IN2014DN06797A - - Google Patents

Download PDF

Info

Publication number
IN2014DN06797A
IN2014DN06797A IN6797DEN2014A IN2014DN06797A IN 2014DN06797 A IN2014DN06797 A IN 2014DN06797A IN 6797DEN2014 A IN6797DEN2014 A IN 6797DEN2014A IN 2014DN06797 A IN2014DN06797 A IN 2014DN06797A
Authority
IN
India
Prior art keywords
wells
sensor wells
array
supporting
sensor
Prior art date
Application number
Inventor
Jason Robert Hyde
James Anthony Clarke
Gaëlle Anne Leonie ANDREATTA
Original Assignee
Oxford Nanopore Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Nanopore Tech Ltd filed Critical Oxford Nanopore Tech Ltd
Publication of IN2014DN06797A publication Critical patent/IN2014DN06797A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/453—Cells therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0472—Diffusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nanotechnology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

An apparatus for supporting an array of layers of amphiphilic molecules the apparatus comprising: a body (11) formed in a surface of the body an array of sensor wells (10) capable of supporting a layer of amphiphilic molecules (30) across the sensor wells the sensor wells each containing an electrode (12) for connection to an electrical circuit and formed in the surface of the body between the sensor wells flow control wells capable of smoothing the flow of a fluid across the surface.
IN6797DEN2014 2012-02-13 2013-02-13 IN2014DN06797A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1202519.3A GB201202519D0 (en) 2012-02-13 2012-02-13 Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
PCT/GB2013/050333 WO2013121193A2 (en) 2012-02-13 2013-02-13 Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules

Publications (1)

Publication Number Publication Date
IN2014DN06797A true IN2014DN06797A (en) 2015-05-22

Family

ID=45930075

Family Applications (1)

Application Number Title Priority Date Filing Date
IN6797DEN2014 IN2014DN06797A (en) 2012-02-13 2013-02-13

Country Status (10)

Country Link
US (3) US10338056B2 (en)
EP (1) EP2815234B1 (en)
JP (1) JP2015508164A (en)
CN (1) CN104246498B (en)
AU (1) AU2013220148B2 (en)
BR (1) BR112014019908A8 (en)
CA (1) CA2864397A1 (en)
GB (1) GB201202519D0 (en)
IN (1) IN2014DN06797A (en)
WO (1) WO2013121193A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2122344B8 (en) 2007-02-20 2019-08-21 Oxford Nanopore Technologies Limited Lipid bilayer sensor system
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
GB201418512D0 (en) 2014-10-17 2014-12-03 Oxford Nanopore Tech Ltd Electrical device with detachable components
GB201611770D0 (en) 2016-07-06 2016-08-17 Oxford Nanopore Tech Microfluidic device
JP6975609B2 (en) * 2017-10-19 2021-12-01 株式会社日立製作所 Hydrophilicity retaining substrate, measuring device, device and hydrophilicity retention method
GB2574048B (en) 2018-05-24 2021-06-16 Oxford Nanopore Tech Ltd Nanopore sensor component with electrostatic discharge protection
MX2019015848A (en) 2018-06-29 2020-08-03 Illumina Inc Flow cells.
KR20210138594A (en) 2019-03-12 2021-11-19 옥스포드 나노포어 테크놀로지즈 피엘씨 Nanopore sensing devices and methods of operating and forming them
JP7229110B2 (en) * 2019-06-25 2023-02-27 株式会社Ｓｃｒｅｅｎホールディングス Cell potential measuring device
CN113061531B (en) * 2021-06-03 2021-08-20 成都齐碳科技有限公司 Chip structure, chip assembly, film forming method, nanopore sequencing device and application
CN116297721A (en) * 2021-12-21 2023-06-23 成都齐碳科技有限公司 Film forming method, system comprising film and application
CN114908358B8 (en) * 2022-04-14 2024-06-21 孔确(成都)科技有限公司 Preparation method and device of amphiphilic molecular layer
CN116090080B (en) * 2023-04-07 2023-10-24 兰州有色冶金设计研究院有限公司 Design method for stepped steeping structure of full-section infiltration line of tailing dam

