IN2014CN02136A - - Google Patents

Download PDF

Info

Publication number
IN2014CN02136A
IN2014CN02136A IN2136CHN2014A IN2014CN02136A IN 2014CN02136 A IN2014CN02136 A IN 2014CN02136A IN 2136CHN2014 A IN2136CHN2014 A IN 2136CHN2014A IN 2014CN02136 A IN2014CN02136 A IN 2014CN02136A
Authority
IN
India
Prior art keywords
biological activity
relates
present
filamentous fungal
recombinant polypeptides
Prior art date
Application number
Other languages
English (en)
Inventor
Debbie Yaver
Qiming Jin
Original Assignee
Novozymes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes Inc filed Critical Novozymes Inc
Publication of IN2014CN02136A publication Critical patent/IN2014CN02136A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01091—Cellulose 1,4-beta-cellobiosidase (3.2.1.91)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0115—Oligoxyloglucan reducing-end-specific cellobiohydrolase (3.2.1.150)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IN2136CHN2014 2011-08-24 2012-08-23 IN2014CN02136A (enrdf_load_html_response)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161526809P 2011-08-24 2011-08-24
PCT/US2012/052143 WO2013028912A2 (en) 2011-08-24 2012-08-23 Methods for producing multiple recombinant polypeptides in a filamentous fungal host cell

Publications (1)

Publication Number Publication Date
IN2014CN02136A true IN2014CN02136A (enrdf_load_html_response) 2015-05-29

Family

ID=47358264

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2136CHN2014 IN2014CN02136A (enrdf_load_html_response) 2011-08-24 2012-08-23

Country Status (7)

Country Link
US (3) US9493790B2 (enrdf_load_html_response)
EP (1) EP2748322A2 (enrdf_load_html_response)
CN (2) CN103890180A (enrdf_load_html_response)
AU (1) AU2012298799B2 (enrdf_load_html_response)
BR (1) BR112014004190A2 (enrdf_load_html_response)
IN (1) IN2014CN02136A (enrdf_load_html_response)
WO (1) WO2013028912A2 (enrdf_load_html_response)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014CN02136A (enrdf_load_html_response) 2011-08-24 2015-05-29 Novozymes Inc
WO2013028915A2 (en) * 2011-08-24 2013-02-28 Novozymes, Inc. Methods for obtaining positive transformants of a filamentous fungal host cell
CN107868758A (zh) 2012-01-05 2018-04-03 诺华股份有限公司 蛋白酶缺陷丝状真菌细胞及其使用方法
US9695454B2 (en) 2012-05-23 2017-07-04 Glykos Finland Oy Production of fucosylated glycoproteins
SG11201600115SA (en) 2013-07-10 2016-02-26 Novartis Ag Multiple proteases deficient filamentous fungal cells and methods of use thereof
US20150147774A1 (en) * 2013-11-22 2015-05-28 National University Of Singapore Expression construct for yeast and a method of using the construct
CN115975994A (zh) * 2014-06-06 2023-04-18 诺维信公司 酶组合物及其用途
EP3172333B1 (en) 2014-07-21 2020-05-13 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
AU2015320214B2 (en) 2014-09-23 2021-04-01 Novozymes A/S Processes for producing ethanol and fermenting organisms
EP3268482B1 (en) 2015-03-09 2019-12-11 Novozymes A/S Methods of introducing multiple expression constructs into a eukaryotic cell
DK3423577T3 (da) 2016-03-02 2024-07-08 Novozymes As Cellobiohydrolasevarianter og polynukleotider til kodning deraf
WO2018093752A1 (en) * 2016-11-15 2018-05-24 Danisco Us Inc. Filamentous fungi with improved protein production
WO2018106792A1 (en) 2016-12-06 2018-06-14 Novozymes A/S Improved processes for production of ethanol from xylose-containing cellulosic substrates using engineered yeast strains
US11091753B2 (en) 2017-05-31 2021-08-17 Novozymes A/S Xylose fermenting yeast strains and processes thereof for ethanol production
WO2018222990A1 (en) 2017-06-02 2018-12-06 Novozymes A/S Improved yeast for ethanol production
CN109988714B (zh) * 2017-12-29 2021-12-28 青岛蔚蓝生物集团有限公司 一种里氏木霉及其应用
AU2019213033A1 (en) 2018-01-29 2020-09-17 Microbiogen Pty. Ltd. Microorganisms with improved nitrogen utilization for ethanol production
AU2019309683A1 (en) 2018-07-25 2021-02-11 Novozymes A/S Enzyme-expressing yeast for ethanol production
WO2020076697A1 (en) 2018-10-08 2020-04-16 Novozymes A/S Enzyme-expressing yeast for ethanol production
EP3894565A1 (en) * 2018-12-12 2021-10-20 Novozymes A/S Methods for increasing the productivity of a filamentous fungal cell in the production of a polypeptide
EP4004029A1 (en) 2019-07-26 2022-06-01 Novozymes A/S Microorganisms with improved nitrogen transport for ethanol production
US20220307036A1 (en) 2019-08-06 2022-09-29 Novozymes A/S Fusion proteins for improved enzyme expression
CN110724643B (zh) * 2019-11-18 2022-07-15 河南省农业科学院植物保护研究所 一株具有防病促生功能的橘灰青霉及其菌剂和应用
WO2021119304A1 (en) 2019-12-10 2021-06-17 Novozymes A/S Microorganism for improved pentose fermentation
CA3191025A1 (en) 2020-09-04 2022-03-10 Roberto Nobuyuki Maeda Improved fermenting organism for ethanol production
CN117795089A (zh) 2021-06-07 2024-03-29 诺维信公司 用于改善的乙醇发酵的工程化微生物
CN114561303B (zh) * 2022-02-14 2023-11-17 大连理工大学 一株分泌高性能纤维素酶的里氏木霉工程菌株及其应用
CN120344672A (zh) 2022-09-23 2025-07-18 诺维信公司 用于乙醇生产的改进发酵生物
WO2025088155A1 (en) 2023-10-25 2025-05-01 Novozymes A/S Improved fermenting organism for ethanol production
CN117757643B (zh) * 2024-01-12 2025-06-13 华东理工大学 一种分泌表达人溶菌酶的里氏木霉工程菌及其构建方法和应用

