IT1115155B - PHARMACEUTICAL PREPARATION CONTAINING A DERIVED ORTHO-AMINOBENZOIC ACID AS ACTIVE INGREDIENT - Google Patents
PHARMACEUTICAL PREPARATION CONTAINING A DERIVED ORTHO-AMINOBENZOIC ACID AS ACTIVE INGREDIENTInfo
- Publication number
- IT1115155B IT1115155B IT21652/79A IT2165279A IT1115155B IT 1115155 B IT1115155 B IT 1115155B IT 21652/79 A IT21652/79 A IT 21652/79A IT 2165279 A IT2165279 A IT 2165279A IT 1115155 B IT1115155 B IT 1115155B
- Authority
- IT
- Italy
- Prior art keywords
- aminobenzoic acid
- mol
- ortho
- derived
- active ingredient
- Prior art date
Links
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 title abstract 5
- 239000004480 active ingredient Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 abstract 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical group O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 abstract 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Chemical group CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical group OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical group OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical group C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 abstract 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Chemical group CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010037660 Pyrexia Diseases 0.000 abstract 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical group OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 abstract 1
- 235000019270 ammonium chloride Nutrition 0.000 abstract 1
- 125000000089 arabinosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O)CO1)* 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical group OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
- 230000027950 fever generation Effects 0.000 abstract 1
- 229930182830 galactose Chemical group 0.000 abstract 1
- 239000008103 glucose Chemical group 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Pharmaceutical compositions for oral or parenteral administration comprises o-aminobenzoic acid derivatives of the formula: <IMAGE> wherein <1>R denotes the group formed by removing OH from the 1 (alpha) or 1 (beta) position of arabinose, xylose, glucose, galactose, rhamnose or mannose, and <2>R denotes H, Na, K, 1/2 mol. Mg, 1/2 mol. Ca, 1/3 mol. Al or methyl, together with a pharmaceutically acceptable diluent or carrier. The compositions have activity against hyperglycemia, hypertension, hyperlipemia, inflammatory diseases, pain, pyrexia and tumours. The compounds (1) may be prepared by reacting o- aminobenzoic acid with the appropriate saccharide in methanolic ammonium chloride.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4059478A JPS54132239A (en) | 1978-04-06 | 1978-04-06 | Anti-tumor agent |
| JP4201578A JPS54135232A (en) | 1978-04-10 | 1978-04-10 | Blood sugar depressing agent |
| JP4201478A JPS54135231A (en) | 1978-04-10 | 1978-04-10 | Cardio-vasocular medicine |
| JP4257678A JPS54135738A (en) | 1978-04-11 | 1978-04-11 | Novel aminobenzoic acid-n-d-mannoside and drugs comprising it |
| JP6314678A JPS54154729A (en) | 1978-05-26 | 1978-05-26 | Aminobenzoic acid derivative and drug preparation containing the same |
| JP16138578A JPS5924966B2 (en) | 1978-12-29 | 1978-12-29 | Anti-inflammatory agent containing an aminobenzoic acid derivative or a pharmaceutically acceptable salt thereof as an active ingredient |
| JP53161386A JPS5924965B2 (en) | 1978-12-29 | 1978-12-29 | Antipyretic analgesic containing an aminobenzoic acid derivative or a pharmaceutically acceptable salt thereof as an active ingredient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7921652A0 IT7921652A0 (en) | 1979-04-06 |
