IN2014MN02197A - - Google Patents
Info
- Publication number
- IN2014MN02197A IN2014MN02197A IN2197MUN2014A IN2014MN02197A IN 2014MN02197 A IN2014MN02197 A IN 2014MN02197A IN 2197MUN2014 A IN2197MUN2014 A IN 2197MUN2014A IN 2014MN02197 A IN2014MN02197 A IN 2014MN02197A
- Authority
- IN
- India
- Prior art keywords
- novel
- full protection
- synthesizing
- reaction
- heparin pentasaccharide
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 3
- 229960001318 fondaparinux Drugs 0.000 abstract 2
- KANJSNBRCNMZMV-ABRZTLGGSA-N fondaparinux Chemical compound O[C@@H]1[C@@H](NS(O)(=O)=O)[C@@H](OC)O[C@H](COS(O)(=O)=O)[C@H]1O[C@H]1[C@H](OS(O)(=O)=O)[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O4)NS(O)(=O)=O)[C@H](O3)C(O)=O)O)[C@@H](COS(O)(=O)=O)O2)NS(O)(=O)=O)[C@H](C(O)=O)O1 KANJSNBRCNMZMV-ABRZTLGGSA-N 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 230000002194 synthesizing effect Effects 0.000 abstract 2
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 239000007806 chemical reaction intermediate Substances 0.000 abstract 1
- 229960003661 fondaparinux sodium Drugs 0.000 abstract 1
- XEKSTYNIJLDDAZ-JASSWCPGSA-F fondaparinux sodium Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O[C@@H]1[C@@H](NS([O-])(=O)=O)[C@@H](OC)O[C@H](COS([O-])(=O)=O)[C@H]1O[C@H]1[C@H](OS([O-])(=O)=O)[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](COS([O-])(=O)=O)O4)NS([O-])(=O)=O)[C@H](O3)C(O)=O)O)[C@@H](COS([O-])(=O)=O)O2)NS([O-])(=O)=O)[C@H](C(O)=O)O1 XEKSTYNIJLDDAZ-JASSWCPGSA-F 0.000 abstract 1
- 239000012450 pharmaceutical intermediate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
- C07H5/10—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium to sulfur
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/076096 WO2013174017A1 (zh) | 2012-05-25 | 2012-05-25 | 制备全保护的肝素五糖的方法及其中间体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MN02197A true IN2014MN02197A (enrdf_load_stackoverflow) | 2015-09-11 |
Family
ID=49623036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2197MUN2014 IN2014MN02197A (enrdf_load_stackoverflow) | 2012-05-25 | 2012-05-25 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20150284419A1 (enrdf_load_stackoverflow) |
| EP (1) | EP2857411B1 (enrdf_load_stackoverflow) |
| JP (1) | JP6138241B2 (enrdf_load_stackoverflow) |
| CN (1) | CN104169292A (enrdf_load_stackoverflow) |
| IN (1) | IN2014MN02197A (enrdf_load_stackoverflow) |
| WO (1) | WO2013174017A1 (enrdf_load_stackoverflow) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2519987A1 (fr) * | 1982-01-15 | 1983-07-22 | Choay Sa | Trisaccharides a structures d-glucosamine, acide d-glucuronique, d-glucosamine et leur preparation |
| US4818816A (en) | 1981-04-28 | 1989-04-04 | Choay, S.A. | Process for the organic synthesis of oligosaccharides and derivatives thereof |
| JPS63218691A (ja) * | 1987-03-09 | 1988-09-12 | Rikagaku Kenkyusho | 新規な５糖類化合物及びその製造法並びに抗凝血及び抗血栓剤 |
| EP1440077B1 (en) * | 2001-09-07 | 2013-05-01 | Alchemia Limited | Synthetic heparin pentasaccharides |
| JP2012106933A (ja) * | 2009-03-10 | 2012-06-07 | Univ Of Tokyo | オリゴアミノ糖化合物 |
| EP2464668B1 (en) * | 2009-07-31 | 2022-12-07 | Reliable Biopharmaceutical Corporation | Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof |