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI864473A7 (fi) * 1985-11-20 1987-05-21 Panlabs Inc Yhdistetyt ilmaisukasetit fungaalitransformaatiota varten.
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
US5989870A (en) 1986-04-30 1999-11-23 Rohm Enzyme Finland Oy Method for cloning active promoters
US5776757A (en) 1988-03-24 1998-07-07 Novo Nordisk A/S Fungal cellulase composition containing alkaline CMC-endoglucanase and essentially no cellobiohydrolase and method of making thereof
DK115890D0 (da) 1990-05-09 1990-05-09 Novo Nordisk As Enzym
EP0553280B2 (en) * 1990-10-05 2010-08-11 Genencor International, Inc. Methods for treating cotton-containing fabrics with cellulase
CA2141431A1 (en) * 1992-07-31 1994-02-17 Helena K. M. Nevalainen Recombinant cells, dna constructs, vectors and methods for expressing phytate degrading enzymes in desired ratios
ATE258224T1 (de) 1993-03-10 2004-02-15 Novozymes As Enzyme mit xylanaseaktivität aus aspergillus aculeatus
CA2191718A1 (en) 1994-06-03 1995-12-14 Randy M. Berka Phosphonyldipeptides useful in the treatment of cardiovascular diseases
US6060305A (en) * 1994-06-30 2000-05-09 Novo Nordisk Biotech, Inc. Non-toxic, non-toxigenic, non-pathogenic Fusarium expression system
JP3167729B2 (ja) 1994-06-30 2001-05-21 ノボ ノルディスク バイオテック，インコーポレイティド 無毒、非毒素原性、非病原性の発現系、並びにその中で利用するためのプロモーター及びターミネーター
US20030044956A1 (en) 1995-08-23 2003-03-06 Short Jay M. Enzymes having carboxymethyl cellulase activity and methods of use thereof
ATE294233T1 (de) 1996-01-19 2005-05-15 Novozymes Biotech Inc Morphologische mutanten von filamentösen pilzen
WO1998011203A1 (en) * 1996-09-13 1998-03-19 Novo Nordisk Biotech, Inc. Cells having dna insertion mutations which produce altered amounts of a polypeptide
US6451063B1 (en) 1996-09-25 2002-09-17 Genencor International, Inc. Cellulase for use in industrial processes
US6017870A (en) 1996-10-09 2000-01-25 Genencor International, Inc. Purified cellulase and method of producing
US5811381A (en) 1996-10-10 1998-09-22 Mark A. Emalfarb Cellulase compositions and methods of use
US7883872B2 (en) 1996-10-10 2011-02-08 Dyadic International (Usa), Inc. Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose
US6265204B1 (en) * 1997-01-17 2001-07-24 Genencor International, Inc. DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi
US6558937B1 (en) 1997-07-31 2003-05-06 Dsm N.V. Cellulose degrading enzymes of aspergillus
US5871550A (en) 1997-08-26 1999-02-16 Genencor International, Inc. Mutant Thermonospora spp. cellulase
WO1999025847A2 (en) 1997-11-19 1999-05-27 Genencor International, Inc. Cellulase produced by actinomycetes and method of producing same
DK1038008T3 (da) 1997-12-16 2007-03-12 Genencor Int Fremgangsmåde til fremstilling af EGIII-lignende enzymer
ES2143408B1 (es) * 1998-04-02 2000-12-01 Urquima Sa Promotor y construcciones para expresion de proteinas recombinantes en hongos filamentosos.
CN1301307A (zh) * 1998-05-15 2001-06-27 诺沃诺尔迪斯克生物技术有限公司 在丝状真菌突变细胞中生产多肽的方法