| IT1115155B true IT1115155B (en) | 1986-02-03 |
Family
ID=27564518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT21652/79A IT1115155B (en) | 1978-04-06 | 1979-04-06 | PHARMACEUTICAL PREPARATION CONTAINING A DERIVED ORTHO-AMINOBENZOIC ACID AS ACTIVE INGREDIENT |
Country Status (8)
| Country | Link |
|---|---|
| AU (1) | AU525638B2 (en) |
| CH (1) | CH638977A5 (en) |
| DE (1) | DE2914005C2 (en) |
| FR (1) | FR2421616A1 (en) |
| GB (1) | GB2018135B (en) |
| IT (1) | IT1115155B (en) |
| PH (7) | PH15664A (en) |
| SE (1) | SE448602B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5716898A (en) * | 1980-07-03 | 1982-01-28 | Kureha Chem Ind Co Ltd | Prostaglandin controller containing aminobenzoic derivative |
| JPS6041079B2 (en) * | 1979-12-14 | 1985-09-13 | 呉羽化学工業株式会社 | Ortho- or meta-aminobenzoic acid derivatives |
| JPS608000B2 (en) * | 1980-04-11 | 1985-02-28 | 呉羽化学工業株式会社 | Aminophenyl derivatives and bioactive agents containing the derivatives |
| AU554396B2 (en) * | 1982-12-03 | 1986-08-21 | Kureha Kagaku Kogyo K.K. | Pharmaceutical compositions of amino benzoic acid derivatives |
| JPS62289594A (en) * | 1986-06-09 | 1987-12-16 | Kureha Chem Ind Co Ltd | Sorbitol accumulation inhibitor composed of aminobenzoic acid derivative |
| JPH0627071B2 (en) * | 1988-08-05 | 1994-04-13 | 呉羽化学工業株式会社 | An immunosuppressant side effect reducing agent containing an aminobenzoic acid derivative as an active ingredient |
| WO1994000135A1 (en) * | 1992-06-30 | 1994-01-06 | Shapiro Howard K | Composition containing amine and amine-related derivatives of benzoic acid and uses therefor including treating inflammatory diseases |
| DE4436127A1 (en) * | 1994-09-27 | 1996-03-28 | Deutsches Rheumaforschungszent | Use of benzoic or pyridine:carboxylic acid or amide cpds. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL62054C (en) * | 1943-09-30 | |||
| DE2627076A1 (en) * | 1976-06-16 | 1977-12-29 | Max Planck Gesellschaft | MEANS OF INHIBITING CELL GROWTH |
-
1979
- 1979-03-30 SE SE7902854A patent/SE448602B/en not_active IP Right Cessation
- 1979-04-03 AU AU45719/79A patent/AU525638B2/en not_active Ceased
- 1979-04-05 CH CH318179A patent/CH638977A5/en not_active IP Right Cessation
- 1979-04-05 GB GB7912020A patent/GB2018135B/en not_active Expired
- 1979-04-06 IT IT21652/79A patent/IT1115155B/en active
- 1979-04-06 FR FR7908739A patent/FR2421616A1/en active Granted
- 1979-04-06 PH PH22378A patent/PH15664A/en unknown
- 1979-04-06 DE DE2914005A patent/DE2914005C2/en not_active Expired
-
1980
- 1980-08-04 PH PH24390A patent/PH15636A/en unknown
- 1980-08-04 PH PH24389A patent/PH15174A/en unknown
- 1980-08-04 PH PH24391A patent/PH15190A/en unknown
- 1980-08-04 PH PH24394A patent/PH15640A/en unknown
- 1980-08-04 PH PH24392A patent/PH15576A/en unknown
- 1980-08-04 PH PH24393A patent/PH15606A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH15636A (en) | 1983-03-11 |
| PH15190A (en) | 1982-09-10 |
| DE2914005C2 (en) | 1985-03-21 |
| SE7902854L (en) | 1979-10-07 |
| GB2018135B (en) | 1982-06-16 |
| AU4571979A (en) | 1979-10-11 |
| FR2421616B1 (en) | 1981-02-13 |
| SE448602B (en) | 1987-03-09 |
| PH15174A (en) | 1982-08-31 |
| AU525638B2 (en) | 1982-11-18 |
| SE446429B (en) | 1986-09-15 |
| IT7921652A0 (en) | 1979-04-06 |
| GB2018135A (en) | 1979-10-17 |
| FR2421616A1 (en) | 1979-11-02 |
| DE2914005A1 (en) | 1979-10-18 |
| PH15640A (en) | 1983-03-11 |
| PH15664A (en) | 1983-03-11 |
| CH638977A5 (en) | 1983-10-31 |
| PH15606A (en) | 1983-02-28 |
| PH15576A (en) | 1983-02-17 |
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