Family Cites Families (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3799743A (en) * 1971-11-22 1974-03-26 Alexander James Stable lysis responsive lipid bilayer
JPS5274882A (en) 1975-12-18 1977-06-23 Fujitsu Ltd Superhigh density liquid contact connector
US4154795A (en) 1976-07-23 1979-05-15 Dynatech Holdings Limited Microtest plates
ATE195022T1 (en) 1987-04-27 2000-08-15 Unilever Nv SPECIFIC BINDING TESTING METHODS
US4874500A (en) 1987-07-15 1989-10-17 Sri International Microelectrochemical sensor and sensor array
US5503803A (en) 1988-03-28 1996-04-02 Conception Technologies, Inc. Miniaturized biological assembly
ATE136119T1 (en) 1988-08-18 1996-04-15 Au Membrane & Biotech Res Inst IMPROVEMENTS IN THE SENSITIVITY AND SELECTIVITY OF ION CHANNEL MEMBRANE SENSORS
GB8924338D0 (en) 1989-10-28 1989-12-13 Atomic Energy Authority Uk Electrodes
JPH0414773A (en) 1990-05-07 1992-01-20 Fujitsu Ltd Electric connecting member and device
JPH04127066A (en) 1990-09-18 1992-04-28 Fujitsu Ltd Method and apparatus for connecting signal terminal
JPH04215052A (en) 1990-10-23 1992-08-05 Yokogawa Electric Corp Lipid film type chemical material sensor
CA2077286C (en) 1991-09-10 1996-08-06 Tatsuo Chiyonobu Electrical connecting method
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
JPH05274882A (en) 1992-03-25 1993-10-22 Seiko Epson Corp Semiconductor memory
CA2157503A1 (en) 1993-03-05 1994-09-15 John M. Riviello Pulsed electrochemical detection using polymer electroactive electrodes
WO1994025862A1 (en) 1993-05-04 1994-11-10 Washington State University Research Foundation Biosensor substrate for mounting bilayer lipid membrane containing a receptor
US6095148A (en) 1995-11-03 2000-08-01 Children's Medical Center Corporation Neuronal stimulation using electrically conducting polymers
JP3822946B2 (en) 1996-05-30 2006-09-20 三洋電機株式会社 Bilayer device
JP3961588B2 (en) 1996-06-18 2007-08-22 日本メジフィジックス株式会社 Radionuclide elution device packaging interior material
WO1998022819A1 (en) 1996-11-16 1998-05-28 Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen In Reutlingen Stiftung Bürgerlichen Rechts Array of microelements, method of contacting cells in a liquid environment and method for the production of an array of microelements
US6503452B1 (en) 1996-11-29 2003-01-07 The Board Of Trustees Of The Leland Stanford Junior University Biosensor arrays and methods
US7144486B1 (en) 1997-04-30 2006-12-05 Board Of Trustees Of The University Of Arkansas Multilayer microcavity devices and methods
US7169272B2 (en) 1997-04-30 2007-01-30 Board Of Trustees Of The University Of Arkansas Microfabricated recessed disk microelectrodes: characterization in static and convective solutions
GB9712386D0 (en) 1997-06-14 1997-08-13 Univ Coventry Biosensor
US6300138B1 (en) 1997-08-01 2001-10-09 Qualigen, Inc. Methods for conducting tests
US6129823A (en) 1997-09-05 2000-10-10 Abbott Laboratories Low volume electrochemical sensor
US6483931B2 (en) 1997-09-11 2002-11-19 Stmicroelectronics, Inc. Electrostatic discharge protection of a capacitve type fingerprint sensing array
US7244349B2 (en) 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
US20020144905A1 (en) 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
AU2536299A (en) 1998-02-17 1999-08-30 University Of Wales College Of Medicine Method and apparatus for introducing substances into the cell plasma membrane and/or cytosol
WO2000025121A1 (en) 1998-10-27 2000-05-04 President And Fellows Of Harvard College Biological ion channels in nanofabricated detectors
US6267872B1 (en) 1998-11-06 2001-07-31 The Regents Of The University Of California Miniature support for thin films containing single channels or nanopores and methods for using same