CN1940067A (zh) 1999-03-22 2007-04-04 诺沃奇梅兹有限公司 用于在真菌细胞中表达基因的启动子
AU2002316785A1 (en) 2001-05-18 2002-12-03 Novozymes A/S Polypeptides having cellobiase activity and polynucleotides encoding same
US6982159B2 (en) 2001-09-21 2006-01-03 Genencor International, Inc. Trichoderma β-glucosidase
US7005289B2 (en) 2001-12-18 2006-02-28 Genencor International, Inc. BGL5 β-glucosidase and nucleic acids encoding the same
US7045332B2 (en) 2001-12-18 2006-05-16 Genencor International, Inc. BGL4 β-glucosidase and nucleic acids encoding the same
US7045331B2 (en) 2001-12-18 2006-05-16 Genencor International, Inc. EGVII endoglucanase and nucleic acids encoding the same
US7049125B2 (en) 2001-12-18 2006-05-23 Genencor International, Inc. EGVIII endoglucanase and nucleic acids encoding the same
US7056721B2 (en) 2001-12-18 2006-06-06 Genencor International, Inc. EGVI endoglucanase and nucleic acids encoding the same
AU2003263842A1 (en) 2002-08-16 2004-03-03 Genencor International, Inc. Novel variant hyprocrea jecorina cbh1 cellulases
DK1556512T3 (en) 2002-11-07 2016-09-12 Danisco Us Inc BGL6 BETA-GLUCOSIDASE AND NUCLEIC ACIDS THEREOF CODED
US7407788B2 (en) 2002-11-21 2008-08-05 Danisco A/S, Genencor Division BGL7 beta-glucosidase and nucleic acids encoding the same
EP2311942A1 (en) 2003-03-21 2011-04-20 Genecor International, Inc. Novel cbh1 homologs and variant cbh1 cellulases
ES2430825T3 (es) 2003-04-01 2013-11-21 Danisco Us Inc. CBH1.1 de Humicola grisea variante
EP2228440B1 (en) 2003-05-02 2012-08-22 Novozymes Inc. Variants of beta-glucosidases
ATE524491T1 (de) 2003-05-29 2011-09-15 Genencor Int Neue trichoderma-gene
DK1682656T3 (da) 2003-10-28 2013-11-18 Novozymes Inc Polypeptider med beta-glucosidaseaktivitet og polynukleotider, der koder for dem
EP2314605B1 (en) 2004-01-30 2014-03-19 Novozymes Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
MXPA06008745A (es) 2004-02-06 2007-01-23 Novozymes Inc Polipeptidos que tienen actividad celulolitica potenciada y polinucleotidos que codifican a los mismos.
DK2322630T3 (en) * 2004-02-12 2017-02-13 Novozymes Inc Polypeptides with xylanase activity and polynucleotides encoding them
US8097445B2 (en) 2004-03-25 2012-01-17 Danisco Us Inc. Exo-endo cellulase fusion protein
EP1735447A2 (en) 2004-03-25 2006-12-27 Genencor International, Inc. Cellulase fusion protein and heterologous cellulase fusion construct encoding the same
US8008056B2 (en) 2004-12-30 2011-08-30 Danisco Us Inc. Variant Hypocrea jecorina CBH2 cellulases
CA2593246C (en) 2005-01-06 2016-06-21 Novozymes, Inc. Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
AR053066A1 (es) 2005-04-26 2007-04-18 Novozymes As Arabinofuranosidasas
DK1874927T3 (da) 2005-04-29 2014-04-22 Ab Enzymes Oy Forbedrede cellulaser
EP1928901B1 (en) 2005-08-04 2011-06-15 Novozymes, Inc. Polypeptides having beta-glucosidase activity and polynucleotides encoding same
RU2441912C2 (ru) 2005-09-30 2012-02-10 Новозаймз, Инк. Способы усиления деградации или превращения целлюлозного материала
