BR112014017645A2 - molécula imunológica; polinucleotídeo; vetor; célula recombinante que compreende o vetor; método para produzir molécula imunológica; anticorpo ou fragmento de ligação de antígeno do mesmo; composição farmacêutica; uso da molécula imunológica, do anticorpo, do fragmento de ligação de anticorpo ou da composição farmacêutica; método diagnóstico para diagnosticar uma doença em um indivíduo, em que a doença é selecionada do grupo que consiste em câncer, uma doença autoimune ou uma doença infecciosa; ensaio para diagnosticar uma doença em uma amostra de tecido tomada de um indivíduo; uso de um anticorpo ou um fragmento que se liga especificamente à seq id no: 10; e método diagnóstico para determinar se realiza o uso ou administra a composição - Google Patents

molécula imunológica; polinucleotídeo; vetor; célula recombinante que compreende o vetor; método para produzir molécula imunológica; anticorpo ou fragmento de ligação de antígeno do mesmo; composição farmacêutica; uso da molécula imunológica, do anticorpo, do fragmento de ligação de anticorpo ou da composição farmacêutica; método diagnóstico para diagnosticar uma doença em um indivíduo, em que a doença é selecionada do grupo que consiste em câncer, uma doença autoimune ou uma doença infecciosa; ensaio para diagnosticar uma doença em uma amostra de tecido tomada de um indivíduo; uso de um anticorpo ou um fragmento que se liga especificamente à seq id no: 10; e método diagnóstico para determinar se realiza o uso ou administra a composição

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Publication number
BR112014017645A2
BR112014017645A2 BR112014017645A BR112014017645A BR112014017645A2 BR 112014017645 A2 BR112014017645 A2 BR 112014017645A2 BR 112014017645 A BR112014017645 A BR 112014017645A BR 112014017645 A BR112014017645 A BR 112014017645A BR 112014017645 A2 BR112014017645 A2 BR 112014017645A2
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Brazil
Prior art keywords
disease
antibody
diagnosing
vector
individual
Prior art date
Application number
BR112014017645A
Other languages
English (en)
Portuguese (pt)
Inventor
Pow Andrew
S Cojocaru Gady
Rotman Galit
Dassa Liat
Levy Ofer
Sameach Greenwald Shirley
Levine Zurit
Original Assignee
Compugen Ltd
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Publication date
Application filed by Compugen Ltd filed Critical Compugen Ltd
Publication of BR112014017645A2 publication Critical patent/BR112014017645A2/pt

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Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007070660A2 (en) 2005-12-13 2007-06-21 President And Fellows Of Harvard College Scaffolds for cell transplantation
CA2813751C (en) 2010-10-06 2019-11-12 President And Fellows Of Harvard College Injectable, pore-forming hydrogels for materials-based cell therapies
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
US9937249B2 (en) 2012-04-16 2018-04-10 President And Fellows Of Harvard College Mesoporous silica compositions for modulating immune responses
US9890215B2 (en) * 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
ES2786083T3 (es) 2012-12-12 2020-10-08 Arch Oncology Inc Anticuerpos terapéuticos CD47
US9221908B2 (en) 2012-12-12 2015-12-29 Vasculox, Inc. Therapeutic CD47 antibodies
US9433689B2 (en) * 2013-03-12 2016-09-06 The Board Of Trustees Of The Leland Stanford Junio Probes and methods of imaging non-Hodgkins lymphoma
EP3041500B1 (en) * 2013-09-06 2021-05-19 New York University Method for inducing antitumor immunity using sindbis viral vectors and tumor associated antigens
JP6466924B2 (ja) 2013-10-04 2019-02-06 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環式化合物及びその使用
ES2989358T3 (es) 2013-12-05 2024-11-26 Rfemb Holdings Llc Inmunoterapia del cáncer por rotura de la membrana eléctrica por radiofrecuencia (RF-EMB)
WO2015098113A1 (ja) * 2013-12-27 2015-07-02 独立行政法人医薬基盤研究所 悪性腫瘍の治療薬
US9394365B1 (en) 2014-03-12 2016-07-19 Yeda Research And Development Co., Ltd Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease
