IN2014CN01834A - - Google Patents
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- Publication number
- IN2014CN01834A IN2014CN01834A IN1834CHN2014A IN2014CN01834A IN 2014CN01834 A IN2014CN01834 A IN 2014CN01834A IN 1834CHN2014 A IN1834CHN2014 A IN 1834CHN2014A IN 2014CN01834 A IN2014CN01834 A IN 2014CN01834A
- Authority
- IN
- India
- Prior art keywords
- nucleic acid
- polymerases
- aspects
- useful
- disclosure relates
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 abstract 5
- 102000039446 nucleic acids Human genes 0.000 abstract 5
- 108020004707 nucleic acids Proteins 0.000 abstract 5
- 230000003197 catalytic effect Effects 0.000 abstract 2
- 238000012163 sequencing technique Methods 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000011143 downstream manufacturing Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000012252 genetic analysis Methods 0.000 abstract 1
- 238000003205 genotyping method Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6846—Common amplification features
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07007—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Polyesters Or Polycarbonates (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161522125P | 2011-08-10 | 2011-08-10 | |
| US201161545434P | 2011-10-10 | 2011-10-10 | |
| US201261585133P | 2012-01-10 | 2012-01-10 | |
| US201261643844P | 2012-05-07 | 2012-05-07 | |
| US201261681593P | 2012-08-09 | 2012-08-09 | |
| PCT/US2012/050423 WO2013023176A2 (en) | 2011-08-10 | 2012-08-10 | Polymerase compositions, methods of making and using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014CN01834A true IN2014CN01834A (https=) | 2015-05-29 |
Family
ID=46755104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1834CHN2014 IN2014CN01834A (https=) | 2011-08-10 | 2012-08-10 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20130040365A1 (https=) |
| EP (2) | EP2742151B1 (https=) |
| CN (2) | CN103857805B (https=) |
| IN (1) | IN2014CN01834A (https=) |
| LT (1) | LT2742151T (https=) |
| WO (1) | WO2013023176A2 (https=) |
Families Citing this family (45)
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| CN114854832A (zh) | 2012-04-19 | 2022-08-05 | 生命技术公司 | 核酸扩增 |
| EP3095879B1 (en) | 2012-04-19 | 2018-09-19 | Life Technologies Corporation | Nucleic acid amplification |
| EP2895620B1 (en) | 2012-09-11 | 2017-08-02 | Life Technologies Corporation | Nucleic acid amplification |
| WO2014043143A1 (en) | 2012-09-11 | 2014-03-20 | Life Technologies Corporation | Nucleic acid amplification |
| US9399766B2 (en) | 2012-10-01 | 2016-07-26 | Pacific Biosciences Of California, Inc. | Recombinant polymerases for incorporation of protein shield nucleotide analogs |
| EP3366769B1 (en) * | 2012-10-16 | 2021-02-17 | DNA Polymerase Technology, Inc. | Inhibition-resistant polymerases |
| US9657281B2 (en) * | 2013-09-30 | 2017-05-23 | Life Technologies Corporation | Polymerase compositions, methods of making and using same |
| WO2015048766A1 (en) | 2013-09-30 | 2015-04-02 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | A home-based heliox system with carbon dioxide removal |
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| CN113403293B (zh) * | 2014-12-16 | 2024-08-16 | 生命技术公司 | 聚合酶组合物和制造与使用其的方法 |
| JP6736565B2 (ja) | 2015-02-02 | 2020-08-05 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ポリメラーゼバリアント |
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| US10526588B2 (en) | 2015-05-14 | 2020-01-07 | Roche Sequencing Solutions, Inc. | Polymerase variants and uses thereof |
| US10344268B2 (en) | 2015-10-01 | 2019-07-09 | Life Technologies Corporation | Polymerase compositions and kits, and methods of using and making the same |
| US10590480B2 (en) | 2016-02-29 | 2020-03-17 | Roche Sequencing Solutions, Inc. | Polymerase variants |
| CN108699539B (zh) | 2016-02-29 | 2022-11-18 | 吉尼亚科技公司 | 外切核酸酶缺陷的聚合酶 |
| EP3423574B1 (en) | 2016-02-29 | 2021-03-17 | Genia Technologies, Inc. | Polymerase-template complexes for nanopore sequencing |
| US10597643B2 (en) | 2016-04-29 | 2020-03-24 | Omniome, Inc. | Polymerases engineered to reduce nucleotide-independent DNA binding |
| CA3022431C (en) | 2016-04-29 | 2023-03-21 | Omniome, Inc. | Method of nucleic acid sequence determination |
| WO2017196676A1 (en) | 2016-05-10 | 2017-11-16 | Life Technologies Corporation | Metal chelation post incorporation detection methods |