DK1969123T3 (en) 2005-12-22 2017-08-28 Ab Enzymes Oy Hitherto UNKNOWN ENZYMS
FI120045B (fi) 2005-12-22 2009-06-15 Roal Oy Selluloosamateriaalin käsittely ja siinä käyttökelpoiset entsyymit
EP2027271A4 (en) * 2006-05-19 2010-06-09 Glycofi Inc RECOMBINANT VECTORS
WO2008008793A2 (en) 2006-07-10 2008-01-17 Dyadic International Inc. Methods and compositions for degradation of lignocellulosic material
GB0614442D0 (en) * 2006-07-20 2006-08-30 Fluxome Sciences As Metabolically engineered cells for the production of pinosylvin
CN101516906B (zh) 2006-07-21 2013-11-06 诺维信股份有限公司 提高具有生物学活性之多肽的分泌的方法
EP2102366A4 (en) * 2006-12-10 2010-01-27 Dyadic International Inc EXPRESSION AND HIGH-DROP SCREENING OF COMPLEX EXPRESSED DNA LIBRARIES IN FADENED MUSHROOMS
BRPI0812035A2 (pt) 2007-05-31 2014-10-14 Novozymes Inc Polipeptídeo isola, polinucleotídeo isolado, construção de ácidos nucleicos, vetor de expressão recombinante, célula hospedeira recombinante, métodos para produzir um polipeptídeo, um mutante de uma célula originária e uma proteína, para inibir a expressão de um polipeptídeo em uma célula, para degradar ou converter um material contendo celulose e para produzir um produto de fermentação, célula mutante, planta, parte de planta ou célula de planta trangênica, e, molécula de rna inibidor de fita dupla
BRPI0812267A2 (pt) 2007-05-31 2014-10-14 Novozymes Inc Célula hospedeira fúngica filamentosa, método para produzir uma composição de proteína celulolítica, composição de proteína celulolítica, e, métodos para degradar ou converter um material, contendo celulose e para produzir um produto de fermentação
US9453213B2 (en) 2007-05-31 2016-09-27 Novozymes, Inc. Methods of increasing the cellulolytic enhancing activity of a polypeptide
DK2195421T3 (en) 2007-09-28 2015-12-14 Novozymes As Polypeptides with acetylxylanesteraseaktivitet and polynucleotides encoding them
WO2009042871A1 (en) 2007-09-28 2009-04-02 Novozymes A/S Polypeptides having cellobiohydrolase ii activity and polynucleotides encoding same
ES2439257T3 (es) 2007-11-27 2014-01-22 Novozymes A/S Polipéptidos que tienen actividad de alfa-glucuronidasa y polinucleótidos que codifican los mismos
CA2707017A1 (en) 2007-11-30 2009-06-11 Novozymes A/S Polypeptides having arabinofuranosidase activity and polynucleotides encoding same
BRPI0820102A2 (pt) 2007-12-05 2017-05-23 Novozymes As polipeptídeo isolado, construção de ácido nucléico, célula hospedeira recombinante, métodos de produzir o polipeptídeo, de produzir um mutante de uma célula precursora, de inibir a expressão de um polipeptídeo tendo atividade de xilanase em uma célula, de produzir uma proteína e para degradar um material cotendo xilano, célula mutante, planta transgênica, parte de planta ou célula vegetal, e, molécula de rna inibidora de filamento duplo
CA2707847A1 (en) 2007-12-06 2009-06-11 Novozymes A/S Polypeptides having acetylxylan esterase activity and polynucleotides encoding same
