IN2014DN03049A - - Google Patents
Info
- Publication number
- IN2014DN03049A IN2014DN03049A IN3049DEN2014A IN2014DN03049A IN 2014DN03049 A IN2014DN03049 A IN 2014DN03049A IN 3049DEN2014 A IN3049DEN2014 A IN 3049DEN2014A IN 2014DN03049 A IN2014DN03049 A IN 2014DN03049A
- Authority
- IN
- India
- Prior art keywords
- extracellular matrix
- tissue
- interstitial
- expression
- ecm
- Prior art date
Links
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 3
- 210000002744 extracellular matrix Anatomy 0.000 abstract 3
- 210000001519 tissue Anatomy 0.000 abstract 2
- 102000012422 Collagen Type I Human genes 0.000 abstract 1
- 108010022452 Collagen Type I Proteins 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 229960003151 mercaptamine Drugs 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 230000002206 pro-fibrotic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 231100000241 scar Toxicity 0.000 abstract 1
- 230000000451 tissue damage Effects 0.000 abstract 1
- 231100000827 tissue damage Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2011/057935 WO2013062544A1 (en) | 2011-10-26 | 2011-10-26 | Cysteamine in the treatment of fibrotic disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN03049A true IN2014DN03049A (enrdf_load_stackoverflow) | 2015-05-15 |
Family
ID=48168215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3049DEN2014 IN2014DN03049A (enrdf_load_stackoverflow) | 2011-10-26 | 2011-10-26 |
Country Status (7)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017004485A1 (en) * | 2015-07-02 | 2017-01-05 | Raptor Pharmaceuticals Inc. | Ado-resistant cysteamine analogs and uses thereof |
| JP7418958B2 (ja) | 2016-03-17 | 2024-01-22 | チオジェネシス セラピューティクス, インコーポレイテッド | システアミンの制御放出のための組成物及びシステアミン感受性障害の全身治療 |
| US10155948B2 (en) * | 2016-05-12 | 2018-12-18 | Kangwon National University University-Industry Cooperation Foundation and | Pharmaceutical composition for preventing or treating diabetic complications and screening method for preventive or therapeutic agent for diabetic complications |
| US10905660B2 (en) | 2016-06-07 | 2021-02-02 | Novabiotics Limited | Microparticles |
| GB201609940D0 (en) * | 2016-06-07 | 2016-07-20 | Novabiotics Ltd | Microparticles |
| EP3579923A4 (en) * | 2017-02-07 | 2020-11-18 | Children's Hospital Medical Center | CYSTEAMINE-INTERVENING ASTHMA TREATMENT |
| CN118924717A (zh) | 2017-09-20 | 2024-11-12 | 硫创治疗公司 | 用于治疗半胱胺敏感性病症的方法 |
| WO2019094862A1 (en) * | 2017-11-10 | 2019-05-16 | Wisconsin Alumni Research Foundation | Compositions and methods for the inhibition of fibrosis |
| EP3953468A4 (en) * | 2019-04-12 | 2023-01-11 | The Regents of The University of California | Methods for treating inherited eye defects |
| WO2022081716A1 (en) * | 2020-10-13 | 2022-04-21 | Accubit LLC - Biotechnology | Methods of treating iga nephropathy with thiol-containing molecules |
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| FR2549051B1 (fr) | 1983-06-22 | 1986-05-16 | Centre Nat Rech Scient | Nouveaux agents radioprotecteurs ayant une structure amino-thioalkyle et procede pour leur preparation |
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| FI906411A7 (fi) | 1988-06-28 | 1990-12-27 | La Jolla Cancer Res Foundation | Solujen lisääntymisen esto Decorinilla |
| US5705609A (en) | 1988-06-28 | 1998-01-06 | La Jolla Cancer Research Foundation | Decorin fragments inhibiting cell regulatory factors |
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| ATE154514T1 (de) | 1989-09-29 | 1997-07-15 | Jolla Cancer Res Found | Inhibierung des transformierenden wachstumsfaktor zur verhinderung der anhäufung extrazellulärer matrix |
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| WO1991010727A1 (en) | 1990-01-22 | 1991-07-25 | La Jolla Cancer Research Foundation | Inhibitors of cell regulatory factors |
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| WO1994009812A1 (en) | 1992-10-26 | 1994-05-11 | Kirin Brewery Company, Limited | METHOD FOR PRODUCING LARGE LATENT TRANSFORMING GROWTH FACTOR-β COMPLEXES AND LARGE LATENCY ASSOCIATED PEPTIDE |
