IN2014CN04002A - - Google Patents

Info

Publication number
IN2014CN04002A
IN2014CN04002A IN4002CHN2014A IN2014CN04002A IN 2014CN04002 A IN2014CN04002 A IN 2014CN04002A IN 4002CHN2014 A IN4002CHN2014 A IN 4002CHN2014A IN 2014CN04002 A IN2014CN04002 A IN 2014CN04002A
Authority
IN
India
Prior art keywords
polymeric
coryneform bacteria
protein secretion
production capabilities
proteins
Prior art date
Application number
Inventor
Yoshihiko Matsuda
Haruki Beppu
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of IN2014CN04002A publication Critical patent/IN2014CN04002A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Provided is a method for secreting and producing polymeric proteins which exploits novel techniques for improving the polymeric protein secretion and production capabilities of coryneform bacteria. Polymeric proteins are secreted and produced using as expression hosts coryneform bacteria which have polymeric protein secretion and production capabilities and which have been modified so as to have improved expression of genes for coding metallopeptidase.
IN4002CHN2014 2011-11-02 2012-11-01 IN2014CN04002A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011240745 2011-11-02
PCT/JP2012/078285 WO2013065772A1 (en) 2011-11-02 2012-11-01 Method for secreting and producing proteins

Publications (1)

Publication Number Publication Date
IN2014CN04002A true IN2014CN04002A (en) 2015-10-23

Family

ID=48192110

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4002CHN2014 IN2014CN04002A (en) 2011-11-02 2012-11-01

Country Status (7)

Country Link
US (1) US9404138B2 (en)
EP (1) EP2774982B1 (en)
JP (1) JP6136930B2 (en)
CN (1) CN103946372B (en)
AU (1) AU2012333515B2 (en)
IN (1) IN2014CN04002A (en)
WO (1) WO2013065772A1 (en)

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WO2016171224A1 (en) 2015-04-24 2016-10-27 味の素株式会社 Method for secretory production of protein
AU2017347017B2 (en) 2016-10-21 2021-10-28 Ajinomoto Co., Inc. Protein secretory production method
AU2017347016B2 (en) 2016-10-21 2021-09-23 Ajinomoto Co., Inc. Secretory production method for protein
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WO2019078095A1 (en) 2017-10-16 2019-04-25 Ajinomoto Co., Inc. A method for production of a protein having peptidylglycine alpha-hydroxylating monooxygenase activity
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EP3783106A4 (en) 2018-04-20 2022-01-05 Ajinomoto Co., Inc. Method for secretory production of protein
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
JP7375767B2 (en) * 2018-10-25 2023-11-08 味の素株式会社 Protein secretion production method
WO2023282315A1 (en) 2021-07-07 2023-01-12 味の素株式会社 Method for secretory production of unnatural-amino-acid-containing protein
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Also Published As

Publication number Publication date
EP2774982A1 (en) 2014-09-10
WO2013065772A1 (en) 2013-05-10
EP2774982B1 (en) 2017-06-21
CN103946372B (en) 2016-06-08
CN103946372A (en) 2014-07-23
US20140234901A1 (en) 2014-08-21
JP6136930B2 (en) 2017-05-31
US9404138B2 (en) 2016-08-02
EP2774982A4 (en) 2015-03-18
JPWO2013065772A1 (en) 2015-04-02
AU2012333515B2 (en) 2015-07-16
AU2012333515A1 (en) 2014-06-12

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