WO2009076122A1 (en) 2007-12-07 2009-06-18 Novozymes A/S Polypeptides having feruloyl esterase activity and polynucleotides encoding same
BRPI0821048A2 (pt) 2007-12-19 2015-06-16 Novozymes As Polipeptídeo e polinucleotídeo isolados, construção de ácido nucléico, célula hospedeira recombinante, métodos para produzir o polipeptídeo, um mutante de uma célula precursora, uma proteína e um produto de fermentação, para inibir a expressão de um polipeptídeo, para degradar ou converter um material celulósico, e para fermentar um material celulósico, planta trangênica, parte vegetal ou célula vegetal, e, melécula de rna inibidora
WO2009085868A1 (en) 2007-12-19 2009-07-09 Novozymes A/S Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
WO2009085864A2 (en) 2007-12-19 2009-07-09 Novozymes A/S Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
AU2008343105A1 (en) 2007-12-19 2009-07-09 Novozymes A/S Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
WO2009106488A1 (en) * 2008-02-25 2009-09-03 Novozymes A/S Method for increasing expression yield of a protein of interest
EP2274322A1 (en) 2008-04-17 2011-01-19 Novozymes A/S Polypeptides having ferulic acid esterase activity and polynucleotides encoding same
WO2010014706A1 (en) 2008-07-29 2010-02-04 Novozymes A/S Polypeptides having alpha-glucuronidase activity and polynucleotides encoding same
US8071335B2 (en) 2008-07-31 2011-12-06 Novozymes, Inc. Polypeptides having acetylxylan esterase activity and polynucleotides encoding same
CN102224245B (zh) 2008-09-30 2016-01-13 诺维信股份有限公司 在丝状真菌细胞中使用阳性和阴性选择性基因的方法
WO2010039840A1 (en) 2008-09-30 2010-04-08 Novozymes, Inc. Methods for producing polypeptides in enzyme-deficient mutants of fusarium venenatum
CA2743049A1 (en) 2008-11-10 2010-05-14 Kimberly Brown Polypeptides having feruloyl esterase activity and polynucleotides encoding same
US8805427B2 (en) 2008-11-14 2014-08-12 Microsoft Corporation Channel reuse with cognitive low interference signals
EP2373684A1 (en) 2008-12-04 2011-10-12 Novozymes Inc. Polypeptides having feruloyl esterase activity and polynucleotides encoding same
EP2373788A1 (en) 2008-12-04 2011-10-12 Novozymes Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
WO2010088387A1 (en) 2009-01-28 2010-08-05 Novozymes, Inc. Polypeptides having beta-glucosidase activity and polynucleotides encoding same
CN102365360A (zh) 2009-03-24 2012-02-29 诺维信公司 具有乙酰木聚糖酯酶活性的多肽和编码该多肽的多核苷酸
WO2010126772A1 (en) 2009-04-30 2010-11-04 Novozymes, Inc. Polypeptides having xylanase activity and polynucleotides encoding same
AU2010253848C1 (en) 2009-05-29 2015-02-19 Novozymes, Inc. Methods for enhancing the degradation or conversion of cellulosic material
EP2438163B1 (en) 2009-06-02 2015-01-21 Novozymes Inc. Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
DK2451957T3 (en) 2009-07-07 2018-02-05 Novozymes Inc POLYPEPTIDES WITH CELLULOLYSE ENHANCING ACTIVITY AND POLYNUCLEOTIDES CODING THEM
EP3805348A3 (en) 2009-09-17 2021-07-14 Novozymes, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
