IN2013CH05537A - - Google Patents
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- Publication number
- IN2013CH05537A IN2013CH05537A IN5537CH2013A IN2013CH05537A IN 2013CH05537 A IN2013CH05537 A IN 2013CH05537A IN 5537CH2013 A IN5537CH2013 A IN 5537CH2013A IN 2013CH05537 A IN2013CH05537 A IN 2013CH05537A
- Authority
- IN
- India
- Prior art keywords
- methyl
- cognition
- schizophrenia
- bromophenyl
- piperazinyl
- Prior art date
Links
- 125000006276 2-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C(*)C([H])=C1[H] 0.000 abstract 1
- -1 4-methyl-l-piperazinyl Chemical group 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 230000019771 cognition Effects 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000013403 hyperactivity Diseases 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 239000003751 serotonin 6 antagonist Substances 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 238000002636 symptomatic treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Priority Applications (28)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MEP-2017-193A ME02843B (me) | 2013-12-02 | 2014-02-20 | Proces za masovnu proizvodnju monohidrata 1- [(2-bromofenil)sulfonil]-5-metoksi-3-[( 4- metil- 1-piperazinil)metil]-1h-indol dimezilata |
| EA201691161A EA028038B1 (ru) | 2013-12-02 | 2014-02-20 | Способ для промышленного производства 1-[(2-бромфенил)сульфонил]-5-метокси-3-[(4-метил-1-пиперазинил)метил]-1h-индол димезилат моногидрата |
| IN5537CH2013 IN2013CH05537A (pl) | 2013-12-02 | 2014-02-20 | |
| CA2929309A CA2929309C (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
| ES14725245.6T ES2638856T3 (es) | 2013-12-02 | 2014-02-20 | Procedimiento para la producción a gran escala de dimesilato de 1-[(2-bromofenil)sulfonil]-5-metoxi-3-[(4-metil-1-piperazinil)metil]-1H-indol monohidrato |
| JP2016535680A JP6151453B2 (ja) | 2013-12-02 | 2014-02-20 | １−［（２−ブロモフェニル）スルホニル］−５−メトキシ−３−［（４−メチル−１−ピペラジニル）メチル］−１ｈ−インドールジメシラート一水和物の大規模合成法 |
| BR112016010788-8A BR112016010788B1 (pt) | 2013-12-02 | 2014-02-20 | Processo para a produção em grande escala de monohidrato de dimesilato de 1-[(2-bromofenil)sulfonil]-5-metoxi-3-[(4-metil-1-piperazinil)metil]-1h- indola |
| RS20170853A RS56323B1 (sr) | 2013-12-02 | 2014-02-20 | Proces za masovnu proizvodnju monohidrata 1-[(2-bromofenil)sulfonil]-5-metoksi-3-[(4-metil-1-piperazinil)metil]-1h-indol dimezilata |
| NZ719671A NZ719671A (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
| LTEP14725245.6T LT3077375T (lt) | 2013-12-02 | 2014-02-20 | 1-[(2-bromfenil)sulfonil]-5-metoksi-3-[(4-metil-1-piperazinil)metil]-1h-indolo dimezilato monohidrato didelio našumo gamybos būdas |
| CN201480065601.9A CN105814020B (zh) | 2013-12-02 | 2014-02-20 | 用于大规模生产1‑[(2‑溴苯基)磺酰基]‑5‑甲氧基‑3‑[(4‑甲基‑1‑哌嗪基)甲基]‑1h‑吲哚二甲磺酸盐一水合物的方法 |
| HUE14725245A HUE036008T2 (hu) | 2013-12-02 | 2014-02-20 | Eljárás 1-[(2-brómfenil)szulfonil]-5-metoxi-3-[(4-metil-1-piperazinil)metil]-1H-indol-dimezilát-monohidrát nagyüzemi léptékben történõ elõállítására |
| AP2016009224A AP2016009224A0 (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
| AU2014358682A AU2014358682B2 (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate monohydrate |
| KR1020167013965A KR101808792B1 (ko) | 2013-12-02 | 2014-02-20 | 1-[(2-브로모페닐)술포닐]-5-메톡시-3-[(4-메틸-1-피페라지닐)메틸]-1h-인돌 디메실레이트 모노히드레이트의 대규모 생산 방법 |
| DK14725245.6T DK3077375T3 (en) | 2013-12-02 | 2014-02-20 | PROCEDURE FOR LARGE SCALE PREPARATION OF 1 - [(2-BROMPHENYL) SULPHONYL] -5-METHOXY-3 - [(4-METHYL-1-PIPERAZINYL) METHYL] -1H-INDOL-DIMESYLATE-MONOHYDRATE |
