピリジン誘導体 |
DE3400765A1 (de) * | 1984-01-12 | 1985-07-18 | Bayer Ag, 5090 Leverkusen | 1.4-dihydropyrazine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
GB8401288D0 (en) * | 1984-01-18 | 1984-02-22 | Pfizer Ltd | Therapeutic agents |
JPS60156671A (ja) * | 1984-01-25 | 1985-08-16 | Yamanouchi Pharmaceut Co Ltd | ジヒドロピリジン誘導体およびその製造法 |
US4755512A (en) * | 1984-04-11 | 1988-07-05 | Bristol-Myers Company | Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moities |
US4895846A (en) * | 1984-04-11 | 1990-01-23 | Bristol-Myers Company | Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moieties |
GR851819B (it) * | 1984-08-17 | 1985-11-26 | Wyeth John & Brother Ltd | |
NZ212895A (en) * | 1984-08-22 | 1988-07-28 | Glaxo Spa | 1,4-dihydropyridine derivatives and pharmaceutical compositions |
IL76366A (en) * | 1984-09-14 | 1989-07-31 | Ciba Geigy Ag | 2,6-dialkyl-4-aryl-3,5-diacyl-1,4-dihydropyridine derivatives,processes for their manufacture and pharmaceutical preparations containing them |
GB8431119D0 (en) * | 1984-12-10 | 1985-01-16 | Fujisawa Pharmaceutical Co | Anti-arteriosclerotic composition |
US4652573A (en) * | 1985-03-14 | 1987-03-24 | Nelson Research & Development Co. | Calcium antagonist N-hetero ester 1,4-dihydropyridines |
US4833150A (en) * | 1985-03-14 | 1989-05-23 | Nelson Research & Development Co. | 1,4-dihydropyridines |
IT1201454B (it) * | 1985-08-19 | 1989-02-02 | Boehringer Biochemia Srl | 1,4-diidropiridine-2-sostituite |
DE3675747D1 (de) * | 1985-08-21 | 1991-01-03 | Glaxo Spa | 1,4-dihydropyridinverbindungen und ihre herstellung und pharmazeutische formulierung. |
IE59632B1 (en) * | 1985-08-21 | 1994-03-09 | Glaxo Spa | Heterocyclic derivatives |
US4659717A (en) * | 1985-08-21 | 1987-04-21 | Eli Lilly And Company | Dihydropyridines useful in the treatment of angina and stroke |
US4771057A (en) * | 1986-02-03 | 1988-09-13 | University Of Alberta | Reduced pyridyl derivatives with cardiovascular regulating properties |
IT1204460B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
US4849436A (en) * | 1986-03-11 | 1989-07-18 | Nelson Research & Development Co. | 1,4-dihydropyridines |
WO1988005043A1 (en) * | 1986-12-24 | 1988-07-14 | Boehringer Biochemia Robin S.P.A. | New aralkyl-1,4-dihydropyridines, a method for their preparation and pharmaceutical compositions containing them |
IT1222591B (it) * | 1987-09-04 | 1990-09-05 | Boehringer Biochemia Srl | 1,4-diidropiridine 2-alchil- ed alchenil-sostituite,metodo per la loro preparazione e composizione farmaceutiche che le contengono |
EP0353692B1 (en) * | 1988-08-02 | 1995-10-04 | Nissan Chemical Industries Ltd. | Drug effect-enhancing agent for antitumor drug |
US6653481B2 (en) * | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3946027A (en) * | 1972-09-30 | 1976-03-23 | Bayer Aktiengesellschaft | 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives |
US3974278A (en) * | 1973-07-12 | 1976-08-10 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine esters |
CH607848A5 (it) * | 1974-06-04 | 1978-11-30 | Bayer Ag | |
GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
GB1591089A (en) * | 1976-12-17 | 1981-06-10 | Fujisawa Pharmaceutical Co | 1,4-dihydropyridine derivatives and process for preparation thereof |
DE2629292A1 (de) * | 1976-06-30 | 1978-01-05 | Wolff Hans Dietrich | Selbsttaetige steuerung- und regelvorrichtung fuer sicherheitsgurt-rueckzugsbegrenzungssperre |
DE2658183A1 (de) * | 1976-12-22 | 1978-07-06 | Bayer Ag | In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
-
1979
- 1979-08-27 US US06/070,098 patent/US4307103A/en not_active Expired - Lifetime
- 1979-09-05 DE DE19792935772 patent/DE2935772A1/de not_active Ceased
- 1979-09-07 GB GB7931030A patent/GB2034693B/en not_active Expired
- 1979-09-07 IT IT25558/79A patent/IT1123568B/it active
- 1979-09-07 FR FR7922511A patent/FR2435471A1/fr active Granted
- 1979-09-07 JP JP11551879A patent/JPS5540678A/ja active Granted
-
1980
- 1980-12-04 US US06/213,047 patent/US4393070A/en not_active Expired - Lifetime
-
1988
- 1988-02-09 JP JP63028275A patent/JPS63211266A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
FR2435471B1 (it) | 1983-06-17 |
JPH0121827B2 (it) | 1989-04-24 |
FR2435471A1 (fr) | 1980-04-04 |
US4307103A (en) | 1981-12-22 |
JPS63211266A (ja) | 1988-09-02 |
JPS5540678A (en) | 1980-03-22 |
IT7925558A0 (it) | 1979-09-07 |
DE2935772A1 (de) | 1980-03-20 |
GB2034693A (en) | 1980-06-11 |
JPS6341903B2 (it) | 1988-08-19 |
GB2034693B (en) | 1982-11-10 |
US4393070A (en) | 1983-07-12 |
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