IN2014KN00920A - - Google Patents

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Publication number
IN2014KN00920A
IN2014KN00920A IN920KON2014A IN2014KN00920A IN 2014KN00920 A IN2014KN00920 A IN 2014KN00920A IN 920KON2014 A IN920KON2014 A IN 920KON2014A IN 2014KN00920 A IN2014KN00920 A IN 2014KN00920A
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India
Prior art keywords
specific
immunotherapy
antibodies
treatment
antigen binding
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English (en)
Inventor
Gady S Cojocaru
Liat Dassa
Galit Rotman
Ofer Levy
Andrew Pow
Greenwald Shirley Sameach
Zurit Levine
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Compugen Ltd
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Application filed by Compugen Ltd filed Critical Compugen Ltd
Publication of IN2014KN00920A publication Critical patent/IN2014KN00920A/en

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    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2632630C (en) 2005-12-13 2016-12-06 President And Fellows Of Harvard College Scaffolds for cell transplantation
DK2624873T3 (da) 2010-10-06 2020-03-02 Harvard College Injicerbare, pore-dannende hydrogeler til materiale-baserede celleterapier
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
US9937249B2 (en) 2012-04-16 2018-04-10 President And Fellows Of Harvard College Mesoporous silica compositions for modulating immune responses
US9890215B2 (en) * 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
MX2015007446A (es) 2012-12-12 2015-12-07 Vasculox Inc Anticuerpos terapeuticos para cd47.
US9221908B2 (en) 2012-12-12 2015-12-29 Vasculox, Inc. Therapeutic CD47 antibodies
US9433689B2 (en) * 2013-03-12 2016-09-06 The Board Of Trustees Of The Leland Stanford Junio Probes and methods of imaging non-Hodgkins lymphoma
WO2015085162A1 (en) 2013-12-05 2015-06-11 Rfemb Holdings, Llc Cancer immunotherapy by radiofrequency electrical membrane breakdown (rf-emb)
CA2922835C (en) * 2013-09-06 2023-09-26 New York University Method for inducing antitumor immunity using sindbis viral vectors and tumor associated antigens
DK3052485T3 (da) 2013-10-04 2021-10-11 Infinity Pharmaceuticals Inc Heterocykliske forbindelser og anvendelser deraf
US10174111B2 (en) 2013-12-27 2019-01-08 National University Corporation Kochi University Therapeutic drug for malignant tumors
WO2015136541A2 (en) 2014-03-12 2015-09-17 Yeda Research And Development Co. Ltd Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns
US10519237B2 (en) 2014-03-12 2019-12-31 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
US9394365B1 (en) 2014-03-12 2016-07-19 Yeda Research And Development Co., Ltd Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease
US10618963B2 (en) 2014-03-12 2020-04-14 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
WO2015143012A1 (en) 2014-03-19 2015-09-24 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
US20150283237A1 (en) * 2014-04-02 2015-10-08 Mitchell S. Felder Ctla-4 blockade with metronomic chemotherapy for the treatment of cancer
US10682400B2 (en) 2014-04-30 2020-06-16 President And Fellows Of Harvard College Combination vaccine devices and methods of killing cancer cells
EP3142689B1 (en) 2014-05-13 2020-11-11 Bavarian Nordic A/S Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and a monoclonal antibody against tim-3
US10092645B2 (en) * 2014-06-17 2018-10-09 Medimmune Limited Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy
US9212225B1 (en) * 2014-07-01 2015-12-15 Amphivena Therapeutics, Inc. Bispecific CD33 and CD3 binding proteins
EP3936145A1 (en) * 2014-07-31 2022-01-12 The University Of Western Australia A method for the identification of immunotherapy-drug combinations using a network approach
AU2015300006B2 (en) * 2014-08-07 2018-08-30 Haruki Okamura Therapeutic agent for cancer which comprises combination of IL-18 and molecule-targeting antibody
US20180228775A1 (en) * 2014-09-08 2018-08-16 Dana-Farber Cancer Institute, Inc. Methods of treating cancer
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
AU2015346295A1 (en) 2014-11-13 2017-05-25 The Johns Hopkins University Checkpoint blockade and microsatellite instability
WO2016123573A1 (en) 2015-01-30 2016-08-04 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
US11596652B2 (en) 2015-02-18 2023-03-07 Enlivex Therapeutics R&D Ltd Early apoptotic cells for use in treating sepsis
US11304976B2 (en) 2015-02-18 2022-04-19 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11000548B2 (en) 2015-02-18 2021-05-11 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11497767B2 (en) 2015-02-18 2022-11-15 Enlivex Therapeutics R&D Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11512289B2 (en) 2015-02-18 2022-11-29 Enlivex Therapeutics Rdo Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11318163B2 (en) 2015-02-18 2022-05-03 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