| US15/100,489 US9540321B2 (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate monohydrate |
| SI201430348T SI3077375T1 (sl) | 2013-12-02 | 2014-02-20 | Postopek za obsežno pripravo 1-((2-bromofenil)sulfonil)-5-metoksi-3- ((4-metil-1-piperazinil)metil)-1h-indol dimesilat monohidrata |
| MX2016006629A MX364930B (es) | 2013-12-02 | 2014-02-20 | Proceso de producción a gran escala de dimesilato de 1-[(2-bromofenil]sulfonil]-5-metoxi-3-[(4-metil-1-piperazinil)met il]-1h-indol monohidratado. |
| PCT/IN2014/000109 WO2015083179A1 (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
| EP14725245.6A EP3077375B1 (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
| PL14725245T PL3077375T3 (pl) | 2013-12-02 | 2014-02-20 | Sposób wytwarzania na dużą skalę monohydratu dimesylanu 1-[(2 bromofenylo)sulfonylo]-5-metoksy-3-[(4-metylo-1-piperazynylo)metylo]-1h-indolu |
| PT147252456T PT3077375T (pt) | 2013-12-02 | 2014-02-20 | Processo para produção em massa de 1-[(2- bromofenil)sulfonilo]-5-metoxi-3-[(4-metilo-1- piperazinil)metilo]-dimesilato de 1h-indol mono-hidratado |
| ZA2016/02954A ZA201602954B (en) | 2013-12-02 | 2016-05-03 | Process for large scale production of 1-{(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
| IL245619A IL245619B (en) | 2013-12-02 | 2016-05-11 | Process for the high-volume production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate salt monohydrate |
| HK16114655A HK1226396B (zh) | 2013-12-02 | 2016-12-23 | 用於大規模生產1-[(2-溴苯基)磺醯基]-5-甲氧基-3-[(4-甲基-1-呱嗪基)甲基]-1h-吲哚二甲磺酸鹽一水合物的方法 |
| HRP20171245TT HRP20171245T1 (hr) | 2013-12-02 | 2017-08-16 | Postupak za proizvodnju velikih razmjera monohidrata 1-[(2-bromofenil)sulfonil]-5-metoksi-3-[(4-metil-1-piperazinil)metil]-1h-indol dimezilata |
| CY20171100904T CY1119298T1 (el) | 2013-12-02 | 2017-08-28 | Διαδικασια για παραγωγη μεγαλης κλιμακας του 1-(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-1 νdole dimesylate mono-enyδρου |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN5537CH2013 IN2013CH05537A (pl) | 2013-12-02 | 2014-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2013CH05537A true IN2013CH05537A (pl) | 2015-06-12 |
Family
ID=54199404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN5537CH2013 IN2013CH05537A (pl) | 2013-12-02 | 2014-02-20 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9540321B2 (pl) |
| EP (1) | EP3077375B1 (pl) |
| JP (1) | JP6151453B2 (pl) |
| KR (1) | KR101808792B1 (pl) |
| CN (1) | CN105814020B (pl) |
| AP (1) | AP2016009224A0 (pl) |
| AU (1) | AU2014358682B2 (pl) |
| BR (1) | BR112016010788B1 (pl) |
| CA (1) | CA2929309C (pl) |
| CY (1) | CY1119298T1 (pl) |
| DK (1) | DK3077375T3 (pl) |
| EA (1) | EA028038B1 (pl) |
| ES (1) | ES2638856T3 (pl) |
| HK (1) | HK1226396B (pl) |
| HR (1) | HRP20171245T1 (pl) |
| HU (1) | HUE036008T2 (pl) |
| IL (1) | IL245619B (pl) |
| IN (1) | IN2013CH05537A (pl) |
| LT (1) | LT3077375T (pl) |
| ME (1) | ME02843B (pl) |
| MX (1) | MX364930B (pl) |
| NZ (1) | NZ719671A (pl) |
| PL (1) | PL3077375T3 (pl) |
| PT (1) | PT3077375T (pl) |
| RS (1) | RS56323B1 (pl) |
| SI (1) | SI3077375T1 (pl) |
| WO (1) | WO2015083179A1 (pl) |
| ZA (1) | ZA201602954B (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6606299B2 (ja) * | 2016-05-18 | 2019-11-13 | スヴェン・ライフ・サイエンシズ・リミテッド | 純粋な５−ｈｔ６受容体アンタゴニストとアセチルコリンエステラーゼ阻害剤の組合せ |
| MD3458039T2 (ro) * | 2016-05-18 | 2020-10-31 | Suven Life Sciences Ltd | Combinație triplă de antagoniști ai receptorilor 5-HT6 puri, inhibitori ai acetilcolinesterazei și antagonistul receptorului NMDA |