US6300141B1 (en) 1999-03-02 2001-10-09 Helix Biopharma Corporation Card-based biosensor device
US7223364B1 (en) 1999-07-07 2007-05-29 3M Innovative Properties Company Detection article having fluid control film
US6916488B1 (en) 1999-11-05 2005-07-12 Biocure, Inc. Amphiphilic polymeric vesicles
JP4014773B2 (en) 1999-12-28 2007-11-28 株式会社リコー Image recording method
AU2001234996A1 (en) 2000-02-11 2001-08-20 Yale University Planar patch clamp electrodes
EP1278821A4 (en) 2000-05-03 2005-11-09 Jen Gau Jr Biological identification system with integrated sensor chip
WO2002024862A2 (en) 2000-09-19 2002-03-28 Cytion S.A. Sample positioning and analysis system
JP4033768B2 (en) 2000-10-02 2008-01-16 ソフィオン・バイオサイエンス・アクティーゼルスカブ Electrophysiological measurement system
GB0026276D0 (en) 2000-10-27 2000-12-13 Univ Ulster Method for chlorine plasma modification of silver electrodes
CN1310379C (en) 2001-01-16 2007-04-11 郑慧光 Method for improving conductive performance of easily detachable connector for electric line
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
AU2002338371A1 (en) 2001-04-06 2002-10-21 The Regents Of The University Of California Silicon-wafer based devices and methods for analyzing biological material
CA2445316A1 (en) 2001-04-26 2002-11-07 Varian, Inc. Hollow fiber membrane sample preparation devices
US7077939B1 (en) 2001-06-18 2006-07-18 The Texas A&M University System Method and apparatus for nanoparticle transport and detection
DK2461156T3 (en) 2001-06-29 2020-08-03 Meso Scale Technologies Llc Device for luminescence test measurements
US6863833B1 (en) 2001-06-29 2005-03-08 The Board Of Trustees Of The Leland Stanford Junior University Microfabricated apertures for supporting bilayer lipid membranes
US6890409B2 (en) 2001-08-24 2005-05-10 Applera Corporation Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices
WO2003052420A2 (en) 2001-10-03 2003-06-26 Purdue Research Foundatio Device and bioanalytical method utilizing asymmetric biofunction alized membrane
US20050230272A1 (en) 2001-10-03 2005-10-20 Lee Gil U Porous biosensing device
WO2003046508A2 (en) 2001-11-09 2003-06-05 Biomicroarrays, Inc. High surface area substrates for microarrays and methods to make same
US6783645B2 (en) 2001-12-18 2004-08-31 Dionex Corporation Disposable working electrode for an electrochemical cell
JP4127066B2 (en) 2002-02-08 2008-07-30 東レ株式会社 Easily dyeable polyester fiber and method for producing the same
US20030224523A1 (en) 2002-05-30 2003-12-04 Thornberg John Herbert Cartridge arrangement, fluid analyzer arrangement, and methods
FR2844052B1 (en) 2002-08-28 2005-07-01 Commissariat Energie Atomique DEVICE FOR MEASURING THE ELECTRIC ACTIVITY OF BIOLOGICAL ELEMENTS AND ITS APPLICATIONS
US8679517B2 (en) * 2002-09-26 2014-03-25 Palmaz Scientific, Inc. Implantable materials having engineered surfaces made by vacuum deposition and method of making same
JP2004158330A (en) 2002-11-07 2004-06-03 Toshiba Corp Test socket of semiconductor device
EP1419818B1 (en) 2002-11-14 2013-10-30 Boehringer Ingelheim microParts GmbH Device for sequential transport of liquids by capillary forces
CN1232813C (en) 2003-03-13 2005-12-21 东南大学 Method for preparing probe tip of nano tube
US7745116B2 (en) 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
JP3801617B2 (en) 2003-06-27 2006-07-26 松下電器産業株式会社 Pharmacological measurement apparatus and system and well container used therefor
US7347921B2 (en) 2003-07-17 2008-03-25 Agilent Technologies, Inc. Apparatus and method for threading a biopolymer through a nanopore
JP4394917B2 (en) 2003-09-19 2010-01-06 独立行政法人科学技術振興機構 Current measuring device with artificial lipid bilayer membrane
