IN2014CN04039A - - Google Patents

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Publication number
IN2014CN04039A
IN2014CN04039A IN4039CHN2014A IN2014CN04039A IN 2014CN04039 A IN2014CN04039 A IN 2014CN04039A IN 4039CHN2014 A IN4039CHN2014 A IN 4039CHN2014A IN 2014CN04039 A IN2014CN04039 A IN 2014CN04039A
Authority
IN
India
Prior art keywords
secretory production
heterologous protein
protein
activity
produce
Prior art date
Application number
Inventor
Yoshihiko Matsuda
Hiroshi Itaya
Yoshimi Kikuchi
Haruki Beppu
Jurgis Antanas Vladovich Jomantas
Ekaterina Aleksandrovna Kutukova
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2011144497/10A external-priority patent/RU2011144497A/en
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of IN2014CN04039A publication Critical patent/IN2014CN04039A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium

Abstract

A method for secretory production of a heterologous protein is provided by developing a novel technique for improving ability of a coryneform bacterium to produce a heterologous protein by secretory production. By utilizing a coryneform bacterium having an ability to produce a heterologous protein by secretory production which has been modified so that activity of a penicillin binding protein is reduced and in which activity of a cell surface layer protein has been reduced as an expression host a heterologous protein is produced by secretory production.
IN4039CHN2014 2011-11-02 2012-11-01 IN2014CN04039A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2011144497/10A RU2011144497A (en) 2011-11-02 2011-11-02 SECRETARY PROTEIN METHOD
JP2011240745 2011-11-02
PCT/JP2012/078906 WO2013065869A1 (en) 2011-11-02 2012-11-01 Method for secretory production of protein

Publications (1)

Publication Number Publication Date
IN2014CN04039A true IN2014CN04039A (en) 2015-10-23

Family

ID=47222244

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4039CHN2014 IN2014CN04039A (en) 2011-11-02 2012-11-01

Country Status (8)

Country Link
US (1) US9187554B2 (en)
EP (1) EP2748340B1 (en)
JP (1) JP6020581B2 (en)
KR (1) KR101653555B1 (en)
CN (1) CN103946371B (en)
AU (1) AU2012333451B2 (en)
IN (1) IN2014CN04039A (en)
WO (1) WO2013065869A1 (en)

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IN2014CN04039A (en) 2011-11-02 2015-10-23 Ajinomoto Kk
JP6136930B2 (en) 2011-11-02 2017-05-31 味の素株式会社 Protein secretory production
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BR112016008830B1 (en) 2013-10-23 2023-02-23 Ajinomoto Co., Inc METHOD FOR PRODUCING A TARGET SUBSTANCE
JP6573398B2 (en) * 2014-05-02 2019-09-11 国立大学法人信州大学 Antibody gene expression and secretion system
NZ729286A (en) * 2014-07-25 2023-12-22 Memorial Sloan Kettering Cancer Center Bispecific her2 and cd3 binding molecules
CN107532163A (en) 2015-04-24 2018-01-02 味之素株式会社 The secretion production method of protein
EP3530747A4 (en) * 2016-10-21 2020-07-22 Ajinomoto Co., Inc. Protein secretory production method
AU2017347016B2 (en) 2016-10-21 2021-09-23 Ajinomoto Co., Inc. Secretory production method for protein
WO2018179834A1 (en) 2017-03-28 2018-10-04 Ajinomoto Co., Inc. Method for producing rna
JP7367667B2 (en) 2018-02-20 2023-10-24 味の素株式会社 Methods of inducing RNA silencing
EP3783106A4 (en) 2018-04-20 2022-01-05 Ajinomoto Co., Inc. Method for secretory production of protein
EP3861109A1 (en) 2018-10-05 2021-08-11 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
JP7375767B2 (en) 2018-10-25 2023-11-08 味の素株式会社 Protein secretion production method
CN111909879B (en) * 2020-08-24 2023-04-28 江南大学 Corynebacterium glutamicum mutagenesis strain capable of efficiently expressing exogenous proteins and application thereof
US20240101982A1 (en) 2021-02-19 2024-03-28 Theripion, Inc. Paraoxonase fusion polypeptides and related compositions and methods
CN117642511A (en) 2021-07-07 2024-03-01 味之素株式会社 Secretion production method of protein containing unnatural amino acid

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Also Published As

Publication number Publication date
AU2012333451B2 (en) 2015-05-21
KR101653555B1 (en) 2016-09-02
US9187554B2 (en) 2015-11-17
WO2013065869A1 (en) 2013-05-10
EP2748340A1 (en) 2014-07-02
CN103946371A (en) 2014-07-23
US20140255996A1 (en) 2014-09-11
JP6020581B2 (en) 2016-11-02
EP2748340B1 (en) 2016-06-01
KR20140088215A (en) 2014-07-09
JP2014532424A (en) 2014-12-08
CN103946371B (en) 2016-07-06
RU2014122201A (en) 2015-12-10
AU2012333451A1 (en) 2014-04-03

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