| CN109069449A (zh) | 2016-05-18 | 2018-12-21 | 苏文生命科学有限公司 | 纯5-ht6受体拮抗剂与nmda受体拮抗剂的组合 |
| US20210346374A1 (en) * | 2016-10-03 | 2021-11-11 | Suven Life Sciences Limited | Pharmaceutical compositions of 5-ht6 receptor antagonist |
| JP6669937B2 (ja) | 2016-10-03 | 2020-03-18 | スヴェン・ライフ・サイエンシズ・リミテッド | ５−ｈｔ６拮抗薬の医薬組成物 |
| NZ761037A (en) | 2017-07-03 | 2022-10-28 | Suven Life Sciences Ltd | New uses of a pure 5-ht6 receptor antagonist |
| MX2022006537A (es) | 2019-12-02 | 2022-12-13 | Suven Life Sciences Ltd | Métodos para tratar síntomas de comportamiento y psicológicos en pacientes con demencia. |
| MX2022006535A (es) | 2019-12-02 | 2022-09-09 | Suven Life Sciences Ltd | Métodos para tratar síntomas de comportamiento y psicológicos en pacientes con demencia. |
| CN111233737B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
| CN111362859B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
| CN111362858B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2749846B1 (fr) * | 1996-06-17 | 1998-09-11 | Pf Medicament | Sel de methanesulfonate d'une arylpiperazine derivee de tryptamine et ses solvates pour usage pharmaceutique |
| NZ572186A (en) * | 2002-11-28 | 2010-02-26 | Suven Life Sciences Ltd | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
| PT1581538E (pt) * | 2002-12-18 | 2007-05-31 | Suven Life Sciences Ltd | Indolos tetracíclicos substituidos na posição 3 que possuem afinidade pelo receptor de serotonina. |
| US7989639B2 (en) * | 2006-06-12 | 2011-08-02 | Novartis Ag | Process for making salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide |
-
2014
- 2014-02-20 HU HUE14725245A patent/HUE036008T2/hu unknown
- 2014-02-20 JP JP2016535680A patent/JP6151453B2/ja active Active
- 2014-02-20 EA EA201691161A patent/EA028038B1/ru unknown
- 2014-02-20 PL PL14725245T patent/PL3077375T3/pl unknown
- 2014-02-20 AU AU2014358682A patent/AU2014358682B2/en active Active
- 2014-02-20 ME MEP-2017-193A patent/ME02843B/me unknown
- 2014-02-20 RS RS20170853A patent/RS56323B1/sr unknown
- 2014-02-20 CA CA2929309A patent/CA2929309C/en active Active
- 2014-02-20 KR KR1020167013965A patent/KR101808792B1/ko active IP Right Grant
- 2014-02-20 BR BR112016010788-8A patent/BR112016010788B1/pt active IP Right Grant
- 2014-02-20 CN CN201480065601.9A patent/CN105814020B/zh active Active
- 2014-02-20 LT LTEP14725245.6T patent/LT3077375T/lt unknown
- 2014-02-20 US US15/100,489 patent/US9540321B2/en active Active
- 2014-02-20 AP AP2016009224A patent/AP2016009224A0/en unknown
- 2014-02-20 SI SI201430348T patent/SI3077375T1/sl unknown
- 2014-02-20 DK DK14725245.6T patent/DK3077375T3/en active
- 2014-02-20 MX MX2016006629A patent/MX364930B/es active IP Right Grant
- 2014-02-20 EP EP14725245.6A patent/EP3077375B1/en active Active
- 2014-02-20 PT PT147252456T patent/PT3077375T/pt unknown
- 2014-02-20 ES ES14725245.6T patent/ES2638856T3/es active Active
- 2014-02-20 WO PCT/IN2014/000109 patent/WO2015083179A1/en active Application Filing
- 2014-02-20 IN IN5537CH2013 patent/IN2013CH05537A/en unknown
- 2014-02-20 NZ NZ719671A patent/NZ719671A/en unknown
-
2016
- 2016-05-03 ZA ZA2016/02954A patent/ZA201602954B/en unknown
- 2016-05-11 IL IL245619A patent/IL245619B/en active IP Right Grant
- 2016-12-23 HK HK16114655A patent/HK1226396B/zh unknown
-
2017
- 2017-08-16 HR HRP20171245TT patent/HRP20171245T1/hr unknown
- 2017-08-28 CY CY20171100904T patent/CY1119298T1/el unknown
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