JP4394916B2 (en) 2003-09-19 2010-01-06 独立行政法人科学技術振興機構 Artificial lipid bilayer membrane formation apparatus, artificial lipid bilayer membrane formation method, and use thereof
JP3769622B2 (en) 2003-09-22 2006-04-26 国立大学法人 東京大学 Artificial lipid membrane formation method and lipid planar membrane formation apparatus therefor
EP1678488A1 (en) 2003-10-22 2006-07-12 Ambri Limited Novel sensor configuration
JP2005164276A (en) 2003-11-28 2005-06-23 Sysmex Corp Analyzer and measuring unit
EP1535667A1 (en) 2003-11-28 2005-06-01 Sysmex Corporation Analyzer, assay cartridge and analyzing method
KR100540143B1 (en) 2003-12-22 2006-01-10 한국전자통신연구원 Microfluidic control device and method for controlling microfluidic
EP1548444A1 (en) * 2003-12-23 2005-06-29 Paul Scherrer Institut An assay chip, and uses of said assay chip to determine molecular structures and functions
WO2005071405A1 (en) * 2004-01-21 2005-08-04 Japan Science And Technology Agency Method of forming planar lipid double membrane for membrane protein analysis and apparatus therefor
US20060257941A1 (en) 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle and membrane sensor elements
JP2005300460A (en) 2004-04-15 2005-10-27 Sony Corp Interaction detecting section and substrate for bioassay equipped with the same, and medium dropping method and method for preventing water in medium from evaporating
WO2005124888A1 (en) 2004-06-08 2005-12-29 President And Fellows Of Harvard College Suspended carbon nanotube field effect transistor
US7622934B2 (en) 2004-07-23 2009-11-24 Electronic Bio Sciences, Llc Method and apparatus for sensing a time varying current passing through an ion channel
US7163830B2 (en) 2004-10-12 2007-01-16 Salmon Peter C Method for temporarily engaging electronic component for test
PL1859330T3 (en) 2005-01-28 2013-01-31 Univ Duke Apparatuses and methods for manipulating droplets on a printed circuit board
KR100698961B1 (en) 2005-02-04 2007-03-26 주식회사 아이센스 Electrochemical Biosensor
WO2006084472A1 (en) 2005-02-10 2006-08-17 Chempaq A/S Dual sample cartridge and method for characterizing particle in liquid
GB0505971D0 (en) 2005-03-23 2005-04-27 Isis Innovation Delivery of molecules to a lipid bilayer
WO2006104639A2 (en) 2005-03-29 2006-10-05 Stanford University Device comprising array of micro-or nano-reservoirs
US20060228402A1 (en) 2005-04-08 2006-10-12 Charite-Universitatsmedizin Berlin Techniques for forming a lipid bilayer membrane
EP1869226A4 (en) 2005-04-15 2009-03-18 Genencor Int Viral nucleoprotein detection using an ion channel switch biosensor
JP4953044B2 (en) 2005-05-09 2012-06-13 財団法人生産技術研究奨励会 Method and apparatus for forming lipid bilayer membrane
EP1909852A4 (en) 2005-06-16 2009-02-18 Univ California Amyloid beta protein channel structure and uses thereof indentifying potential drug molecules for neurodegenerative diseases
US7713218B2 (en) * 2005-06-23 2010-05-11 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
JP5114702B2 (en) 2005-07-29 2013-01-09 国立大学法人 東京大学 Method and apparatus for forming bilayer film by contact with amphiphilic monolayer
US8005526B2 (en) 2005-08-31 2011-08-23 The Regents Of The University Of Michigan Biologically integrated electrode devices
US8986781B2 (en) 2005-10-27 2015-03-24 Corning Incorporated Immobilized multi-layer artificial membrane for permeability measurements (PAMPA)
WO2007049576A1 (en) 2005-10-28 2007-05-03 Kuraray Co., Ltd. Cell culture container and cell culture method
RU2422204C2 (en) 2006-03-20 2011-06-27 Конинклейке Филипс Электроникс Н.В. Encased carrier system for electronic micro fluid devices
