IN2015DN00922A - - Google Patents
Info
- Publication number
- IN2015DN00922A IN2015DN00922A IN922DEN2015A IN2015DN00922A IN 2015DN00922 A IN2015DN00922 A IN 2015DN00922A IN 922DEN2015 A IN922DEN2015 A IN 922DEN2015A IN 2015DN00922 A IN2015DN00922 A IN 2015DN00922A
- Authority
- IN
- India
- Prior art keywords
- clavine
- polynucleotides
- chanoclavine
- manufacture
- type alkaloids
- Prior art date
Links
- 229930013930 alkaloid Natural products 0.000 abstract 2
- VLMZMRDOMOGGFA-WDBKCZKBSA-N festuclavine Chemical compound C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C)=C3C2=CNC3=C1 VLMZMRDOMOGGFA-WDBKCZKBSA-N 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- XJOOMMHNYOJWCZ-UHFFFAOYSA-N Agroclavine Natural products C1=CC(C2C=C(C)CN(C2C2)C)=C3C2=CNC3=C1 XJOOMMHNYOJWCZ-UHFFFAOYSA-N 0.000 abstract 1
- ZWJHDICNUKHUGE-UHFFFAOYSA-N Cycloclavine Natural products C1=CC(C23CC2(C)CN(C3C2)C)=C3C2=CNC3=C1 ZWJHDICNUKHUGE-UHFFFAOYSA-N 0.000 abstract 1
- SAHHMCVYMGARBT-UHFFFAOYSA-N Isochanoclavine I Natural products C1=CC(C(C(NC)C2)C=C(C)CO)=C3C2=CNC3=C1 SAHHMCVYMGARBT-UHFFFAOYSA-N 0.000 abstract 1
- VLMZMRDOMOGGFA-PSOPSSQASA-N Pyroclavine Natural products C1=CC([C@H]2C[C@@H](CN(C)[C@@H]2C2)C)=C3C2=CNC3=C1 VLMZMRDOMOGGFA-PSOPSSQASA-N 0.000 abstract 1
- UPKBEIIDYOMDQW-UKRRQHHQSA-N agroclavine Chemical compound C1=CC=C2[C@H]3C=C(C)CN(C)[C@@H]3CC3=CN=C1[C]32 UPKBEIIDYOMDQW-UKRRQHHQSA-N 0.000 abstract 1
- SAHHMCVYMGARBT-HEESEWQSSA-N chanoclavine-I Chemical compound C1=CC([C@H]([C@H](NC)C2)\C=C(/C)CO)=C3C2=CNC3=C1 SAHHMCVYMGARBT-HEESEWQSSA-N 0.000 abstract 1
- XFKPUSAZRRAPSC-HEESEWQSSA-N chanoclavine-I aldehyde Chemical compound C1=CC([C@H]([C@H](NC)C2)\C=C(/C)C=O)=C3C2=CNC3=C1 XFKPUSAZRRAPSC-HEESEWQSSA-N 0.000 abstract 1
- ZWJHDICNUKHUGE-FVQBIDKESA-N cycloclavine Chemical compound C1=CC([C@@]23C[C@]2(C)CN([C@@H]3C2)C)=C3C2=CNC3=C1 ZWJHDICNUKHUGE-FVQBIDKESA-N 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
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- C—CHEMISTRY; METALLURGY
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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- C12N9/90—Isomerases (5.)