WO2011035029A1 (en) 2009-09-18 2011-03-24 Novozymes, Inc. Polypeptides having beta-glucosidase activity and polynucleotides encoding same
CN102648276A (zh) 2009-09-29 2012-08-22 诺维信股份有限公司 具有木聚糖酶活性的多肽和编码该多肽的多核苷酸
DK2483295T3 (en) 2009-09-29 2016-02-22 Novozymes Inc Polypeptides having cellulolytic enhancing activity and polynucleotides encoding them
WO2011039319A1 (en) 2009-09-30 2011-04-07 Novozymes A/S Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
US8586827B2 (en) 2009-09-30 2013-11-19 Novozymes, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
WO2011050037A1 (en) * 2009-10-23 2011-04-28 Novozymes, Inc. Cellobiohydrolase variants and polynucleotides encoding same
EP2494042A1 (en) 2009-10-29 2012-09-05 Novozymes Inc. Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
WO2011057083A1 (en) 2009-11-06 2011-05-12 Novozymes, Inc. Polypeptides having xylanase activity and polynucleotides encoding same
CN102947442B (zh) 2009-11-06 2016-03-09 诺维信股份有限公司 用于糖化纤维素材料的组合物
CN111500474B (zh) 2009-12-18 2023-10-03 诺维信股份有限公司 用于在木霉属的蛋白酶缺陷突变体中产生多肽的方法
EP2371963A1 (en) * 2010-03-29 2011-10-05 Heinrich-Heine-Universität Düsseldorf Protein production in filamentous fungi
EP2558566A4 (en) * 2010-04-14 2013-10-02 Penn State Res Found TRANSGENIC HANDLING STRATEGIES OF FILAMENTOUS FUNGI
WO2012074818A2 (en) * 2010-11-22 2012-06-07 Novozymes, Inc. Compositions and methods for 3-hydroxypropionic acid production
WO2013024710A1 (ja) * 2011-08-12 2013-02-21 国立大学法人東北大学 免疫応答を回避するための薬剤
IN2014CN02136A (enrdf_load_html_response) * 2011-08-24 2015-05-29 Novozymes Inc
WO2013028915A2 (en) * 2011-08-24 2013-02-28 Novozymes, Inc. Methods for obtaining positive transformants of a filamentous fungal host cell
CA2851308A1 (en) * 2011-10-31 2013-05-10 Bp Corporation North America Inc. Use of mammalian promoters in filamentous fungi
WO2013076280A1 (en) * 2011-11-23 2013-05-30 Dsm Ip Assets B.V. Nucleic acid assembly system
CN104066841B (zh) * 2012-01-23 2018-01-02 旭硝子株式会社 表达载体和蛋白质的制造方法
CN104884631A (zh) * 2012-12-21 2015-09-02 诺维信股份有限公司 用于在木霉属的突变体中产生异源多肽的方法
WO2014138672A1 (en) * 2013-03-08 2014-09-12 Novozymes A/S Cellobiohydrolase variants and polynucleotides encoding same
WO2014145768A2 (en) * 2013-03-15 2014-09-18 Bp Corporation North America Inc. Use of non-fungal 5' utrs in filamentous fungi
EP2840139A1 (en) * 2013-08-23 2015-02-25 Wageningen Universiteit Method for the single step introduction of a plurality of genes in microbial cells
CN115975994A (zh) * 2014-06-06 2023-04-18 诺维信公司 酶组合物及其用途
CN106661573B (zh) * 2014-08-20 2021-07-27 诺维信公司 多核苷酸文库的重组酶介导的整合
EP3268482B1 (en) * 2015-03-09 2019-12-11 Novozymes A/S Methods of introducing multiple expression constructs into a eukaryotic cell
EP3596199A1 (en) * 2017-03-13 2020-01-22 DSM IP Assets B.V. Zinc binuclear cluster transcriptional regulator-deficient strain
CA3061984A1 (en) * 2017-06-06 2018-12-13 Zymergen Inc. A htp genomic engineering platform for improving fungal strains