JP2009156572A (en) 2006-04-06 2009-07-16 National Institutes Of Natural Sciences Ion channel protein biosensor
US20070298511A1 (en) 2006-04-27 2007-12-27 The Texas A&M University System Nanopore sensor system
CN101490277B (en) 2006-05-17 2013-10-23 埃佩多夫阵列技术股份有限公司 Identification and quantification of plurality of biological (micro)organisms or their components
GB0614835D0 (en) 2006-07-26 2006-09-06 Isis Innovation Formation of bilayers of amphipathic molecules
US9018019B2 (en) 2006-10-04 2015-04-28 President And Fellows Of Harvard College Engineered conductive polymer films to mediate biochemical interactions
JP2008194573A (en) 2007-02-09 2008-08-28 Matsushita Electric Ind Co Ltd Lipid double film forming method
GB2446823A (en) 2007-02-20 2008-08-27 Oxford Nanolabs Ltd Formulation of lipid bilayers
EP2122344B8 (en) 2007-02-20 2019-08-21 Oxford Nanopore Technologies Limited Lipid bilayer sensor system
US20080254995A1 (en) * 2007-02-27 2008-10-16 Drexel University Nanopore arrays and sequencing devices and methods thereof
CA2684801C (en) 2007-04-04 2017-10-10 The Regents Of The University Of California Compositions, devices, systems, and methods for using a nanopore
CN100448007C (en) 2007-04-19 2008-12-31 浙江大学 Grid-shaped electrostatic discharge protection device
WO2008137008A2 (en) 2007-05-04 2008-11-13 Claros Diagnostics, Inc. Fluidic connectors and microfluidic systems
EP2169049B1 (en) 2007-06-18 2018-01-17 Kuraray Co., Ltd. Cell culture container and cell culture method
CN100523799C (en) 2007-06-27 2009-08-05 浙江大学 Polyelectrolyte / intrinsic conducting polymer composite humidity sensor and its production method
GB0716264D0 (en) 2007-08-21 2007-09-26 Isis Innovation Bilayers
EP3540436B1 (en) 2007-09-12 2023-11-01 President And Fellows Of Harvard College High-resolution molecular sensor
JP5441142B2 (en) 2007-11-26 2014-03-12 国立大学法人 東京大学 Microfluidic planar lipid bilayer array and analytical method using the planar lipid bilayer membrane
GB2467479B (en) 2007-11-30 2011-12-28 Electronic Bio Sciences Llc Method and apparatus for single side bilayer formation
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
ATE530497T1 (en) 2008-03-31 2011-11-15 Sony Deutschland Gmbh METHOD FOR PRODUCING A MEMBRANE WITH A CONICAL PORE
US8697007B2 (en) 2008-08-06 2014-04-15 The Trustees Of The University Of Pennsylvania Biodetection cassette with automated actuator
US20100190146A1 (en) 2009-01-29 2010-07-29 Bynum Magdalena A Microfluidic Glycan Analysis
EP2391655B1 (en) 2009-01-30 2017-10-11 Oxford Nanopore Technologies Limited Hybridization linkers
JP2010186677A (en) 2009-02-13 2010-08-26 Ritsumeikan Conductive structure, actuator, variable resistor, turning member, turning connector, electric motor, controller, rotation information detecting device, stroke detection device, and method of manufacturing conductive terminal
US8986928B2 (en) 2009-04-10 2015-03-24 Pacific Biosciences Of California, Inc. Nanopore sequencing devices and methods
AU2010240670B2 (en) 2009-04-20 2015-08-20 Oxford Nanopore Technologies Limited Lipid bilayer sensor array
GB0909923D0 (en) 2009-06-09 2009-07-22 Oxford Gene Tech Ip Ltd Picowell capture devices for analysing single cells or other particles
CA2772789C (en) 2009-09-18 2018-10-30 President And Fellows Of Harvard College Bare single-layer graphene membrane having a nanopore enabling high-sensitivity molecular detection and analysis
WO2011067559A1 (en) 2009-12-01 2011-06-09 Oxford Nanopore Technologies Limited Biochemical analysis instrument
US20120010085A1 (en) 2010-01-19 2012-01-12 Rava Richard P Methods for determining fraction of fetal nucleic acids in maternal samples
