IN2015DN01361A - - Google Patents
Info
- Publication number
- IN2015DN01361A IN2015DN01361A IN1361DEN2015A IN2015DN01361A IN 2015DN01361 A IN2015DN01361 A IN 2015DN01361A IN 1361DEN2015 A IN1361DEN2015 A IN 1361DEN2015A IN 2015DN01361 A IN2015DN01361 A IN 2015DN01361A
- Authority
- IN
- India
- Prior art keywords
- antibodies
- fusion proteins
- constant regions
- incorporating
- igg
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 abstract 4
- 108020001507 fusion proteins Proteins 0.000 abstract 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 2
- 235000018417 cysteine Nutrition 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- 230000009870 specific binding Effects 0.000 abstract 2
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 abstract 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 abstract 1
- 101710120037 Toxin CcdB Proteins 0.000 abstract 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000014207 opsonization Effects 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261679045P | 2012-08-02 | 2012-08-02 | |
| US201361767724P | 2013-02-21 | 2013-02-21 | |
| PCT/US2013/053086 WO2014022592A1 (en) | 2012-08-02 | 2013-07-31 | Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN01361A true IN2015DN01361A (forum.php) | 2015-07-03 |
Family
ID=50025683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1361DEN2015 IN2015DN01361A (forum.php) | 2012-08-02 | 2013-07-31 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9540442B2 (forum.php) |
| EP (1) | EP2880057A4 (forum.php) |
| JP (1) | JP2015524821A (forum.php) |
| CN (1) | CN104684928A (forum.php) |
| CA (1) | CA2879814A1 (forum.php) |
| IN (1) | IN2015DN01361A (forum.php) |
| WO (1) | WO2014022592A1 (forum.php) |
Families Citing this family (70)
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| ES3027182T3 (en) | 2011-12-23 | 2025-06-13 | Pfizer | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
| CN108690132B (zh) | 2012-05-10 | 2022-10-14 | 生物蛋白有限公司 | 多特异单克隆抗体 |
| CN104684928A (zh) | 2012-08-02 | 2015-06-03 | Jn生物科学有限责任公司 | 通过半胱氨酸突变和μ尾端多聚化的抗体或融合蛋白 |
| KR20160127821A (ko) * | 2014-03-05 | 2016-11-04 | 유씨비 바이오파마 에스피알엘 | 다량체 Fc 단백질 |
| JP6851200B2 (ja) * | 2014-03-05 | 2021-03-31 | ユーシービー バイオファルマ エスアールエル | 多量体Fcタンパク質 |
| JP6744822B2 (ja) | 2014-04-03 | 2020-08-19 | アイジーエム バイオサイエンシズ インコーポレイテッド | 修飾j鎖 |
| PL3148579T3 (pl) | 2014-05-28 | 2021-07-19 | Agenus Inc. | Przeciwciała anty-gitr i sposoby ich zastosowania |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US10905743B2 (en) | 2014-12-19 | 2021-02-02 | Jiangsu Hengrui Medicine Co., Ltd. | Interleukin 15 protein complex |
| US10538589B2 (en) * | 2015-01-14 | 2020-01-21 | Armagen Inc. | Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU |
| DK3247728T3 (da) * | 2015-01-20 | 2020-07-13 | Igm Biosciences Inc | Tumornekrosefaktor-(tnf)-superfamiliereceptorbindende molekyler og anvendelser deraf |
| SI3265575T1 (sl) * | 2015-03-04 | 2021-08-31 | Igm Biosciences, Inc. | Vezne molekule CD20 in njihove uporabe |
| WO2016154593A1 (en) * | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| KR20180002653A (ko) * | 2015-04-07 | 2018-01-08 | 제넨테크, 인크. | 효능작용 활성을 갖는 항원 결합 복합체 및 사용 방법 |
| JP6811723B2 (ja) * | 2015-04-17 | 2021-01-13 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多価ヒト免疫不全ウイルス抗原結合分子およびその使用方法 |
| BR112017023849A2 (pt) | 2015-05-07 | 2018-07-17 | Agenus Inc. | anticorpos anti-ox40 e métodos de uso dos mesmos |