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- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
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- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
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- C12N2523/00—Culture process characterised by temperature
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- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
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- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
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Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261691848P | 2012-08-22 | 2012-08-22 | |
| EP12181388 | 2012-08-22 | ||
| US201361786841P | 2013-03-15 | 2013-03-15 | |
| EP13159444 | 2013-03-15 | ||
| EP13178008 | 2013-07-25 | ||
| PCT/IB2013/056604 WO2014030096A2 (en) | 2012-08-22 | 2013-08-13 | Genes and processes for the production of clavine-type alkaloids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN00922A true IN2015DN00922A (enrdf_load_stackoverflow) | 2015-06-12 |
Family
ID=50150439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN922DEN2015 IN2015DN00922A (enrdf_load_stackoverflow) | 2012-08-22 | 2013-08-13 |
Country Status (12)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210133323A (ko) | 2013-12-13 | 2021-11-05 | 바스프 에스이 | 정밀 화학물질의 개선된 생산을 위한 재조합 미생물 |
| WO2015195535A2 (en) * | 2014-06-16 | 2015-12-23 | West Virginia University | Production of lysergic acid by genetic modification of a fungus |
| RU2017137403A (ru) | 2015-03-26 | 2019-04-26 | Басф Се | Биокаталитическое получение l-фукозы |
| WO2019183193A1 (en) * | 2018-03-20 | 2019-09-26 | Manus Bio, Inc. | Enzymes, cells, and methods for production of 3-(4-farnesyloxyphenyl)propionic acid |
| EP3714959A1 (en) * | 2019-03-29 | 2020-09-30 | Basf Se | Isolation of small molecules from the fermentation broth of a eukaryotic microorganism |
| CZ308933B6 (cs) * | 2019-07-19 | 2021-09-15 | Univerzita Palackého v Olomouci | Houba Claviceps purpurea se zvýšenou produkcí námelových alkaloidů, způsob její přípravy, expresní kazeta |
| CN113174399A (zh) * | 2021-04-28 | 2021-07-27 | 天津大学 | 重组酿酒酵母菌株及其发酵方法 |
| CN113308442B (zh) * | 2021-04-28 | 2023-06-27 | 天津大学 | 重组酿酒酵母菌株及其构建方法 |
| CN115948442A (zh) * | 2022-08-04 | 2023-04-11 | 杭州佳嘉乐生物技术有限公司 | 一种提高植物发酵原浆中生物碱含量的方法 |
| US20240271170A1 (en) * | 2022-09-22 | 2024-08-15 | Tryptagenix, Inc. | Polynucleotides, polypeptides, recombinant cells and methods for generating ergolines and precursors and metabolites thereof |
| CN116103351B (zh) * | 2023-03-06 | 2025-06-10 | 天津大学 | 高产田麦角碱重组酵母构建方法与应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192751B2 (en) | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| CN101238208A (zh) | 2005-11-07 | 2008-08-06 | 伊瓦克斯制药有限公司 | 真菌麦角菌（Fr.)Tul.的工业生产菌株 |
| EP2680845A2 (en) | 2011-03-03 | 2014-01-08 | Basf Se | Gene cluster for biosynthesis of cycloclavine |
-
2013
- 2013-08-13 CA CA2880845A patent/CA2880845A1/en active Pending
- 2013-08-13 EP EP13831449.7A patent/EP2888351A4/en not_active Withdrawn
- 2013-08-13 WO PCT/IB2013/056604 patent/WO2014030096A2/en active Application Filing
- 2013-08-13 MX MX2015002294A patent/MX2015002294A/es unknown
- 2013-08-13 IN IN922DEN2015 patent/IN2015DN00922A/en unknown
- 2013-08-13 BR BR112015003695A patent/BR112015003695A8/pt not_active IP Right Cessation
- 2013-08-13 CN CN201380054217.4A patent/CN104736696B/zh not_active Expired - Fee Related
- 2013-08-13 US US14/421,872 patent/US9828617B2/en not_active Expired - Fee Related
- 2013-08-13 KR KR1020157006881A patent/KR20150042856A/ko not_active Withdrawn
- 2013-08-13 JP JP2015527987A patent/JP2015530879A/ja active Pending
- 2013-08-13 AU AU2013307289A patent/AU2013307289A1/en not_active Abandoned
-
2015
- 2015-02-10 IL IL237170A patent/IL237170A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2888351A4 (en) | 2016-04-27 |
| CA2880845A1 (en) | 2014-02-27 |
| CN104736696A (zh) | 2015-06-24 |
| EP2888351A2 (en) | 2015-07-01 |
| MX2015002294A (es) | 2015-10-09 |
| US9828617B2 (en) | 2017-11-28 |
| US20150211036A1 (en) | 2015-07-30 |
| KR20150042856A (ko) | 2015-04-21 |
| IL237170A0 (en) | 2015-04-30 |
| JP2015530879A (ja) | 2015-10-29 |
| BR112015003695A2 (pt) | 2017-12-12 |
| CN104736696B (zh) | 2018-08-28 |
| AU2013307289A1 (en) | 2015-02-19 |
| BR112015003695A8 (pt) | 2018-04-10 |
| WO2014030096A2 (en) | 2014-02-27 |
| WO2014030096A3 (en) | 2014-04-17 |
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