IN2014MN02197A - - Google Patents

Info

Publication number
IN2014MN02197A
IN2014MN02197A IN2197MUN2014A IN2014MN02197A IN 2014MN02197 A IN2014MN02197 A IN 2014MN02197A IN 2197MUN2014 A IN2197MUN2014 A IN 2197MUN2014A IN 2014MN02197 A IN2014MN02197 A IN 2014MN02197A
Authority
IN
India
Prior art keywords
novel
full protection
synthesizing
reaction
heparin pentasaccharide
Prior art date
Application number
Inventor
Yili Ding
Yanghui Guo
Hua Bai
Yingqiu Wu
Xuan Yang
Qingyan Yan
Jian Chai
Original Assignee
Zhejiang Hisun Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Hisun Pharm Co Ltd filed Critical Zhejiang Hisun Pharm Co Ltd
Publication of IN2014MN02197A publication Critical patent/IN2014MN02197A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
    • C07H5/10—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium to sulfur

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Disclosed is a process for chemically synthesizing a pharmaceutical intermediate in particular to a novel intermediate and novel process for synthesizing an anticoagulant drug fondaparinux sodium intermediate full protection heparin pentasaccharide. The process has a high reaction efficiency and a simple reaction operation and enables the reaction intermediate to be easily purified thus being suitable for the industrialized production of the full protection heparin pentasaccharide.
IN2197MUN2014 2012-05-25 2012-05-25 IN2014MN02197A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2012/076096 WO2013174017A1 (en) 2012-05-25 2012-05-25 Method for preparing fully protection heparin pentasaccharide and intermediate thereof

Publications (1)

Publication Number Publication Date
IN2014MN02197A true IN2014MN02197A (en) 2015-09-11

Family

ID=49623036

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2197MUN2014 IN2014MN02197A (en) 2012-05-25 2012-05-25

Country Status (6)

Country Link
US (1) US20150284419A1 (en)
EP (1) EP2857411B1 (en)
JP (1) JP6138241B2 (en)
CN (1) CN104169292A (en)
IN (1) IN2014MN02197A (en)
WO (1) WO2013174017A1 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2519987A1 (en) * 1982-01-15 1983-07-22 Choay Sa Uronic acid derivs. - useful as glycoside intermediates or hapten(s)
US4818816A (en) 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
JPS63218691A (en) * 1987-03-09 1988-09-12 Rikagaku Kenkyusho Novel pentasaccharide compound, production thereof, anticoagulant and antithrombotic agent
ES2423888T3 (en) * 2001-09-07 2013-09-25 Alchemia Limited Synthetic heparin pentasaccharides
JP2012106933A (en) * 2009-03-10 2012-06-07 Univ Of Tokyo Oligo-aminosaccharide compound
WO2011014793A2 (en) * 2009-07-31 2011-02-03 Reliable Biopharmaceutical Corporation Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof
US8420790B2 (en) * 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium

Also Published As

Publication number Publication date
CN104169292A (en) 2014-11-26
WO2013174017A1 (en) 2013-11-28
JP2015517536A (en) 2015-06-22
EP2857411B1 (en) 2017-12-06
EP2857411A1 (en) 2015-04-08
US20150284419A1 (en) 2015-10-08
JP6138241B2 (en) 2017-05-31
EP2857411A4 (en) 2016-03-09

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