IN2014MN01033A - - Google Patents

Info

Publication number
IN2014MN01033A
IN2014MN01033A IN1033MUN2014A IN2014MN01033A IN 2014MN01033 A IN2014MN01033 A IN 2014MN01033A IN 1033MUN2014 A IN1033MUN2014 A IN 1033MUN2014A IN 2014MN01033 A IN2014MN01033 A IN 2014MN01033A
Authority
IN
India
Prior art keywords
diseases
formula
methods
novel compounds
lung
Prior art date
Application number
Other languages
English (en)
Inventor
Frédéric Gilbert Labéguère
Gregory John Robert Newsome
Luke Jonathan Alvey
Laurent Raymond Maurice Sanière
Stephen Robert Fletcher
Original Assignee
Galapagos Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galapagos Nv filed Critical Galapagos Nv
Publication of IN2014MN01033A publication Critical patent/IN2014MN01033A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IN1033MUN2014 2011-12-22 2012-12-20 IN2014MN01033A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161578979P 2011-12-22 2011-12-22
PCT/EP2012/076275 WO2013092791A1 (fr) 2011-12-22 2012-12-20 Nouvelles dihydropyrimidinoisoquinoléinones et compositions pharmaceutique à base de celles-ci pour le traitement de troubles inflammatoires

Publications (1)

Publication Number Publication Date
IN2014MN01033A true IN2014MN01033A (fr) 2015-05-01

Family

ID=47520068

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1033MUN2014 IN2014MN01033A (fr) 2011-12-22 2012-12-20

Country Status (35)

Country Link
US (5) US8927543B2 (fr)
EP (3) EP2794604B1 (fr)
JP (1) JP6062453B2 (fr)
KR (1) KR102012268B1 (fr)
CN (1) CN103998448B (fr)
AR (1) AR089284A1 (fr)
AU (1) AU2012357067B2 (fr)
BR (1) BR112014015142B1 (fr)
CA (1) CA2859578C (fr)
CL (1) CL2014001664A1 (fr)
CO (1) CO7010835A2 (fr)
CR (1) CR20140305A (fr)
CY (1) CY1119434T1 (fr)
DK (2) DK2794604T3 (fr)
EA (1) EA023826B1 (fr)
ES (2) ES2643379T3 (fr)
HK (1) HK1201528A1 (fr)
HR (2) HRP20220456T1 (fr)
HU (1) HUE12812237T4 (fr)
IL (2) IL233212B (fr)
IN (1) IN2014MN01033A (fr)
LT (2) LT2794604T (fr)
MX (1) MX351681B (fr)
NI (1) NI201400060A (fr)
PE (1) PE20141685A1 (fr)
PH (1) PH12014501178B1 (fr)
PL (2) PL3378862T3 (fr)
PT (2) PT3378862T (fr)
SG (1) SG11201403169PA (fr)
SI (2) SI2794604T1 (fr)
TW (1) TWI567073B (fr)
UA (1) UA111767C2 (fr)
UY (1) UY34545A (fr)
WO (1) WO2013092791A1 (fr)
ZA (1) ZA201404607B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2794627T3 (pl) 2011-12-22 2019-04-30 Alios Biopharma Inc Podstawione nukleozydy, nukleotydy i ich analogi
AR089284A1 (es) 2011-12-22 2014-08-13 Galapagos Nv Dihidropirimidinoisoquinolinonas y composiciones farmaceuticas de las mismas para el tratamiento de trastornos inflamatorios
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EP2935262B1 (fr) 2012-12-20 2017-03-15 Galapagos NV Nouvelles dihydropyrimidinoisoquinoléinones et compositions pharmaceutique à base de celles-ci pour le traitement de troubles inflammatoires (antagonistes de gpr84)
GB201319677D0 (en) * 2013-11-07 2013-12-25 Eth Z Rich Cyclopropanation
GB201411241D0 (en) * 2014-06-25 2014-08-06 Galapagos Nv Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
GB201506894D0 (en) * 2015-04-23 2015-06-10 Galapagos Nv Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
WO2018161831A1 (fr) * 2017-03-06 2018-09-13 中国科学院上海药物研究所 Antagoniste du récepteur gpr84 et son utilisation
EP3403649A1 (fr) 2017-05-16 2018-11-21 Bayer Pharma Aktiengesellschaft Inhibiteurs et antagonistes de gpr84 pour le traitement de l'endométriose
RU2020119415A (ru) * 2017-11-15 2021-12-16 Галапагос Нв Соединения и их фармацевтические композиции для применения при лечении фиброзных заболеваний
TW202136271A (zh) 2019-12-19 2021-10-01 德商拜耳廠股份有限公司 呋喃并吲唑衍生物
WO2021123394A1 (fr) 2019-12-20 2021-06-24 University Of Copenhagen Modulateurs du récepteur couplé à la protéine g et composition pharmaceutique
WO2022112186A1 (fr) 2020-11-24 2022-06-02 Galapagos Nv Procédés de traitement de maladies fibrotiques et composé destiné à être utilisé dans ces procédés
CA3211437A1 (fr) 2021-02-23 2022-09-01 Bayer Aktiengesellschaft Derives de furoindazole utilises en tant qu'antagonistes de gpr84
WO2022194267A1 (fr) * 2021-03-18 2022-09-22 武汉人福创新药物研发中心有限公司 Antagoniste gpr84, son procédé de préparation et son utilisation
WO2022218372A1 (fr) * 2021-04-14 2022-10-20 武汉人福创新药物研发中心有限公司 Dérivé de dihydropyrimidoisoquinoléinone et son utilisation
WO2022229061A1 (fr) 2021-04-29 2022-11-03 Bayer Aktiengesellschaft Dérivés de furoindazole utilisés comme antagonistes ou inhibiteurs de gpr84
EP4355743A1 (fr) 2021-06-18 2024-04-24 University of Copenhagen Dérivés de 4-hydroxypyridine et de 4-hydroxyquinoléine polysubstitués utilisés comme antagonistes de gpr84
CN115572293A (zh) * 2021-06-21 2023-01-06 武汉人福创新药物研发中心有限公司 用于gpr84拮抗剂的三环化合物
CN115611944A (zh) 2021-07-15 2023-01-17 中国科学院上海药物研究所 不对称gpr84拮抗剂及其用途
WO2023076668A1 (fr) * 2021-10-29 2023-05-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions et méthodes de traitement du cancer
WO2024083705A1 (fr) 2022-10-18 2024-04-25 Bayer Aktiengesellschaft Dérivés de furoindazole pour le traitement de la douleur