| DK3356401T3 (da) | 2015-09-30 | 2020-09-07 | Igm Biosciences Inc | Bindingsmolekyler med modificeret j-kæde |
| AU2016329197B2 (en) | 2015-09-30 | 2021-01-21 | Igm Biosciences, Inc. | Binding molecules with modified J-chain |
| CN116333125A (zh) | 2015-10-30 | 2023-06-27 | 银河生物技术有限责任公司 | 结合死亡受体4和死亡受体5的抗体 |
| US20170216452A1 (en) * | 2015-11-30 | 2017-08-03 | Pfizer Inc. | Antibodies and antibody fragments for site-specific conjugation |
| TWI778491B (zh) | 2015-11-30 | 2022-09-21 | 美商輝瑞股份有限公司 | 位點專一性her2抗體藥物共軛體 |
| MX2018006477A (es) | 2015-12-02 | 2018-09-03 | Agenus Inc | Anticuerpos y metodos de uso de estos. |
| CA3009075A1 (en) * | 2016-01-11 | 2017-07-20 | Inhibrx, Inc. | Multivalent and multispecific ox40-binding fusion proteins |
| AU2017238172B2 (en) | 2016-03-21 | 2024-06-27 | Marengo Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| ES2874974T3 (es) | 2016-05-11 | 2021-11-05 | Cytiva Bioprocess R & D Ab | Matriz de separación |
| US11708390B2 (en) | 2016-05-11 | 2023-07-25 | Cytiva Bioprocess R&D Ab | Method of storing a separation matrix |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| ES2909833T3 (es) | 2016-05-11 | 2022-05-10 | Cytiva Bioprocess R & D Ab | Método de limpieza y/o desinfección de una matriz de separación |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| EP3496536A4 (en) * | 2016-07-20 | 2020-02-12 | IGM Biosciences, Inc. | MULTIMERE CD40-BINDING MOLECULES AND USES THEREOF |
| EP3487298A4 (en) * | 2016-07-20 | 2020-03-11 | IGM Biosciences, Inc. | MULTIMERE CD137 / 4-1BB-BINDING MOLECULES AND USES THEREOF |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| EP3538152A4 (en) | 2016-11-09 | 2020-09-30 | Agenus Inc. | ANTI-OX40 ANTIBODIES, ANTI-GITR ANTIBODIES, AND PROCESSES FOR USE |
| US20200291089A1 (en) | 2017-02-16 | 2020-09-17 | Elstar Therapeutics, Inc. | Multifunctional molecules comprising a trimeric ligand and uses thereof |
| US20210246227A1 (en) | 2017-05-31 | 2021-08-12 | Elstar Therapeutics, Inc. | Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof |
| BR112020002871A2 (pt) | 2017-08-15 | 2020-07-28 | Kindred Biosciences, Inc. | variantes fc de igg para uso veterinário |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| US11364303B2 (en) | 2017-09-29 | 2022-06-21 | Pfizer Inc. | Cysteine engineered antibody drug conjugates |
| TWI850203B (zh) | 2017-10-14 | 2024-08-01 | 美商Cytomx生物製藥公司 | 抗體、可活化之抗體、雙特異性抗體、和雙特異性可活化之抗體、及其使用方法 |
| EP3737692A4 (en) | 2018-01-09 | 2021-09-29 | Elstar Therapeutics, Inc. | CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| US20210009711A1 (en) | 2018-03-14 | 2021-01-14 | Elstar Therapeutics, Inc. | Multifunctional molecules and uses thereof |
| SG11202012405WA (en) | 2018-06-14 | 2021-01-28 | Bioatla Inc | Multi-specific antibody constructs |
| JP7554742B2 (ja) | 2018-07-03 | 2024-09-20 | マレンゴ・セラピューティクス,インコーポレーテッド | 抗tcr抗体分子およびその使用 |
| KR102232659B1 (ko) * | 2018-07-16 | 2021-03-26 | 전북대학교 산학협력단 | 항원전달용 폴리펩타이드, 이를 포함하는 Fc-융합 단백질 및 이의 용도 |
| KR20210044243A (ko) | 2018-08-13 | 2021-04-22 | 인히브릭스, 인크. | Ox40 결합 폴리펩티드 및 이의 용도 |
| CN120904316A (zh) * | 2018-12-27 | 2025-11-07 | 伊兰科美国公司 | 兽用IgG Fc变体 |
| AU2020226904B2 (en) | 2019-02-21 | 2025-05-01 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| EP3927744A1 (en) | 2019-02-21 | 2021-12-29 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| SG11202109056TA (en) | 2019-02-21 | 2021-09-29 | Marengo Therapeutics Inc | Multifunctional molecules that bind to calreticulin and uses thereof |