KR20200029627A (ko) 2014-03-12 2020-03-18 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소
US10519237B2 (en) 2014-03-12 2019-12-31 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
US10618963B2 (en) 2014-03-12 2020-04-14 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
EP4066834A1 (en) 2014-03-19 2022-10-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
US20150283237A1 (en) * 2014-04-02 2015-10-08 Mitchell S. Felder Ctla-4 blockade with metronomic chemotherapy for the treatment of cancer
WO2015168379A2 (en) 2014-04-30 2015-11-05 President And Fellows Of Harvard College Combination vaccine devices and methods of killing cancer cells
AU2015259516B2 (en) 2014-05-13 2020-05-28 Bavarian Nordic A/S Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and a monoclonal antibody against TIM-3
US10092645B2 (en) * 2014-06-17 2018-10-09 Medimmune Limited Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy
US9212225B1 (en) * 2014-07-01 2015-12-15 Amphivena Therapeutics, Inc. Bispecific CD33 and CD3 binding proteins
EP3195168B1 (en) * 2014-07-31 2022-09-07 The University Of Western Australia A method for the identification of immunotherapy-drug combinations using a network approach
JP6245622B2 (ja) * 2014-08-07 2017-12-13 学校法人兵庫医科大学 Ｉｌ−１８と分子標的抗体とを併用する癌治療薬
AU2015315324A1 (en) * 2014-09-08 2017-03-09 Dana-Farber Cancer Institute, Inc. Methods of treating cancer comprising administering a PPAR-gamma agonist
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
AU2015346295A1 (en) 2014-11-13 2017-05-25 The Johns Hopkins University Checkpoint blockade and microsatellite instability
US11786457B2 (en) 2015-01-30 2023-10-17 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
US11497767B2 (en) 2015-02-18 2022-11-15 Enlivex Therapeutics R&D Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11000548B2 (en) 2015-02-18 2021-05-11 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11318163B2 (en) 2015-02-18 2022-05-03 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11304976B2 (en) 2015-02-18 2022-04-19 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
AU2016221305B2 (en) 2015-02-18 2021-05-27 Enlivex Therapeutics Rdo Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11596652B2 (en) 2015-02-18 2023-03-07 Enlivex Therapeutics R&D Ltd Early apoptotic cells for use in treating sepsis
JP7094533B2 (ja) 2015-04-10 2022-07-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 免疫細胞捕捉デバイスおよびその製造および使用方法
CN107743401B (zh) * 2015-04-17 2021-08-24 百时美施贵宝公司 包含抗pd-1抗体和另外的抗体的组合的组合物
EP3285877B1 (en) 2015-04-21 2022-10-19 Enlivex Therapeutics Rdo Ltd Therapeutic pooled blood apoptotic cell preparations and uses thereof
MA42043A (fr) 2015-05-07 2018-03-14 Agenus Inc Anticorps anti-ox40 et procédés d'utilisation de ceux-ci
EA201792581A1 (ru) 2015-05-29 2018-07-31 Амфивена Терапьютикс, Инк. Способы применения биспецифических cd33- и cd3- связывающих белков
CN114146056A (zh) * 2015-07-29 2022-03-08 纳米提克斯有限责任公司 用于清除可溶性生物分子的模块化组合物及其相关方法
LU92821B1 (en) * 2015-09-09 2017-03-20 Mologen Ag Combination comprising immunostimulatory oligonucleotides
JP6980649B2 (ja) 2015-09-14 2021-12-15 インフィニティー ファーマシューティカルズ， インコーポレイテッド イソキノリノン誘導体の固体形態、それを製造する方法、それを含む組成物、及びそれを使用する方法
CN116425875A (zh) 2015-09-18 2023-07-14 安驰肿瘤公司 治疗性cd47抗体
CA3004117A1 (en) 2015-11-03 2017-05-11 Janssen Biotech, Inc. Antibodies specifically binding pd-1 and their uses
CA3007233A1 (en) 2015-12-02 2017-06-08 Agenus Inc. Antibodies and methods of use thereof
WO2017136837A1 (en) 2016-02-06 2017-08-10 President And Fellows Of Harvard College Recapitulating the hematopoietic niche to reconstitute immunity
CA3014885A1 (en) 2016-02-18 2017-08-24 Enlivex Therapeutics Ltd. Combination immune therapy and cytokine control therapy for cancer treatment
WO2017143308A1 (en) * 2016-02-19 2017-08-24 Virogin Biotech Canada Ltd Compositions and methods of using stat1/3 inhibitors with oncolytic herpes virus
MX2018011169A (es) * 2016-03-14 2018-12-06 Millennium Pharm Inc Metodo para prevenir la enfermedad del injerto contra huesped.