CN107708756A (zh) 2015-04-10 2018-02-16 哈佛学院院长等 免疫细胞捕获装置及其制备和使用方法
EP3283107B1 (en) * 2015-04-17 2020-05-27 Bristol-Myers Squibb Company Compositions comprising a combination of ipilimumab and nivolumab
EP3285877B1 (en) 2015-04-21 2022-10-19 Enlivex Therapeutics Rdo Ltd Therapeutic pooled blood apoptotic cell preparations and uses thereof
CN108137686B (zh) 2015-05-07 2022-06-17 阿吉纳斯公司 抗ox40抗体及其使用方法
CA2987037A1 (en) 2015-05-29 2016-12-08 Amphivena Therapeutics, Inc. Use of cd33/cd3 bispecific tandem diabodies for the treatment of acute myeloid leukemia (aml)
EP3328362A4 (en) * 2015-07-29 2019-03-06 Nanotics, LLC MODULAR COMPOSITIONS FOR THE DISPOSAL OF SOLUBLE BIOMOLECULES AND RELATED METHODS
LU92821B1 (en) * 2015-09-09 2017-03-20 Mologen Ag Combination comprising immunostimulatory oligonucleotides
NZ740616A (en) 2015-09-14 2023-05-26 Infinity Pharmaceuticals Inc Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
CA2998644A1 (en) 2015-09-18 2017-03-23 Arch Oncology, Inc. Therapeutic cd47 antibodies
CR20180234A (es) 2015-11-03 2018-09-11 Janssen Biotech Inc Anticuerpos que se unen especificamente a pd-1 y sus usos
IL299072A (en) 2015-12-02 2023-02-01 Memorial Sloan Kettering Cancer Center Antibodies and methods of use thereof
CN115531609A (zh) 2016-02-06 2022-12-30 哈佛学院校长同事会 重塑造血巢以重建免疫
AU2017219415B2 (en) 2016-02-18 2023-08-10 Enlivex Therapeutics Rdo Ltd Combination immune therapy and cytokine control therapy for cancer treatment
WO2017143308A1 (en) * 2016-02-19 2017-08-24 Virogin Biotech Canada Ltd Compositions and methods of using stat1/3 inhibitors with oncolytic herpes virus
KR102710759B1 (ko) * 2016-03-14 2024-09-25 밀레니엄 파머슈티컬스 인코퍼레이티드 이식편대숙주 질환을 예방하는 방법
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
EP3464349A4 (en) 2016-05-23 2020-08-26 New York University COMPOSITIONS AND METHODS ASSOCIATED WITH ANTIBODIES TARGETING STAPHYLOCCAL LEUCOTOXINS
CA3025713A1 (en) * 2016-06-06 2017-12-14 SOTIO a.s. Immunotherapy for cancer
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN115305229B (zh) 2016-07-13 2025-08-19 哈佛学院院长等 抗原呈递细胞模拟支架及其制备和使用方法
JP7274214B2 (ja) 2016-08-02 2023-05-16 プレジデント アンド フェローズ オブ ハーバード カレッジ 免疫応答を調節するための生体材料
EP3529276A4 (en) 2016-10-21 2020-06-17 Arch Oncology, Inc. CD47 THERAPEUTIC ANTIBODIES
EP3538152A4 (en) 2016-11-09 2020-09-30 Agenus Inc. ANTI-OX40 ANTIBODIES, ANTI-GITR ANTIBODIES, AND PROCESSES FOR USE
AU2018240377A1 (en) * 2017-03-22 2019-10-31 Arch Oncology, Inc. Combination therapy for the treatment of solid and hematological cancers
KR102653567B1 (ko) * 2017-03-28 2024-04-02 오하이오 스테이트 이노베이션 파운데이션 인간 pd1 펩티드 백신 및 이의 용도
CN107082812B (zh) 2017-03-29 2018-11-13 上海科医联创生物科技有限公司 一种恢复衰竭性免疫细胞功能的融合蛋白及其应用
US20200108066A1 (en) * 2017-03-30 2020-04-09 Shorn Goel Methods for modulating regulatory t cells and immune responses using cdk4/6 inhibitors
JOP20190222A1 (ar) * 2017-04-11 2019-09-24 Zymeworks Inc الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3
CN110869049A (zh) * 2017-06-09 2020-03-06 葛兰素史克知识产权开发有限公司 组合疗法
CA3066007A1 (en) * 2017-06-09 2018-12-13 Glaxosmithkline Intellectual Property Development Limited Combination therapy with icos agonist and ox40 agonist to treat cancer
US12398209B2 (en) 2018-01-22 2025-08-26 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-PD-1 antibodies
WO2020061129A1 (en) 2018-09-19 2020-03-26 President And Fellows Of Harvard College Compositions and methods for labeling and modulation of cells in vitro and in vivo
CN109886170B (zh) * 2019-02-01 2019-12-17 河海大学 一种钉螺智能检测识别与统计系统
CN109884319B (zh) * 2019-03-21 2022-05-10 福建师范大学 一种卵巢癌肿瘤标记物的双模式免疫分析方法
EP3725370A1 (en) 2019-04-19 2020-10-21 ImmunoBrain Checkpoint, Inc. Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease
CA3196402A1 (en) * 2020-10-22 2022-04-28 Dale L. Ludwig Combination radioimmunotherapy and cd47 blockade in the treatment of cancer
JPWO2024101382A1 (OSRAM) * 2022-11-09 2024-05-16
CN117054649A (zh) * 2023-08-04 2023-11-14 广州中医药大学第一附属医院 一种慢性萎缩性胃炎向胃癌转化标志物及其应用
CN120420412A (zh) * 2025-07-04 2025-08-05 山东大学齐鲁医院 Ildr3基因和/或ildr3蛋白在制备预防和/或治疗肿瘤的药物、诊断肿瘤的产品中的应用
CN120505318A (zh) * 2025-07-22 2025-08-19 山东大学齐鲁医院 LSR、LncRNA-LSR-AS1或靶向siRNA在预防和/或治疗高脂血症或其相关疾病中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2767135B1 (fr) * 1997-08-06 2002-07-12 Genset Sa Recepteur complexe lsr, activite, clonage, et application au diagnostic, a la prevention et/ou au traitement de d'obesite et des risques ou complications associes
AU4082100A (en) * 1999-06-18 2001-01-09 Immunex Corporation Lsr, a cdna of the ig superfamily expressed in human leukocytes
US20120064100A1 (en) * 2009-03-18 2012-03-15 Simon Barry Biomarkers and uses thereof
EP2697256A1 (en) * 2011-04-15 2014-02-19 Compugen Ltd. Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer

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