| CN114127111B (zh) | 2019-02-21 | 2024-09-10 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| CN114127112A (zh) | 2019-02-21 | 2022-03-01 | 马伦戈治疗公司 | 与t细胞结合的多功能分子及其治疗自身免疫性病症的用途 |
| WO2021138407A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
| CA3180321A1 (en) | 2020-04-24 | 2021-10-28 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| EP4204450A4 (en) | 2020-08-26 | 2024-11-13 | Marengo Therapeutics, Inc. | MULTIFUNCTIONAL CALRETICULIN-BINDING MOLECULES AND RELATED USES |
| CN116917316A (zh) | 2020-08-26 | 2023-10-20 | 马伦戈治疗公司 | 与NKp30结合的抗体分子及其用途 |
| EP4204458A4 (en) | 2020-08-26 | 2024-10-09 | Marengo Therapeutics, Inc. | METHODS FOR DETECTION OF TRBC1 OR TRBC2 |
| KR20220029343A (ko) | 2020-08-31 | 2022-03-08 | (주)메디톡스 | 항-vegf 육량체 항체, 및 이를 포함하는 조성물 |
| US20240067711A1 (en) * | 2020-08-31 | 2024-02-29 | Medytox Inc. | Anti-vegf hexameric antibody and composition comprising same |
| GB2623199A (en) | 2021-04-08 | 2024-04-10 | Marengo Therapeutics Inc | Multifunctional molecules binding to TCR and uses thereof |
| CN118359707A (zh) * | 2021-04-28 | 2024-07-19 | 恩格姆生物制药公司 | 具有抗体恒定区变体的结合分子的多聚化 |
| CN115724985A (zh) * | 2021-08-27 | 2023-03-03 | 三生国健药业(上海)股份有限公司 | 一种cdc平台抗体 |
| GB202319645D0 (en) * | 2023-12-20 | 2024-01-31 | Kbio Holdings Ltd | Hexameric protein |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020147326A1 (en) * | 1996-06-14 | 2002-10-10 | Smithkline Beecham Corporation | Hexameric fusion proteins and uses therefor |
| GB9720054D0 (en) | 1997-09-19 | 1997-11-19 | Celltech Therapeutics Ltd | Biological products |
| US6475749B1 (en) * | 1999-08-11 | 2002-11-05 | The Regents Of The University Of California | Rh hybrid antibody |
| US20090068178A1 (en) * | 2002-05-08 | 2009-03-12 | Genentech, Inc. | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin |
| EP1697415A1 (en) * | 2003-11-12 | 2006-09-06 | Biogen Idec MA Inc. | NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO |
| CN101124245A (zh) * | 2003-11-12 | 2008-02-13 | 比奥根艾迪克Ma公司 | 新生儿Fc受体(FcRn)-结合多肽变体、二聚体Fc结合蛋白及其相关方法 |
| JPWO2008032833A1 (ja) * | 2006-09-14 | 2010-01-28 | 株式会社医学生物学研究所 | Adcc活性を増強させた抗体及びその製造方法 |
| GB0922209D0 (en) | 2009-12-18 | 2010-02-03 | Univ Nottingham | Proteins, nucleic acid molecules and compositions |
| CN103974977A (zh) | 2011-09-26 | 2014-08-06 | Jn生物科学有限责任公司 | 杂交恒定区 |
| CN104684928A (zh) | 2012-08-02 | 2015-06-03 | Jn生物科学有限责任公司 | 通过半胱氨酸突变和μ尾端多聚化的抗体或融合蛋白 |
-
2013
- 2013-07-31 CN CN201380041074.3A patent/CN104684928A/zh active Pending
- 2013-07-31 US US13/956,121 patent/US9540442B2/en active Active
- 2013-07-31 IN IN1361DEN2015 patent/IN2015DN01361A/en unknown
- 2013-07-31 WO PCT/US2013/053086 patent/WO2014022592A1/en not_active Ceased
- 2013-07-31 EP EP13825409.9A patent/EP2880057A4/en not_active Withdrawn
- 2013-07-31 CA CA2879814A patent/CA2879814A1/en active Pending
- 2013-07-31 JP JP2015525568A patent/JP2015524821A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US9540442B2 (en) | 2017-01-10 |
| EP2880057A1 (en) | 2015-06-10 |
| EP2880057A4 (en) | 2016-03-23 |
| CN104684928A (zh) | 2015-06-03 |
| WO2014022592A1 (en) | 2014-02-06 |
| CA2879814A1 (en) | 2014-02-06 |
| JP2015524821A (ja) | 2015-08-27 |
| US20140037621A1 (en) | 2014-02-06 |
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