IN2015DN03962A - - Google Patents
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- Publication number
- IN2015DN03962A IN2015DN03962A IN3962DEN2015A IN2015DN03962A IN 2015DN03962 A IN2015DN03962 A IN 2015DN03962A IN 3962DEN2015 A IN3962DEN2015 A IN 3962DEN2015A IN 2015DN03962 A IN2015DN03962 A IN 2015DN03962A
- Authority
- IN
- India
- Prior art keywords
- mycobacterium
- proteins
- esx
- secreted
- tuberculosis
- Prior art date
Links
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- IMCUVBSHZXQITN-UHFFFAOYSA-N 4-[[4-(4-chlorophenyl)-5-(2-methoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino]-4-oxobutanoic acid Chemical compound S1C(NC(=O)CCC(O)=O)=NC(C=2C=CC(Cl)=CC=2)=C1CC(=O)OC IMCUVBSHZXQITN-UHFFFAOYSA-N 0.000 abstract 1
- 241001467553 Mycobacterium africanum Species 0.000 abstract 1
- 241000186366 Mycobacterium bovis Species 0.000 abstract 1
- 241001312372 Mycobacterium canettii Species 0.000 abstract 1
- 241000187919 Mycobacterium microti Species 0.000 abstract 1
- 241000699502 Mycobacterium mungi Species 0.000 abstract 1
- 241001457456 Mycobacterium pinnipedii Species 0.000 abstract 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 201000008827 tuberculosis Diseases 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201200652 | 2012-10-23 | ||
| DKPA201200653 | 2012-10-23 | ||
| DKPA201200654 | 2012-10-23 | ||
| DKPA201300477 | 2013-08-23 | ||
| PCT/DK2013/000070 WO2014063704A2 (en) | 2012-10-23 | 2013-10-18 | M. tuberculosis vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN03962A true IN2015DN03962A (enExample) | 2015-10-02 |
Family
ID=49679267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3962DEN2015 IN2015DN03962A (enExample) | 2012-10-23 | 2013-10-18 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9526773B2 (enExample) |
| EP (1) | EP2912056B1 (enExample) |
| JP (1) | JP6470179B2 (enExample) |
| CN (1) | CN104736555B (enExample) |
| BR (1) | BR112015009070A2 (enExample) |
| IN (1) | IN2015DN03962A (enExample) |
| WO (1) | WO2014063704A2 (enExample) |
| ZA (1) | ZA201503467B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10765731B2 (en) | 2014-01-09 | 2020-09-08 | Transgene Sa | Fusion of heterooligomeric mycobacterial antigens |
| BR112016023778A2 (pt) | 2014-04-24 | 2017-10-17 | Statens Seruminstitut | proteína de fusão ou coquetel antígeno, uso de uma proteína de fusão ou coquetel antígeno, vacina, e método para a imunização de um animal, incluindo um ser humano, contra a tuberculose causada por micobactérias virulentas |
| KR20180061338A (ko) * | 2015-09-30 | 2018-06-07 | 베링거잉겔하임베트메디카게엠베하 | 동물에서의 개선된 모듈러 항원 수송 분자 및 이의 용도 |
| CN105218680B (zh) * | 2015-10-21 | 2019-06-25 | 中山大学 | 一种用于诱导外周血单个核细胞产生细胞因子的结核分支杆菌融合蛋白 |
| CN105218681B (zh) * | 2015-10-21 | 2019-06-25 | 中山大学 | 一种用于诱导外周血单个核细胞产生结核特异性细胞因子的融合蛋白 |
| CN105567660B (zh) * | 2016-01-08 | 2018-11-20 | 中国人民解放军第四军医大学 | 一种大肠杆菌重组表达结核分枝杆菌Rv2837c活性蛋白的方法及其应用 |
| MX2018014270A (es) * | 2016-05-21 | 2019-02-14 | Infectious Disease Res Inst | Composiciones y metodos para tratar la tuberculosis secundaria e infecciones po micobacteria no tuberculosa. |
| CN109843321A (zh) | 2016-06-22 | 2019-06-04 | 国际艾滋病疫苗行动组织公司 | 作为结核病疫苗的重组巨细胞病毒载体 |
