IN2014DN09026A - - Google Patents
Info
- Publication number
- IN2014DN09026A IN2014DN09026A IN9026DEN2014A IN2014DN09026A IN 2014DN09026 A IN2014DN09026 A IN 2014DN09026A IN 9026DEN2014 A IN9026DEN2014 A IN 9026DEN2014A IN 2014DN09026 A IN2014DN09026 A IN 2014DN09026A
- Authority
- IN
- India
- Prior art keywords
- easy
- reaction
- purified
- preparation
- appropriate
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 2
- 239000007806 chemical reaction intermediate Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- KANJSNBRCNMZMV-ABRZTLGGSA-N fondaparinux Chemical compound O[C@@H]1[C@@H](NS(O)(=O)=O)[C@@H](OC)O[C@H](COS(O)(=O)=O)[C@H]1O[C@H]1[C@H](OS(O)(=O)=O)[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O4)NS(O)(=O)=O)[C@H](O3)C(O)=O)O)[C@@H](COS(O)(=O)=O)O2)NS(O)(=O)=O)[C@H](C(O)=O)O1 KANJSNBRCNMZMV-ABRZTLGGSA-N 0.000 abstract 1
- 229960001318 fondaparinux Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210102415.0A CN103360439B (zh) | 2012-04-02 | 2012-04-02 | 制备肝素五糖的新中间体及其制备方法 |
| PCT/CN2013/073601 WO2013149576A1 (zh) | 2012-04-02 | 2013-04-02 | 制备肝素五糖的新中间体及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN09026A true IN2014DN09026A (enrdf_load_stackoverflow) | 2015-05-22 |
Family
ID=49299997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN9026DEN2014 IN2014DN09026A (enrdf_load_stackoverflow) | 2012-04-02 | 2013-04-02 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9624315B2 (enrdf_load_stackoverflow) |
| EP (1) | EP2837635B1 (enrdf_load_stackoverflow) |
| JP (1) | JP2015514098A (enrdf_load_stackoverflow) |
| CN (1) | CN103360439B (enrdf_load_stackoverflow) |
| IN (1) | IN2014DN09026A (enrdf_load_stackoverflow) |
| WO (1) | WO2013149576A1 (enrdf_load_stackoverflow) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102718808A (zh) * | 2012-06-04 | 2012-10-10 | 浙江星月药物科技股份有限公司 | 一类多糖衍生物及其中间体的制备方法 |
| CN103570774B (zh) * | 2012-08-07 | 2017-08-25 | 博瑞生物医药（苏州）股份有限公司 | 一种戊糖化合物的纯化方法 |
| CN103992364B (zh) * | 2014-03-25 | 2016-08-10 | 南京天翔医药科技有限公司 | 一种磺达肝癸钠的分离提取方法 |
| CN103965269B (zh) * | 2014-04-16 | 2018-05-04 | 杭州华东医药集团新药研究院有限公司 | 低水分高纯度的磺达肝癸钠及其制备方法 |
| CN104098618A (zh) * | 2014-07-25 | 2014-10-15 | 河北常山生化药业股份有限公司 | 磺达肝癸钠中间体及其中间体和磺达肝癸钠的制备方法 |
| CN105037452B (zh) * | 2015-06-19 | 2018-10-09 | 天津红日药业股份有限公司 | 一种快速制备高纯度磺达肝癸钠的精制方法 |
| JP6741277B2 (ja) * | 2015-12-30 | 2020-08-19 | シェンツェン ヘパリンク ファーマスーティカル グループ カンパニー リミテッドＳｈｅｎｚｈｅｎ Ｈｅｐａｌｉｎｋ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｇｒｏｕｐ Ｃｏ．， Ｌｔｄ． | 硫酸化ヘパリン由来オリゴ糖及びその調製法と施用 |
| CN108148101B (zh) * | 2016-12-03 | 2021-12-24 | 烟台东诚药业集团股份有限公司 | 一种制备磺达肝癸钠的新工艺方法 |
| CN115057896A (zh) * | 2022-07-28 | 2022-09-16 | 苏州柯默拓医药科技有限公司 | 一种磺达肝癸钠的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4818816A (en) * | 1981-04-28 | 1989-04-04 | Choay, S.A. | Process for the organic synthesis of oligosaccharides and derivatives thereof |
| EP0300099A1 (en) | 1987-07-20 | 1989-01-25 | Akzo N.V. | New pentasaccharides |
| EP1440077B1 (en) * | 2001-09-07 | 2013-05-01 | Alchemia Limited | Synthetic heparin pentasaccharides |
| EP2421877A4 (en) * | 2008-10-03 | 2013-03-20 | Glycan Biosciences Llc | ANIONIC CONJUGATES OF GLYCOSYLATED BACTERIAL METABOLITE |
| ES2336297B1 (es) * | 2008-10-08 | 2011-01-24 | Laboratorios Farmaceuticos Rovi, S.A. | Procedimiento de sintesis de pentasacaridos desprotegidos a partir deun pentasacarido precursos protegido. |
| JP2012106933A (ja) * | 2009-03-10 | 2012-06-07 | Univ Of Tokyo | オリゴアミノ糖化合物 |
| EP2464668B1 (en) * | 2009-07-31 | 2022-12-07 | Reliable Biopharmaceutical Corporation | Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof |
| CN102718808A (zh) * | 2012-06-04 | 2012-10-10 | 浙江星月药物科技股份有限公司 | 一类多糖衍生物及其中间体的制备方法 |
-
2012
- 2012-04-02 CN CN201210102415.0A patent/CN103360439B/zh not_active Expired - Fee Related
-
2013
- 2013-04-02 IN IN9026DEN2014 patent/IN2014DN09026A/en unknown
- 2013-04-02 EP EP13772346.6A patent/EP2837635B1/en not_active Not-in-force
- 2013-04-02 WO PCT/CN2013/073601 patent/WO2013149576A1/zh active Application Filing
- 2013-04-02 US US14/389,806 patent/US9624315B2/en not_active Expired - Fee Related
- 2013-04-02 JP JP2015503738A patent/JP2015514098A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2837635B1 (en) | 2017-10-18 |
| EP2837635A4 (en) | 2015-05-27 |
| JP2015514098A (ja) | 2015-05-18 |
| WO2013149576A1 (zh) | 2013-10-10 |
| CN103360439B (zh) | 2017-12-15 |
| EP2837635A1 (en) | 2015-02-18 |
| US20150299340A1 (en) | 2015-10-22 |
| CN103360439A (zh) | 2013-10-23 |
| US9624315B2 (en) | 2017-04-18 |
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