IN2014CH00290A - - Google Patents

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Publication number
IN2014CH00290A
IN2014CH00290A IN290CH2014A IN2014CH00290A IN 2014CH00290 A IN2014CH00290 A IN 2014CH00290A IN 290CH2014 A IN290CH2014 A IN 290CH2014A IN 2014CH00290 A IN2014CH00290 A IN 2014CH00290A
Authority
IN
India
Prior art keywords
rivaroxaban
highly pure
crystal modification
free
polymorphs
Prior art date
Application number
Other languages
English (en)
Inventor
Rao Dodda Mohan
Bingi Venugopal
Original Assignee
Symed Labs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symed Labs Ltd filed Critical Symed Labs Ltd
Priority to IN290CH2014 priority Critical patent/IN2014CH00290A/en
Priority to PCT/IN2015/000031 priority patent/WO2015111076A2/en
Priority to US14/601,419 priority patent/US9469628B2/en
Publication of IN2014CH00290A publication Critical patent/IN2014CH00290A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IN290CH2014 2014-01-23 2015-01-19 IN2014CH00290A (en, 2012)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IN290CH2014 IN2014CH00290A (en, 2012) 2014-01-23 2015-01-19
PCT/IN2015/000031 WO2015111076A2 (en) 2014-01-23 2015-01-19 Improved processes for the preparation of highly pure rivaroxaban crystal modification i
US14/601,419 US9469628B2 (en) 2014-01-23 2015-01-21 Processes for the preparation of highly pure Rivaroxaban crystal modification I

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN290CH2014 IN2014CH00290A (en, 2012) 2014-01-23 2015-01-19

Publications (1)

Publication Number Publication Date
IN2014CH00290A true IN2014CH00290A (en, 2012) 2015-08-14

Family

ID=53544199

Family Applications (1)

Application Number Title Priority Date Filing Date
IN290CH2014 IN2014CH00290A (en, 2012) 2014-01-23 2015-01-19

Country Status (3)

Country Link
US (1) US9469628B2 (en, 2012)
IN (1) IN2014CH00290A (en, 2012)
WO (1) WO2015111076A2 (en, 2012)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015111076A2 (en) 2014-01-23 2015-07-30 Symed Labs Limited Improved processes for the preparation of highly pure rivaroxaban crystal modification i
EA034656B1 (ru) * 2014-10-22 2020-03-03 Закляды Фармацеутычне Польфарма С.А Способ получения полиморфа ривароксабана
CN105440028B (zh) * 2015-12-07 2018-03-13 石家庄康贺威药业有限公司 一种利伐沙班化合物及其制备方法
CN105651871A (zh) * 2015-12-18 2016-06-08 重庆植恩药业有限公司 一种利伐沙班及有关物质的测定方法
CN109142601B (zh) * 2018-10-25 2021-03-12 重庆华邦胜凯制药有限公司 一种分离利伐沙班中间体及其杂质的方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE102004002044A1 (de) 2004-01-15 2005-08-04 Bayer Healthcare Ag Herstellverfahren
BRPI0616801B8 (pt) * 2005-10-04 2021-05-25 Bayer Healthcare Ag "forma polimórfica de 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofenocarboxamida, seus processos de preparação e seus usos, medicamento, e processo para prevenção de coagulação de sangue in vitro
DE102008028071A1 (de) 2008-06-12 2009-12-17 Bayer Schering Pharma Aktiengesellschaft Neue Cokristall-Verbindung von Rivaroxaban und Malonsäure
US20100168111A1 (en) 2008-12-31 2010-07-01 Apotex Pharmachem Inc. Polymorphic form of 5 chloro n {[(5s) 2 oxo 3 [4 (3 oxomorpholin 4 yl)phenyl]oxa-zolidin 5 yl]-methyl}thiophene 2 carboxamide
US7816355B1 (en) 2009-04-28 2010-10-19 Apotex Pharmachem Inc Processes for the preparation of rivaroxaban and intermediates thereof
EP2459555B1 (en) * 2009-07-31 2021-11-03 KRKA, D.D., Novo Mesto Processes for crystallization of rivaroxaban
US20120283434A1 (en) 2010-01-04 2012-11-08 Enantia, S.L. Process for the preparation of rivaroxaban and intermediates thereof
EP2354128A1 (en) 2010-02-10 2011-08-10 Sandoz Ag Method for the preparation of rivaroxaban
EP2404920A1 (en) 2010-07-06 2012-01-11 Sandoz AG Crystalline form of Rivaroxaban dihydrate
WO2012032533A2 (en) 2010-09-07 2012-03-15 Symed Labs Limited Processes for the preparation of 4-{4-[5(s)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl} morpholin-3-one
WO2012156983A1 (en) 2011-05-16 2012-11-22 Symed Labs Limited Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide
WO2013027225A1 (en) 2011-08-19 2013-02-28 Symed Labs Limited Processes for the preparation of 4-{4-[5(s)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl} morpholin-3-one
WO2013046211A1 (en) 2011-09-27 2013-04-04 Symed Labs Limited Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide and intermediates thereof
WO2013105100A1 (en) 2012-01-09 2013-07-18 Symed Labs Limited Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide and intermediates thereof
WO2013121436A2 (en) * 2012-02-06 2013-08-22 Megafine Pharma (P) Ltd A process for preparation of rivaroxaban and intermediates thereof
WO2013118130A1 (en) 2012-02-06 2013-08-15 Symed Labs Limited A process for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene carboxamide
CN104487436B (zh) * 2012-05-02 2017-05-24 信谊实验室有限公司 使用中间产物制备利伐沙班的改良方法
WO2015111076A2 (en) 2014-01-23 2015-07-30 Symed Labs Limited Improved processes for the preparation of highly pure rivaroxaban crystal modification i

Also Published As

Publication number Publication date
WO2015111076A3 (en) 2015-11-12
WO2015111076A2 (en) 2015-07-30
US9469628B2 (en) 2016-10-18
US20150203482A1 (en) 2015-07-23

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