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DE2720085A1 (de) 1977-05-05 1978-11-16 Hoechst Ag Pyrimido(6,1-a)isochinolin-2-on- derivate
AU744986B2 (en) * 1997-07-12 2002-03-07 Cancer Research Technology Limited Cyclin dependent kinase inhibiting purine derivatives
AU3974700A (en) * 1999-03-31 2000-10-16 Vernalis Limited Derivatives of pyrimido(6,1-a)isoquinolin-4-one
JP2007525475A (ja) * 2003-07-08 2007-09-06 スミスクライン・ビーチャム・コーポレイション 新規化学化合物
WO2005050225A2 (fr) 2003-10-31 2005-06-02 Bayer Healthcare Ag Outils de diagnostic et de traitement de maladies associees au recepteur 84 couple aux proteines g (gpr84)
CA2621144A1 (fr) * 2005-09-02 2007-03-08 Arena Pharmaceuticals, Inc. Utilisation du recepteur humain couple aux proteines g et de ses modulateurs pour le traitement de l'atherosclerose et de troubles atherosclerotiques, et d'etats lies a l'expression du mcp-1
US7989461B2 (en) 2005-12-23 2011-08-02 Amgen Inc. Substituted quinazolinamine compounds for the treatment of cancer
US8217177B2 (en) * 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
AU2009276339B2 (en) 2008-07-31 2012-06-07 Genentech, Inc. Pyrimidine compounds, compositions and methods of use
JP2011088847A (ja) * 2009-10-21 2011-05-06 Takeda Chem Ind Ltd 三環性化合物およびその用途
AR089284A1 (es) 2011-12-22 2014-08-13 Galapagos Nv Dihidropirimidinoisoquinolinonas y composiciones farmaceuticas de las mismas para el tratamiento de trastornos inflamatorios
SG11201403266RA (en) 2011-12-22 2014-07-30 Connexios Life Sciences Pvt Ltd Derivatives of aza adamantane and uses thereof
WO2013128465A1 (fr) 2011-12-22 2013-09-06 Connexios Life Sciences Pvt. Ltd. Dérivés d'amide cycliques à utiliser en tant qu'inhibiteurs de 11-bêta-hydroxystéroïde déshydrogénase et utilisations de ceux-ci
CR20200286A (es) 2011-12-22 2020-09-23 Novartis Ag DERIVADOS DE DIHIDRO-BENZO-OXAZINA Y DIHIDRO-PIRIDO-OXAZINA (Divisional 2014-0294)
EP2935262B1 (fr) 2012-12-20 2017-03-15 Galapagos NV Nouvelles dihydropyrimidinoisoquinoléinones et compositions pharmaceutique à base de celles-ci pour le traitement de troubles inflammatoires (antagonistes de gpr84)

