IN2014DN07325A - - Google Patents
Info
- Publication number
- IN2014DN07325A IN2014DN07325A IN7325DEN2014A IN2014DN07325A IN 2014DN07325 A IN2014DN07325 A IN 2014DN07325A IN 7325DEN2014 A IN7325DEN2014 A IN 7325DEN2014A IN 2014DN07325 A IN2014DN07325 A IN 2014DN07325A
- Authority
- IN
- India
- Prior art keywords
- roflumilast
- preparation
- provides
- vic
- synthesis
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 abstract 2
- 229960002586 roflumilast Drugs 0.000 abstract 2
- -1 N-substituted benzamides Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
- C07C43/2055—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring containing more than one ether bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/307—Compounds having groups having acetal carbon atoms bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/072020 WO2013131255A1 (en) | 2012-03-07 | 2012-03-07 | Preparation method of roflumilast |
| PCT/CN2013/072286 WO2013131484A1 (en) | 2012-03-07 | 2013-03-07 | Process for preparation of roflumilast |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN07325A true IN2014DN07325A (da) | 2015-04-24 |
Family
ID=49115870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN7325DEN2014 IN2014DN07325A (da) | 2012-03-07 | 2013-03-07 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9085533B2 (da) |
| EP (1) | EP2822929B1 (da) |
| JP (1) | JP6122042B2 (da) |
| KR (1) | KR101680182B1 (da) |
| AU (1) | AU2013230356B2 (da) |
| BR (1) | BR112014022074A2 (da) |
| CA (1) | CA2865539C (da) |
| ES (1) | ES2640470T3 (da) |
| IL (1) | IL234366A (da) |
| IN (1) | IN2014DN07325A (da) |
| NZ (1) | NZ629161A (da) |
| TW (1) | TWI460163B (da) |
| WO (2) | WO2013131255A1 (da) |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2102036T3 (es) | 1992-06-15 | 1997-07-16 | Celltech Therapeutics Ltd | Derivados con grupo fenilo trisustituido utilizados como inhibidores selectivos de la fosfodiesterasa iv. |
| CZ14795A3 (en) | 1992-07-28 | 1996-07-17 | Rhone Poulenc Rorer Ltd | Benzene derivative containing phenyl group bound to aryl or heteroaryl fraction through an aliphatic or hetero atom containing group, process of its preparation and pharmaceutical composition containing thereof |
| DE59410119D1 (de) | 1993-07-02 | 2002-06-20 | Byk Gulden Lomberg Chem Fab | Fluoralkoxy substituierte benzamide und ihre verwendung als zyklisch-nukleotid phosphodiesterase-inhibitoren |
| JPH07316054A (ja) * | 1993-09-06 | 1995-12-05 | Ishihara Sangyo Kaisha Ltd | ピリダジノン誘導体またはその塩、それらの製造方法およびそれらを含有する抗ショック剤 |
| EP1289961A1 (en) | 2000-05-25 | 2003-03-12 | Merck Frosst Canada & Co. | Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor |
| JP4182218B2 (ja) * | 2001-05-30 | 2008-11-19 | 学校法人東京理科大学 | アポトーシスを誘導する新規なグルコース誘導体、その製造方法及び医薬としてのその用途 |
| US6822114B1 (en) | 2002-10-08 | 2004-11-23 | Albemarle Corporation | Process for production of fluoroalkoxy-substituted benzamides and their intermediates |
| ES2335498T3 (es) * | 2003-03-10 | 2010-03-29 | Nycomed Gmbh | Nuevo proceso para la preparacion de reflumilast. |
| CA2542277A1 (en) * | 2003-10-21 | 2005-05-12 | Pharmacia Corporation | Method for the treatment or prevention of respiratory inflammation with a cyclooxygenase-2 inhibitor in combination with a phosphodiesterase 4 inhibitor and compositions therewith |
| JP4996834B2 (ja) * | 2005-07-06 | 2012-08-08 | 高砂香料工業株式会社 | バニリンアセタール類およびそれを含有する感覚刺激剤組成物 |
| CN101490004B (zh) | 2006-07-14 | 2012-01-11 | 奇斯药制品公司 | 作为磷酸二酯酶抑制剂的1-苯基-2-吡啶基烯基醇的衍生物 |
| EP1975166A1 (en) * | 2007-03-30 | 2008-10-01 | Bayer Schering Pharma AG | Synthesis of anthranilamides |
| CN102336703B (zh) * | 2011-07-20 | 2013-09-25 | 华润赛科药业有限责任公司 | 一种制备罗氟司特的方法 |
| CN102351787B (zh) * | 2011-08-18 | 2014-08-13 | 天津市汉康医药生物技术有限公司 | 高生物利用度的罗氟司特化合物 |
-
2012
- 2012-03-07 WO PCT/CN2012/072020 patent/WO2013131255A1/en not_active Ceased
-
2013
- 2013-03-07 JP JP2014560237A patent/JP6122042B2/ja active Active
- 2013-03-07 NZ NZ629161A patent/NZ629161A/en not_active IP Right Cessation
- 2013-03-07 IN IN7325DEN2014 patent/IN2014DN07325A/en unknown
- 2013-03-07 ES ES13757220.2T patent/ES2640470T3/es active Active
- 2013-03-07 AU AU2013230356A patent/AU2013230356B2/en not_active Ceased
- 2013-03-07 CA CA2865539A patent/CA2865539C/en active Active
- 2013-03-07 WO PCT/CN2013/072286 patent/WO2013131484A1/en not_active Ceased
- 2013-03-07 EP EP13757220.2A patent/EP2822929B1/en active Active
- 2013-03-07 TW TW102108114A patent/TWI460163B/zh active
- 2013-03-07 KR KR1020147028243A patent/KR101680182B1/ko active Active
- 2013-03-07 BR BR112014022074A patent/BR112014022074A2/pt not_active IP Right Cessation
- 2013-03-07 US US14/382,967 patent/US9085533B2/en active Active
-
2014
- 2014-08-28 IL IL234366A patent/IL234366A/en active IP Right Grant
-
2015
- 2015-06-10 US US14/736,062 patent/US9233925B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20150025246A1 (en) | 2015-01-22 |
| WO2013131255A1 (en) | 2013-09-12 |
| NZ629161A (en) | 2015-08-28 |
| EP2822929A1 (en) | 2015-01-14 |
| JP2015510869A (ja) | 2015-04-13 |
| CA2865539C (en) | 2016-08-23 |
| WO2013131484A1 (en) | 2013-09-12 |
| US9085533B2 (en) | 2015-07-21 |
| TW201341362A (zh) | 2013-10-16 |
| KR101680182B1 (ko) | 2016-11-28 |
| BR112014022074A2 (pt) | 2018-05-22 |
| US20150274667A1 (en) | 2015-10-01 |
| EP2822929B1 (en) | 2017-06-14 |
| AU2013230356A1 (en) | 2014-09-25 |
| US9233925B2 (en) | 2016-01-12 |
| JP6122042B2 (ja) | 2017-04-26 |
| ES2640470T3 (es) | 2017-11-03 |
| IL234366A (en) | 2016-12-29 |
| TWI460163B (zh) | 2014-11-11 |
| CA2865539A1 (en) | 2013-09-12 |
| EP2822929A4 (en) | 2016-01-13 |
| AU2013230356B2 (en) | 2016-12-22 |
| KR20140138879A (ko) | 2014-12-04 |
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