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
EP3464349A4 (en) 2016-05-23 2020-08-26 New York University COMPOSITIONS AND METHODS ASSOCIATED WITH ANTIBODIES TARGETING STAPHYLOCCAL LEUCOTOXINS
CN109310723A (zh) * 2016-06-06 2019-02-05 Sotio公司 癌症的免疫疗法
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN109789092A (zh) 2016-07-13 2019-05-21 哈佛学院院长等 抗原呈递细胞模拟支架及其制备和使用方法
WO2018026884A1 (en) 2016-08-02 2018-02-08 President And Fellows Of Harvard College Biomaterials for modulating immune responses
WO2018075960A1 (en) 2016-10-21 2018-04-26 Tioma Therapeutics, Inc. Therapeutic cd47 antibodies
AU2017359467A1 (en) 2016-11-09 2019-05-02 Agenus Inc. Anti-OX40 antibodies, anti-GITR antibodies, and methods of use thereof
SG11201908602UA (en) * 2017-03-22 2019-10-30 Arch Oncology Inc Combination therapy for the treatment of solid and hematological cancers
BR112019020386A2 (pt) * 2017-03-28 2020-06-09 Mayo Found Medical Education & Res vacinas de peptídeos de pd-1 humana e usos das mesmas
CN107082812B (zh) 2017-03-29 2018-11-13 上海科医联创生物科技有限公司 一种恢复衰竭性免疫细胞功能的融合蛋白及其应用
WO2018183479A1 (en) * 2017-03-30 2018-10-04 Dana-Farber Cancer Institute, Inc. Methods for modulating regulatory t cells and immune responses using cdk4/6 inhibitors
JOP20190222A1 (ar) * 2017-04-11 2019-09-24 Zymeworks Inc الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3
EP3634483A1 (en) * 2017-06-09 2020-04-15 GlaxoSmithKline Intellectual Property Development Limited Combination therapy
CN110709423A (zh) * 2017-06-09 2020-01-17 葛兰素史克知识产权开发有限公司 用icos激动剂和ox40激动剂治疗癌症的组合疗法
US12398209B2 (en) 2018-01-22 2025-08-26 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-PD-1 antibodies
WO2020061129A1 (en) 2018-09-19 2020-03-26 President And Fellows Of Harvard College Compositions and methods for labeling and modulation of cells in vitro and in vivo
CN109886170B (zh) * 2019-02-01 2019-12-17 河海大学 一种钉螺智能检测识别与统计系统
CN109884319B (zh) * 2019-03-21 2022-05-10 福建师范大学 一种卵巢癌肿瘤标记物的双模式免疫分析方法
EP3725370A1 (en) 2019-04-19 2020-10-21 ImmunoBrain Checkpoint, Inc. Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease
WO2022087416A1 (en) * 2020-10-22 2022-04-28 Actinium Pharmaceuticals, Inc. Combination radioimmunotherapy and cd47 blockade in the treatment of cancer
WO2024101382A1 (ja) * 2022-11-09 2024-05-16 学校法人 岩手医科大学 免疫チェックポイントの調節に用いるための組成物
CN117054649A (zh) * 2023-08-04 2023-11-14 广州中医药大学第一附属医院 一种慢性萎缩性胃炎向胃癌转化标志物及其应用
CN120420412A (zh) * 2025-07-04 2025-08-05 山东大学齐鲁医院 Ildr3基因和/或ildr3蛋白在制备预防和/或治疗肿瘤的药物、诊断肿瘤的产品中的应用
CN120505318A (zh) * 2025-07-22 2025-08-19 山东大学齐鲁医院 LSR、LncRNA-LSR-AS1或靶向siRNA在预防和/或治疗高脂血症或其相关疾病中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2767135B1 (fr) * 1997-08-06 2002-07-12 Genset Sa Recepteur complexe lsr, activite, clonage, et application au diagnostic, a la prevention et/ou au traitement de d'obesite et des risques ou complications associes
WO2000078962A1 (en) * 1999-06-18 2000-12-28 Immunex Corporation Lsr, a cdna of the ig superfamily expressed in human leukocytes
EP2408934B1 (en) * 2009-03-18 2014-11-12 Adelaide Research & Innovation Pty Ltd. Peptidase inhibitor 16 (pi16) as a biomarker for regulatory t (treg) cells and uses thereof
JP2014517685A (ja) * 2011-04-15 2014-07-24 コンピュゲン エルティーディー． 免疫関連疾患およびがんの治療のためのポリペプチドおよびポリヌクレオチドならびにそれらの使用

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