US20110287414A1 (en) 2010-02-08 2011-11-24 Genia Technologies, Inc. Systems and methods for identifying a portion of a molecule
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
KR20110100963A (en) 2010-03-05 2011-09-15 삼성전자주식회사 Microfluidic device and method for deterimining sequences of target nucleic acids using the same
WO2011118211A1 (en) 2010-03-23 2011-09-29 株式会社クラレ Culture method for causing differentiation of pluripotent mammalian cells
DE102010022929B4 (en) 2010-06-07 2013-07-18 Albert-Ludwigs-Universität Freiburg Method for producing a bilipid layer and microstructure and measuring arrangement
CN103392008B (en) 2010-09-07 2017-10-20 加利福尼亚大学董事会 Movement by continuation enzyme with the precision controlling DNA of a nucleotides in nano-pore
CN103370617B (en) 2010-10-01 2015-11-25 牛津纳米孔技术有限公司 Biochemical analysis equipment and rotary valve
WO2012107778A2 (en) 2011-02-11 2012-08-16 Oxford Nanopore Technologies Limited Mutant pores
US9347929B2 (en) 2011-03-01 2016-05-24 The Regents Of The University Of Michigan Controlling translocation through nanopores with fluid wall
CN103842519B (en) 2011-04-04 2018-02-06 哈佛大学校长及研究员协会 The nano-pore carried out by local potential measurement senses
JP2012247231A (en) 2011-05-25 2012-12-13 Fujikura Kasei Co Ltd Inspection instrument
CN102263104B (en) 2011-06-16 2013-04-17 北京大学 Electrostatic discharge (ESD) protection device with metal oxide semiconductor (MOS) structure
US10761043B2 (en) 2011-07-22 2020-09-01 The Trustees Of The University Of Pennsylvania Graphene-based nanopore and nanostructure devices and methods for macromolecular analysis
US10175195B2 (en) 2011-07-27 2019-01-08 The Board Of Trustees Of The University Of Illinois Nanopore sensors for biomolecular characterization
JP6457811B2 (en) 2011-09-23 2019-01-23 オックスフォード ナノポール テクノロジーズ リミテッド Analysis of polymers containing polymer units
US9758823B2 (en) 2011-10-21 2017-09-12 Oxford Nanopore Technologies Limited Enzyme method
US9696277B2 (en) 2011-11-14 2017-07-04 The Regents Of The University Of California Two-chamber dual-pore device
US10385382B2 (en) 2011-12-29 2019-08-20 Oxford Nanopore Technologies Ltd. Enzyme method
WO2013098561A1 (en) 2011-12-29 2013-07-04 Oxford Nanopore Technologies Limited Method for characterising a polynucelotide by using a xpd helicase
JP5898969B2 (en) 2012-01-18 2016-04-06 株式会社日立製作所 Semiconductor device
JP5912582B2 (en) 2012-01-27 2016-04-27 ローム株式会社 Microchip with built-in liquid reagent containing packaging material and method of using the same
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
US8541849B2 (en) 2012-02-14 2013-09-24 Genia Technologies, Inc. Noise shielding techniques for ultra low current measurements in biochemical applications
EP3736339B1 (en) 2012-02-16 2022-07-27 Oxford Nanopore Technologies plc Analysis of measurements of a polymer
AU2013221356B2 (en) 2012-02-16 2018-10-18 The Regents Of The University Of California Nanopore sensor for enzyme-mediated protein translocation
EP2836506B1 (en) 2012-04-10 2017-04-19 Oxford Nanopore Technologies Limited Mutant lysenin pores
US9758821B2 (en) 2012-04-17 2017-09-12 International Business Machines Corporation Graphene transistor gated by charges through a nanopore for bio-molecular sensing and DNA sequencing
JP5692164B2 (en) 2012-05-22 2015-04-01 ウシオ電機株式会社 Reagent supply method to microchip and reagent supply apparatus to microchip
CA2879355C (en) 2012-07-19 2021-09-21 Oxford Nanopore Technologies Limited Helicase construct and its use in characterising polynucleotides
CA2879261C (en) 2012-07-19 2022-12-06 Oxford Nanopore Technologies Limited Modified helicases