| US8420790B2 (en) * | 2009-10-30 | 2013-04-16 | Reliable Biopharmaceutical Corporation | Efficient and scalable process for the manufacture of Fondaparinux sodium |
-
2012
- 2012-05-25 IN IN2197MUN2014 patent/IN2014MN02197A/en unknown
- 2012-05-25 US US14/399,148 patent/US20150284419A1/en not_active Abandoned
- 2012-05-25 EP EP12877493.2A patent/EP2857411B1/en not_active Not-in-force
- 2012-05-25 JP JP2015512988A patent/JP6138241B2/ja not_active Expired - Fee Related
- 2012-05-25 CN CN201280071540.8A patent/CN104169292A/zh active Pending
- 2012-05-25 WO PCT/CN2012/076096 patent/WO2013174017A1/zh active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| US20150284419A1 (en) | 2015-10-08 |
| WO2013174017A1 (zh) | 2013-11-28 |
| JP6138241B2 (ja) | 2017-05-31 |
| CN104169292A (zh) | 2014-11-26 |
| EP2857411A1 (en) | 2015-04-08 |
| EP2857411B1 (en) | 2017-12-06 |
| EP2857411A4 (en) | 2016-03-09 |
| JP2015517536A (ja) | 2015-06-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2014DN09026A (enrdf_load_stackoverflow) | ||
| PH12015500644A1 (en) | Novel rig-i ligands and methods for producing them | |
| IN2015KN00262A (enrdf_load_stackoverflow) | ||
| MD20140137A2 (ro) | Derivaţi noi de tienopirimidină, procedeu de preparare a acestora, compoziţii farmaceutice care îi conţin | |
| EP2712928A4 (en) | Method for producing natural -carotene by fermentation and use thereof | |
| UA110054C2 (uk) | Розгалужені похідні 3-фенілпропіонової кислоти і їх застосування | |
| PL2771307T3 (pl) | Proces produkcji akrylanów z epoksydów | |
| EP2905267A4 (en) | METHOD FOR PRODUCING COATED GLASS | |
| MY158251A (en) | Method for the preparation of nalmefene hydrochloride | |
| EP2703101A4 (en) | METHOD FOR PRODUCING A METAL-GLASS NANODRAHT, METAL-GLASS NANODRAW AND METAL-GLASS NANODRAHT PRODUCED BY THIS METHOD | |
| EP2922569A4 (en) | PREPARATION OF BACTERIAL POLYSACCHARIDES WITH HIGH PURITY | |
| PL2858652T3 (pl) | Wieloetapowy proces produkcji modulatora odpornościowego | |
| EP2894225A4 (en) | METHOD FOR PRODUCING A CAPSULE POLYSACCHARIDE WITH A PNEUMOKOKEN SEROTYPE | |
| MX2014004920A (es) | Nuevos derivados de pirazina. | |
| MX357722B (es) | Produccion de glicerol proveniente de residuos parcialmente refinados. | |
| MY171201A (en) | New carbamate glycolipid and use thereof | |
| EP2719393A4 (en) | FREEZE-DRIED PREPARATION WITH HIGH-PURITY PTH AND METHOD OF MANUFACTURING THEREOF | |
| BR112015013567A8 (pt) | extrato de algas que compreende polissacarídeos polianiônicos sulfatados e não sulfatados e suas aplicações. | |
| EP2939999A4 (en) | HIGH-PURITY MONOALKENYL-HOLDING GLYCERIN DERIVATIVE AND METHOD FOR THE PRODUCTION THEREOF | |
| IN2015DN00725A (enrdf_load_stackoverflow) | ||
| IN2014MN02197A (enrdf_load_stackoverflow) | ||
| MY165746A (en) | Method for the production of 2-octyl acrylate by means of transesterification | |
| EP2918614A4 (en) | PROCESS FOR PREPARING A POLYMER, POLYMER SOLUTION AND POLYMER | |
| RU2012133403A (ru) | Способ получения микрокапсул лекарственных препаратов группы цефалоспоринов в конжаковой камеди в бутиловом спирте | |
| RU2012112563A (ru) | Способ получения хитозана |