| US11268117B2 (en) | 2016-06-10 | 2022-03-08 | Life Technologies Corporation | Methods and compositions for nucleic acid amplification |
| US10829747B2 (en) | 2016-09-22 | 2020-11-10 | Roche Sequencing Solutions, Inc. | Polymerase variants |
| WO2018132389A1 (en) * | 2017-01-10 | 2018-07-19 | Omniome, Inc. | Polymerases engineered to reduce nucleotide-independent dna binding |
| EP4310196A3 (en) | 2017-11-07 | 2024-04-24 | Life Technologies Corporation | Methods and compositions for manipulating nucleic acids |
| US12226745B2 (en) | 2017-11-07 | 2025-02-18 | Life Technologies Corporation | Methods and compositions for manipulating nucleic acids |
| GB201721053D0 (en) * | 2017-12-15 | 2018-01-31 | Univ I Tromsø - Norges Arktiske Univ | DNA polymerases |
| US10961518B2 (en) | 2018-01-19 | 2021-03-30 | Bio-Rad Laboratories, Inc. | Mutant DNA polymerases |
| CN112941155B (zh) * | 2018-05-14 | 2023-07-14 | 北京艾克伦医疗科技有限公司 | 具有茎环结构的dna引物对及其应用 |
| AU2020222888B2 (en) | 2019-02-11 | 2024-08-01 | Ultima Genomics, Inc. | Methods for nucleic acid analysis |
| CN113383086A (zh) | 2019-03-10 | 2021-09-10 | 武汉爱博泰克生物科技有限公司 | 用于在提高的盐浓度或体液中扩增的突变型Taq聚合酶 |
| US10865441B2 (en) * | 2019-03-13 | 2020-12-15 | Abclonal Science, Inc. | Mutant Taq polymerase for faster amplification |
| WO2020227031A1 (en) | 2019-05-03 | 2020-11-12 | Life Technologies Corporation | Methods and compositions for manipulating nucleic acids |
| US11613738B2 (en) | 2019-05-14 | 2023-03-28 | Abclonal Science, Inc. | Mutant Taq polymerase resistant to inhibition of amplification in the presence of cyanine dye |
| CN111154739B (zh) * | 2020-02-06 | 2021-03-02 | 广州普世利华科技有限公司 | 一种新型重组酶依赖型扩增方法及试剂盒 |
| CN115820595A (zh) * | 2020-05-11 | 2023-03-21 | 南京君华基因科技有限公司 | 一种优化的扩增目标核酸的聚合酶、复合体系及应用 |
| US11649441B2 (en) * | 2020-10-07 | 2023-05-16 | Abclonal Science, Inc. | Taq DNA polymerase mutants for probe qPCR |
| EP4232569B1 (en) * | 2020-10-23 | 2026-03-11 | LineaRX, Inc. | Compositions and methods for rna synthesis |
| TWI869710B (zh) * | 2021-09-29 | 2025-01-11 | 呈堯 陳 | 用於無模板ｒｎａ合成的核酸聚合酶變體、試劑套組及方法 |
| CN116419993A (zh) * | 2021-11-09 | 2023-07-11 | 京东方科技集团股份有限公司 | Dna末端修复、连接接头试剂、试剂盒及dna文库构建方法 |
| WO2025144744A1 (en) | 2023-12-29 | 2025-07-03 | Life Technologies Corporation | Enrichment of clonal substrates |
| CN119842661B (zh) * | 2025-03-21 | 2025-07-15 | 中国农业科学院生物技术研究所 | Bst DNA聚合酶突变体及其制备方法与应用 |
| CN121204003A (zh) * | 2025-10-17 | 2025-12-26 | 珠海宝锐生物科技有限公司 | 一种mmlv酶突变体、制备方法及其应用 |
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| US9657281B2 (en) | 2013-09-30 | 2017-05-23 | Life Technologies Corporation | Polymerase compositions, methods of making and using same |
| US10344268B2 (en) | 2015-10-01 | 2019-07-09 | Life Technologies Corporation | Polymerase compositions and kits, and methods of using and making the same |
-
2012
- 2012-08-10 CN CN201280048344.9A patent/CN103857805B/zh active Active
- 2012-08-10 WO PCT/US2012/050423 patent/WO2013023176A2/en not_active Ceased
- 2012-08-10 US US13/572,488 patent/US20130040365A1/en not_active Abandoned
- 2012-08-10 EP EP12751661.5A patent/EP2742151B1/en active Active
- 2012-08-10 CN CN201710614722.XA patent/CN107326079B/zh active Active
- 2012-08-10 LT LTEP12751661.5T patent/LT2742151T/lt unknown
- 2012-08-10 IN IN1834CHN2014 patent/IN2014CN01834A/en unknown
- 2012-08-10 EP EP17198055.0A patent/EP3293274B1/en active Active
-
2015
- 2015-06-29 US US14/754,203 patent/US9976128B2/en active Active
-
2018
- 2018-04-23 US US15/959,839 patent/US10633641B2/en active Active
-
2021
- 2021-12-20 US US17/645,146 patent/US12338465B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN107326079A (zh) | 2017-11-07 |
| US10633641B2 (en) | 2020-04-28 |
| WO2013023176A2 (en) | 2013-02-14 |
| US12338465B2 (en) | 2025-06-24 |
| US9976128B2 (en) | 2018-05-22 |
| US20130040365A1 (en) | 2013-02-14 |
| LT2742151T (lt) | 2018-02-12 |
| EP3293274A3 (en) | 2018-03-28 |
| US20180305673A1 (en) | 2018-10-25 |
| EP2742151A2 (en) | 2014-06-18 |
| CN103857805A (zh) | 2014-06-11 |
| EP2742151B1 (en) | 2017-10-25 |
| WO2013023176A3 (en) | 2013-04-18 |
| EP3293274B1 (en) | 2020-04-01 |
| EP3293274A2 (en) | 2018-03-14 |
| CN107326079B (zh) | 2021-04-20 |
| US20220162573A1 (en) | 2022-05-26 |
| CN103857805B (zh) | 2017-07-18 |
| US20150368626A1 (en) | 2015-12-24 |
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