IN2014DN00145A - - Google Patents

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Publication number
IN2014DN00145A
IN2014DN00145A IN145DEN2014A IN2014DN00145A IN 2014DN00145 A IN2014DN00145 A IN 2014DN00145A IN 145DEN2014 A IN145DEN2014 A IN 145DEN2014A IN 2014DN00145 A IN2014DN00145 A IN 2014DN00145A
Authority
IN
India
Prior art keywords
solid forms
amide
pharmaceutical compositions
present
relates
Prior art date
Application number
Other languages
English (en)
Inventor
Isabelle Sylvie Gallou
Cornelius Gauer
Frank Stowasser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IN2014DN00145A publication Critical patent/IN2014DN00145A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IN145DEN2014 2011-06-21 2012-06-19 IN2014DN00145A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161499222P 2011-06-21 2011-06-21
PCT/EP2012/061756 WO2012175522A1 (en) 2011-06-21 2012-06-19 Polymorphs of (s)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide

Publications (1)

Publication Number Publication Date
IN2014DN00145A true IN2014DN00145A (da) 2015-05-22

Family

ID=46319784

Family Applications (1)

Application Number Title Priority Date Filing Date
IN145DEN2014 IN2014DN00145A (da) 2011-06-21 2012-06-19

Country Status (11)

Country Link
US (1) US9006270B2 (da)
EP (1) EP2723733A1 (da)
JP (1) JP2014517049A (da)
KR (1) KR20140033432A (da)
CN (1) CN103619840B (da)
BR (1) BR112013032687A2 (da)
CA (1) CA2839621A1 (da)
IN (1) IN2014DN00145A (da)
MX (1) MX2013014887A (da)
RU (1) RU2014101626A (da)
WO (1) WO2012175522A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2796457T (lt) 2009-11-27 2016-09-12 Genzyme Corporation Genz 112638, skirtas gošė arba fabri ligos gydymui kombinuota terapija
CN104244949A (zh) * 2012-03-30 2014-12-24 诺华股份有限公司 用于治疗神经母细胞瘤、尤文氏肉瘤或横纹肌肉瘤的化合物
KR20160095035A (ko) * 2013-12-06 2016-08-10 노파르티스 아게 알파-이소형 선택성 포스파티딜이노시톨 3-키나제 억제제를 위한 투여 요법
JP6723229B2 (ja) * 2014-10-03 2020-07-15 ノバルティス アーゲー アルペリシブを含む医薬組成物
AU2020257301A1 (en) 2019-04-18 2021-11-11 The Johns Hopkins University Substituted 2-amino-pyrazolyl-(1,2,4)triazolo(1,5a) pyridine derivatives and use thereof
CN112961090A (zh) * 2019-12-13 2021-06-15 武汉九州钰民医药科技有限公司 合成Alpelisib的关键中间体及其制备方法
CN110964005A (zh) * 2019-12-16 2020-04-07 武汉九州钰民医药科技有限公司 一种Alpelisib的制备工艺
CN111057051A (zh) * 2019-12-16 2020-04-24 武汉九州钰民医药科技有限公司 PI3K抑制剂Alpelisib的新合成方法
JP2022061050A (ja) 2020-10-06 2022-04-18 エルジー ディスプレイ カンパニー リミテッド 伝送装置及び表示システム
KR20240004683A (ko) * 2021-05-03 2024-01-11 노파르티스 아게 알펠리십 제형

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY29149A1 (es) * 2004-10-07 2006-05-31 Boehringer Ingelheim Int Tiazolil-dihidro-indazoles
EP2016075A1 (en) * 2006-05-03 2009-01-21 AstraZeneca AB Thiazole derivatives and their use as anti-tumour agents
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
AR082418A1 (es) * 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico

Also Published As

Publication number Publication date
AU2012274141B2 (en) 2015-12-24
AU2012274141A1 (en) 2013-12-12
US9006270B2 (en) 2015-04-14
EP2723733A1 (en) 2014-04-30
JP2014517049A (ja) 2014-07-17
CN103619840A (zh) 2014-03-05
CA2839621A1 (en) 2012-12-27
MX2013014887A (es) 2014-02-17
WO2012175522A1 (en) 2012-12-27
RU2014101626A (ru) 2015-07-27
BR112013032687A2 (pt) 2016-08-30
KR20140033432A (ko) 2014-03-18
US20140171470A1 (en) 2014-06-19
CN103619840B (zh) 2016-01-20

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