IT1059511B - Aminoalkoxyphenoxy-alkenones - with local anaesthetic, antiarrhythmic and hypotensive activity and active on CNS system - Google Patents

Aminoalkoxyphenoxy-alkenones - with local anaesthetic, antiarrhythmic and hypotensive activity and active on CNS system

Info

Publication number
IT1059511B
IT1059511B IT2019974A IT2019974A IT1059511B IT 1059511 B IT1059511 B IT 1059511B IT 2019974 A IT2019974 A IT 2019974A IT 2019974 A IT2019974 A IT 2019974A IT 1059511 B IT1059511 B IT 1059511B
Authority
IT
Italy
Prior art keywords
alkyl
substd
antiarrhythmic
active
opt
Prior art date
Application number
IT2019974A
Other languages
Italian (it)
Inventor
E Manghisi
A Salimbeni
G Fregnan
Original Assignee
Luso Farmaco Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luso Farmaco Inst filed Critical Luso Farmaco Inst
Priority to IT2019974A priority Critical patent/IT1059511B/en
Priority to ZA00750667A priority patent/ZA75667B/en
Priority to US05/545,946 priority patent/US3988475A/en
Priority to FR7503404A priority patent/FR2259594B1/fr
Priority to ES434421A priority patent/ES434421A1/en
Priority to CA219,402A priority patent/CA1052791A/en
Priority to NL7501371.A priority patent/NL162062C/en
Priority to JP1522575A priority patent/JPS5412458B2/ja
Priority to DE2504790A priority patent/DE2504790C3/en
Priority to BE153097A priority patent/BE825223A/en
Priority to AU77888/75A priority patent/AU483171B2/en
Priority to GB4926/75A priority patent/GB1500734A/en
Application granted granted Critical
Publication of IT1059511B publication Critical patent/IT1059511B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Phenoxyalkylamines, their stereoisomers and acid-addn. salts of formula (I) (where R1 is 1-4C alkyl, monocyclic aryl opt. substd. by one or more halo, Me. Ome; R2 is 1-4C alkyl, monocyclic aryl opt. substd. by one or more 1-4C alkyl, OMe, halo; Alk is 1-4C alkylene opt. substd. by OH; R3, R4 are H, 1-4C alkyl, dialkylaminoalkyl, aryl, 3-8C cycloalkyl, aralkyl (1-4C alkyl), 1-4C hydroxyalkyl provided that the OH and N-atom are sepd. by at least 2 C atoms; or - is 3-8C N-alkyleneimino, N,N-oxoalkyleneimino (4C) N, N-thioalkylene-imino (4C) N, N-azaalkyleneimino (4-6C) in which the aza N-atom may be substd. by alkyl, hydroxyalkyl, alkoxyalkyl, aralkyl, monocyclic aryl opt. substd. by halo, alkyl, alkoxy, NO2; monocyclic heterocyclic aryl). Have local anaesthetic, antiarrhythmic and hypotensive activity, are active on CNS system and adrenergic receptors and on agglutination of blood platelets.
IT2019974A 1974-02-05 1974-02-05 Aminoalkoxyphenoxy-alkenones - with local anaesthetic, antiarrhythmic and hypotensive activity and active on CNS system IT1059511B (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT2019974A IT1059511B (en) 1974-02-05 1974-02-05 Aminoalkoxyphenoxy-alkenones - with local anaesthetic, antiarrhythmic and hypotensive activity and active on CNS system
US05/545,946 US3988475A (en) 1974-02-05 1975-01-31 Phenoxyalkylamines
ZA00750667A ZA75667B (en) 1974-02-05 1975-01-31 Phenoxyalkylamines and their preparation
ES434421A ES434421A1 (en) 1974-02-05 1975-02-04 Phenoxyalkylamines
FR7503404A FR2259594B1 (en) 1974-02-05 1975-02-04
CA219,402A CA1052791A (en) 1974-02-05 1975-02-05 Phenoxyalkylamines and their preparation
NL7501371.A NL162062C (en) 1974-02-05 1975-02-05 METHOD FOR PREPARING A MEDICINAL PRODUCT WITH ANTI-ARRHYTHMIC ACTIVITY, PRODUCED PRODUCTS USED BY THE USE OF THIS METHOD AND METHOD FOR PREPARING MEDICINAL PHENOXYALKYCLES, PREPARED FORES.
JP1522575A JPS5412458B2 (en) 1974-02-05 1975-02-05
DE2504790A DE2504790C3 (en) 1974-02-05 1975-02-05 Amino alcohol. yphenyl (3-keto-1-propen-2-yl) ethers and their salts, their manufacturing processes and pharmaceutical preparations based on them
BE153097A BE825223A (en) 1974-02-05 1975-02-05 PHENOXYALKYLAMINES AND THEIR PREPARATION
AU77888/75A AU483171B2 (en) 1975-02-05 Phenoxyalkylamines and their preparation
GB4926/75A GB1500734A (en) 1974-02-05 1975-02-05 Phenoxyalkylamines and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2019974A IT1059511B (en) 1974-02-05 1974-02-05 Aminoalkoxyphenoxy-alkenones - with local anaesthetic, antiarrhythmic and hypotensive activity and active on CNS system

Publications (1)

Publication Number Publication Date
IT1059511B true IT1059511B (en) 1982-06-21

Family

ID=11164654

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2019974A IT1059511B (en) 1974-02-05 1974-02-05 Aminoalkoxyphenoxy-alkenones - with local anaesthetic, antiarrhythmic and hypotensive activity and active on CNS system

Country Status (3)

Country Link
BE (1) BE825223A (en)
IT (1) IT1059511B (en)
ZA (1) ZA75667B (en)

Also Published As

Publication number Publication date
ZA75667B (en) 1976-01-28
BE825223A (en) 1975-05-29

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