IN2015DN00976A - - Google Patents
Info
- Publication number
- IN2015DN00976A IN2015DN00976A IN976DEN2015A IN2015DN00976A IN 2015DN00976 A IN2015DN00976 A IN 2015DN00976A IN 976DEN2015 A IN976DEN2015 A IN 976DEN2015A IN 2015DN00976 A IN2015DN00976 A IN 2015DN00976A
- Authority
- IN
- India
- Prior art keywords
- epcs
- pah
- treated
- treating
- prostacyclin
- Prior art date
Links
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 abstract 3
- 230000002491 angiogenic effect Effects 0.000 abstract 1
- 230000003511 endothelial effect Effects 0.000 abstract 1
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 abstract 1
- 229960001123 epoprostenol Drugs 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0692—Stem cells; Progenitor cells; Precursor cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
- F04C2270/00—Control; Monitoring or safety arrangements
- F04C2270/04—Force
- F04C2270/041—Controlled or regulated
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261678208P | 2012-08-01 | 2012-08-01 | |
US201361750458P | 2013-01-09 | 2013-01-09 | |
PCT/US2013/052700 WO2014022376A2 (en) | 2012-08-01 | 2013-07-30 | Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2015DN00976A true IN2015DN00976A (ru) | 2015-06-12 |
Family
ID=50028652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN976DEN2015 IN2015DN00976A (ru) | 2012-08-01 | 2013-07-30 |
Country Status (9)
Country | Link |
---|---|
US (4) | US10016463B2 (ru) |
EP (2) | EP2879684B1 (ru) |
JP (2) | JP6746313B2 (ru) |
KR (1) | KR102143961B1 (ru) |
CN (1) | CN104936603A (ru) |
CA (1) | CA2880811C (ru) |
ES (2) | ES2869701T3 (ru) |
IN (1) | IN2015DN00976A (ru) |
WO (1) | WO2014022376A2 (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2880811C (en) * | 2012-08-01 | 2021-12-07 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells |
WO2014022373A1 (en) | 2012-08-01 | 2014-02-06 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with mesenchymal stem cells |
EP3878452B1 (en) * | 2013-01-09 | 2023-09-20 | United Therapeutics Corporation | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
MX2020004912A (es) | 2013-10-25 | 2021-05-21 | Insmed Inc | Compuestos derivados de prostaciclinas, y el uso de los mismo para el tratamiento de la hipertension pulmonar. |
WO2015164506A1 (en) * | 2014-04-23 | 2015-10-29 | Texas Heart Institute | Methods of enhancing stem cell engraftment |
CA2967385C (en) | 2014-11-18 | 2023-05-16 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
WO2016105468A1 (en) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
JP7061076B2 (ja) | 2016-04-07 | 2022-04-27 | プロテオステイシス セラピューティクス,インコーポレイテッド | アイバカフトール類似体を含有するケイ素原子 |
WO2018080990A1 (en) * | 2016-10-24 | 2018-05-03 | United Therapeutics Corporation | Enhancement of msc immunomodulatory properties by treprostinil |
WO2018106632A1 (en) * | 2016-12-05 | 2018-06-14 | Corsair Pharma, Inc. | Dermal and transdermal administration of treprostinil and salts thereof |
CA3114681A1 (en) | 2018-10-05 | 2020-04-09 | Xenotherapeutics, Inc. | Xenotransplantation products and methods |
US10883084B2 (en) | 2018-10-05 | 2021-01-05 | Xenotherapeutics, Inc. | Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same |
CA3138530A1 (en) | 2019-04-29 | 2020-11-05 | Insmed Incorporated | Dry powder compositions of treprostinil prodrugs and methods of use thereof |
US20220233573A1 (en) * | 2019-07-15 | 2022-07-28 | Yale University | Methods and compositions for treating pulmonary arterial hypternsion |
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CA2880811C (en) * | 2012-08-01 | 2021-12-07 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells |
WO2014022373A1 (en) | 2012-08-01 | 2014-02-06 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with mesenchymal stem cells |
EP3878452B1 (en) | 2013-01-09 | 2023-09-20 | United Therapeutics Corporation | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
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WO2018080990A1 (en) | 2016-10-24 | 2018-05-03 | United Therapeutics Corporation | Enhancement of msc immunomodulatory properties by treprostinil |
-
2013
- 2013-07-30 CA CA2880811A patent/CA2880811C/en active Active
- 2013-07-30 WO PCT/US2013/052700 patent/WO2014022376A2/en active Application Filing
- 2013-07-30 EP EP13824807.5A patent/EP2879684B1/en active Active
- 2013-07-30 JP JP2015525509A patent/JP6746313B2/ja active Active
- 2013-07-30 ES ES18212217T patent/ES2869701T3/es active Active
- 2013-07-30 KR KR1020157004319A patent/KR102143961B1/ko active IP Right Grant
- 2013-07-30 US US14/418,557 patent/US10016463B2/en active Active
- 2013-07-30 ES ES13824807T patent/ES2713988T3/es active Active
- 2013-07-30 CN CN201380050778.7A patent/CN104936603A/zh active Pending
- 2013-07-30 EP EP18212217.6A patent/EP3492084B1/en active Active
- 2013-07-30 IN IN976DEN2015 patent/IN2015DN00976A/en unknown
-
2018
- 2018-04-05 JP JP2018073109A patent/JP6810717B2/ja active Active
- 2018-06-07 US US16/002,250 patent/US10842823B2/en active Active
-
2020
- 2020-10-16 US US17/072,430 patent/US11839631B2/en active Active
-
2023
- 2023-12-11 US US18/535,745 patent/US20240131078A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2880811A1 (en) | 2014-02-06 |
US11839631B2 (en) | 2023-12-12 |
EP3492084B1 (en) | 2021-02-17 |
US20150216909A1 (en) | 2015-08-06 |
KR20150036716A (ko) | 2015-04-07 |
JP6746313B2 (ja) | 2020-08-26 |
WO2014022376A3 (en) | 2015-07-16 |
KR102143961B1 (ko) | 2020-08-12 |
WO2014022376A2 (en) | 2014-02-06 |
US20210030812A1 (en) | 2021-02-04 |
CN104936603A (zh) | 2015-09-23 |
EP2879684A4 (en) | 2016-07-20 |
ES2713988T3 (es) | 2019-05-24 |
ES2869701T3 (es) | 2021-10-25 |
JP2018135352A (ja) | 2018-08-30 |
US10016463B2 (en) | 2018-07-10 |
EP3492084A1 (en) | 2019-06-05 |
US20240131078A1 (en) | 2024-04-25 |
JP6810717B2 (ja) | 2021-01-06 |
JP2015524438A (ja) | 2015-08-24 |
CA2880811C (en) | 2021-12-07 |
EP2879684A2 (en) | 2015-06-10 |
EP2879684B1 (en) | 2019-01-30 |
US10842823B2 (en) | 2020-11-24 |
US20180280445A1 (en) | 2018-10-04 |
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