Also Published As

Publication number Publication date
CN103998448A (zh) 2014-08-20
EP2794604A1 (fr) 2014-10-29
CR20140305A (es) 2014-07-23
BR112014015142B1 (pt) 2022-03-29
KR20140117427A (ko) 2014-10-07
TWI567073B (zh) 2017-01-21
US8927543B2 (en) 2015-01-06
ES2911449T3 (es) 2022-05-19
UY34545A (es) 2013-07-31
PT2794604T (pt) 2017-10-23
BR112014015142A2 (pt) 2017-06-13
KR102012268B1 (ko) 2019-08-21
ZA201404607B (en) 2020-02-26
EP4019519A1 (fr) 2022-06-29
IL233212A0 (en) 2014-08-31
HRP20171404T1 (hr) 2017-11-17
DK2794604T3 (da) 2017-11-06
JP2015500861A (ja) 2015-01-08
IL257581A (en) 2018-04-30
NI201400060A (es) 2015-04-27
WO2013092791A1 (fr) 2013-06-27
HK1201528A1 (en) 2015-09-04
HUE12812237T4 (hu) 2017-12-28
EP3378862A1 (fr) 2018-09-26
CA2859578A1 (fr) 2013-06-27
NZ626473A (en) 2016-03-31
US11220499B2 (en) 2022-01-11
US9255095B2 (en) 2016-02-09
AR089284A1 (es) 2014-08-13
SG11201403169PA (en) 2014-07-30
LT2794604T (lt) 2017-10-25
HRP20220456T1 (hr) 2022-05-27
US20190002458A1 (en) 2019-01-03
CN103998448B (zh) 2016-04-20
DK3378862T3 (da) 2022-04-11
US20140121204A1 (en) 2014-05-01
US20220227751A1 (en) 2022-07-21
SI3378862T1 (sl) 2022-05-31
CY1119434T1 (el) 2018-03-07
US20130165437A1 (en) 2013-06-27
ES2643379T9 (es) 2018-01-05
PE20141685A1 (es) 2014-11-25
US10047083B2 (en) 2018-08-14
IL233212B (en) 2018-03-29
PL2794604T3 (pl) 2017-12-29
MX351681B (es) 2017-10-25
CA2859578C (fr) 2020-03-10
AU2012357067A1 (en) 2014-07-10
AU2012357067B2 (en) 2017-01-05
PL3378862T3 (pl) 2022-05-16
PH12014501178A1 (en) 2014-10-20
CO7010835A2 (es) 2014-07-31
UA111767C2 (uk) 2016-06-10
EA023826B1 (ru) 2016-07-29
EP2794604B1 (fr) 2017-09-13
CL2014001664A1 (es) 2014-10-03
EA201491245A1 (ru) 2014-10-30
TW201331201A (zh) 2013-08-01
LT3378862T (lt) 2022-04-25
SI2794604T1 (sl) 2017-12-29
EP3378862B1 (fr) 2022-03-16
ES2643379T3 (es) 2017-11-22
JP6062453B2 (ja) 2017-01-18
US20160244442A1 (en) 2016-08-25
MX2014007363A (es) 2014-08-01
PH12014501178B1 (en) 2014-10-20
PT3378862T (pt) 2022-04-11

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