WO2014019603A1 (en) 2012-07-30 2014-02-06 Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universitaet Tuebingen Connector plate for a microfluidic sample chip, microfluidic sample chip and examination method using a microfluidic sample arrangement region
US10876157B2 (en) 2012-09-27 2020-12-29 The Trustees Of The University Of Pennsylvania Insulated nanoelectrode-nanopore devices and related methods
WO2014064444A1 (en) 2012-10-26 2014-05-01 Oxford Nanopore Technologies Limited Droplet interfaces
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
US9739714B2 (en) 2012-10-29 2017-08-22 Mbio Diagnostics, Inc. Particle identification system, cartridge and associated methods
DE112013000972T5 (en) 2013-02-26 2014-11-06 Hitachi, Ltd. FET array substrate, analysis system and analysis method
BR112015022755B8 (en) 2013-03-14 2020-08-04 Arkema Inc process for curing an elastomer composition, elastomer composition, method for making an article and process for reducing mold fouling in the presence of oxygen during the manufacture of elastomeric articles
JP2014190891A (en) 2013-03-28 2014-10-06 Hitachi High-Technologies Corp Voltage applying system of nanopore type analyzer
US9279801B2 (en) 2013-07-26 2016-03-08 Axion Biosystems, Inc. Devices, systems and methods for high-throughput electrophysiology
CN203466320U (en) 2013-09-20 2014-03-05 番禺得意精密电子工业有限公司 Electric connector
CN105899678A (en) 2013-10-18 2016-08-24 牛津纳米孔技术公司 Modified enzymes
CA2949984C (en) 2014-05-27 2021-10-19 Illumina, Inc. Systems and methods for biochemical analysis including a base instrument and a removable cartridge
CN103995035A (en) 2014-05-29 2014-08-20 东南大学 Multi-grid graphene field-effect tube structure for detection of base sequence and preparation method thereof
EP3154691B1 (en) 2014-06-16 2022-06-29 Siemens Healthineers Nederland B.V. Cartridge for fast sample intake
KR20170042794A (en) 2014-09-01 2017-04-19 브이아이비 브이지더블유 Mutant csgg pores
KR102551897B1 (en) 2014-10-16 2023-07-06 옥스포드 나노포어 테크놀로지즈 피엘씨 Analysis of a polymer
GB201418512D0 (en) 2014-10-17 2014-12-03 Oxford Nanopore Tech Ltd Electrical device with detachable components
CN105701440B (en) 2014-12-11 2019-01-15 义隆电子股份有限公司 fingerprint sensor with electrostatic protection
CN105701441B (en) 2014-12-15 2018-10-09 义隆电子股份有限公司 Sensing method and circuit of fingerprint sensor
US9658190B2 (en) 2014-12-18 2017-05-23 Genia Technologies, Inc. Printed electrode
JP6800862B2 (en) 2015-02-05 2020-12-16 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ Nanopore sensor including fluid passage
AU2016253147B2 (en) 2015-04-24 2021-07-22 Mesa Biotech, Inc. Fluidic test cassette
GB201508669D0 (en) 2015-05-20 2015-07-01 Oxford Nanopore Tech Ltd Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown
JPWO2017061600A1 (en) 2015-10-08 2018-08-02 凸版印刷株式会社 Microfluidic device and sample analysis method
GB201611770D0 (en) 2016-07-06 2016-08-17 Oxford Nanopore Tech Microfluidic device
CN205828393U (en) 2016-07-15 2016-12-21 中芯国际集成电路制造(北京)有限公司 A kind of high density gated diode for electrostatic discharge (ESD) protection
KR102377508B1 (en) 2017-06-21 2022-03-23 온테라 인크. Dual pore-control and sensor device
CA3076415C (en) 2017-09-28 2022-06-28 Oxford Nanopore Technologies Plc Kit of first and second parts adapted for connection to each other
GB2568895B (en) 2017-11-29 2021-10-27 Oxford Nanopore Tech Ltd Microfluidic device
CN111094976B (en) 2018-02-16 2022-05-13 伊鲁米纳公司 Apparatus for sequencing
GB2574048B (en) 2018-05-24 2021-06-16 Oxford Nanopore Tech Ltd Nanopore sensor component with electrostatic discharge protection
KR20210138594A (en) 2019-03-12 2021-11-19 옥스포드 나노포어 테크놀로지즈 피엘씨 Nanopore sensing devices and methods of operating and forming them