| ES2950436T3 (es) | 2016-12-14 | 2023-10-10 | Becton Dickinson Co | Métodos y composiciones para obtener una valoración de tuberculosis en un sujeto |
| IL267886B2 (en) * | 2017-01-09 | 2024-11-01 | Biomunex Pharmaceuticals | A polypeptide linker for preparing multispecific antibodies |
| US11638749B2 (en) | 2017-10-17 | 2023-05-02 | International Aids Vaccine Initiative, Inc. | Tuberculosis antigen cassettes |
| EP3983011A1 (en) | 2019-06-14 | 2022-04-20 | Statens Serum Institut | Fusion proteins for tuberculosis vaccines |
| EP4007600A4 (en) * | 2019-08-01 | 2023-08-23 | Trustees of Tufts College | VACCINE COMPOSITION AND METHODS OF SELECTING ANTIGENS |
| CN110590958B (zh) * | 2019-09-11 | 2021-04-13 | 中国人民解放军总医院第八医学中心 | 一种串联多肽及其在抗结核分枝杆菌的免疫保护中的应用 |
| WO2023156676A1 (en) | 2022-02-21 | 2023-08-24 | Statens Serum Institut | A novel cationic adjuvant composition |
| CN115300618B (zh) * | 2022-05-11 | 2026-03-27 | 中国农业大学 | 基于牛β防御素5的结核疫苗及其在预防结核病中的应用 |
| CN115184603B (zh) * | 2022-06-30 | 2024-02-06 | 首都医科大学附属北京胸科医院 | EspC蛋白在制备结核分枝杆菌分离或富集产品中的应用 |
| KR20250087737A (ko) * | 2023-12-06 | 2025-06-17 | 주식회사 미코라파 | 결핵균에 대한 살균면역을 유도하는 융합단백질을 포함하는 결핵 백신 조성물 |
| CN118108815B (zh) * | 2024-04-23 | 2024-07-23 | 成都康华生物制品股份有限公司 | 结核分枝杆菌多免疫原抗原、编码其的mRNA、应用 |
| WO2025265101A1 (en) * | 2024-06-21 | 2025-12-26 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of vaccine for prevention of tuberculosis |
| CN119823286B (zh) * | 2025-01-16 | 2026-02-06 | 中国动物卫生与流行病学中心 | 一种重组蛋白抗原及其在制备用于检测牛伽马干扰素试剂盒中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100797876B1 (ko) * | 1998-04-07 | 2008-01-24 | 코릭사 코포레이션 | 마이코박테리움 튜베르쿨로시스 항원의 융합 단백질 및이의 용도 |
| ES2346043T3 (es) * | 2002-04-05 | 2010-10-08 | Institut Pasteur | Identificacion de las regiones rd1 y rd5 asociadas con la virulencia que permite el desarrollo de vacunas mejoradas de m. bovis bcg y m. microti. |
| KR20170072366A (ko) * | 2009-04-24 | 2017-06-26 | 스태튼스 세룸 인스티튜트 | 재활성화를 예방하기 위한 결핵 백신 |
| WO2012057904A1 (en) | 2010-10-27 | 2012-05-03 | Infectious Disease Research Institute | Mycobacterium tuberculosis antigens and combinations thereof having high seroreactivity |
-
2013
- 2013-10-18 IN IN3962DEN2015 patent/IN2015DN03962A/en unknown
- 2013-10-18 BR BR112015009070A patent/BR112015009070A2/pt not_active IP Right Cessation
- 2013-10-18 US US14/437,998 patent/US9526773B2/en not_active Expired - Fee Related
- 2013-10-18 CN CN201380054841.4A patent/CN104736555B/zh not_active Expired - Fee Related
- 2013-10-18 JP JP2015537146A patent/JP6470179B2/ja not_active Expired - Fee Related
- 2013-10-18 WO PCT/DK2013/000070 patent/WO2014063704A2/en not_active Ceased
- 2013-10-18 EP EP13798236.9A patent/EP2912056B1/en active Active
-
2015
- 2015-05-18 ZA ZA2015/03467A patent/ZA201503467B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014063704A2 (en) | 2014-05-01 |
| CN104736555B (zh) | 2019-06-21 |
| US20150290311A1 (en) | 2015-10-15 |
| EP2912056B1 (en) | 2020-02-12 |
| EP2912056A2 (en) | 2015-09-02 |
| JP2015536309A (ja) | 2015-12-21 |
| BR112015009070A2 (pt) | 2017-07-04 |
| CN104736555A (zh) | 2015-06-24 |
| ZA201503467B (en) | 2016-11-30 |
| WO2014063704A8 (en) | 2015-07-30 |
| WO2014063704A3 (en) | 2014-06-19 |
| JP6470179B2 (ja) | 2019-02-13 |
| US9526773B2 (en) | 2016-12-27 |
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