IN2015DN02616A - - Google Patents
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- Publication number
- IN2015DN02616A IN2015DN02616A IN2616DEN2015A IN2015DN02616A IN 2015DN02616 A IN2015DN02616 A IN 2015DN02616A IN 2616DEN2015 A IN2616DEN2015 A IN 2616DEN2015A IN 2015DN02616 A IN2015DN02616 A IN 2015DN02616A
- Authority
- IN
- India
- Prior art keywords
- preparation
- present
- dabigatran etexilate
- relates
- crystalline form
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/19—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/08—Acetic acid
- C07C53/10—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/38—Acyl halides
- C07C53/46—Acyl halides containing halogen outside the carbonyl halide group
- C07C53/48—Halogenated acetyl halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2616DEN2015 IN2015DN02616A (ru) | 2012-09-28 | 2013-09-30 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3066DE2012 | 2012-09-28 | ||
| IN3065DE2012 | 2012-09-28 | ||
| PCT/IB2013/059016 WO2014049585A2 (en) | 2012-09-28 | 2013-09-30 | Process for the preparation of dabigatran etexilate or pharmaceutically acceptable salt thereof |
| IN2616DEN2015 IN2015DN02616A (ru) | 2012-09-28 | 2013-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN02616A true IN2015DN02616A (ru) | 2015-09-18 |
Family
ID=49765594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2616DEN2015 IN2015DN02616A (ru) | 2012-09-28 | 2013-09-30 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20150246899A1 (ru) |
| EP (1) | EP2900651A2 (ru) |
| CA (1) | CA2885994A1 (ru) |
| IN (1) | IN2015DN02616A (ru) |
| WO (1) | WO2014049585A2 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3169677A1 (en) * | 2014-07-18 | 2017-05-24 | OLON S.p.A. | Crystalline compounds of dabigatran etexilate |
| CN104744438A (zh) * | 2014-12-17 | 2015-07-01 | 烟台东诚药业集团股份有限公司 | 一种用于合成制备达比加群酯苯并咪唑中间体的方法 |
| CN104725360A (zh) * | 2015-04-09 | 2015-06-24 | 重庆东得医药科技有限公司 | 一种甲磺酸达比加群酯ⅰ晶型的制备方法 |
| CN105906607A (zh) * | 2015-12-23 | 2016-08-31 | 嘉实（湖南）医药科技有限公司 | 一种达比加群酯的合成方法 |
| CN108658939B (zh) * | 2018-07-16 | 2021-07-20 | 上海现代制药股份有限公司 | 一种甲磺酸达比加群酯关键中间体的合成方法 |
| CN115322172B (zh) * | 2022-09-22 | 2024-01-26 | 安徽美诺华药物化学有限公司 | 一种达比加群酯中间体的高收率合成工艺 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087380A (en) | 1949-11-24 | 2000-07-11 | Boehringer Ingelheim Pharma Kg | Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions |
| JP3866715B2 (ja) | 2002-03-07 | 2007-01-10 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | ３−［（２−｛［４−（ヘキシルオキシカルボニルアミノ−イミノ−メチル）−フェニルアミノ］−メチル｝−１−メチル−１ｈ−ベンゾイミダゾール−５−カルボニル）−ピリジン−２−イル−アミノ］−プロピオン酸エチルエステル及びその塩の経口適用の投与形態 |
| EP1609784A1 (de) * | 2004-06-25 | 2005-12-28 | Boehringer Ingelheim Pharma GmbH & Co.KG | Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen |
| DE102005020002A1 (de) | 2005-04-27 | 2006-11-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Physiologisch verträgliche Salze von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester |
| DE102005025728A1 (de) | 2005-06-04 | 2006-12-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-Propionsäure-ethylester |
| US20100087488A1 (en) | 2006-10-10 | 2010-04-08 | Boehringer Ingelheim International Gmgh | Physiologically Acceptable Salts of 3-[(2--1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester |
| DE102006054005A1 (de) | 2006-11-16 | 2008-05-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester |
| HUP1000069A2 (en) | 2010-02-02 | 2012-05-02 | Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag | New salts for the preparation of pharmaceutical composition |
| US20130149346A1 (en) | 2010-03-08 | 2013-06-13 | ratiopharm GmbH Graf-Arco-Strasse 3 | Dabigatran etexilate-containing pharmaceutical composition |
| CN103025715A (zh) * | 2010-07-09 | 2013-04-03 | 埃斯特维化学股份有限公司 | 用于制备凝血酶特异性抑制剂的中间体和方法 |
| WO2012027543A1 (en) | 2010-08-25 | 2012-03-01 | Teva Pharmaceuticals Usa, Inc. | Solid state forms of dabigatran etexilate, dabigatran etexilate mesylate and processes for preparation thereof |
| WO2012044595A1 (en) | 2010-09-27 | 2012-04-05 | Ratiopharm Gmbh | Dabigatran etexilate bismesylate salt, solid state forms and process for preparation thereof |
-
2013
- 2013-09-30 IN IN2616DEN2015 patent/IN2015DN02616A/en unknown
- 2013-09-30 US US14/430,303 patent/US20150246899A1/en not_active Abandoned
- 2013-09-30 WO PCT/IB2013/059016 patent/WO2014049585A2/en active Application Filing
- 2013-09-30 CA CA 2885994 patent/CA2885994A1/en not_active Abandoned
- 2013-09-30 EP EP13805553.8A patent/EP2900651A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20150246899A1 (en) | 2015-09-03 |
| WO2014049585A2 (en) | 2014-04-03 |
| EP2900651A2 (en) | 2015-08-05 |
| WO2014049585A3 (en) | 2014-09-12 |
| CA2885994A1 (en) | 2014-04-03 |
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