Also Published As

Publication number Publication date
CN103890180A (zh) 2014-06-25
US10301610B2 (en) 2019-05-28
AU2012298799B2 (en) 2018-02-01
US20170015986A1 (en) 2017-01-19
AU2012298799A1 (en) 2014-02-13
BR112014004190A2 (pt) 2017-03-01
EP2748322A2 (en) 2014-07-02
WO2013028912A3 (en) 2013-06-06
WO2013028912A2 (en) 2013-02-28
CN109136114A (zh) 2019-01-04
US20190249161A1 (en) 2019-08-15
US20140212977A1 (en) 2014-07-31
US9493790B2 (en) 2016-11-15
US10822601B2 (en) 2020-11-03

Similar Documents

Publication Publication Date Title
IN2014CN02136A (enrdf_load_html_response)
SG10201805291TA (en) Production of heterodimeric proteins
IL232048B (en) A spray generating system with improved spray production
ZA201208575B (en) Yeast production culture for the production of butanol
PL3263303T3 (pl) Sposób wytwarzania półwyrobu do wytwarzania kształtki kompozytowej, zwłaszcza kształtki z kompozytu włóknistego
PL2681313T3 (pl) Komórka drożdżowa do wytwarzania terpenów i jej zastosowania
SI2758228T1 (sl) Vlaknati polizdelek, vlaknati kompozitni material in postopek za izdelavo le-teh
MX2013007567A (es) Procedimiento para preparar poliestereteroles.
EP2829173A4 (en) NOVEL FUNGAL STRAIN FOR CELLULASE PRODUCTION AND METHOD OF SACCHARIFICATION USING THE SAME
MY197890A (en) Mutant strains of trichoderma reesei
PT2925854T (pt) Método de melhoramento de estirpes de levedura
PT2725098T (pt) Estirpe de levedura kluyveromyces lactis e métodos para a produção de açúcares, etanol, beta-galactosidase e biomassa
IL229058A0 (en) A method for increasing the productivity of eukaryotic cells in the production of recombinant fviii
HK1205188A1 (en) Process for making recombinant antidote to factor xa inhibitor
WO2012115903A3 (en) Yeast strain for the production of proteins with modified o-glycosylation
ZA201402335B (en) Production of isopropanol by improved recombinant strains
IN2014MN01621A (enrdf_load_html_response)
MX2012010317A (es) ß-HIDROXIALQUILAMIDAS, METODO PARA SU PRODUCCION Y SU USO.
MX2014000916A (es) Proceso para la produccion continua de polieteroles.
RS60837B1 (sr) Proizvodnja enzima za ligno-celuloznu biomasu
MX2014003936A (es) Procedimiento para preparar ditiina-tetracarboximidas.
HK40113551A (en) Production of heterodimeric proteins
ZA201307057B (en) Proteins for biocontrol of plant pathogenic fungi
IN2014CN02645A (enrdf_load_html_response)
HK40032845A (en) Production of heterodimeric proteins