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| AU6984594A (en) | 1993-06-15 | 1995-01-17 | Hun Taeg Chung | Anti-sense oligodeoxynucleotide to fibrogenic cytokines and use thereof |
| AU8016894A (en) | 1993-10-15 | 1995-05-04 | La Jolla Cancer Research Foundation | Betaglycan polypeptides having tgf-beta binding activity |
| ATE208494T1 (de) | 1994-05-04 | 2001-11-15 | Mount Sinai Hospital Corp | Modulatoren der cytokine der tgf-beta überfamilie und verfahren zu ihrer bestimmung |
| US5772995A (en) | 1994-07-18 | 1998-06-30 | Sidney Kimmel Cancer Center | Compositions and methods for enhanced tumor cell immunity in vivo |
| CA2156767A1 (en) | 1994-08-25 | 1996-02-26 | Kenichi Matsunaga | Binding agent for growth factor |
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| US5824655A (en) | 1995-02-15 | 1998-10-20 | The University Of Utah | Anti-transforming growth factor-β gene therapy |
| US5714519A (en) | 1995-06-07 | 1998-02-03 | Ergo Science Incorporated | Method for regulating glucose metabolism |
| GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
| CA2232682A1 (en) | 1996-04-30 | 1997-11-06 | Susan M. Richards | Use of prolactin as a tgf-beta antagonist |
| JPH1067674A (ja) | 1996-06-19 | 1998-03-10 | Advanced Sukin Res Kenkyusho:Kk | 細胞外マトリツクスの異常蓄積抑制剤 |
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| US6468522B1 (en) | 1999-07-22 | 2002-10-22 | University Of Medicine And Dentistry Of New Jersey | Controlled release of thioamide moiety-containing therapeutic agents |
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| GB0102665D0 (en) | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
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| GB0102672D0 (en) | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
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| DE102004019253A1 (de) | 2004-04-16 | 2005-11-10 | Codewrights Gmbh | Verfahren zum Fernbedienen eines Feldgerätes der Prozessautomatisierungstechnik |
| EP1786803A1 (en) | 2004-08-31 | 2007-05-23 | Biogen Idec MA, Inc. | Pyrimidinylpyrazoles as tgf-beta inhibitors |
| AU2005280168A1 (en) | 2004-08-31 | 2006-03-09 | Biogen Idec Ma Inc. | Pyrimidinylimidazoles as TGF-beta inhibitors |
| EP1812450A2 (en) | 2004-11-10 | 2007-08-01 | Eli Lilly And Company | Tgf-beta inhibitors |
| LT1850873T (lt) | 2005-02-08 | 2019-04-10 | Genzyme Corporation | Antikūnas prieš tgf beta |
| MX382184B (es) | 2006-01-27 | 2025-03-13 | Univ California | Cisteamina recubierta entericamente, cistamina y derivados de ellas. |
| AU2007328206B2 (en) * | 2006-12-04 | 2013-08-01 | Promedior, Inc. | Conjoint therapy for treating fibrotic diseases |
| MX2010005921A (es) * | 2007-11-30 | 2010-06-11 | Univ California | Metodos para tratar la esteatohepatitis no alcoholica (nash) usando productos de cisteamina. |
-
2011
- 2011-10-26 IN IN3049DEN2014 patent/IN2014DN03049A/en unknown
- 2011-10-26 MX MX2014004994A patent/MX2014004994A/es unknown
- 2011-10-26 WO PCT/US2011/057935 patent/WO2013062544A1/en active Application Filing
- 2011-10-26 AU AU2011379972A patent/AU2011379972B2/en not_active Expired - Fee Related
- 2011-10-26 US US14/353,273 patent/US9468612B2/en active Active
- 2011-10-26 BR BR112014009789A patent/BR112014009789A2/pt not_active IP Right Cessation
- 2011-10-26 CA CA2853484A patent/CA2853484C/en active Active
-
2016
- 2016-10-03 US US15/284,416 patent/US9925154B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2853484A1 (en) | 2013-05-02 |
| WO2013062544A1 (en) | 2013-05-02 |
| US9925154B2 (en) | 2018-03-27 |
| US20140275279A1 (en) | 2014-09-18 |
| BR112014009789A2 (pt) | 2017-04-25 |
| AU2011379972A1 (en) | 2014-05-15 |
| AU2011379972B2 (en) | 2016-05-12 |
| US20170165207A1 (en) | 2017-06-15 |
| US9468612B2 (en) | 2016-10-18 |
| CA2853484C (en) | 2018-08-21 |
| MX2014004994A (es) | 2014-08-27 |
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