Also Published As

Publication number Publication date
US10338056B2 (en) 2019-07-02
US20230228733A1 (en) 2023-07-20
GB201202519D0 (en) 2012-03-28
US20190391128A1 (en) 2019-12-26
AU2013220148B2 (en) 2018-10-11
CN104246498A (en) 2014-12-24
CN104246498B (en) 2016-06-29
WO2013121193A2 (en) 2013-08-22
EP2815234B1 (en) 2018-04-11
EP2815234A2 (en) 2014-12-24
BR112014019908A2 (en) 2017-06-20
US11913936B2 (en) 2024-02-27
CA2864397A1 (en) 2013-08-22
BR112014019908A8 (en) 2017-07-11
WO2013121193A3 (en) 2013-10-24
AU2013220148A1 (en) 2014-08-28
US11561216B2 (en) 2023-01-24
US20150014160A1 (en) 2015-01-15
JP2015508164A (en) 2015-03-16

Similar Documents

Publication Publication Date Title
IN2014DN06797A (en)
WO2013113568A3 (en) Substrate holder and lithographic apparatus
IN2015DN01180A (en)
EP2838140B8 (en) Electrode having porous coating layer, manufacturing method thereof and electrochemical device containing the same
WO2011099831A3 (en) Flexible transparent heating element using graphene and method for manufacturing same
WO2014100027A3 (en) System and method for production reservoir and well management using continuous chemical measurement
EP2543086A4 (en) Semiconductor devices including an electrically percolating source layer and methods of fabricating the same
WO2013021095A3 (en) Field effect transistor apparatus, device and method for sensing deformation
WO2010014679A3 (en) Methods of making composite electrodes
SG10201402882PA (en) Chamber wall of a plasma processing apparatus including a flowing protective liquid layer
IN2015DN01179A (en)
MX2010000720A (en) Apparatus and method for removal of ions from a porous electrode that is part of a deionization system.
WO2013178722A3 (en) A device for treating a liquid
GB2514518A (en) Electronic Device With Inverted Liquid Crystal Display
EP3000599A4 (en) Multilayer structure having liquid layer on surface
WO2016106320A3 (en) Foldable opposing sensor array
IN2015DN02796A (en)
TW201614895A (en) Light-emitting element, display device, and lighting device
MX2016006182A (en) Folded core absorbent article and related method.
GB201306913D0 (en) A method of electrically measuring the size of individual particles flowing in a liquid
GB2497482A (en) Acoustic transducers using quantum tunneling composite active elements
WO2014038141A3 (en) Display unit, method of manufacturing display unit, and electronic apparatus
GB2534475A (en) Apparatus and methods for determining surface wetting of material under subterranian wellbore conditions
EP3037811A4 (en) Hydrogen ion electrode composed of composite material of nano iridium oxide and polymer resin and enabling surface regeneration, ph sensor using same, and method for manufacturing same
EP2879143A4 (en) Polarizable electrode material and electric double layer capacitor using same